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AR061476A1 - Composicion farmaceutica con efecto anticonvulsivo sinergico - Google Patents

Composicion farmaceutica con efecto anticonvulsivo sinergico

Info

Publication number
AR061476A1
AR061476A1 ARP070102636A ARP070102636A AR061476A1 AR 061476 A1 AR061476 A1 AR 061476A1 AR P070102636 A ARP070102636 A AR P070102636A AR P070102636 A ARP070102636 A AR P070102636A AR 061476 A1 AR061476 A1 AR 061476A1
Authority
AR
Argentina
Prior art keywords
alkyl
heterocyclic
aryl
group
unsubstituted
Prior art date
Application number
ARP070102636A
Other languages
English (en)
Inventor
Thomas Stohr
Original Assignee
Sanol Arznei Schwarz Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42738170&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR061476(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from EP06021470A external-priority patent/EP1920780A1/en
Priority claimed from EP06024241A external-priority patent/EP1925314A1/en
Application filed by Sanol Arznei Schwarz Gmbh filed Critical Sanol Arznei Schwarz Gmbh
Publication of AR061476A1 publication Critical patent/AR061476A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A61P25/10—Antiepileptics; Anticonvulsants for petit-mal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A61P25/12—Antiepileptics; Anticonvulsants for grand-mal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/32—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents for packaging two or more different materials which must be maintained separate prior to use in admixture

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Mechanical Engineering (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

Una composicion farmacéutica que comprende un compuesto (a) de una clase de compuestos péptidos y al menos un compuesto adicional (b) para la prevencion, alivio y/o tratamiento de ataques epilépticos. Reivindicacion 1: Una composicion farmacéutica caracterizada porque comprende (a) un compuesto que tiene la formula general (1) en donde, R es hidrogeno, alquilo, alquenilo, alquinilo, arilo, aril alquilo heterocíclico, heterocíclico alquilo, alquilo heterocíclico, cicloalquilo o cicloalquil alquilo, y R está insustituido o está sustituido con al menos un grupo aceptor de electrones, y/o al menos un grupo donante de electrones; R1 es hidrogeno o alquilo, alquenilo, alquinilo, aril alquilo, arilo, heterocíclico alquilo, alquilo heterocíclico, heterocíclico, cicloalquilo, cicloalquil alquilo, cada uno insustituido o sustituido con al menos un grupo donante de electrones y/o al menos un grupo aceptor de electrones; R2 y R3 son independientemente hidrogeno, alquilo, alquenilo, alquinilo, alcoxi, alcoxialquilo, aril alquilo, arilo, halo, heterocíclico, heterocíclico alquilo, alquilo heterocíclico, cicloalquilo, cicloalquil alquilo, o Z-Y en donde R2 y R3 pueden estar insustituidos o sustituidos con al menos un grupo aceptor de electrones y/o al menos un grupo donante de electrones; y en donde el heterocíclico en R2 y R3 es furilo, tienilo, pirazolilo, pirrolilo, metilpirrolilo, imidazolilo, indolilo, tiazolilo, oxazolilo, isotiazolilo, isoxazolilo, piperidilo, pirrolinilo, piperazinilo, quinolilo, triazolilo, tetrazolilo, isoquinolilo, benzofurilo, benzotienilo, morfolinilo, benzoxazolilo, tetrahidrofurilo, piranilo, indazolilo, purinilo, indolinilo, pirazolindinilo, imidazolinilo, imadazolindinilo, pirrolidinilo, furazanilo, N-metilindofilo, metilfurilo, piridazinilo, pirimidinilo, pirazinilo, piridilo, epoxi, aziridino, oxetanilo, azetidinilo, o cuando N está presente en el heterocíclico, un N-oxido del mismo; Z es O, S, S(O)a, NR4, NR'6, PR4 o un enlace químico; Y es hidrogeno, alquilo, arilo, aril alquilo, alquenilo, alquinilo, halo, heterocíclico, heterocíclico alquilo, alquil heterocíclico e Y puede estar insustituido o sustituido con al menos un grupo donante de electrones y/o al menos un grupo aceptor de electrones, en donde el heterocíclico tiene el mismo significado que en R2 o R3 y, con la condicion de que, cuando Y es halo, Z es un enlace químico, o ZY tomados conjuntamente son NR4NR5R7, NR4OR5, ONR4R7, OPR4R5, PR4OR5, SNR4R7, NR4SR7, SPR4R5, PR4SR7, NR4PR5R6, PR4NR5R7, N+R5R6R7, NR4C(=O)R5, SC(=O)R5, NR4C(=O)OR5, SC(=O)OR5 o NR4NR5C(=O)OR6; R'6 es hidrogeno, alquilo, alquenilo o alquinilo y que puede estar insustituido o sustituido con al menos un grupo aceptor de electrones y/o al menos un grupo donante de electrones; R4, R5 y R6 son independientemente hidrogeno, alquilo, arilo, aril alquilo, alquenilo, o alquinilo, en donde R4, R5 y R6 pueden estar independientemente insustituidos o sustituidos con al menos un grupo aceptor de electrones y/o al menos un grupo donante de electrones; y R7 es R6 o COOR8 o COR8, en donde R7 puede estar insustituido o sustituido con al menos un grupo aceptor de electrones y/o al menos un grupo donante de electrones; R8 es hidrogeno o alquilo, o aril alquilo, y el grupo arilo o alquilo puede estar insustituido o sustituido con al menos un grupo aceptor de electrones y/o al menos un grupo donante de electrones; y n es 1-4; a es 1-3; o una sal farmacéuticamente aceptable del mismo; y (b) al menos un compuesto adicional para la prevencion, alivio y/o tratamiento de ataques epilépticos, que es diferente del compuesto (a), opcionalmente junto con un portador, diluyente, y/o adyuvante farmacéuticamente aceptable, en donde esta composicion tiene un efecto sinérgico para la prevencion, alivio y/o tratamiento de ataques epilépticos a comparacion con el efecto de los compuestos (a) y (b) provistos en forma individual.
ARP070102636A 2006-06-15 2007-06-15 Composicion farmaceutica con efecto anticonvulsivo sinergico AR061476A1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US81396706P 2006-06-15 2006-06-15
EP06021470A EP1920780A1 (en) 2006-10-12 2006-10-12 Peptide compounds for the treatment of hyperexcitability disorders
EP06021469 2006-10-12
EP06024241A EP1925314A1 (en) 2006-11-22 2006-11-22 Pharmaceutical composition with synergistic anticonvulsant effect

Publications (1)

Publication Number Publication Date
AR061476A1 true AR061476A1 (es) 2008-08-27

Family

ID=42738170

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP070102636A AR061476A1 (es) 2006-06-15 2007-06-15 Composicion farmaceutica con efecto anticonvulsivo sinergico

Country Status (19)

Country Link
US (4) US8735356B2 (es)
EP (4) EP2992891B1 (es)
JP (3) JP5443981B2 (es)
KR (2) KR101518427B1 (es)
CN (1) CN102846601B (es)
AR (1) AR061476A1 (es)
AU (1) AU2007260207B2 (es)
BR (1) BRPI0713594A2 (es)
CA (1) CA2651679C (es)
CY (1) CY1114920T1 (es)
DK (1) DK2462990T3 (es)
EA (2) EA027836B1 (es)
ES (4) ES2450070T5 (es)
MX (1) MX2008016000A (es)
PL (1) PL2462990T3 (es)
PT (1) PT2462990E (es)
SI (1) SI2462990T1 (es)
TW (1) TWI397417B (es)
WO (1) WO2007144195A2 (es)

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US8933065B2 (en) * 2008-04-01 2015-01-13 The University Of North Carolina At Chapel Hill N-benzylamide substituted derivatives of 2-(acylamido)acetic acid and 2-(acylamido)propionic acids: potent neurological agents
JP2010024156A (ja) * 2008-07-16 2010-02-04 Ucb Pharma Sa レベチラセタムを含む医薬組成物
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EP2468261A1 (en) 2010-12-02 2012-06-27 UCB Pharma GmbH Formulation of lacosamide
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US20170035733A1 (en) * 2013-11-29 2017-02-09 Ucb Pharma Gmbh Pharmaceutical composition comprising lacosamide and levetiracetam
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