AR066834A1 - Espirobenzoazepanos como antagonistas de vasopresina, composiciones farmaceuticas que los contienen, proceso de preparacion y usos para el tratamiento de afecciones cardiacas, renales y del sistema nervioso central. - Google Patents
Espirobenzoazepanos como antagonistas de vasopresina, composiciones farmaceuticas que los contienen, proceso de preparacion y usos para el tratamiento de afecciones cardiacas, renales y del sistema nervioso central.Info
- Publication number
- AR066834A1 AR066834A1 ARP080102341A ARP080102341A AR066834A1 AR 066834 A1 AR066834 A1 AR 066834A1 AR P080102341 A ARP080102341 A AR P080102341A AR P080102341 A ARP080102341 A AR P080102341A AR 066834 A1 AR066834 A1 AR 066834A1
- Authority
- AR
- Argentina
- Prior art keywords
- amino
- alkyl
- imino
- ring
- carbonyl
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title 1
- 230000000747 cardiac effect Effects 0.000 title 1
- 210000000653 nervous system Anatomy 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- -1 phenyl-carbonyl-amino, biphenyl-carbonyl-amino Chemical group 0.000 abstract 8
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 125000001072 heteroaryl group Chemical group 0.000 abstract 7
- 125000000623 heterocyclic group Chemical group 0.000 abstract 4
- 125000003282 alkyl amino group Chemical group 0.000 abstract 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 125000002349 hydroxyamino group Chemical group [H]ON([H])[*] 0.000 abstract 2
- 125000006274 (C1-C3)alkoxy group Chemical group 0.000 abstract 1
- 125000003830 C1- C4 alkylcarbonylamino group Chemical group 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/32—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems containing carbocyclic rings other than six-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Reivindicacion 1: Un compuesto que tiene la estructura general mostrada en la formula (1), o una forma del mismo, donde, El Anillo A se selecciona del grupo formado por el Anillo R1a, el Anillo R1b, el Anillo R1c, el Anillo R1d, el Anillo R1e, el Anillo R1f, el Anillo R1g, el Anillo R1h, el Anillo R1i, el Anillo R2a, el Anillo R2b, el Anillo R2c, el Anillo R2d, el Anillo R2e, el Anillo R2f, el Anillo R2g, el Anillo R2h, y el Anillo R2i, de las formulas (2), U es fenil-carbonil-amino, bifenil-carbonil-amino, heterociclilo o heteroarilo, donde heterociclilo y heteroarilo están opcionalmente sustituidos, en forma individual, con aIquiIo C1-4, y donde cada fenilo está opcionalmente sustituido con uno, dos o tres sustituyentes seleccionados independientemente de alquiIo C1-4, alcoxi C1-4, halogeno, hidroxi, carboxi, amino, aIquil C1-4-amino o dialquil C1-4-amino; Ves CH o N; W es hidrogeno o alcoxi C1-3; R1 es amino, aIquil C1-4-amino, dialquil C1-4-amino, hidroxi-amino, amino-alquil C1-4-carbonil-amino, alquiI C1-4-amino-aIquil C1-4-carbonil-amino, dialquil C1-4-amino-alquilC1-4-carbonil-amino, amino-sulfonil-amino, alquil C1-4-imino, alcoxi C1-4-imino, hidroxi-imino, amino-imino, alquil C1-4-amino-imino, dialquil C1-4-amino-imino, amino-alcoxi C1-4-imino, alquil C1-4-amino-alcoxi C1-4-imino, dialquil C1-4-amino-alcoxi C1-4-imino, heteroarilo, heteroaril-amino-imino o heteroaril-carbonil-amino-imino, donde cada heteroarilo está opcionalmente sustituido con alquiIo C1-4; y, R2 es oxo, amino, alquil C1-4-amino, dialquil C1-4-amino, hidroxi-amino, amino-alquilo C1-4, alquiI C1-4-amino-aIquilo C1-4, dialquil C1-4-amino-alquilo C1-4, amino-alquil C1-4-amino, alquil C1-4-amino-alquil C1-4-amino, dialquil C1-4-amino-alquil C1-4-amino, amino-sulfonil-amino, amino-sulfonil-amino-carbonilo, alquil C1-4-amino-sulfonil-amino-carbonilo, dialquil C1-4-amino-sulfonil-amino-carbonilo, alcoxi C1-4-carbonil-metileno, carboxi-metileno, amino-carbonil-metileno, alquil C1-4-amino-carbonil-metileno, dialquil C1-4-amino-carbonil-metileno, hidroxi-alquil C1-4-amino-carbonil-metileno, amino-alquil C1-4-amino-carbonil-metileno, alquil C1-4-amino-alquil C1-4-amino-carbonil-metileno, dialquil C1-4-amino-alquil C1-4-amino-carbonil-metileno, heterociclil-alquil C1-4-amino-carbonil-metileno, alquil C1-4-imino, alcoxi C1-4-imino, hidroxi-imino, carboxi-alcoxi C1-4-imino, amino-imino, alquil C1-4-amino-imino, dialquil C1-4-amino-imino, aril-oxi-imino, heterociclilo o heteroarilo, donde heterociclilo y heteroarilo están opcionalmente sustituidos, en forma individual, con alquilo C1-4.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94221607P | 2007-06-06 | 2007-06-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR066834A1 true AR066834A1 (es) | 2009-09-16 |
Family
ID=39816444
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP080102341A AR066834A1 (es) | 2007-06-06 | 2008-06-03 | Espirobenzoazepanos como antagonistas de vasopresina, composiciones farmaceuticas que los contienen, proceso de preparacion y usos para el tratamiento de afecciones cardiacas, renales y del sistema nervioso central. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20080306044A1 (es) |
| AR (1) | AR066834A1 (es) |
| CL (1) | CL2008001649A1 (es) |
| PA (1) | PA8782601A1 (es) |
| PE (1) | PE20090360A1 (es) |
| TW (1) | TW200911269A (es) |
| UY (1) | UY31120A1 (es) |
| WO (1) | WO2008154347A1 (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014062888A1 (en) | 2012-10-18 | 2014-04-24 | University Of South Florida | Compositions and methods for treating stroke |
| WO2014134391A1 (en) | 2013-02-28 | 2014-09-04 | Bristol-Myers Squibb Company | Phenylpyrazole derivatives as potent rock1 and rock2 inhibitors |
| TW201444798A (zh) | 2013-02-28 | 2014-12-01 | 必治妥美雅史谷比公司 | 作爲強效ｒｏｃｋ１及ｒｏｃｋ２抑制劑之苯基吡唑衍生物 |
| WO2022032073A2 (en) * | 2020-08-07 | 2022-02-10 | Casma Therapeutics, Inc. | Trpml modulators |
| EP4253367A4 (en) * | 2020-11-26 | 2024-10-23 | Shanghai Jemincare Pharmaceuticals Co., Ltd. | NOVEL BENZAZEPINESPIRO DERIVATIVE |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE305454T1 (de) * | 2000-07-05 | 2005-10-15 | Ortho Mcneil Pharm Inc | Nichtpeptidische substituierte spirobenzoazepine als vasopressin antagonisten |
| AU2004281257C1 (en) * | 2003-06-17 | 2010-07-01 | Janssen Pharmaceutica N.V. | Substituted spirobenzazepines |
| EA200501829A1 (ru) * | 2003-06-17 | 2006-06-30 | Янссен Фармацевтика Н. В. | Способ получения непептидных замещённых спиробензоазепиновых производных |
| AU2007299822A1 (en) * | 2006-09-22 | 2008-03-27 | Janssen Pharmaceutica N.V. | Spiro benzazepines as vasopressin antagonists |
-
2008
- 2008-06-03 AR ARP080102341A patent/AR066834A1/es unknown
- 2008-06-04 PA PA20088782601A patent/PA8782601A1/es unknown
- 2008-06-04 PE PE2008000946A patent/PE20090360A1/es not_active Application Discontinuation
- 2008-06-05 CL CL200801649A patent/CL2008001649A1/es unknown
- 2008-06-05 TW TW097120840A patent/TW200911269A/zh unknown
- 2008-06-05 UY UY31120A patent/UY31120A1/es unknown
- 2008-06-06 US US12/134,291 patent/US20080306044A1/en not_active Abandoned
- 2008-06-06 WO PCT/US2008/066053 patent/WO2008154347A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| TW200911269A (en) | 2009-03-16 |
| WO2008154347A1 (en) | 2008-12-18 |
| PA8782601A1 (es) | 2009-01-23 |
| CL2008001649A1 (es) | 2008-10-03 |
| PE20090360A1 (es) | 2009-04-01 |
| US20080306044A1 (en) | 2008-12-11 |
| UY31120A1 (es) | 2009-01-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CL2017001191A1 (es) | Compuestos derivados de carbamoilpiridona policíclicos; composición farmacéutica que los comprende; y su uso para el tratamiento de una infección de vih en un humano que tiene o se encuentra en riesgo de tener la infección. | |
| MX2013007295A (es) | Quinoxalinas y aza-quinoxalinas como moduladores del receptor de crth2. | |
| ECSP12012326A (es) | Derivados de aminopirimidina como moduladores de la lrrk2 | |
| PE20141557A1 (es) | Derivado de pirazoloquinolina | |
| PE20090492A1 (es) | Compuestos heterociclos como inhibidores de cinasa de fosfatidil-inositol-3 | |
| PH12013502463A1 (en) | Trpv4 antagonists | |
| PH12018500763A1 (en) | New spiro[3h-indole-3,2'-pyrrolidin]-2(1h)-one compounds and derivatives as mdm2-p53 inhibitors | |
| CO6390080A2 (es) | Compuestos organicos | |
| BR112014015720A2 (pt) | derivados de tieno[3,2-d]pirimidina que têm atividade inibidora de proteinas quinases | |
| AR064454A1 (es) | Derivados de pirazol con efecto inhibitorio de fgfr, metodos para su sintesis, composicion farmaceutica que los comprende, un proceso para la preparacion de la misma y su uso en la fabricacion de un medicamento para el tratamiento del cancer. | |
| UY35377A (es) | Compuestos de 1,3-oxazin-2-amina fusionados con ciclopropilo perfluorado como inhibidores de beta-secretasa y métodos de uso | |
| AR078786A1 (es) | Derivados de la cromenona | |
| AR074002A1 (es) | Pirazolo e imidazopiridinilpirimidinaminas como inhibidores de la tirosina kinasa (igr-ir) | |
| PE20150776A1 (es) | 6-aminoacido-heteroarildihidropirimidinas para el tratamiento y profilaxis de la infeccion del virus de la hepatitis b | |
| UY32462A (es) | Derivados de bifenilo novedosos para el tratamiento de infección por virus de hepatitis c 644 | |
| MX390286B (es) | Combinaciones que comprenden brexpiprazol o una sal del mismo y un segundo farmaco para el uso en el tratamiento de un trastorno del sistema nervioso central. | |
| SV2010003662A (es) | Derivados de azetidina y ciclobutano como inhibidores de jak ref. x-19081 | |
| CR11641A (es) | Derivados heterociclicos de urea y metodos de uso de los mismos-211 | |
| AR061620A1 (es) | Suspensiones acuosas de tmc278 | |
| CL2007001711A1 (es) | Compuestos derivados de pirazolopiridina sustituida;composicion farmaceutica que los comprende;metodo de preparacion de los compuestos ,compuestos intermediarios;y su uso en el tratamiento de enfermedades,tales como tumores,artritis reumatoide,enfermedades del crecimiento vascular desregulado, entre otras. | |
| AR071120A1 (es) | Derivados de diosmetina, su procedimiento de preparacion, las composiciones farmaceuticas que los contienen y su uso en el tratamiento de las enfermedades venosas cronicas. | |
| ECSP12012201A (es) | Inhibidores no nucleosídicos de la transcriptasa inversa | |
| AR066834A1 (es) | Espirobenzoazepanos como antagonistas de vasopresina, composiciones farmaceuticas que los contienen, proceso de preparacion y usos para el tratamiento de afecciones cardiacas, renales y del sistema nervioso central. | |
| AR084637A1 (es) | Compuestos heterociclicos apropiados para el tratamiento de la dislipidemia | |
| AR078461A1 (es) | Inhibidores macrociclicos de la replicacion de virus de la hepatitis c |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |