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MX2013007295A - Quinoxalinas y aza-quinoxalinas como moduladores del receptor de crth2. - Google Patents

Quinoxalinas y aza-quinoxalinas como moduladores del receptor de crth2.

Info

Publication number
MX2013007295A
MX2013007295A MX2013007295A MX2013007295A MX2013007295A MX 2013007295 A MX2013007295 A MX 2013007295A MX 2013007295 A MX2013007295 A MX 2013007295A MX 2013007295 A MX2013007295 A MX 2013007295A MX 2013007295 A MX2013007295 A MX 2013007295A
Authority
MX
Mexico
Prior art keywords
quinoxalines
aza
receptor modulators
crth2 receptor
compounds
Prior art date
Application number
MX2013007295A
Other languages
English (en)
Inventor
Xiao Chen
Dong Xiao
Younong Yu
Xianhai Huang
Anandan Palani
Li Dong
Jun Qin
Kevin D Mccormick
Christopher W Boyce
Salem Fevrier
Henry M Vaccaro
Robert D Mazzola Jr
Sylvia Joanna Degrado
Jie Wu
Ashwin Umesh Rao
Purakkattle Johny Biju
Pawan K Dhondi
Robert George Aslanian
Phieng Siliphaivanh
Joey Lee Methot
Hongjun Zhang
Elizabeth Helen Kelley
William Colby Brown
Qin Jiang
Jolicia Polivina Gauuan
Andrew J Leyhane
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of MX2013007295A publication Critical patent/MX2013007295A/es

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    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
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  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La invención proporciona ciertas quinoxalinas y aza-quinoxaIinas de Fórmula (I), (Ver Formula) y sus sales farmacéuticamente aceptables, en la que J1, J2, R1, R2, R3, R22, Ra, Rb, Rc, Rd, X, Y, b, n y q son como se definen en el presente documento; la invención también proporciona composiciones farmacéuticas que comprenden dichos compuestos, y procedimientos de uso de los compuestos para tratar enfermedades o afecciones asociadas con la estimulación incontrolada o inapropiada de la función de CRTH2.
MX2013007295A 2010-12-23 2011-12-19 Quinoxalinas y aza-quinoxalinas como moduladores del receptor de crth2. MX2013007295A (es)

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KR20130133219A (ko) 2013-12-06
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US9469615B2 (en) 2016-10-18
EP2661428A4 (en) 2014-12-17
JP5952829B2 (ja) 2016-07-13
ES2635030T3 (es) 2017-10-02
AU2011349524A1 (en) 2013-05-30
CA2818597A1 (en) 2012-06-28
RU2589709C2 (ru) 2016-07-10
TW201307302A (zh) 2013-02-16
US20130303517A1 (en) 2013-11-14
WO2012087861A1 (en) 2012-06-28
EP2661428A1 (en) 2013-11-13
AR084573A1 (es) 2013-05-29
CN103702985A (zh) 2014-04-02
JP2014500323A (ja) 2014-01-09
RU2013134334A (ru) 2015-01-27
BR112013015397A2 (pt) 2016-09-20
AU2011349524B2 (en) 2016-06-02

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