PE20090689A1 - Anticuerpos del antagonista ox40 y su uso en el tratamiento de enfermedades inflamatorias y autoinmunes - Google Patents
Anticuerpos del antagonista ox40 y su uso en el tratamiento de enfermedades inflamatorias y autoinmunesInfo
- Publication number
- PE20090689A1 PE20090689A1 PE2008000393A PE2008000393A PE20090689A1 PE 20090689 A1 PE20090689 A1 PE 20090689A1 PE 2008000393 A PE2008000393 A PE 2008000393A PE 2008000393 A PE2008000393 A PE 2008000393A PE 20090689 A1 PE20090689 A1 PE 20090689A1
- Authority
- PE
- Peru
- Prior art keywords
- amino acid
- acid sequence
- seq
- antibody
- inflammatory
- Prior art date
Links
- 208000023275 Autoimmune disease Diseases 0.000 title abstract 2
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 title abstract 2
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 title abstract 2
- 208000027866 inflammatory disease Diseases 0.000 title abstract 2
- 230000002757 inflammatory effect Effects 0.000 title abstract 2
- 239000005557 antagonist Substances 0.000 title 1
- 150000001413 amino acids Chemical group 0.000 abstract 6
- 208000011231 Crohn disease Diseases 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 201000006417 multiple sclerosis Diseases 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C07—ORGANIC CHEMISTRY
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Hematology (AREA)
- Biophysics (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Transplantation (AREA)
- Endocrinology (AREA)
- Otolaryngology (AREA)
- Gastroenterology & Hepatology (AREA)
- Emergency Medicine (AREA)
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Abstract
SE REFIERE A UN ANTICUERPO QUIMERICO, HUMANIZADO, MONOCLONAL O RECOMBINANTE QUE SE ENLAZA A UN EPITOPE OX40 HUMANO, QUE COMPRENDE: A) UNA REGION VARIABLE DE CADENA PESADA QUE COMPRENDE i) UN VH CDR1 QUE TIENE LA SECUENCIA DE AMINOACIDOS DE ID SEC NO. 17, ii) UN VH CDR2 QUE TIENE LA SECUENCIA DE AMINOACIDOS DE ID SEC NO. 18, Y iii) UN VH CDR3 QUE TIENE LA SECUENCIA DE AMINOACIDOS DE ID SEC NO. 19; B) UNA REGION VARIABLE DE CADENA LIGERA QUE COMPRENDE: i) UN VL CDR1 QUE TIENE LA SECUENCIA DE AMINOACIDOS DE ID SEC NO. 12, 15 O 61, ii) UN VL CDR2 QUE TIENE LA SECUENCIA DE AMINOACIDOS DE ID SEC NO. 13, Y iii) UN VL CDR3 QUE TIENE LA SECUENCIA DE AMINOACIDOS DE ID SEC NO. 14 O 16; Y C) UNA REGION CONSTANTE DE DOMINIO CH1, CH2 O CH3 QUE ES DE UN ANTICUERPO DE IgG1, IgG2, IgG3 O IgG4. SE REFIERE TAMBIEN A UNA MOLECULA DE ACIDO NUCLEICO QUE CODIFICA EL ANTICUERPO, UN VECTOR, UNA CELULA HUESPED, UNA COMPOSICION FARMACEUTICA QUE LO CONTIENE Y A UN METODO DE PRODUCCION. DICHO ANTICUERPO ES UTIL PARA EL TRATAMIENTO DE ENFERMEDADES INFLAMATORIAS Y AUTOINMUNES TALES COMO ESCLEROSIS MULTIPLE, ARTRITIS REUMATOIDE, ENFERMEDAD DE CROHN
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90369307P | 2007-02-27 | 2007-02-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20090689A1 true PE20090689A1 (es) | 2009-06-20 |
Family
ID=39620235
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2008000393A PE20090689A1 (es) | 2007-02-27 | 2008-02-27 | Anticuerpos del antagonista ox40 y su uso en el tratamiento de enfermedades inflamatorias y autoinmunes |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US20100136030A1 (es) |
| EP (1) | EP2125891A2 (es) |
| JP (1) | JP2010518873A (es) |
| KR (1) | KR20100014588A (es) |
| CN (1) | CN101668776A (es) |
| AR (1) | AR065506A1 (es) |
| AU (1) | AU2008219666A1 (es) |
| BR (1) | BRPI0807269A2 (es) |
| CA (1) | CA2679399A1 (es) |
| CL (1) | CL2008000578A1 (es) |
| CO (1) | CO6231009A2 (es) |
| CR (1) | CR11042A (es) |
| EC (1) | ECSP099656A (es) |
| IL (1) | IL200572A0 (es) |
| MA (1) | MA31246B1 (es) |
| MX (1) | MX2009009194A (es) |
| PE (1) | PE20090689A1 (es) |
| RU (1) | RU2009135824A (es) |
| TW (1) | TW200846367A (es) |
| WO (1) | WO2008106116A2 (es) |
Families Citing this family (89)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7291331B1 (en) | 2002-09-11 | 2007-11-06 | La Jolla Institute For Allergy And Immunology | Methods of treating OX40 medicated recall immune responses |
| ZA200804868B (en) | 2005-12-16 | 2009-10-28 | Genentech Inc | Anti-OX40L antibodies and methods using same |
| ES2825173T3 (es) | 2009-01-21 | 2021-05-14 | Amgen Inc | Composiciones y métodos de tratamiento de enfermedades inflamatorias y autoinmunitarias |
| JP5782385B2 (ja) * | 2009-02-17 | 2015-09-24 | ユーシービー ファーマ ソシエテ アノニム | ヒトｏｘ４０に対する特異性を有する抗体分子 |
| SI2609118T1 (sl) | 2010-08-23 | 2017-05-31 | The Board Of Regents, The University Of Texas System | Protitelesa proti ox40 in postopki uporabe istih |
| WO2013028231A1 (en) * | 2011-08-23 | 2013-02-28 | Board Of Regents, The University Of Texas System | Anti-ox40 antibodies and methods of using the same |
| EA036047B1 (ru) | 2011-07-11 | 2020-09-18 | Икнос Сайенсиз Са | Антитела, которые связываются с ox40, и их применение |
| GB201116092D0 (en) | 2011-09-16 | 2011-11-02 | Bioceros B V | Antibodies and uses thereof |
| UA112203C2 (uk) | 2011-11-11 | 2016-08-10 | Юсб Фарма С.А. | Злитий білок біоспецифічного антитіла, який зв'язується з ox40 людини та сироватковим альбуміном людини |
| JP6415437B2 (ja) * | 2012-09-17 | 2018-10-31 | ガレクティン・セラピューティクス・インコーポレイテッドＧａｌｅｃｔｉｎ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． | 癌の処置における特異的免疫療法を向上する方法 |
| AU2014238546C1 (en) | 2013-03-18 | 2019-01-17 | Biocerox Products B.V. | Humanized anti-CD134 (OX40) antibodies and uses thereof |
| GB201403775D0 (en) | 2014-03-04 | 2014-04-16 | Kymab Ltd | Antibodies, uses & methods |
| BR112016023238A2 (pt) | 2014-04-11 | 2017-10-17 | Novartis Ag | processos de tratamento seletivo de asma usando antagonistas de il-13 |
| SG11201609721WA (en) | 2014-05-28 | 2016-12-29 | Agenus Inc | Anti-gitr antibodies and methods of use thereof |
| US11111284B2 (en) | 2014-08-21 | 2021-09-07 | The General Hospital Corporation | Tumor necrosis factor superfamily and TNF-like ligand muteins and methods of preparing |
| TW201619200A (zh) * | 2014-10-10 | 2016-06-01 | 麥迪紐有限責任公司 | 人類化抗－ｏｘ４０抗體及其用途 |
| HRP20220811T1 (hr) | 2015-01-08 | 2022-09-30 | BioNTech SE | Agonistička sredstva za vezanje tnf receptora |
| PT3265123T (pt) | 2015-03-03 | 2023-02-01 | Kymab Ltd | Anticorpos, usos e métodos |
| US9512229B2 (en) | 2015-03-03 | 2016-12-06 | Kymab Limited | Synergistic combinations of OX40L antibodies for the treatment of GVHD |
| RU2017134104A (ru) * | 2015-03-11 | 2019-04-03 | Провиденс Хелт Энд Сервисиз-Орегон | Композиции и способы повышения эффективности противораковой терапии |
| WO2016164920A1 (en) * | 2015-04-09 | 2016-10-13 | Cornell University | Gene therapy to prevent reactions to allergens |
| TN2017000432A1 (en) | 2015-04-10 | 2019-04-12 | Amgen Inc | Interleukin-2 muteins for the expansion of t-regulatory cells |
| SG11201708804WA (en) | 2015-05-07 | 2017-11-29 | Agenus Inc | Anti-ox40 antibodies and methods of use thereof |
| SI3303396T1 (sl) | 2015-05-29 | 2023-01-31 | Bristol-Myers Squibb Company | Protitelesa proti OX40 in njihova uporaba |
| WO2017046746A1 (en) | 2015-09-15 | 2017-03-23 | Acerta Pharma B.V. | Therapeutic combinations of a btk inhibitor and a gitr binding molecule, a 4-1bb agonist, or an ox40 agonist |
| CA2999369C (en) * | 2015-09-22 | 2023-11-07 | Spring Bioscience Corporation | Anti-ox40 antibodies and diagnostic uses thereof |
| CN114380908B (zh) * | 2015-10-15 | 2023-03-17 | 苏州丁孚靶点生物技术有限公司 | 抗ox40抗体及其应用 |
| SG10201912984WA (en) * | 2015-12-02 | 2020-03-30 | Agenus Inc | Antibodies and methods of use thereof |
| WO2017134292A1 (en) * | 2016-02-04 | 2017-08-10 | Glenmark Pharmaceuticals S.A. | Anti-ox40 antagonistic antibodies for the treatment of atopic dermatitis |
| WO2017220988A1 (en) | 2016-06-20 | 2017-12-28 | Kymab Limited | Multispecific antibodies for immuno-oncology |
| TWI788307B (zh) | 2016-10-31 | 2023-01-01 | 美商艾歐凡斯生物治療公司 | 用於擴增腫瘤浸潤性淋巴細胞之工程化人造抗原呈現細胞 |
| EP3534947A1 (en) | 2016-11-03 | 2019-09-11 | Kymab Limited | Antibodies, combinations comprising antibodies, biomarkers, uses & methods |
| CA3041340A1 (en) | 2016-11-09 | 2018-05-17 | Agenus Inc. | Anti-ox40 antibodies, anti-gitr antibodies, and methods of use thereof |
| US11117963B2 (en) * | 2016-12-26 | 2021-09-14 | Kyowa Hakko Kirin Co., Ltd. | Antibody which binds to myelin oligodendrocyte glycoprotein |
| US11840565B2 (en) | 2016-12-29 | 2023-12-12 | University Of Miami | Methods and compositions for treating virus-associated inflammation |
| US20190336598A1 (en) | 2016-12-29 | 2019-11-07 | University Of Miami | Methods for modulating inflammasome activity and inflammation in the lung |
| AU2018205234B2 (en) | 2017-01-06 | 2024-09-19 | Iovance Biotherapeutics, Inc. | Expansion of tumor infiltrating lymphocytes (TILs) with tumor necrosis factor receptor superfamily (TNFRSF) agonists and therapeutic combinations of TILs and TNFRSF agonists |
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| US5821332A (en) * | 1993-11-03 | 1998-10-13 | The Board Of Trustees Of The Leland Stanford Junior University | Receptor on the surface of activated CD4+ T-cells: ACT-4 |
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2008
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- 2008-02-26 US US12/526,550 patent/US20100136030A1/en not_active Abandoned
- 2008-02-26 BR BRPI0807269-8A2A patent/BRPI0807269A2/pt not_active IP Right Cessation
- 2008-02-26 CA CA002679399A patent/CA2679399A1/en not_active Abandoned
- 2008-02-26 AU AU2008219666A patent/AU2008219666A1/en not_active Abandoned
- 2008-02-26 CL CL200800578A patent/CL2008000578A1/es unknown
- 2008-02-26 CN CN200880013914A patent/CN101668776A/zh active Pending
- 2008-02-26 KR KR1020097020065A patent/KR20100014588A/ko not_active Withdrawn
- 2008-02-26 EP EP08726081A patent/EP2125891A2/en not_active Withdrawn
- 2008-02-26 WO PCT/US2008/002498 patent/WO2008106116A2/en not_active Ceased
- 2008-02-26 MX MX2009009194A patent/MX2009009194A/es unknown
- 2008-02-26 JP JP2009551698A patent/JP2010518873A/ja not_active Withdrawn
- 2008-02-27 PE PE2008000393A patent/PE20090689A1/es not_active Application Discontinuation
- 2008-02-27 TW TW097106870A patent/TW200846367A/zh unknown
- 2008-02-27 AR ARP080100818A patent/AR065506A1/es unknown
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2009
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- 2009-09-10 MA MA32212A patent/MA31246B1/fr unknown
- 2009-09-23 CO CO09103883A patent/CO6231009A2/es not_active Application Discontinuation
- 2009-09-24 CR CR11042A patent/CR11042A/es unknown
- 2009-09-25 EC EC2009009656A patent/ECSP099656A/es unknown
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| IL200572A0 (en) | 2010-05-17 |
| MX2009009194A (es) | 2009-10-08 |
| WO2008106116A3 (en) | 2008-10-16 |
| EP2125891A2 (en) | 2009-12-02 |
| CA2679399A1 (en) | 2008-09-04 |
| WO2008106116A2 (en) | 2008-09-04 |
| CN101668776A (zh) | 2010-03-10 |
| TW200846367A (en) | 2008-12-01 |
| CO6231009A2 (es) | 2010-12-20 |
| JP2010518873A (ja) | 2010-06-03 |
| ECSP099656A (es) | 2009-10-30 |
| US20100136030A1 (en) | 2010-06-03 |
| BRPI0807269A2 (pt) | 2014-04-29 |
| CR11042A (es) | 2009-11-03 |
| AR065506A1 (es) | 2009-06-10 |
| RU2009135824A (ru) | 2011-04-10 |
| MA31246B1 (fr) | 2010-03-01 |
| CL2008000578A1 (es) | 2008-10-10 |
| KR20100014588A (ko) | 2010-02-10 |
| AU2008219666A1 (en) | 2008-09-04 |
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