AR064002A1 - Quinazolinas sustituidas - Google Patents
Quinazolinas sustituidasInfo
- Publication number
- AR064002A1 AR064002A1 ARP070105272A ARP070105272A AR064002A1 AR 064002 A1 AR064002 A1 AR 064002A1 AR P070105272 A ARP070105272 A AR P070105272A AR P070105272 A ARP070105272 A AR P070105272A AR 064002 A1 AR064002 A1 AR 064002A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- hydrogen
- bromine
- iodine
- alkyl
- Prior art date
Links
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- HXELGNKCCDGMMN-UHFFFAOYSA-N [F].[Cl] Chemical compound [F].[Cl] HXELGNKCCDGMMN-UHFFFAOYSA-N 0.000 abstract 2
- 230000000903 blocking effect Effects 0.000 abstract 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 2
- 229910052794 bromium Inorganic materials 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 229910052740 iodine Inorganic materials 0.000 abstract 2
- 239000011630 iodine Substances 0.000 abstract 2
- 238000006241 metabolic reaction Methods 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 abstract 1
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 210000001772 blood platelet Anatomy 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 229910021645 metal ion Inorganic materials 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Los compuestos de la presente actuan por inhibicion de la megacariocitopoiesis y en consecuencia la formacion de plaquetas sanguíneas. Reivindicacion 1: Un compuesto de la formula (1) o una de sus sales o solvatos farmacéuticamente aceptables, caracterizado porque R1, R2, R3 y R4 independientemente representan hidrogeno o un grupo bloqueador con funcion de prevencion de la reaccion metabolica en la posicion de sustitucion 3; o en donde R1 y R2, y/o R3 y R4 junto con el carbono al que están adosados forman un grupo bloqueador que funciona para prevenir en forma directa o indirecta las reacciones metabolicas en la posicion 3, en donde el resto de los grupos R1 a R4 son hidrogeno; R5 se selecciona del grupo que comprende: fluor cloro, bromo y yodo; R6 se selecciona del grupo que comprende: fluor cloro, bromo y yodo; R7 y R8 son seleccionados independientemente del grupo que comprende: H; halo; ciano; alquilo C1-6, haloalquilo C1-6, alcoxi C1-6, y haloalcoxi C1-6; y R9 es H, alquilo C1-6, o un ion metálico de Grupo I; siempre que R1, R2, R3 y R4 no sean todos hidrogeno, o que cuando uno de R1 y R2 es metilo y R3 y R4 son hidrogeno, entonces el otro de R1 y R2 no es hidrogeno.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0623750.7A GB0623750D0 (en) | 2006-11-28 | 2006-11-28 | Substituted quinazolines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR064002A1 true AR064002A1 (es) | 2009-03-04 |
Family
ID=37671460
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070105272A AR064002A1 (es) | 2006-11-28 | 2007-11-28 | Quinazolinas sustituidas |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP2099802A2 (es) |
| JP (1) | JP2010511030A (es) |
| KR (1) | KR20090094268A (es) |
| CN (1) | CN101558071B (es) |
| AR (1) | AR064002A1 (es) |
| AU (1) | AU2007327047B2 (es) |
| BR (1) | BRPI0719570A2 (es) |
| CA (1) | CA2670123A1 (es) |
| EA (1) | EA018259B1 (es) |
| GB (1) | GB0623750D0 (es) |
| IL (1) | IL198809A0 (es) |
| MX (1) | MX2009005579A (es) |
| TW (1) | TW200838537A (es) |
| WO (1) | WO2008065444A2 (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0808944D0 (en) * | 2008-05-16 | 2008-06-25 | Shire Llc | Substituted quinazolines |
| GB2460915B (en) * | 2008-06-16 | 2011-05-25 | Biovascular Inc | Controlled release compositions of agents that reduce circulating levels of platelets and methods therefor |
| GB0822970D0 (en) | 2008-12-17 | 2009-01-21 | Shire Llc | Process for the preparation of anagrelide and analogues |
| GB201004495D0 (en) | 2010-03-18 | 2010-05-05 | Shire Llc | Subtituted quinazolines |
| GB201017783D0 (en) | 2010-10-21 | 2010-12-01 | Shire Llc | Process for the preparation of anagrelide and analogues thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL7807507A (nl) * | 1977-07-25 | 1979-01-29 | Hoffmann La Roche | Tricyclische verbindingen. |
| CA1131631A (en) | 1979-06-20 | 1982-09-14 | Madhukar S. Chodnekar | Quinazoline derivatives and pharmaceutical preparations |
| ZA803535B (en) * | 1979-06-20 | 1981-06-24 | Hoffmann La Roche | Novel quinazoline derivatives and pharmaceutical preparations |
| OA13018A (en) * | 2003-01-23 | 2006-11-10 | Shire Holings Ag | Formulation and methods for the treatment of thrombocythemia. |
| US7700608B2 (en) * | 2004-08-04 | 2010-04-20 | Shire Holdings Ag | Quinazoline derivatives and their use in the treatment of thrombocythemia |
| US20060030574A1 (en) * | 2004-08-04 | 2006-02-09 | Shire Holdings Ag | Quinazoline derivatives useful for the treatment of peripheral arterial disease and as phosphodiesterase inhibitors |
-
2006
- 2006-11-28 GB GBGB0623750.7A patent/GB0623750D0/en not_active Ceased
-
2007
- 2007-11-19 EA EA200900740A patent/EA018259B1/ru not_active IP Right Cessation
- 2007-11-19 KR KR1020097011682A patent/KR20090094268A/ko not_active Ceased
- 2007-11-19 MX MX2009005579A patent/MX2009005579A/es unknown
- 2007-11-19 AU AU2007327047A patent/AU2007327047B2/en not_active Expired - Fee Related
- 2007-11-19 BR BRPI0719570-2A patent/BRPI0719570A2/pt not_active IP Right Cessation
- 2007-11-19 EP EP07824909A patent/EP2099802A2/en not_active Withdrawn
- 2007-11-19 JP JP2009538792A patent/JP2010511030A/ja active Pending
- 2007-11-19 CN CN2007800442429A patent/CN101558071B/zh not_active Expired - Fee Related
- 2007-11-19 WO PCT/GB2007/050697 patent/WO2008065444A2/en not_active Ceased
- 2007-11-19 CA CA002670123A patent/CA2670123A1/en not_active Abandoned
- 2007-11-27 TW TW096145020A patent/TW200838537A/zh unknown
- 2007-11-28 AR ARP070105272A patent/AR064002A1/es unknown
-
2009
- 2009-05-19 IL IL198809A patent/IL198809A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN101558071A (zh) | 2009-10-14 |
| BRPI0719570A2 (pt) | 2013-12-10 |
| IL198809A0 (en) | 2010-02-17 |
| EA200900740A1 (ru) | 2010-02-26 |
| CA2670123A1 (en) | 2008-06-05 |
| EA018259B1 (ru) | 2013-06-28 |
| WO2008065444B1 (en) | 2008-10-09 |
| JP2010511030A (ja) | 2010-04-08 |
| CN101558071B (zh) | 2013-04-24 |
| AU2007327047B2 (en) | 2012-08-30 |
| MX2009005579A (es) | 2009-08-12 |
| GB0623750D0 (en) | 2007-01-10 |
| WO2008065444A2 (en) | 2008-06-05 |
| TW200838537A (en) | 2008-10-01 |
| KR20090094268A (ko) | 2009-09-04 |
| AU2007327047A1 (en) | 2008-06-05 |
| EP2099802A2 (en) | 2009-09-16 |
| WO2008065444A3 (en) | 2008-07-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2524045T3 (es) | Nuevas amidas y tioamidas heteroaromáticas como plaguicidas | |
| CO6382182A2 (es) | Proceso para la preparación de benzonorbornen-5-il-amidas del ácido pirazolil-4-carboxílico. | |
| AR064452A1 (es) | Derivados de 1,2,4 oxadiazol-indol,composiciones farmaceuticas que los comprenden y usos en trastornos asociados a receptores s1p1. | |
| AR083542A1 (es) | Piperidin-4-il-azetidin diamidas como inhibidores de monoacilglicerol lipasa | |
| AR073892A1 (es) | Proceso de preparacion de inhibidores de sglt | |
| NI200800008A (es) | Métodos para la neuroprotección | |
| PE20121047A1 (es) | Derivados de tiazolilpiperidina como fungicidas | |
| RU2014128826A (ru) | Дисоли малоновой кислоты и способ получения малонилдигалогенидов | |
| AR071385A1 (es) | Compuestos de 2-imino-3-metil pirrolopirimidinona sustituida con tiofenilo,composiciones farmaceuticas que los contienen,y uso de los mismos para el tratamiento de patologias asociadas con la proteina beta amiloide,tales como alzheimer y otros formas de demencia. | |
| CO6210770A2 (es) | Compuestos 2-aril-5-heterociclil-ciclohexan-1, 3 diona y su uso como herbicidas | |
| AR064002A1 (es) | Quinazolinas sustituidas | |
| AR083180A1 (es) | Amidas de oxopiperazina-azetidina y amidas oxodiazepina-azetidina como inhibidores de monoacilglicerol lipasa | |
| AR063464A1 (es) | Procedimiento para preparar difluorometilpirazolil carboxilatos | |
| AR073136A1 (es) | Compuestos de pirrol | |
| PE20081530A1 (es) | Nuevos compuestos 617 | |
| AR059590A1 (es) | Inhibidores de quinasa basados en la hidantoina | |
| PE20071326A1 (es) | Inhibidores de la polimerasa viral | |
| CO6331462A2 (es) | Compuesto de fenil pirrol o una sal farmaceuticamente aceptable del mismo con actividad activadora de la glucoquinasa | |
| AR084913A1 (es) | Derivados de aril-benzocicloalquil-amida | |
| AR063449A1 (es) | Proceso quimico para derivados de quinazolina, intermediarios | |
| CO2020001326A2 (es) | Nuevos compuestos heterocíclicos como inhibidores de cdk8/19 | |
| CO6150150A2 (es) | Derivados de 7-alquinil-1,8-naftiridonas su prepacion y su aplicacion en terapeutica | |
| AR051995A1 (es) | Derivados de tieno-piridina como intensificadores alostericos de gaba -b | |
| AR087494A1 (es) | Derivados de isoxazolina como compuestos insecticidas | |
| CO6251235A2 (es) | Compuestos derivados de azetidinas su preparacion y su aplicacion en terapeutica |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |