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MX2009005579A - Quinazolinas sustituidas. - Google Patents

Quinazolinas sustituidas.

Info

Publication number
MX2009005579A
MX2009005579A MX2009005579A MX2009005579A MX2009005579A MX 2009005579 A MX2009005579 A MX 2009005579A MX 2009005579 A MX2009005579 A MX 2009005579A MX 2009005579 A MX2009005579 A MX 2009005579A MX 2009005579 A MX2009005579 A MX 2009005579A
Authority
MX
Mexico
Prior art keywords
relates
present
platelet lowering
substituted quinazolines
discovery
Prior art date
Application number
MX2009005579A
Other languages
English (en)
Inventor
Richard Franklin
Bernard Golding
Original Assignee
Shire Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shire Llc filed Critical Shire Llc
Publication of MX2009005579A publication Critical patent/MX2009005579A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Esta invención se refiere al descubrimiento de análogos 3- ó 5- sustituidos del agente reductor de plaquetas selectivo anagrelida con potencial reducido para efectos colaterales cardiovasculares que deben conducir a acatamiento por el paciente y seguridad mejorados en el tratamiento de enfermedades mieloproliferativas; de manera más específica, la presente invención se refiere a ciertos derivados de imidazoquinazolina que tienen utilidad como agentes reductores de plaquetas en humanos; los compuestos de la presente invención funcionan inhibiendo la megacariocitopoyesis y por lo tanto la formación de plaquetas de la sangre.
MX2009005579A 2006-11-28 2007-11-19 Quinazolinas sustituidas. MX2009005579A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0623750.7A GB0623750D0 (en) 2006-11-28 2006-11-28 Substituted quinazolines
PCT/GB2007/050697 WO2008065444A2 (en) 2006-11-28 2007-11-19 Substituted quinazolines

Publications (1)

Publication Number Publication Date
MX2009005579A true MX2009005579A (es) 2009-08-12

Family

ID=37671460

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009005579A MX2009005579A (es) 2006-11-28 2007-11-19 Quinazolinas sustituidas.

Country Status (14)

Country Link
EP (1) EP2099802A2 (es)
JP (1) JP2010511030A (es)
KR (1) KR20090094268A (es)
CN (1) CN101558071B (es)
AR (1) AR064002A1 (es)
AU (1) AU2007327047B2 (es)
BR (1) BRPI0719570A2 (es)
CA (1) CA2670123A1 (es)
EA (1) EA018259B1 (es)
GB (1) GB0623750D0 (es)
IL (1) IL198809A0 (es)
MX (1) MX2009005579A (es)
TW (1) TW200838537A (es)
WO (1) WO2008065444A2 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0808944D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substituted quinazolines
GB2460915B (en) * 2008-06-16 2011-05-25 Biovascular Inc Controlled release compositions of agents that reduce circulating levels of platelets and methods therefor
GB0822970D0 (en) 2008-12-17 2009-01-21 Shire Llc Process for the preparation of anagrelide and analogues
GB201004495D0 (en) 2010-03-18 2010-05-05 Shire Llc Subtituted quinazolines
GB201017783D0 (en) 2010-10-21 2010-12-01 Shire Llc Process for the preparation of anagrelide and analogues thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7807507A (nl) * 1977-07-25 1979-01-29 Hoffmann La Roche Tricyclische verbindingen.
CA1131631A (en) 1979-06-20 1982-09-14 Madhukar S. Chodnekar Quinazoline derivatives and pharmaceutical preparations
ZA803535B (en) * 1979-06-20 1981-06-24 Hoffmann La Roche Novel quinazoline derivatives and pharmaceutical preparations
OA13018A (en) * 2003-01-23 2006-11-10 Shire Holings Ag Formulation and methods for the treatment of thrombocythemia.
US7700608B2 (en) * 2004-08-04 2010-04-20 Shire Holdings Ag Quinazoline derivatives and their use in the treatment of thrombocythemia
US20060030574A1 (en) * 2004-08-04 2006-02-09 Shire Holdings Ag Quinazoline derivatives useful for the treatment of peripheral arterial disease and as phosphodiesterase inhibitors

Also Published As

Publication number Publication date
CN101558071A (zh) 2009-10-14
BRPI0719570A2 (pt) 2013-12-10
IL198809A0 (en) 2010-02-17
EA200900740A1 (ru) 2010-02-26
CA2670123A1 (en) 2008-06-05
EA018259B1 (ru) 2013-06-28
WO2008065444B1 (en) 2008-10-09
JP2010511030A (ja) 2010-04-08
CN101558071B (zh) 2013-04-24
AU2007327047B2 (en) 2012-08-30
GB0623750D0 (en) 2007-01-10
WO2008065444A2 (en) 2008-06-05
TW200838537A (en) 2008-10-01
KR20090094268A (ko) 2009-09-04
AU2007327047A1 (en) 2008-06-05
EP2099802A2 (en) 2009-09-16
AR064002A1 (es) 2009-03-04
WO2008065444A3 (en) 2008-07-31

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Legal Events

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HH Correction or change in general