AR053203A1 - Pirazoles y sus derivados - Google Patents
Pirazoles y sus derivadosInfo
- Publication number
- AR053203A1 AR053203A1 ARP060101312A ARP060101312A AR053203A1 AR 053203 A1 AR053203 A1 AR 053203A1 AR P060101312 A ARP060101312 A AR P060101312A AR P060101312 A ARP060101312 A AR P060101312A AR 053203 A1 AR053203 A1 AR 053203A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- substituted
- hydroxy
- phenyl
- unsubstituted
- Prior art date
Links
- 125000000217 alkyl group Chemical group 0.000 abstract 8
- FCEHBMOGCRZNNI-UHFFFAOYSA-N 1-benzothiophene Chemical compound C1=CC=C2SC=CC2=C1 FCEHBMOGCRZNNI-UHFFFAOYSA-N 0.000 abstract 4
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 125000000623 heterocyclic group Chemical group 0.000 abstract 3
- YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical compound C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 abstract 2
- UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical compound C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 abstract 2
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 abstract 2
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 abstract 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
- -1 cyan Chemical group 0.000 abstract 2
- TXCDCPKCNAJMEE-UHFFFAOYSA-N dibenzofuran Chemical compound C1=CC=C2C3=CC=CC=C3OC2=C1 TXCDCPKCNAJMEE-UHFFFAOYSA-N 0.000 abstract 2
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000003884 phenylalkyl group Chemical group 0.000 abstract 2
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 2
- 229920006395 saturated elastomer Polymers 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- FTNJQNQLEGKTGD-UHFFFAOYSA-N 1,3-benzodioxole Chemical compound C1=CC=C2OCOC2=C1 FTNJQNQLEGKTGD-UHFFFAOYSA-N 0.000 abstract 1
- BLRHMMGNCXNXJL-UHFFFAOYSA-N 1-methylindole Chemical compound C1=CC=C2N(C)C=CC2=C1 BLRHMMGNCXNXJL-UHFFFAOYSA-N 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000004442 acylamino group Chemical group 0.000 abstract 1
- 125000005037 alkyl phenyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- BNBQRQQYDMDJAH-UHFFFAOYSA-N benzodioxan Chemical compound C1=CC=C2OCCOC2=C1 BNBQRQQYDMDJAH-UHFFFAOYSA-N 0.000 abstract 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 1
- 125000002619 bicyclic group Chemical group 0.000 abstract 1
- 235000010290 biphenyl Nutrition 0.000 abstract 1
- 239000004305 biphenyl Substances 0.000 abstract 1
- 125000002837 carbocyclic group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 229930192474 thiophene Natural products 0.000 abstract 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Child & Adolescent Psychology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Reivindicacion 1: Un compuesto de la formula (1) en la que uno de R1 y R2 es H o alquilo y el otro es alquilo inferior o (CH2)pY, en el que Y es un anillo cicloalquilo mono-, bi- o tricíclico, saturado, parcialmente insaturado o insaturado, de 5 a 10 eslabones, sustituidos o sin sustituir y p es el numero 0 o 1, y en la que los sustituyentes de Y son alquilo inferior, alcoxi inferior, hidroxi, hidroxi-alquilo, alquil-fenilo, fenil-alquilo, piridina halogeno, o bien R1 y R2, junto con e átomo de N al que están unidos, forman un anillo Sustituido o sin sustituir, en el que Z es un anillo heterocíclico saturado, parcialmente insaturado o insaturado, sustituido o sin sustituir, monocíclico de 5 a 7 eslabones o bicíclico de 7 a 10 eslabones, que contiene el átomo de N al que están unidos R1 y R2, y opcionalmente otro heteroátomo que se elige entre N, O y S, en la que el anillo heterocíclico sustituido está mono- o disustituido por alquilo inferior, hidroxi, hidroxi-alquilo, alquil- fenilo, fenil-alquilo, piridina o halogeno; R3 es un sistema de anillo aromático que se elige entre el grupo formado por [2,2']bitiofenilo, 1-metil-indol, 2,3-dihidro-benzo[1,4]dioxina, benzo[1,3]dioxol, benzo[b]tiofeno, benzotiofeno, dibenzofurano, furano, naftaleno, fenilo, bifenilo, quinolina, tiantreno y tiofeno, en la que dicho anillo aromático puede estar sin sustituir o sustituido por uno o varios grupos amino, cian, formilo, halo, hidroxi, hidroxi-metilo, acilo inferior, acilo inferior- amino, alcoxi inferior, alcoxi inferior-carbonilo, 2-(alcoxi inferior-carbonil)etenilo, alquilo inferior, alquil-tio inferior, nitro, trifluormetoxi o trifluormetilo, dicho anillo fenilo puede estar además sustituido por fenoxi o benciloxi, o R3 es como se muestra en la formula (2) en la que Ar es un grupo arilo carbocíclico o heterocíclico que puede estar sin sustituir o sustituido por uno o varios restos elegidos entre el grupo formad por halogeno, alquilo inferior, alcoxi inferior, trifluormetilo, ciano y nitro; y R4 es alquilo inferior; y las sales farmacéuticamente aceptables del mismo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66836705P | 2005-04-05 | 2005-04-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR053203A1 true AR053203A1 (es) | 2007-04-25 |
Family
ID=36514279
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060101312A AR053203A1 (es) | 2005-04-05 | 2006-04-03 | Pirazoles y sus derivados |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US7345058B2 (es) |
| EP (1) | EP1928840B1 (es) |
| JP (1) | JP4880671B2 (es) |
| KR (1) | KR100931411B1 (es) |
| CN (1) | CN101155783B (es) |
| AR (1) | AR053203A1 (es) |
| AT (1) | ATE519744T1 (es) |
| AU (1) | AU2006232660B2 (es) |
| BR (1) | BRPI0610459A2 (es) |
| CA (1) | CA2602781C (es) |
| DK (1) | DK1928840T3 (es) |
| ES (1) | ES2369389T3 (es) |
| IL (1) | IL186118A0 (es) |
| MX (1) | MX2007012212A (es) |
| NO (1) | NO20074872L (es) |
| PL (1) | PL1928840T3 (es) |
| PT (1) | PT1928840E (es) |
| RU (1) | RU2381217C2 (es) |
| TW (1) | TWI309645B (es) |
| WO (1) | WO2006106052A1 (es) |
| ZA (1) | ZA200708419B (es) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2443689C2 (ru) | 2005-11-21 | 2012-02-27 | Сионоги Энд Ко., Лтд. | ГЕТЕРОЦИКЛИЧЕСКИЕ СОЕДИНЕНИЯ, ОБЛАДАЮЩИЕ ИНГИБИРУЮЩЕЙ АКТИВНОСТЬЮ ПО ОТНОШЕНИЮ К 11β-ГИДРОКСИСТЕРОИДДЕГИДРОГЕНАЗЕ 1 ТИПА |
| RS54216B1 (sr) * | 2006-03-22 | 2015-12-31 | F. Hoffmann-La Roche Ag. | Pirazoli kao 11-beta-hsd-1 |
| PE20080251A1 (es) | 2006-05-04 | 2008-04-25 | Boehringer Ingelheim Int | Usos de inhibidores de dpp iv |
| AU2007275301A1 (en) * | 2006-07-20 | 2008-01-24 | Amgen Inc. | Substituted azole aromatic heterocycles as inhibitors of 11-beta-HSD-1 |
| TW200827346A (en) * | 2006-11-03 | 2008-07-01 | Astrazeneca Ab | Chemical compounds |
| TW200836719A (en) * | 2007-02-12 | 2008-09-16 | Astrazeneca Ab | Chemical compounds |
| JP5319518B2 (ja) * | 2007-04-02 | 2013-10-16 | Ｍｓｄ株式会社 | インドールジオン誘導体 |
| ES2535317T3 (es) | 2007-05-18 | 2015-05-08 | Shionogi & Co., Ltd. | Derivado heterocíclico que contiene nitrógeno que tiene actividad inhibidora de la 11 beta-hidroxiesteroide deshidrogenasa de tipo 1 |
| BRPI0814825A2 (pt) | 2007-07-17 | 2015-02-03 | Hoffmann La Roche | Composto, processo para a preparação do composto, composição farmacêutica que o compreende, seu uso e métodos para o tratamento ou profilaxia de diabetes, obesidade, distúrbios de alimentação ou dislipimedia e diabetes do tipo ii |
| FR2924931B1 (fr) * | 2007-12-12 | 2010-01-15 | Oreal | Utilisations de derives 1-°(1h-pyrazol-4-y!heterocycliques pour stimuler ou induire la pousse des fibres keratiniques et/ou freiner leur chute ; nouveaux composes ; compositions les contenant. |
| SA109300090B1 (ar) * | 2008-02-04 | 2011-10-03 | استرازينيكا ايه بي | صور متبلرة جديدة من 4- [4- (2- أدامنتيل كربامويل) -5- ثلاثي- بيوتيل – بيرازول -1- يل] حمض بنزويك 471 |
| JP2012516327A (ja) * | 2009-01-30 | 2012-07-19 | アストラゼネカ アクチボラグ | カルボキシ含有ピラゾールアミド化合物を製造するための新規な方法 |
| TWI531571B (zh) * | 2009-11-06 | 2016-05-01 | 維它藥物公司 | 六氫茚并吡啶及八氫苯并喹啉之芳基－及雜芳基羰基衍生物 |
| KR20150009599A (ko) | 2012-06-20 | 2015-01-26 | 에프. 호프만-라 로슈 아게 | 탄키라아제의 피라노피리돈 억제제 |
| EP3074011B1 (en) | 2013-11-25 | 2019-07-24 | Corcept Therapeutics Incorporated | Octahydro fused azadecalin glucocorticoid receptor modulators |
| US9273254B2 (en) * | 2013-12-20 | 2016-03-01 | Ecolab Usa Inc. | Amino acetals and ketals as hydrogen sulfide and mercaptan scavengers |
| CN103772282B (zh) * | 2014-02-26 | 2015-09-23 | 上海毕得医药科技有限公司 | 一种3-叔丁基-1h-吡唑-4-甲醛的制备方法 |
| US11234971B2 (en) | 2018-12-19 | 2022-02-01 | Corcept Therapeutics Incorporated | Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent |
| WO2020132046A1 (en) | 2018-12-19 | 2020-06-25 | Corcept Therapeutics Incorporated | Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent |
| IL284061B2 (en) | 2018-12-19 | 2025-02-01 | Corcept Therapeutics Inc | A preparation containing a relaxant |
| PH12021552025A1 (en) * | 2019-02-22 | 2022-08-22 | Corcept Therapeutics Inc | Therapeutic uses of relacorilant, a heteroaryl-ketone fused azadecalin glucocorticoid receptor modulator |
| CA3158745A1 (en) | 2019-12-11 | 2021-06-17 | Corcept Therapeutics Incorporated | Methods of treating antipsychotic-induced weight gain with miricorilant |
| CN115666573A (zh) * | 2020-05-27 | 2023-01-31 | 科赛普特治疗学股份有限公司 | 糖皮质激素受体调节剂瑞拉可兰和cyp2c8底物的并行给药 |
| CN114560811B (zh) * | 2022-03-11 | 2023-09-01 | 上海立森印迹医药技术有限公司 | 1,3,5-三取代-吡唑-4羧酸衍生物及其制备方法和应用 |
| WO2024092195A1 (en) | 2022-10-28 | 2024-05-02 | Corcept Therapeutics Incorporated | Treatments for amyotrophic lateral sclerosis using dazucorilant |
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| JPH0768220B2 (ja) * | 1986-04-24 | 1995-07-26 | 三井東圧化学株式会社 | 新規ピラゾ−ル誘導体、その製造法およびそれらを含有する農園芸用殺菌剤 |
| US4792565A (en) * | 1986-04-24 | 1988-12-20 | Mitsui Toatsu Chemicals, Inc. | Pyrazolecarbonylamine derivatives and agricultural and horticultural fungicides containing said compounds |
| IL91418A (en) * | 1988-09-01 | 1997-11-20 | Rhone Poulenc Agrochimie | (hetero) cyclic amide derivatives, process for their preparation and fungicidal compositions containing them |
| MY138097A (en) | 2000-03-22 | 2009-04-30 | Du Pont | Insecticidal anthranilamides |
| SE0001899D0 (sv) | 2000-05-22 | 2000-05-22 | Pharmacia & Upjohn Ab | New compounds |
| JP2002003410A (ja) | 2000-06-27 | 2002-01-09 | Fuji Photo Film Co Ltd | 芳香族ハロゲン化物の製造方法。 |
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| AU2002353717B2 (en) | 2001-11-22 | 2006-08-03 | Biovitrum Ab | Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 |
| WO2003044009A1 (en) | 2001-11-22 | 2003-05-30 | Biovitrum Ab | Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 |
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| WO2003075660A1 (en) | 2002-03-06 | 2003-09-18 | Merck & Co., Inc. | Method of treatment or prevention of obesity |
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-
2006
- 2006-03-27 WO PCT/EP2006/061057 patent/WO2006106052A1/en not_active Ceased
- 2006-03-27 AT AT06725326T patent/ATE519744T1/de active
- 2006-03-27 JP JP2008504736A patent/JP4880671B2/ja not_active Expired - Fee Related
- 2006-03-27 DK DK06725326.0T patent/DK1928840T3/da active
- 2006-03-27 CA CA2602781A patent/CA2602781C/en not_active Expired - Fee Related
- 2006-03-27 KR KR1020077022649A patent/KR100931411B1/ko not_active Expired - Fee Related
- 2006-03-27 MX MX2007012212A patent/MX2007012212A/es active IP Right Grant
- 2006-03-27 PL PL06725326T patent/PL1928840T3/pl unknown
- 2006-03-27 RU RU2007140737/04A patent/RU2381217C2/ru not_active IP Right Cessation
- 2006-03-27 AU AU2006232660A patent/AU2006232660B2/en not_active Ceased
- 2006-03-27 ES ES06725326T patent/ES2369389T3/es active Active
- 2006-03-27 EP EP06725326A patent/EP1928840B1/en not_active Not-in-force
- 2006-03-27 PT PT06725326T patent/PT1928840E/pt unknown
- 2006-03-27 BR BRPI0610459-2A patent/BRPI0610459A2/pt not_active IP Right Cessation
- 2006-03-27 CN CN2006800111775A patent/CN101155783B/zh not_active Expired - Fee Related
- 2006-03-31 US US11/395,763 patent/US7345058B2/en not_active Expired - Fee Related
- 2006-04-03 TW TW095111719A patent/TWI309645B/zh not_active IP Right Cessation
- 2006-04-03 AR ARP060101312A patent/AR053203A1/es unknown
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2007
- 2007-09-20 IL IL186118A patent/IL186118A0/en unknown
- 2007-09-25 NO NO20074872A patent/NO20074872L/no not_active Application Discontinuation
- 2007-10-02 ZA ZA200708419A patent/ZA200708419B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20060223852A1 (en) | 2006-10-05 |
| TWI309645B (en) | 2009-05-11 |
| PL1928840T3 (pl) | 2012-01-31 |
| CN101155783B (zh) | 2012-01-04 |
| EP1928840B1 (en) | 2011-08-10 |
| IL186118A0 (en) | 2008-01-20 |
| BRPI0610459A2 (pt) | 2010-06-22 |
| EP1928840A1 (en) | 2008-06-11 |
| JP4880671B2 (ja) | 2012-02-22 |
| CA2602781A1 (en) | 2006-10-12 |
| MX2007012212A (es) | 2007-12-07 |
| AU2006232660B2 (en) | 2010-03-25 |
| ATE519744T1 (de) | 2011-08-15 |
| ZA200708419B (en) | 2008-11-26 |
| ES2369389T3 (es) | 2011-11-30 |
| KR20070108937A (ko) | 2007-11-13 |
| RU2007140737A (ru) | 2009-05-20 |
| TW200643013A (en) | 2006-12-16 |
| NO20074872L (no) | 2007-10-30 |
| CA2602781C (en) | 2011-02-08 |
| CN101155783A (zh) | 2008-04-02 |
| WO2006106052A1 (en) | 2006-10-12 |
| US7345058B2 (en) | 2008-03-18 |
| DK1928840T3 (da) | 2011-09-12 |
| JP2008534647A (ja) | 2008-08-28 |
| RU2381217C2 (ru) | 2010-02-10 |
| AU2006232660A1 (en) | 2006-10-12 |
| PT1928840E (pt) | 2011-10-03 |
| KR100931411B1 (ko) | 2009-12-10 |
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