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AR051334A1 - Derivados de 2- amido-4-feniltiazol - Google Patents

Derivados de 2- amido-4-feniltiazol

Info

Publication number
AR051334A1
AR051334A1 ARP050104349A ARP050104349A AR051334A1 AR 051334 A1 AR051334 A1 AR 051334A1 AR P050104349 A ARP050104349 A AR P050104349A AR P050104349 A ARP050104349 A AR P050104349A AR 051334 A1 AR051334 A1 AR 051334A1
Authority
AR
Argentina
Prior art keywords
alkyl
alkoxy
group
cycloalkyl
trifluoro
Prior art date
Application number
ARP050104349A
Other languages
English (en)
Inventor
Pierre Casellas
Daniel Floutard
Pierre Lionel Fraisse
Samir Jegham
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of AR051334A1 publication Critical patent/AR051334A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/427Thiazoles not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/02Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pulmonology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Virology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Composiciones farmacéuticas que los contienen, usos terapéuticos y método de preparacion. Reivindicacion 1: Compuesto de formula (1), en la cual: R1 representa un átomo de hidrogeno o de halogeno, un grupo alquilo-C1-4, trifluoro-alquilo-C1-4, hidroxilo, alcoxi-C1-4, trifluoro-alcoxi-C1-4, cicloalquil-C3-10-alcoxi-C1-4, cicloalquiloxi-C3-10, aliloxi, alquiltio-C1-4; R2 representa un átomo de hidrogeno o de halogeno, un grupo hidroxilo, alquilo-C1-4, trifluoro-alquilo-C1-4, perfluoro- alquilo-C1-4, cicloalquilo-C3-10, alcoxi-C1-4, cicloalquil-C3-10-alcoxi-C1-4, cicloalquiloxi-C3-10, aliloxi, cicloalquil-C3-8-alquilo-C1-4; Y representa un átomo de hidrogeno o un halogeno; y R3 representa: un grupo fenilo, sustituido por uno o varios átomos de halogeno y/o por uno o varios grupos; alquilo-C1-6; alcoxi-C1-6; -NO2; ciano; -COR4; -SO2R4; -CO2R4, en el cual R4 representa un grupo alquilo-C1-4; y -(CH2)qNR5R6 en el cual R5 y r6 representan independientemente el uno del otro un átomo de hidrogeno, un grupo alquilo-C1-4 o R5 y R6 forman juntos con el átomo de nitrogeno al cual están unidos un grupo cicloalquilo de 5 o 6 eslabones y q representan 0, 1 o 2; un grupo heterociclo eventualmente sustituido por uno o varios halogenos y/o por uno o varios grupos: alquilo-C1-4; hidroxilo; alcoxi-C1-4; ciano; morfolino; trifluoro-alquilo-C1-4; -COR4; -SO2R4, en el cual R4 es tal como se define en lo que se precede, -(CH2)qNR5R6, en el cual R5, R6 y q son tales como se definen en lo que precede; fenilo; piridina; y -SCH3; estando el o los átomos de nitrogeno del grupo heterocíclico eventualmente sustituido por un grupo alquilo-C1-4; estando el o los átomos de nitrogeno del grupo heterocíclico eventualmente bajo su forma de N-oxido; un grupo heterobicíclico eventualmente sustituido por uno o varios halogenos y/o por uno o varios grupos hidroxilos, alquilo-C1-4 o alcoxi-C1-4; m representa 2, 3 o 4; n representa 0, 1 o 2; y p representa 0, 1, 2 o 3; en el estado de base o de sal de adicion a un ácido farmacéuticamente aceptable, en estado de hidratos o de solvatos, así como en forma de enantiomeros, de diastereoisomeros y su mezcla.
ARP050104349A 2004-10-19 2005-10-18 Derivados de 2- amido-4-feniltiazol AR051334A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0411083A FR2876692B1 (fr) 2004-10-19 2004-10-19 Derives de 2-amido-4-phenylthiazole, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
AR051334A1 true AR051334A1 (es) 2007-01-03

Family

ID=34950743

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP050104349A AR051334A1 (es) 2004-10-19 2005-10-18 Derivados de 2- amido-4-feniltiazol

Country Status (27)

Country Link
US (1) US7598392B2 (es)
EP (1) EP1807421B1 (es)
JP (1) JP2008517042A (es)
KR (1) KR20070085395A (es)
CN (1) CN101065376A (es)
AR (1) AR051334A1 (es)
AT (1) ATE502035T1 (es)
AU (1) AU2005296958A1 (es)
BR (1) BRPI0518231A2 (es)
CA (1) CA2584774A1 (es)
DE (1) DE602005026964D1 (es)
EA (1) EA200700901A1 (es)
EC (1) ECSP077402A (es)
FR (1) FR2876692B1 (es)
GT (1) GT200500292A (es)
IL (1) IL182624A0 (es)
MA (1) MA29017B1 (es)
MX (1) MX2007004740A (es)
NO (1) NO20072515L (es)
PA (1) PA8649901A1 (es)
PE (1) PE20060585A1 (es)
SV (1) SV2006002274A (es)
TN (1) TNSN07145A1 (es)
TW (1) TW200630364A (es)
UY (1) UY29169A1 (es)
WO (1) WO2006042954A1 (es)
ZA (1) ZA200703876B (es)

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* Cited by examiner, † Cited by third party
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FR2854158B1 (fr) 2003-04-25 2006-11-17 Sanofi Synthelabo Derives de 2-acylamino-4-phenylethiazole, leur preparation et leur application en therapeutique
FR2872813B1 (fr) 2004-07-09 2007-01-19 Sanofi Synthelabo Derives de 2-carbamide-4-phenylthiazole, leur preparation et leur application en therapeutique
TW200730476A (en) * 2005-12-12 2007-08-16 Genelabs Tech Inc N-(5-membered aromatic ring)-amido anti-viral compounds
FR2895989B1 (fr) 2006-01-06 2010-04-30 Sanofi Aventis Derives de 2-carbamide-4-phenylthiazole, leur preparation et leur application en therapeutique
WO2009076404A1 (en) * 2007-12-10 2009-06-18 Epix Delaware, Inc. Carboxamide compounds and their use as antagonists of the chemokine ccr2 receptor
EP2280766A1 (en) * 2007-12-11 2011-02-09 CytoPathfinder, Inc. Carboxamide compounds and their use as chemokine receptor agonists
PE20110105A1 (es) 2008-07-15 2011-02-25 Novartis Ag Derivados de heteroarilo como inhibidores de dgat1
EP4015504A1 (en) * 2008-12-22 2022-06-22 ChemoCentryx, Inc. C5ar antagonists
CN103402996B (zh) 2011-01-04 2015-02-11 诺瓦提斯公司 可用于治疗年龄相关性黄斑变性(amd)的吲哚化合物或其类似物
US9464081B2 (en) 2012-06-28 2016-10-11 Novartis Ag Pyrrolidine derivatives and their use as complement pathway modulators
EP2867225B1 (en) 2012-06-28 2017-08-09 Novartis AG Pyrrolidine derivatives and their use as complement pathway modulators
ES2710491T3 (es) 2012-06-28 2019-04-25 Novartis Ag Moduladores de la vía del complemento y sus usos
CN104640855B (zh) 2012-06-28 2017-08-29 诺华股份有限公司 补体途经调节剂及其用途
WO2014002053A1 (en) 2012-06-28 2014-01-03 Novartis Ag Pyrrolidine derivatives and their use as complement pathway modulators
CN104684910B (zh) 2012-07-12 2016-10-12 诺华股份有限公司 补体途经调节剂及其用途
MX2022010944A (es) 2020-03-03 2022-11-09 Pic Therapeutics Inc Inhibidores del factor de iniciacion de traduccion eucariotica 4e (eif4e) y sus usos.
WO2023028235A1 (en) 2021-08-25 2023-03-02 PIC Therapeutics, Inc. Eif4e inhibitors and uses thereof
CN118019739A (zh) 2021-08-25 2024-05-10 皮克医疗公司 Eif4e抑制剂及其用途
KR20240140019A (ko) * 2023-03-15 2024-09-24 현대약품 주식회사 신규한 화합물, 및 이를 포함하는 약학적 조성물

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AR044098A1 (es) 2003-04-30 2005-08-24 Hoffmann La Roche Derivados de anilina, su elaboracion, composiciones farmaceuticas y su uso para elaborar medicamentos para el tratamiento del cancer
FR2872813B1 (fr) 2004-07-09 2007-01-19 Sanofi Synthelabo Derives de 2-carbamide-4-phenylthiazole, leur preparation et leur application en therapeutique
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FR2895989B1 (fr) 2006-01-06 2010-04-30 Sanofi Aventis Derives de 2-carbamide-4-phenylthiazole, leur preparation et leur application en therapeutique

Also Published As

Publication number Publication date
SV2006002274A (es) 2006-06-28
UY29169A1 (es) 2006-05-31
CA2584774A1 (fr) 2006-04-27
EP1807421A1 (fr) 2007-07-18
ECSP077402A (es) 2007-05-30
WO2006042954A8 (fr) 2008-03-13
US7598392B2 (en) 2009-10-06
MA29017B1 (fr) 2007-11-01
EP1807421B1 (fr) 2011-03-16
EA200700901A1 (ru) 2007-10-26
IL182624A0 (en) 2007-07-24
PE20060585A1 (es) 2006-08-18
WO2006042954A1 (fr) 2006-04-27
US20070259847A1 (en) 2007-11-08
CN101065376A (zh) 2007-10-31
NO20072515L (no) 2007-06-28
BRPI0518231A2 (pt) 2008-11-11
PA8649901A1 (es) 2006-06-02
FR2876692A1 (fr) 2006-04-21
AU2005296958A1 (en) 2006-04-27
JP2008517042A (ja) 2008-05-22
ATE502035T1 (de) 2011-04-15
MX2007004740A (es) 2007-06-18
DE602005026964D1 (de) 2011-04-28
KR20070085395A (ko) 2007-08-27
GT200500292A (es) 2006-05-11
ZA200703876B (en) 2008-12-31
TW200630364A (en) 2006-09-01
FR2876692B1 (fr) 2007-02-23
TNSN07145A1 (fr) 2008-11-21

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