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AR050711A1 - Derivados arilsulfonilestilbeno para el tratamiento y/o prevencion de afecciones del sistema nervioso central - Google Patents

Derivados arilsulfonilestilbeno para el tratamiento y/o prevencion de afecciones del sistema nervioso central

Info

Publication number
AR050711A1
AR050711A1 ARP050103543A ARP050103543A AR050711A1 AR 050711 A1 AR050711 A1 AR 050711A1 AR P050103543 A ARP050103543 A AR P050103543A AR P050103543 A ARP050103543 A AR P050103543A AR 050711 A1 AR050711 A1 AR 050711A1
Authority
AR
Argentina
Prior art keywords
arilsulfonylestilben
affections
prevention
derivatives
treatment
Prior art date
Application number
ARP050103543A
Other languages
English (en)
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33104758&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR050711(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of AR050711A1 publication Critical patent/AR050711A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/28—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/10—Sulfides; Sulfoxides; Sulfones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C—CHEMISTRY; METALLURGY
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/04—Preparation of sulfones; Preparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
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    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
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    • C07C317/36—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring with the nitrogen atoms of the amino groups bound to hydrogen atoms or to carbon atoms
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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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  • Hydrogenated Pyridines (AREA)
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  • Thiazole And Isothizaole Compounds (AREA)

Abstract

Un compuesto de formula (1), o una sal o hidrato farmacéuticamente aceptable del mismo, en el que: n es 0 o 1; R1 representa H o F; R2 representa halogeno, CN, CONH2, alquilo C1-4 o alcoxi C1-4; R7 representa H o alquilo C1-4; y Z representa hidroxialquilo C1-6, o alcoxicarbonilo C1-6, o un anillo heteroaromático de 5- o 6- miembros el cual lleva opcionalmente un sustituyente de metilo. Composiciones farmacéuticas que los contienen, método de preparacion y usos para trastornos del sueno, esquizofrenia, ansiedad y otros.
ARP050103543A 2004-08-27 2005-08-23 Derivados arilsulfonilestilbeno para el tratamiento y/o prevencion de afecciones del sistema nervioso central AR050711A1 (es)

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WO2006021805A1 (en) 2006-03-02
NZ552328A (en) 2009-07-31
CR8928A (es) 2007-08-28
US7468393B2 (en) 2008-12-23
US20090170824A1 (en) 2009-07-02
CA2577837A1 (en) 2006-03-02
GB0419192D0 (en) 2004-09-29
NI200700032A (es) 2007-08-03
JP5111108B2 (ja) 2012-12-26
DE602005020338D1 (de) 2010-05-12
ECSP077277A (es) 2007-03-29
CA2577837C (en) 2013-06-11
ZA200610690B (en) 2008-07-30
WO2006021806A1 (en) 2006-03-02
JP2008510785A (ja) 2008-04-10
BRPI0514579A (pt) 2008-06-17
RU2007111123A (ru) 2008-10-10
TW200621222A (en) 2006-07-01
US20060052445A1 (en) 2006-03-09
NO20071574L (no) 2007-03-26
CN101014565A (zh) 2007-08-08
EP1786768A1 (en) 2007-05-23
KR20070046153A (ko) 2007-05-02
PE20060632A1 (es) 2006-07-14
AU2005276233B2 (en) 2011-03-17
IL180737A0 (en) 2007-06-03
RU2382766C2 (ru) 2010-02-27
MX2007002308A (es) 2007-04-16
US20070203205A1 (en) 2007-08-30
MA28806B1 (fr) 2007-08-01
ATE462688T1 (de) 2010-04-15
EP1807393A1 (en) 2007-07-18
US7217740B2 (en) 2007-05-15
IL180737A (en) 2011-10-31
AU2005276233A1 (en) 2006-03-02
EP1807393B1 (en) 2010-03-31

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