AR058800A1 - Heterociclos condensados con anillos bencenicos como inhibidores de comt, composiciones farmaceuticas que los contienen y su uso en la fabricacion de un medicamento para el tratamiento del mal de parkinson - Google Patents
Heterociclos condensados con anillos bencenicos como inhibidores de comt, composiciones farmaceuticas que los contienen y su uso en la fabricacion de un medicamento para el tratamiento del mal de parkinsonInfo
- Publication number
- AR058800A1 AR058800A1 ARP060103074A ARP060103074A AR058800A1 AR 058800 A1 AR058800 A1 AR 058800A1 AR P060103074 A ARP060103074 A AR P060103074A AR P060103074 A ARP060103074 A AR P060103074A AR 058800 A1 AR058800 A1 AR 058800A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- alkoxy
- hydroxy
- independently
- ring
- Prior art date
Links
- 239000003543 catechol methyltransferase inhibitor Substances 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 17
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 8
- 229910052736 halogen Inorganic materials 0.000 abstract 8
- 150000002367 halogens Chemical class 0.000 abstract 8
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 7
- 125000003118 aryl group Chemical group 0.000 abstract 6
- 125000004432 carbon atom Chemical group C* 0.000 abstract 6
- -1 halo C1-6 alkyl Chemical group 0.000 abstract 6
- 229910052799 carbon Inorganic materials 0.000 abstract 5
- 125000001424 substituent group Chemical group 0.000 abstract 5
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 4
- 125000000623 heterocyclic group Chemical group 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- 125000002837 carbocyclic group Chemical group 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- VZLZTYLOKPAJSZ-UHFFFAOYSA-N 2-benzyl-7-bromo-6-nitro-1-benzofuran-4,5-diol Chemical compound O1C=2C(Br)=C([N+]([O-])=O)C(O)=C(O)C=2C=C1CC1=CC=CC=C1 VZLZTYLOKPAJSZ-UHFFFAOYSA-N 0.000 abstract 1
- 108020002739 Catechol O-methyltransferase Proteins 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000002102 aryl alkyloxo group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
- 125000006413 ring segment Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
- C07D277/66—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2 with aromatic rings or ring systems directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/84—Naphthothiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
- C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
- C07D307/89—Benzo [c] furans; Hydrogenated benzo [c] furans with two oxygen atoms directly attached in positions 1 and 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D333/70—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Furan Compounds (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Compuestos con actividad inhibidora de la enzima COMT y son por consiguiente utiles como inhibidores de COMT y para la elaboracion de medicamentos para el tratamiento de la enfermedad de Parkinson. Reivindicacion 1: Un compuesto de Formula (1), en donde R2 está en una posicion orto a R3 y R1 está en una posicion orto a R2 o R1 está en una posicion orto a R3 y R4 está en una posicion orto a R1; R1 es cuano o nitro; R2 es hidroxi; R3 es hidroxi; R4 es H, (alquilo de C1-6, halo alquilo de C1-6, ciano, formilo, alquilo de C1-6-(C=O)-, halogeno o nitro; la línea punteada representa un enlace simple o uno doble; dos de X, Y o Z son independientemente CR5(R6)m, N(R7)n, O o S y uno de X, Y o Z es N(R7)n, o S; m es independientemente en cada ocurrencia, 0 o 1; n es independientemente en cada ocurrencia 0, 1 o 2; R5 es, independientemente en cada ocurrencia, H, alquilo de C1-6, alqunilo de C2-6, halogeno, hidroxi, alcoxi de C1-6, halo-alquilo de C1-6, hidroxi-alquilo de C1-6, alquilo de C1-6-(C=O)-, alcoxi de C1-8-(C=O)-, ciano, formilo, alquilo de C1-6-(C=S)-, (R8)2N-(C=S)-, R8-(C=NR8)-, carboxi, cicloalquilo de C3-7, heterociclilo, arilo, heteroarilo, heterociclilo-(C=O)-, aril-alquilo de C1-6, (R8)2N-, (R8)2N-alquilo de C1-6-S-, R9-(S=O)-, R9-(O=S=O)-, alcoxi de C1-6-alquilo de C1-6, alcoxi de C1-6-(C=O)-alquilo de C1-6, alquilo de C1-6-(=O)-O-, alquilo de C1-6-(C=O)-O-alquilo de C1-6, hidroxi-alcoxi de C1-6-alquilo de C1-6, alquilo de C1-6-S-alquilo de C1-6, alquilo de C1- 6-S-(C=O)-, cicloalquilo de C3-7-alquilo de C1-6, ariloxi, ariloxi-alquilo de C1-6, aril-alcoxi de C1-6, aril-alcoxi de C1-6-alquilo de C1-6 o heterociclil-(C=S)-, en donde dicho cicloalquilo de C3-7, heterociclilo, arilo o heteroarilo como tales o como parte de otro grupo son no substituidos o substituidos con 1, 2 o 3 substituyentes cada uno que es independientemente alquilo de C1-6, halogeno, hidroxi, carboxi, alcoxi de C1-6 o (R8)2N-; R6 es, independientemente en cada ocurrencia, H, (alquilo de C1-6, halogeno, hidroxi, hidroxi-alquilo de C1-6 o alcoxi de C1-6 o R5 y R6, ambos fijados al mismo átomo de carbono del anillo forman, junto con el átomo de carbono del anillo al cual están fijados, un grupo -(C=O)-; o R5 y R6, ambos fijados al mismo átomo de carbono del anillo, forman con el átomo de carbono del anillo al cual están fijados, C=C(R8)2; o R5 y R6 ambos fijados al mismo átomo de carbono del anillo forman, junto con el átomo de carbono del anillo al cual están fijados, un anillo carbocíclico insaturado o saturado de 5, 6 o 7 elementos, en donde dicho anillo es no substituido o substituido con 1 o 2 substituyentes, siendo cada uno independientemente alquilo de C1-6, halogeno, hidroxi, alcoxi o carboxi de C1-6; R7 es, independientemente de cada ocurrencia, H, alquilo de C1-6, cicloalquilo de C3-7, alcoxi de C1-6, arilo u O-, en donde dicho cicloalquilo C3-7 o arilo es substituido o no substituido con 1, 2 o 3 substituyentes siendo cada uno independientemente alquilo de C1-6, halogeno, hidroxi, alcoxi o carboxi de C1-6; o R5 y R5, R5 y R7, o R7 y R7 fijados al átomo adyacente del anillo forman, junto con los átomos anillo al cual están fijados un anillo carbocíclico saturado o insaturado de 5, 6, o 7 elementos condensado o un anillo heterocíclico saturado o insaturado de 5, 6, o 7 elementos, condensado que contiene 1 o 2 heteroátomos seleccionados de N, O y S, en donde el anillo carbo- o heterocíclico es substituido o no substituido con 1 o 2 sustituyentes siendo cada uno independientemente, alquilo de C1-6, halogeno, hidroxi, alcoxi de C1-6, carboxi u oxo; R8 es independientemente en cada ocurrencia, H, alquilo de C1-6, alcoxi de C1-6, arilo o aril-alquilo de C1-6, en donde dicho arilo como tal o como parte de otro grupo es no substituido o substituido con 1 o 2 substituido con 1 o 2 substituyentes, siendo cada uno independientemente, alquilo de C1-6, halogeno, hidroxi, carboxi o alcoxi de C1-6; R9 es independientemente en cada ocurrencia, alquilo de C1-6, (R8)2N-, hidroxi o alcoxi de C1-6; o una sal o éter de los mismos aceptables farmacéuticamente; con la condicion de que el compuesto no sea 2-bencil-7-bromo-6-nitro-benzofuran-4, 5-diol.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69989805P | 2005-07-18 | 2005-07-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR058800A1 true AR058800A1 (es) | 2008-02-27 |
Family
ID=37500024
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060103074A AR058800A1 (es) | 2005-07-18 | 2006-07-18 | Heterociclos condensados con anillos bencenicos como inhibidores de comt, composiciones farmaceuticas que los contienen y su uso en la fabricacion de un medicamento para el tratamiento del mal de parkinson |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US8318785B2 (es) |
| EP (1) | EP1910325B1 (es) |
| JP (1) | JP5015152B2 (es) |
| KR (1) | KR20080035571A (es) |
| CN (1) | CN101282957B (es) |
| AR (1) | AR058800A1 (es) |
| AT (1) | ATE483702T1 (es) |
| AU (1) | AU2006271631B2 (es) |
| BR (1) | BRPI0613778A2 (es) |
| CA (1) | CA2615466C (es) |
| DE (1) | DE602006017378D1 (es) |
| DK (1) | DK1910325T3 (es) |
| EA (1) | EA017329B1 (es) |
| EC (1) | ECSP088156A (es) |
| ES (1) | ES2354114T3 (es) |
| GE (1) | GEP20115222B (es) |
| IL (1) | IL188438A (es) |
| MX (1) | MX2008000875A (es) |
| MY (1) | MY148644A (es) |
| NO (1) | NO20080779L (es) |
| NZ (1) | NZ565112A (es) |
| PE (1) | PE20070206A1 (es) |
| TW (1) | TW200745074A (es) |
| UA (1) | UA98608C2 (es) |
| WO (1) | WO2007010085A2 (es) |
| ZA (1) | ZA200800368B (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5369854B2 (ja) | 2008-04-21 | 2013-12-18 | 住友化学株式会社 | 有害節足動物防除組成物および縮合複素環化合物 |
| JP5540640B2 (ja) | 2009-10-07 | 2014-07-02 | 住友化学株式会社 | 複素環化合物及びその有害節足動物防除用途 |
| AU2011222856B2 (en) | 2010-03-04 | 2015-10-15 | Orion Corporation | Use of levodopa, carbidopa and entacapone for treating Parkinson's disease |
| CN103037694B (zh) | 2010-06-23 | 2014-08-13 | 住友化学株式会社 | 防治有害节肢动物的组合物和杂环化合物 |
| MX2013000651A (es) * | 2010-07-27 | 2013-03-22 | Hoffmann La Roche | Metodo para la identificacion de moduladores de catecol o-metiltransferasa. |
| JP5918264B2 (ja) | 2010-12-22 | 2016-05-18 | アッヴィ・インコーポレイテッド | Ｃ型肝炎阻害剤およびその使用 |
| TWI638802B (zh) | 2012-05-24 | 2018-10-21 | 芬蘭商奧利安公司 | 兒茶酚ｏ－甲基轉移酶活性抑制化合物 |
| KR101551313B1 (ko) * | 2014-07-28 | 2015-09-09 | 충남대학교산학협력단 | 신규한 인덴 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 망막 질환의 예방 또는 치료용 약학적 조성물 |
| CN108698984B (zh) * | 2015-12-18 | 2022-05-10 | H·科斯特 | 用作药物、特别是用于治疗帕金森氏病的双环化合物 |
| GB201617339D0 (en) | 2016-10-12 | 2016-11-23 | Lytix Biopharma As | Therapeutic compounds |
| CN111253335B (zh) * | 2020-03-12 | 2023-06-06 | 浙江扬帆新材料股份有限公司 | 一种n-取代苯并异噻唑啉-3-酮衍生物的新合成方法 |
| CN113121472B (zh) * | 2021-03-05 | 2022-12-16 | 上海应用技术大学 | 一种利用金配合物制备n-磺酰基四氢吡咯类化合物的方法 |
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| DE3832848A1 (de) | 1988-09-28 | 1990-03-29 | Bayer Ag | Benzothiophen-2-carboxamid-s,s-dioxide |
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| GB9626472D0 (en) * | 1996-12-20 | 1997-02-05 | Aperia Anita C | New use of comt inhibitors |
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| US20060173074A1 (en) | 2004-11-10 | 2006-08-03 | Juha Ellmen | Treatment of restless legs syndrome |
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