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AR058284A1 - Proceso ajustable a escala para la preparacion de un 42- ester de rapamicina a partir de un boronato de 42- ester de rapamicina - Google Patents

Proceso ajustable a escala para la preparacion de un 42- ester de rapamicina a partir de un boronato de 42- ester de rapamicina

Info

Publication number
AR058284A1
AR058284A1 ARP060105390A ARP060105390A AR058284A1 AR 058284 A1 AR058284 A1 AR 058284A1 AR P060105390 A ARP060105390 A AR P060105390A AR P060105390 A ARP060105390 A AR P060105390A AR 058284 A1 AR058284 A1 AR 058284A1
Authority
AR
Argentina
Prior art keywords
rapamycin ester
rapamycin
preparation
ester
boronate
Prior art date
Application number
ARP060105390A
Other languages
English (en)
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37813522&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR058284(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of AR058284A1 publication Critical patent/AR058284A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Reivindicacion 1: Un proceso para la preparacion de 42-éster de rapamicina que comprende los siguientes pasos: (a) hacer reaccionar un boronato de 42-éster de rapamicina con un diol en una mezcla de solvente para producir 42-éster de rapamicina crudo y (b) purificar el 42-éster de rapamicina crudo mediante recristalizacion y tratamiento con un diol.
ARP060105390A 2005-12-07 2006-12-06 Proceso ajustable a escala para la preparacion de un 42- ester de rapamicina a partir de un boronato de 42- ester de rapamicina AR058284A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US74814305P 2005-12-07 2005-12-07

Publications (1)

Publication Number Publication Date
AR058284A1 true AR058284A1 (es) 2008-01-30

Family

ID=37813522

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP060105390A AR058284A1 (es) 2005-12-07 2006-12-06 Proceso ajustable a escala para la preparacion de un 42- ester de rapamicina a partir de un boronato de 42- ester de rapamicina

Country Status (18)

Country Link
US (1) US7622578B2 (es)
EP (1) EP1957501A2 (es)
JP (1) JP2009518412A (es)
KR (1) KR20080077619A (es)
CN (1) CN101321770A (es)
AR (1) AR058284A1 (es)
AU (1) AU2006322024A1 (es)
BR (1) BRPI0619578A2 (es)
CA (1) CA2630645A1 (es)
CR (1) CR9986A (es)
EC (1) ECSP088516A (es)
GT (1) GT200800087A (es)
IL (1) IL191550A0 (es)
NO (1) NO20082375L (es)
PE (1) PE20070748A1 (es)
RU (2) RU2008120670A (es)
TW (1) TW200804399A (es)
WO (1) WO2007067560A2 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI307277B (en) * 2002-07-30 2009-03-11 Wyeth Corp Parenteral formulations
WO2007075621A1 (en) * 2005-12-20 2007-07-05 Wyeth Control of cci-779 dosage form stability through control of drug substance impurities
TW200824713A (en) * 2006-10-18 2008-06-16 Wyeth Corp Processes for the synthesis of individual isomers of mono-PEG CCI-779
CN102020661B (zh) * 2011-01-07 2013-02-13 天津市炜杰科技有限公司 一种驮瑞塞尔合成方法
EP2694520A1 (en) 2011-04-01 2014-02-12 Sandoz AG Regioselective acylation of rapamycin at the c-42 position
US9446977B2 (en) 2012-12-10 2016-09-20 Corning Incorporated Method and system for making a glass article with uniform mold temperature

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5358909A (en) * 1991-02-27 1994-10-25 Nippon Steel Corporation Method of manufacturing field-emitter
US5358908A (en) * 1992-02-14 1994-10-25 Micron Technology, Inc. Method of creating sharp points and other features on the surface of a semiconductor substrate
US5385908A (en) 1993-11-22 1995-01-31 American Home Products Corporation Hindered esters of rapamycin
US5385909A (en) 1993-11-22 1995-01-31 American Home Products Corporation Heterocyclic esters of rapamycin
US5362718A (en) * 1994-04-18 1994-11-08 American Home Products Corporation Rapamycin hydroxyesters
US6277983B1 (en) * 2000-09-27 2001-08-21 American Home Products Corporation Regioselective synthesis of rapamycin derivatives
JP2004509898A (ja) * 2000-09-19 2004-04-02 ワイス 水溶性ラパマイシンエステル
DK1658295T3 (da) 2003-08-07 2007-09-24 Wyeth Corp Regioselektiv syntese af CCI-779
WO2005023254A1 (en) * 2003-09-03 2005-03-17 Wyeth Amorphous rapamycin 42-ester with 3-hydroxy-2-(hydroxymethyl)-2-methylpropionic acid and its pharmaceutical compositions containing the same
US7202256B2 (en) * 2004-04-14 2007-04-10 Wyeth Proline CCI-779, production of and uses therefor, and two-step enzymatic synthesis of proline CCI-779 and CCI-779
DE602005010228D1 (de) * 2004-04-14 2008-11-20 Wyeth Corp Verfahren zur herstellung von rapamycin-42-estern und fk-506-32-estern mit dicarbonsäure, vorstufen für rapamycinkonjugate und antikörper
BRPI0509852A (pt) * 2004-04-14 2007-10-23 Wyeth Corp método para a preparação regioespecìfica dos derivados de 42-éster de rapamicina, preparação regioespecìfica do 42-éster de rapamicina, composição, produto, e, kit farmacêutico
GT200500216A (es) * 2004-08-10 2006-03-02 Derivados de cci-779 y metodos para su preparacion
WO2006068932A2 (en) * 2004-12-20 2006-06-29 Wyeth Rapamycin analogues and the uses thereof in the treatment of neurological, proliferative, and inflammatory disorders
CA2590254A1 (en) * 2004-12-20 2006-06-29 Wyeth Rapamycin derivatives and the uses thereof in the treatment of neurological disorders
CN101115759A (zh) * 2005-02-09 2008-01-30 惠氏公司 Cci-779多晶形物及其应用
JP2008531685A (ja) * 2005-03-02 2008-08-14 ワイス 母液からのｃｃｉ−７７９の回収
WO2006096325A1 (en) * 2005-03-07 2006-09-14 Wyeth Oxepane isomer of 42-o-(2-hydroxy)ethyl-rapamycin

Also Published As

Publication number Publication date
US7622578B2 (en) 2009-11-24
CN101321770A (zh) 2008-12-10
TW200804399A (en) 2008-01-16
IL191550A0 (en) 2008-12-29
JP2009518412A (ja) 2009-05-07
AU2006322024A1 (en) 2007-06-14
RU2008120670A (ru) 2010-01-20
PE20070748A1 (es) 2007-08-08
WO2007067560A2 (en) 2007-06-14
NO20082375L (no) 2008-09-04
KR20080077619A (ko) 2008-08-25
EP1957501A2 (en) 2008-08-20
BRPI0619578A2 (pt) 2011-10-04
CR9986A (es) 2008-08-21
US20070129541A1 (en) 2007-06-07
WO2007067560A3 (en) 2007-08-02
ECSP088516A (es) 2008-07-30
CA2630645A1 (en) 2007-06-14
GT200800087A (es) 2008-10-06
RU2008142554A (ru) 2010-05-10

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