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AR058055A1 - Analogos de feniletilamina y su uso para el tratamiento del glaucoma - Google Patents

Analogos de feniletilamina y su uso para el tratamiento del glaucoma

Info

Publication number
AR058055A1
AR058055A1 ARP060104098A ARP060104098A AR058055A1 AR 058055 A1 AR058055 A1 AR 058055A1 AR P060104098 A ARP060104098 A AR P060104098A AR P060104098 A ARP060104098 A AR P060104098A AR 058055 A1 AR058055 A1 AR 058055A1
Authority
AR
Argentina
Prior art keywords
alkyl
independently
glaucoma
treatment
composition
Prior art date
Application number
ARP060104098A
Other languages
English (en)
Original Assignee
Alcon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Inc filed Critical Alcon Inc
Publication of AR058055A1 publication Critical patent/AR058055A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Análogos de feniletilamina utiles para el tratamiento del glaucoma. Reivindicacion 1: Uso de una composicion que comprende un portador farmacéuticamente aceptable y una cantidad farmacéuticamente efectiva de un compuesto de la formula (1) en donde R1 y R2 son independientemente H o alquilo C1-4; R3 y R4 son independientemente H, alquilo C1-4, o R3, R4 y el átomo de C al cual ellos están unidos pueden formar un anillo ciclopropilo; Y es H, alquilo C1-4, u OR5; R5 es H o alquilo C1-4; A y B son independientemente OH, alcoxi C1-3, OS(O)2W, OC(=O)W, u OC(=O)NW2W3; W es alquilo C1-4; W2 y W3 son independientemente H o alquilo C1-4; X es CH(OH)R6, C(=O)R6, (CH2)nZ, o (CH2)mZ'; R6 es alquilo C1-4, (CH2)m2SR8, o (CH2)m2OR8; n es 1-4; m es 2-4; m2 es 1-4; Z es OCF3, CN, S(O)n2R6, C(O)NR7R8, C(C=O)R6, CH(OH)R6, SO2NR7R8, NR6R9, CO2R6, S(O)n2CH2CH(OH)R6, S(O)n2CH2C(=O)R6, S(O)n2CH2CO2R6, S(O)n2CH2C(=O)NR7R8, arilo, heterociclilo, o heteroarilo; Z' es OH u OR6; n2 es 0 o 1; R7 es H, alquilo C1-4, OH, u OCH3; y R8 y R9 son independientemente H o alquilo C1-4, para disminuir y controlar la PIO normal o elevada. Reivindicacion 4: Uso de la reivindicacion 1 en donde la composicion es una composicion oftálmica administrada por vía topica y la cantidad farmacéuticamente efectiva del compuesto es 0,1-2% (p/v).
ARP060104098A 2005-09-23 2006-09-19 Analogos de feniletilamina y su uso para el tratamiento del glaucoma AR058055A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US72024805P 2005-09-23 2005-09-23

Publications (1)

Publication Number Publication Date
AR058055A1 true AR058055A1 (es) 2008-01-23

Family

ID=37527034

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP060104098A AR058055A1 (es) 2005-09-23 2006-09-19 Analogos de feniletilamina y su uso para el tratamiento del glaucoma

Country Status (5)

Country Link
US (1) US20070072920A1 (es)
AR (1) AR058055A1 (es)
TW (1) TW200744567A (es)
UY (1) UY29802A1 (es)
WO (1) WO2007038372A1 (es)

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US8076516B2 (en) 2007-11-01 2011-12-13 Acucela, Inc. Amine derivative compounds for treating ophthalmic diseases and disorders
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HK1210969A1 (en) 2012-01-20 2016-05-13 奥克塞拉有限公司 Substituted heterocyclic compounds for disease treatment
CN102993032B (zh) * 2012-12-20 2014-08-27 山东阿如拉药物研究开发有限公司 一种盐酸甲氧明的合成方法
MY194736A (en) 2015-09-23 2022-12-15 Aerpio Therapeutics Inc Methods of treating intraocular pressure with activators of tie-2
CN109369353A (zh) * 2018-11-28 2019-02-22 嘉实（湖南）医药科技有限公司 一种美托洛尔中间体的制备方法
GB201909680D0 (en) * 2019-07-05 2019-08-21 Malvern Cosmeceutics Ltd Hypercoiling polymer derivatives
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US20250270173A1 (en) * 2022-04-19 2025-08-28 Gilgamesh Pharmaceuticals, Inc. Pyridine derivatives for treating psychiatric disorders
WO2024059090A1 (en) * 2022-09-12 2024-03-21 Gilgamesh Pharmaceuticals, Inc. Phenalkylamines and methods of making and using the same
WO2025085701A1 (en) * 2023-10-18 2025-04-24 Gilgamesh Pharmaceuticals, Inc. Pyridine derivatives for treating psychiatric disorders

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Also Published As

Publication number Publication date
US20070072920A1 (en) 2007-03-29
UY29802A1 (es) 2007-02-28
WO2007038372A1 (en) 2007-04-05
TW200744567A (en) 2007-12-16

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