PE20140411A1 - Derivados de 2,3-dihidroimidazo[1,2-c]quinazolina sustituidos con aminoalcoholes que son de utilidad para tratar trastornos hiperproliferativos y enfermedades asociadas a la angiogenesis - Google Patents
Derivados de 2,3-dihidroimidazo[1,2-c]quinazolina sustituidos con aminoalcoholes que son de utilidad para tratar trastornos hiperproliferativos y enfermedades asociadas a la angiogenesisInfo
- Publication number
- PE20140411A1 PE20140411A1 PE2013001051A PE2013001051A PE20140411A1 PE 20140411 A1 PE20140411 A1 PE 20140411A1 PE 2013001051 A PE2013001051 A PE 2013001051A PE 2013001051 A PE2013001051 A PE 2013001051A PE 20140411 A1 PE20140411 A1 PE 20140411A1
- Authority
- PE
- Peru
- Prior art keywords
- dihydroimidazo
- aminoalcohols
- useful
- angiogenesis
- derivatives
- Prior art date
Links
- NTTQCLSBWRKUIJ-UHFFFAOYSA-N 2,3-dihydroimidazo[1,2-c]quinazoline Chemical group C1=CC=C2C3=NCCN3C=NC2=C1 NTTQCLSBWRKUIJ-UHFFFAOYSA-N 0.000 title abstract 2
- 150000001414 amino alcohols Chemical group 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 2
- 230000033115 angiogenesis Effects 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 230000003463 hyperproliferative effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 abstract 2
- 206010025323 Lymphomas Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 108091007960 PI3Ks Proteins 0.000 abstract 1
- 102000003993 Phosphatidylinositol 3-kinases Human genes 0.000 abstract 1
- 108090000430 Phosphatidylinositol 3-kinases Proteins 0.000 abstract 1
- OCBFFGCSTGGPSQ-UHFFFAOYSA-N [CH2]CC Chemical compound [CH2]CC OCBFFGCSTGGPSQ-UHFFFAOYSA-N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 208000032839 leukemia Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical group [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- JWVCLYRUEFBMGU-UHFFFAOYSA-N quinazoline Chemical compound N1=CN=CC2=CC=CC=C21 JWVCLYRUEFBMGU-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE REFIERE A COMPUESTOS DERIVADOS DE 2,3-DIHIDROIMIDAZO[1,2-c]QUINAZOLINA SUSTITUIDOS CON AMINOALCOHOLES DE FORMULA (I) DONDE R1 ES -(CH2)n-(CHR4)-(CH2)m-N(R5)(R5') EN DONDE R4 ES HIDROXI; R5 Y R5' SON CADA UNO H, ALQUILO(C1-C6), CICLOALQUIL(C3-C6)-ALQUILO(C1-C6), ENTRE OTROS; n Y m SON 1; R2 ES UN HETEROARILO DE FORMULA (i) OPCIONALMENTE SUSTITUIDO CON R6, EN DONDE X ES N O CR6; X' ES O, S, NH, NR6, ENTRE OTROS; R6 ES H, HALOGENO, ALQUILO(C1-C6), ALQUENILO(C2-C6), ENTRE OTROS; R3 ES METILO. SON COMPUESTOS PREFERIDOS: N-(8-{[(2R)-2-HIDROXI-3-(MORFOLIN-4-IL)PROPIL]OXI}-7-METOXI-2,3-DIHIDROIMIDAZO[1,2-c]QUINAZOLIN-5-IL)PIRIDIN-3-CARBOXAMIDA; N-[8-({(2R)-3-[(2R,6S)-2,6-DIMETILMORFOLIN-4-IL]-2-HIDROXIPROPIL}OXI)-7-METOXI-2,3-DIHIDROIMIDAZO[1,2-c]QUINAZOLIN-5-IL]PIRIDIN-3-CARBOXAMIDA; ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA FOSFATIDILINOSITOL-3-QUINASA ALFA Y BETA SIENDO UTILES EN EL TRATAMIENTO DE LEUCEMIA, LINFOMA MALIGNO, TUMOR DE CABEZA
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41255610P | 2010-11-11 | 2010-11-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20140411A1 true PE20140411A1 (es) | 2014-04-13 |
Family
ID=44999756
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2013001051A PE20140411A1 (es) | 2010-11-11 | 2011-11-08 | Derivados de 2,3-dihidroimidazo[1,2-c]quinazolina sustituidos con aminoalcoholes que son de utilidad para tratar trastornos hiperproliferativos y enfermedades asociadas a la angiogenesis |
Country Status (31)
| Country | Link |
|---|---|
| US (2) | US8895549B2 (es) |
| EP (1) | EP2638045B1 (es) |
| JP (1) | JP6196156B2 (es) |
| KR (1) | KR20140003436A (es) |
| CN (1) | CN102906094B (es) |
| AP (1) | AP3337A (es) |
| AR (1) | AR083842A1 (es) |
| AU (1) | AU2011328192B2 (es) |
| BR (1) | BR112013011634A2 (es) |
| CA (1) | CA2817317C (es) |
| CL (1) | CL2013001295A1 (es) |
| CO (1) | CO6761350A2 (es) |
| CR (1) | CR20130213A (es) |
| CU (1) | CU20130069A7 (es) |
| DO (1) | DOP2013000105A (es) |
| EA (1) | EA024406B1 (es) |
| EC (1) | ECSP13012618A (es) |
| GT (1) | GT201300121A (es) |
| IL (1) | IL226066A0 (es) |
| MA (1) | MA34655B1 (es) |
| MX (1) | MX2013005305A (es) |
| MY (1) | MY164730A (es) |
| NZ (1) | NZ610018A (es) |
| PE (1) | PE20140411A1 (es) |
| PH (1) | PH12013500938A1 (es) |
| SG (1) | SG190100A1 (es) |
| TW (1) | TW201305170A (es) |
| UA (1) | UA113280C2 (es) |
| UY (1) | UY33719A (es) |
| WO (1) | WO2012062748A1 (es) |
| ZA (1) | ZA201304244B (es) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2817287A1 (en) * | 2010-11-11 | 2012-05-18 | Bayer Intellectual Property Gmbh | Arylaminoalcohol-substituted 2,3-dihydroimidazo[1,2-c]quinolines |
| UA113280C2 (xx) * | 2010-11-11 | 2017-01-10 | АМІНОСПИРТЗАМІЩЕНІ ПОХІДНІ 2,3-ДИГІДРОІМІДАЗО$1,2-c]ХІНАЗОЛІНУ, ПРИДАТНІ ДЛЯ ЛІКУВАННЯ ГІПЕРПРОЛІФЕРАТИВНИХ ПОРУШЕНЬ І ЗАХВОРЮВАНЬ, ПОВ'ЯЗАНИХ З АНГІОГЕНЕЗОМ | |
| CA2817312A1 (en) * | 2010-11-11 | 2012-05-18 | Bayer Intellectual Property Gmbh | Alkoxy-substituted 2,3-dihydroimidazo[1,2-c]quinazolines |
| JO3733B1 (ar) | 2011-04-05 | 2021-01-31 | Bayer Ip Gmbh | استخدام 3,2-دايهيدروايميدازو[1, 2 -c]كوينازولينات مستبدلة |
| EP2508525A1 (en) | 2011-04-05 | 2012-10-10 | Bayer Pharma Aktiengesellschaft | Substituted 2,3-dihydroimidazo[1,2-c]quinazoline salts |
| CN103214489B (zh) * | 2013-02-25 | 2016-10-26 | 中国人民解放军第二军医大学 | 一类具有抗肿瘤活性的多靶点激酶抑制剂及其制备方法 |
| JP6368353B2 (ja) * | 2013-04-08 | 2018-08-01 | バイエル ファーマ アクチエンゲゼルシャフト | 置換された２，３−ジヒドロイミダゾ［１，２−ｃ］キナゾリン類のリンパ腫治療への使用 |
| US10124007B2 (en) | 2013-12-03 | 2018-11-13 | Bayer Pharma Aktiengesellschaft | Combination of PI3K-inhibitors |
| JP6499657B2 (ja) | 2013-12-03 | 2019-04-10 | バイエル ファーマ アクチエンゲゼルシャフト | Ｐｉ３ｋ阻害剤の組み合わせ |
| WO2015082376A2 (en) | 2013-12-03 | 2015-06-11 | Bayer Pharma Aktiengesellschaft | Use of pi3k-inhibitors |
| WO2016071380A1 (en) * | 2014-11-07 | 2016-05-12 | Bayer Pharma Aktiengesellschaft | Synthesis of pi3k inhibitor and salts thereof |
| WO2016071382A1 (en) * | 2014-11-07 | 2016-05-12 | Bayer Pharma Aktiengesellschaft | Synthesis of pi3k inhibitor and salts thereof |
| WO2016087488A1 (en) * | 2014-12-03 | 2016-06-09 | Bayer Pharma Aktiengesellschaft | Administration regime for aminoalcohol substituted 2,3-dihydroimidazo[1,2-c]quinazoline derivatives |
| WO2016087490A1 (en) * | 2014-12-03 | 2016-06-09 | Bayer Pharma Aktiengesellschaft | Combination of pi3k-inhibitors |
| JP2018532810A (ja) | 2015-11-07 | 2018-11-08 | マルチビア インコーポレイテッド | がんの処置のための腫瘍抑制因子遺伝子治療および免疫チェックポイント治療を含む組成物 |
| WO2018054782A1 (en) | 2016-09-23 | 2018-03-29 | Bayer Pharma Aktiengesellschaft | Combination of pi3k-inhibitors |
| AU2017375958A1 (en) | 2016-12-12 | 2019-07-04 | Multivir Inc. | Methods and compositions comprising viral gene therapy and an immune checkpoint inhibitor for treatment and prevention of cancer and infectious diseases |
| WO2018215282A1 (en) | 2017-05-26 | 2018-11-29 | Bayer Pharma Aktiengesellschaft | Combination of bub1 and pi3k inhibitors |
| US11185549B2 (en) | 2017-06-28 | 2021-11-30 | Bayer Consumer Care Ag | Combination of a PI3K-inhibitor with an androgen receptor antagonist |
| CN112020510B (zh) | 2018-03-19 | 2024-10-11 | 茂体外尔公司 | 包含用于治疗癌症的肿瘤抑制基因疗法和cd122/cd132激动剂的方法及组合物 |
| CN108383849B (zh) * | 2018-04-26 | 2020-11-06 | 浙江大学 | 咪唑并喹唑啉衍生物及其在抗肿瘤抗炎中的应用 |
| SG11202108752YA (en) * | 2019-03-07 | 2021-09-29 | BioNTech SE | Process for the preparation of a substituted imidazoquinoline |
| EP4045505A1 (en) * | 2019-10-15 | 2022-08-24 | Bayer Aktiengesellschaft | 2-methyl-aza-quinazolines |
| WO2021113644A1 (en) | 2019-12-05 | 2021-06-10 | Multivir Inc. | Combinations comprising a cd8+ t cell enhancer, an immune checkpoint inhibitor and radiotherapy for targeted and abscopal effects for the treatment of cancer |
| WO2021260443A1 (en) | 2020-06-24 | 2021-12-30 | Bayer Aktiengesellschaft | Combinations of 2,3-dihydroimidazo[1,2-c]quinazolines |
| CN115572256B (zh) * | 2021-06-21 | 2025-01-24 | 武汉睿健医药科技有限公司 | Oct4高选择性活化剂 |
| CN113512040B (zh) * | 2021-08-25 | 2023-10-13 | 河南牧业经济学院 | 一种血根碱仿生化合物及其制备方法 |
| EP4511373A1 (en) * | 2022-04-20 | 2025-02-26 | Synnovation Therapeutics, Inc. | Pi3k? inhibitors |
| US20250346603A1 (en) * | 2022-05-26 | 2025-11-13 | Pikavation Therapeutics, Inc. | Tricyclic compounds as pi3kalpha inhibitors |
| AR134129A1 (es) * | 2023-10-17 | 2025-12-03 | Synnovation Therapeutics Inc | COMPUESTOS TRICÍCLICOS COMO INHIBIDORES DE PI3Ka |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5023252A (en) | 1985-12-04 | 1991-06-11 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery of drugs |
| US5011472A (en) | 1988-09-06 | 1991-04-30 | Brown University Research Foundation | Implantable delivery system for biological factors |
| GB9400680D0 (en) | 1994-01-14 | 1994-03-09 | Sandoz Ltd | Improvements in or relating to organic compounds |
| US5792766A (en) | 1996-03-13 | 1998-08-11 | Neurogen Corporation | Imidazo 1,5-c! quinazolines; a new class of GABA brain receptor ligands |
| ATE411996T1 (de) * | 2002-09-30 | 2008-11-15 | Bayer Healthcare Ag | Kondensierte azolpyrimidinderivate |
| DE602004004553T2 (de) | 2003-09-19 | 2007-10-25 | Astrazeneca Ab | Chinazolinderivate |
| NZ546273A (en) * | 2003-10-03 | 2009-05-31 | Coley Pharm Group Inc | Alkoxy substituted imidazoquinolines |
| EP1719771A1 (en) * | 2004-02-19 | 2006-11-08 | Takeda Pharmaceutical Company Limited | Pyrazoloquinolone derivative and use thereof |
| CA2659696C (en) | 2006-08-03 | 2014-04-22 | Rottapharm S.P.A. | 6-1h-imidazo-quinazoline and quinolines derivatives, new potent analgesics and anti-inflammatory agents |
| AR064106A1 (es) * | 2006-12-05 | 2009-03-11 | Bayer Schering Pharma Ag | Derivados de 2,3-dihidroimidazo [1,2-c] quinazolina sustituida utiles para el tratamiento de enfermedades y trastornos hiper-proliferativos asociados con la angiogenesis |
| GB2454549B (en) * | 2007-09-25 | 2009-09-23 | Medical & Pharm Ind Tech & Dev | Uses of 2-[piperidinyl]methyl-2,3-dihydroimidazo[1,2-c]quinazolin-5(6H)-one for providing an anti-allergic effect and histamine H1 receptor antagonism effect |
| CA2728376C (en) | 2008-06-20 | 2015-05-12 | Rottapharm S.P.A. | 6-1h-imidazo-quinazoline and quinolines derivatives/mao inhibitors for treating depression |
| US8846701B2 (en) | 2008-06-26 | 2014-09-30 | Nerviano Medical Sciences S.R.L. | Pyrazolo-quinazolines |
| EP2168583A1 (en) * | 2008-09-24 | 2010-03-31 | Bayer Schering Pharma Aktiengesellschaft | Use of substituted 2,3-dihydroimidazo[1,2-c]quinazolines for the treatment of myeloma |
| MA34158B1 (fr) | 2010-04-16 | 2013-04-03 | Bayer Ip Gmbh | Combinaisons contenant une 2,3-dihydroimidazo{1,2-c]quinazoline substituée |
| CA2817312A1 (en) * | 2010-11-11 | 2012-05-18 | Bayer Intellectual Property Gmbh | Alkoxy-substituted 2,3-dihydroimidazo[1,2-c]quinazolines |
| CA2817287A1 (en) * | 2010-11-11 | 2012-05-18 | Bayer Intellectual Property Gmbh | Arylaminoalcohol-substituted 2,3-dihydroimidazo[1,2-c]quinolines |
| UA113280C2 (xx) * | 2010-11-11 | 2017-01-10 | АМІНОСПИРТЗАМІЩЕНІ ПОХІДНІ 2,3-ДИГІДРОІМІДАЗО$1,2-c]ХІНАЗОЛІНУ, ПРИДАТНІ ДЛЯ ЛІКУВАННЯ ГІПЕРПРОЛІФЕРАТИВНИХ ПОРУШЕНЬ І ЗАХВОРЮВАНЬ, ПОВ'ЯЗАНИХ З АНГІОГЕНЕЗОМ |
-
2011
- 2011-08-11 UA UAA201307179A patent/UA113280C2/uk unknown
- 2011-11-08 AP AP2013006921A patent/AP3337A/xx active
- 2011-11-08 MY MYPI2013700753A patent/MY164730A/en unknown
- 2011-11-08 JP JP2013538163A patent/JP6196156B2/ja active Active
- 2011-11-08 EA EA201300556A patent/EA024406B1/ru not_active IP Right Cessation
- 2011-11-08 KR KR1020137014882A patent/KR20140003436A/ko not_active Ceased
- 2011-11-08 CN CN201180023122.7A patent/CN102906094B/zh not_active Expired - Fee Related
- 2011-11-08 US US13/885,122 patent/US8895549B2/en active Active
- 2011-11-08 NZ NZ610018A patent/NZ610018A/en not_active IP Right Cessation
- 2011-11-08 PE PE2013001051A patent/PE20140411A1/es not_active Application Discontinuation
- 2011-11-08 WO PCT/EP2011/069637 patent/WO2012062748A1/en not_active Ceased
- 2011-11-08 CA CA2817317A patent/CA2817317C/en active Active
- 2011-11-08 MA MA35889A patent/MA34655B1/fr unknown
- 2011-11-08 BR BR112013011634A patent/BR112013011634A2/pt not_active IP Right Cessation
- 2011-11-08 MX MX2013005305A patent/MX2013005305A/es unknown
- 2011-11-08 SG SG2013033634A patent/SG190100A1/en unknown
- 2011-11-08 PH PH1/2013/500938A patent/PH12013500938A1/en unknown
- 2011-11-08 AU AU2011328192A patent/AU2011328192B2/en not_active Ceased
- 2011-11-08 EP EP11784978.6A patent/EP2638045B1/en active Active
- 2011-11-10 UY UY0001033719A patent/UY33719A/es not_active Application Discontinuation
- 2011-11-11 AR ARP110104216A patent/AR083842A1/es unknown
- 2011-11-11 TW TW100141328A patent/TW201305170A/zh unknown
-
2013
- 2013-04-30 IL IL226066A patent/IL226066A0/en unknown
- 2013-05-10 CO CO13117697A patent/CO6761350A2/es not_active Application Discontinuation
- 2013-05-10 EC ECSP13012618 patent/ECSP13012618A/es unknown
- 2013-05-10 DO DO2013000105A patent/DOP2013000105A/es unknown
- 2013-05-10 CR CR20130213A patent/CR20130213A/es unknown
- 2013-05-10 GT GT201300121A patent/GT201300121A/es unknown
- 2013-05-10 CU CU2013000069A patent/CU20130069A7/es unknown
- 2013-05-10 CL CL2013001295A patent/CL2013001295A1/es unknown
- 2013-06-10 ZA ZA2013/04244A patent/ZA201304244B/en unknown
-
2014
- 2014-11-25 US US14/553,280 patent/US9902727B2/en active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PE20140411A1 (es) | Derivados de 2,3-dihidroimidazo[1,2-c]quinazolina sustituidos con aminoalcoholes que son de utilidad para tratar trastornos hiperproliferativos y enfermedades asociadas a la angiogenesis | |
| PE20140571A1 (es) | Uso de 2,3-dihidroimidazo[1,2-c]quinazolinas sustituidas | |
| UY28885A1 (es) | 4-fenilamino-quinazolin-6-il-amidas referencia cruzada a solicitud(es) relacionada(s) | |
| EA200870360A1 (ru) | Бензимидазолы, обладающие активностью в отношении рецепторов м1, и их применение в медицине | |
| PE20221264A1 (es) | Inhibidores de egfr | |
| PE20151249A1 (es) | Derivados de pirazolopirimidina como inhibidores de jak quinasas | |
| PE20142454A1 (es) | Compuestos de benzaldehido sustituidos y metodos para su uso en incrementar la oxigenacion del tejido | |
| RU2016140420A (ru) | Производное 1,3-бензодиоксола | |
| PE20141205A1 (es) | Spiro-[1,3]-oxacinas y spiro-[1,4]-oxacepinas como inhibidores de bace1 y/o bace2 | |
| PE20121352A1 (es) | Derivados de heteroarilo que contienen n como inhibidores de cinasa jak3 | |
| PE20071311A1 (es) | Compuestos 8-azabiciclo[3.2.1]octano como antagonistas del receptor opioide mu | |
| RU2013148721A (ru) | Комбинации соединений, ингибирующих акт и вемурафениба и способы их применения | |
| ECSP066730A (es) | Compuestos y procedimientos para uso | |
| AR064010A1 (es) | Inhibidores de la actividad de la akt | |
| PE20110588A1 (es) | Derivados de benzotiazol como agentes anticancerigenos | |
| MX2010010151A (es) | Moduladores de cinasa aurora y metodo de uso. | |
| PE20110545A1 (es) | Compuestos de triazolopiridina como inhibidores de jak | |
| PE20130149A1 (es) | Derivados de la cromenona con actividad anti-tumoral | |
| PE20091315A1 (es) | Ciclopentanos de pirimidilo como inhibidores de la proteina cinasa akt | |
| RU2016134751A (ru) | Соединения | |
| MX2012000809A (es) | Formas cristalinas de n-[3-fluoro-4-({6-(metiloxi)-7-[(3-morfolin- 4-ilpropil)oxi]-quinolin-4-il}oxi)fenil]-n'-(4-fluorofenil)ciclop ropan-1,1-dicarboxamida. | |
| MX387207B (es) | Inhibidores de proteína quinasa, método de preparación y su uso médico. | |
| PE20141553A1 (es) | Compuestos de triazolopiridina como inhibidores de la ped10a | |
| RU2013144571A (ru) | Алинзамещенные хиназолины и способы их применения | |
| RU2014152790A (ru) | Пирролопиразоновые ингибиторы танкиразы |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |