AR057515A1 - Composiciones incecticidas y metodos para crear plantas transgenicas resistentes a los insectos - Google Patents
Composiciones incecticidas y metodos para crear plantas transgenicas resistentes a los insectosInfo
- Publication number
- AR057515A1 AR057515A1 ARP060103814A ARP060103814A AR057515A1 AR 057515 A1 AR057515 A1 AR 057515A1 AR P060103814 A ARP060103814 A AR P060103814A AR P060103814 A ARP060103814 A AR P060103814A AR 057515 A1 AR057515 A1 AR 057515A1
- Authority
- AR
- Argentina
- Prior art keywords
- diabrotica
- corn
- worm
- transgenic plants
- proteins
- Prior art date
Links
- 230000009261 transgenic effect Effects 0.000 title abstract 3
- 241000238631 Hexapoda Species 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title 1
- 240000008042 Zea mays Species 0.000 abstract 5
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 abstract 5
- 235000002017 Zea mays subsp mays Nutrition 0.000 abstract 5
- 235000005822 corn Nutrition 0.000 abstract 5
- 241000196324 Embryophyta Species 0.000 abstract 3
- 102000004169 proteins and genes Human genes 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 241000381325 Diabrotica virgifera zeae Species 0.000 abstract 2
- 108091033319 polynucleotide Proteins 0.000 abstract 2
- 239000002157 polynucleotide Substances 0.000 abstract 2
- 102000040430 polynucleotide Human genes 0.000 abstract 2
- 206010004194 Bed bug infestation Diseases 0.000 abstract 1
- 241001414835 Cimicidae Species 0.000 abstract 1
- 241001529600 Diabrotica balteata Species 0.000 abstract 1
- 241000489972 Diabrotica barberi Species 0.000 abstract 1
- 241000916731 Diabrotica speciosa Species 0.000 abstract 1
- 241000916730 Diabrotica viridula Species 0.000 abstract 1
- 241000258937 Hemiptera Species 0.000 abstract 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 230000004927 fusion Effects 0.000 abstract 1
- 239000002917 insecticide Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
- C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
- C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
- C12N15/8286—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance for insect resistance
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
- A01N63/50—Isolated enzymes; Isolated proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
- C07K14/325—Bacillus thuringiensis crystal peptides, i.e. delta-endotoxins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/10—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in agriculture
- Y02A40/146—Genetically Modified [GMO] plants, e.g. transgenic plants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pest Control & Pesticides (AREA)
- Crystallography & Structural Chemistry (AREA)
- Insects & Arthropods (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Virology (AREA)
- Agronomy & Crop Science (AREA)
- Environmental Sciences (AREA)
- Dentistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
Abstract
Secuencias polinucleotídicas aisladas que codifican proteínas ET37, TIC810 y TIC812 de Bacilus thuringiensis, secuencias de nucleotidos para usar en la expresion de TIC809, ET37, TIC810 y TIC812 y fusiones de diversas combinaciones efectivas como insecticidas de estas proteínas tales como TIC127, en las plantas. Se describe método para eleaboracion y uso de las secuencias polinucleotídicas y las proteínas en el desarrollo de células de plantas transgénicas y plantas transgénicas que exhiben resistencia mejorada contra (1) insectos Coliopteros, que incluyen el gusano de las raíces del maíz del oeste (Dibrotica virgifera), el gusano de las raíces del maíz del sur (Dibrotica undecempunctata ), el gusano de las raíces del maíz del Norte (Diabrotica barberi), el gusano de las raíces del maíz de Méjico (Diabrotica virgifera zeae), el gusano de las raíces del maíz de Brasil (Diabrotica balteata) y el complejo del gusano de las raíces del maíz de Brasil (Diabrotica viridula y Diabrotica speciosa), y contra insectos Hemípteros tales como chinches Lygos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71311105P | 2005-08-31 | 2005-08-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR057515A1 true AR057515A1 (es) | 2007-12-05 |
Family
ID=37698224
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060103814A AR057515A1 (es) | 2005-08-31 | 2006-08-31 | Composiciones incecticidas y metodos para crear plantas transgenicas resistentes a los insectos |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US9121035B2 (es) |
| EP (1) | EP1920060B1 (es) |
| CN (1) | CN101300353A (es) |
| AR (1) | AR057515A1 (es) |
| AT (1) | ATE505548T1 (es) |
| AU (1) | AU2006284856B2 (es) |
| BR (1) | BRPI0615649A2 (es) |
| CA (1) | CA2618430A1 (es) |
| CR (1) | CR9769A (es) |
| DE (1) | DE602006021318D1 (es) |
| EC (1) | ECSP088226A (es) |
| MX (1) | MX2008002801A (es) |
| RU (1) | RU2008112187A (es) |
| WO (1) | WO2007027776A2 (es) |
| ZA (1) | ZA200801477B (es) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013032527A1 (en) | 2011-09-02 | 2013-03-07 | The Regents Of The University Of California | Llp2a-bisphosphonate conjugates for osteoporosis treatment |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060200878A1 (en) | 2004-12-21 | 2006-09-07 | Linda Lutfiyya | Recombinant DNA constructs and methods for controlling gene expression |
| US10501375B2 (en) | 2006-06-30 | 2019-12-10 | Corning Incorporated | Cordierite aluminum magnesium titanate compositions and ceramic articles comprising same |
| US8956436B2 (en) | 2006-06-30 | 2015-02-17 | Corning Incorporated | Cordierite aluminum magnesium titanate compositions and ceramic articles comprising same |
| US8946511B2 (en) * | 2006-10-12 | 2015-02-03 | Monsanto Technology Llc | Plant microRNAs and methods of use thereof |
| US10036036B1 (en) * | 2007-03-15 | 2018-07-31 | Monsanto Technology Llc | Compositions and methods for deploying a transgenic refuge as a seed blend |
| US8609936B2 (en) * | 2007-04-27 | 2013-12-17 | Monsanto Technology Llc | Hemipteran-and coleopteran active toxin proteins from Bacillus thuringiensis |
| AU2009285624B2 (en) | 2008-08-29 | 2013-12-05 | Monsanto Technology Llc | Novel Hemipteran and coleopteran active toxin proteins from Bacillus thuringiensis |
| MX383565B (es) * | 2008-10-15 | 2025-03-14 | Centro De Investigacion Y De Estudios Avanzados Del Instituto Politecnico Nac | Proteinas derivadas de genes cry de bacillus thuringiensis. |
| WO2011050271A1 (en) | 2009-10-23 | 2011-04-28 | Monsanto Technology Llc | Methods and compositions for expression of transgenes in plants |
| US9238678B2 (en) | 2011-04-07 | 2016-01-19 | Monsanto Technology Llc | Insect inhibitory toxin family active against hemipteran and/or lepidopteran insects |
| WO2012174271A2 (en) | 2011-06-16 | 2012-12-20 | The Regents Of The University Of California | Synthetic gene clusters |
| US20130227743A1 (en) * | 2011-08-19 | 2013-08-29 | Christopher J. Grandlic | Integrated method for high-throughput identification of novel pesticidal compositions and uses therefor |
| WO2013052870A2 (en) * | 2011-10-06 | 2013-04-11 | Dow Agrosciences Llc | Nucleic acid molecules that target pp1-87b and confer resistance to coleopteran pests |
| BR112014022195A2 (pt) | 2012-03-09 | 2020-05-12 | Vestaron Corporation | Produção de peptídeo tóxico, expressão de peptídeo em plantas e combinações de peptídeos ricos em cisteína |
| US11692016B2 (en) | 2012-03-09 | 2023-07-04 | Vestaron Corporation | High gene expression yeast strain |
| SG11201406327YA (en) | 2012-04-06 | 2014-11-27 | Monsanto Technology Llc | Proteins toxic to hemipteran insect species |
| US9688730B2 (en) * | 2012-07-02 | 2017-06-27 | Pioneer Hi-Bred International, Inc. | Insecticidal proteins and methods for their use |
| US10968446B2 (en) | 2012-11-01 | 2021-04-06 | Massachusetts Institute Of Technology | Directed evolution of synthetic gene cluster |
| CN102993282B (zh) * | 2012-11-19 | 2014-10-15 | 北京大北农科技集团股份有限公司 | 杀虫蛋白质、其编码基因及用途 |
| WO2014182473A1 (en) * | 2013-05-08 | 2014-11-13 | Monsanto Technology Llc | Compositions and methods for deploying a transgenic refuge seed blend |
| CN106232820A (zh) * | 2013-08-16 | 2016-12-14 | 先锋国际良种公司 | 杀昆虫蛋白及其使用方法 |
| BR112017010574B1 (pt) * | 2014-11-20 | 2024-01-30 | Monsanto Technology Llc | Cassete de expressão, célula hospedeira bacteriana, composição inibidora de inseto, método para controlar uma praga de espécie coleoptera, e vetor recombinante |
| TW201629221A (zh) * | 2014-12-16 | 2016-08-16 | 陶氏農業科學公司 | 以克魯拜爾基因(KRUPPEL GENE)之親代RNA干擾(RNAi)抑制作用來控制半翅目害蟲之技術 |
| BR102016005404A2 (pt) * | 2015-03-13 | 2016-09-20 | Dow Agrosciences Llc | moléculas de ácido nucléico de rna polimerase ii33 para controlar as pragas de inseto |
| BR102016005432A2 (pt) * | 2015-03-13 | 2016-09-13 | Dow Agrosciences Llc | moléculas de ácido nucléico de rna polimerase ii33 para controlar as pragas de inseto |
| AU2016294506B2 (en) | 2015-07-13 | 2020-02-13 | Pivot Bio, Inc. | Methods and compositions for improving plant traits |
| HRP20211858T1 (hr) * | 2015-07-30 | 2022-03-04 | Monsanto Technology, Llc | Novi proteini za inhibiciju insekata |
| EP3943602A1 (en) | 2015-08-06 | 2022-01-26 | Pioneer Hi-Bred International, Inc. | Plant derived insecticidal proteins and methods for their use |
| US10676757B2 (en) | 2015-08-25 | 2020-06-09 | Dow Agrosciences Llc | IRDIG17912 insecticidal Cry toxins |
| AU2016336328A1 (en) | 2015-10-05 | 2018-04-19 | Massachusetts Institute Of Technology | Nitrogen fixation using refactored nif clusters |
| WO2017079266A1 (en) | 2015-11-02 | 2017-05-11 | Monsanto Technology Llc | Cotton transgenic event mon 88702 and methods for detection and uses thereof |
| US10612037B2 (en) | 2016-06-20 | 2020-04-07 | Monsanto Technology Llc | Insecticidal proteins toxic or inhibitory to hemipteran pests |
| AU2017347761C1 (en) | 2016-10-21 | 2024-03-28 | Vestaron Corporation | Cleavable peptides and insecticidal and nematicidal proteins comprising same |
| EP3568385A4 (en) | 2017-01-12 | 2021-03-03 | Pivot Bio, Inc. | PROCEDURES AND COMPOSITIONS FOR IMPROVING PLANT PROPERTIES |
| CN120041362A (zh) | 2017-10-25 | 2025-05-27 | 皮沃特生物股份有限公司 | 用于改良固氮的工程微生物的方法和组合物 |
| CA3080172C (en) | 2017-10-25 | 2025-11-25 | Pivot Bio, Inc. | Genetic targets for nitrogen fixation targeting to improve plant traits |
| WO2019103986A1 (en) * | 2017-11-27 | 2019-05-31 | Bayer Cropscience Lp | Microtiter plates designed for high-throughput screening of piercing-sucking pests such as arthropods |
| EP3755797A1 (en) | 2018-02-22 | 2020-12-30 | Zymergen, Inc. | Method for creating a genomic library enriched for bacillus and identification of novel cry toxins |
| KR20200127180A (ko) | 2018-03-02 | 2020-11-10 | 지머젠 인코포레이티드 | 살충 단백질 발견 플랫폼 및 이로부터 발견된 살충 단백질 |
| US20190276840A1 (en) | 2018-03-09 | 2019-09-12 | James A. Baum | Methods and compositions for making and using compatible insecticidal proteins |
| AU2019291824A1 (en) * | 2018-06-27 | 2021-01-14 | Pivot Bio, Inc. | Agricultural compositions comprising remodeled nitrogen fixing microbes |
| BR112021000268A2 (pt) | 2018-07-11 | 2021-05-11 | Pivot Bio, Inc. | liberação dinâmica de nitrogênio temporalmente e espacialmente direcionada por micróbios remodelados |
| WO2020190363A1 (en) | 2019-03-19 | 2020-09-24 | Massachusetts Institute Of Technology | Control of nitrogen fixation in rhizobia that associate with cereals |
| US12281980B2 (en) | 2020-05-01 | 2025-04-22 | Pivot Bio, Inc. | Measurement of nitrogen fixation and incorporation |
| CN116676304B (zh) * | 2023-07-20 | 2023-09-26 | 隆平生物技术(海南)有限公司 | 转基因玉米事件lp016-1及其检测方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0413019T3 (da) | 1989-02-24 | 2001-11-12 | Monsanto Technology Llc | Syntetiske plantegener og fremgangsmåde til fremstilling af disse |
| US5849870A (en) * | 1993-03-25 | 1998-12-15 | Novartis Finance Corporation | Pesticidal proteins and strains |
| US5322687A (en) | 1993-07-29 | 1994-06-21 | Ecogen Inc. | Bacillus thuringiensis cryet4 and cryet5 toxin genes and proteins toxic to lepidopteran insects |
| US5723440A (en) * | 1995-06-07 | 1998-03-03 | Mycogen Corporation | Controlling hemipteran insect pests with Bacillus thuringiensis |
| US6093695A (en) | 1996-09-26 | 2000-07-25 | Monsanto Company | Bacillus thuringiensis CryET29 compositions toxic to coleopteran insects and ctenocephalides SPP |
| US6063597A (en) | 1997-12-18 | 2000-05-16 | Monsanto Company | Polypeptide compositions toxic to coleopteran insects |
| WO2001064024A1 (en) * | 2000-02-29 | 2001-09-07 | Auburn University | Multiple gene expression for engineering novel pathways and hyperexpression of foreign proteins in plants |
-
2006
- 2006-08-30 US US12/064,840 patent/US9121035B2/en active Active
- 2006-08-30 WO PCT/US2006/033867 patent/WO2007027776A2/en not_active Ceased
- 2006-08-30 MX MX2008002801A patent/MX2008002801A/es unknown
- 2006-08-30 BR BRPI0615649-5A patent/BRPI0615649A2/pt not_active IP Right Cessation
- 2006-08-30 AU AU2006284856A patent/AU2006284856B2/en not_active Ceased
- 2006-08-30 DE DE602006021318T patent/DE602006021318D1/de active Active
- 2006-08-30 EP EP06813950A patent/EP1920060B1/en active Active
- 2006-08-30 RU RU2008112187/13A patent/RU2008112187A/ru not_active Application Discontinuation
- 2006-08-30 AT AT06813950T patent/ATE505548T1/de active
- 2006-08-30 CN CNA2006800404600A patent/CN101300353A/zh active Pending
- 2006-08-30 CA CA002618430A patent/CA2618430A1/en not_active Abandoned
- 2006-08-31 AR ARP060103814A patent/AR057515A1/es unknown
-
2008
- 2008-02-13 ZA ZA200801477A patent/ZA200801477B/xx unknown
- 2008-02-26 EC EC2008008226A patent/ECSP088226A/es unknown
- 2008-02-27 CR CR9769A patent/CR9769A/es unknown
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013032527A1 (en) | 2011-09-02 | 2013-03-07 | The Regents Of The University Of California | Llp2a-bisphosphonate conjugates for osteoporosis treatment |
| EP2753626A1 (en) | 2011-09-02 | 2014-07-16 | The Regents of The University of California | Llp2a-bisphosphonate conjugates for osteoporosis treatment |
Also Published As
| Publication number | Publication date |
|---|---|
| ATE505548T1 (de) | 2011-04-15 |
| AU2006284856A1 (en) | 2007-03-08 |
| AU2006284856B2 (en) | 2011-06-02 |
| BRPI0615649A2 (pt) | 2011-05-24 |
| ECSP088226A (es) | 2008-03-26 |
| US20090068159A1 (en) | 2009-03-12 |
| CN101300353A (zh) | 2008-11-05 |
| WO2007027776A3 (en) | 2007-08-02 |
| EP1920060B1 (en) | 2011-04-13 |
| EP1920060A2 (en) | 2008-05-14 |
| US9121035B2 (en) | 2015-09-01 |
| WO2007027776A2 (en) | 2007-03-08 |
| MX2008002801A (es) | 2008-04-07 |
| ZA200801477B (en) | 2009-09-30 |
| RU2008112187A (ru) | 2009-10-10 |
| CR9769A (es) | 2008-08-06 |
| CA2618430A1 (en) | 2007-03-08 |
| DE602006021318D1 (de) | 2011-05-26 |
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