NO20075997L - Methoder til furifysering av tigecyklin - Google Patents

Methoder til furifysering av tigecyklin

Info

Publication number: NO20075997L
Authority: NO; Norway
Prior art keywords: methods; tigecycline; furphysing; preparations; tetracyclines
Prior art date: 2005-05-27

Application number

NO20075997A

Other languages

English (en)

Norwegian (no)

Inventor

Phaik-Eng Sum

Sylvain Daigneault

Michel Bernatchez

Anthony Scott Pilcher

Lalitha Krishnan

Jeffrey Marshall Horne

Adam Joseph Tuper

Iii Joseph James Mccauley

Adam P Michaud

Original Assignee

Wyeth Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-05-27

Filing date

2007-11-23

Publication date

2008-02-19

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36997702&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20075997(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2007-11-23 Application filed by Wyeth Corp filed Critical Wyeth Corp

2008-02-19 Publication of NO20075997L publication Critical patent/NO20075997L/no

Links

238000000034 method Methods 0.000 title abstract 3
229960004089 tigecycline Drugs 0.000 title abstract 2
FPZLLRFZJZRHSY-HJYUBDRYSA-N tigecycline Chemical compound C([C@H]1C2)C3=C(N(C)C)C=C(NC(=O)CNC(C)(C)C)C(O)=C3C(=O)C1=C(O)[C@@]1(O)[C@@H]2[C@H](N(C)C)C(O)=C(C(N)=O)C1=O FPZLLRFZJZRHSY-HJYUBDRYSA-N 0.000 title 1
238000002360 preparation method Methods 0.000 abstract 3
239000004098 Tetracycline Substances 0.000 abstract 2
235000019364 tetracycline Nutrition 0.000 abstract 2
150000003522 tetracyclines Chemical class 0.000 abstract 2
SOVUOXKZCCAWOJ-HJYUBDRYSA-N (4s,4as,5ar,12ar)-9-[[2-(tert-butylamino)acetyl]amino]-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1C2=C(N(C)C)C=C(NC(=O)CNC(C)(C)C)C(O)=C2C(O)=C2[C@@H]1C[C@H]1[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]1(O)C2=O SOVUOXKZCCAWOJ-HJYUBDRYSA-N 0.000 abstract 1
102000016736 Cyclin Human genes 0.000 abstract 1
108050006400 Cyclin Proteins 0.000 abstract 1
241000282376 Panthera tigris Species 0.000 abstract 1
238000000746 purification Methods 0.000 abstract 1
229960002180 tetracycline Drugs 0.000 abstract 1
229930101283 tetracycline Natural products 0.000 abstract 1
229940040944 tetracyclines Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/22—Separation; Purification; Stabilisation; Use of additives
- C07C231/24—Separation; Purification
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
- C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
- C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
- C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
- C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

NO20075997A 2005-05-27 2007-11-23 Methoder til furifysering av tigecyklin NO20075997L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US68562605P	2005-05-27	2005-05-27
PCT/US2006/020270 WO2006130431A1 (en)	2005-05-27	2006-05-25	Methods of purifying tigecycline

Publications (1)

Publication Number	Publication Date
NO20075997L true NO20075997L (no)	2008-02-19

Family

ID=36997702

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20075997A NO20075997L (no)	2005-05-27	2007-11-23	Methoder til furifysering av tigecyklin

Country Status (22)

Country	Link
US (1)	US20070049561A1 (es)
EP (1)	EP1890997A1 (es)
JP (1)	JP2008545702A (es)
KR (1)	KR20080016892A (es)
CN (1)	CN101228114A (es)
AR (1)	AR057034A1 (es)
AU (1)	AU2006252796A1 (es)
BR (1)	BRPI0610057A2 (es)
CA (1)	CA2609307A1 (es)
CR (1)	CR9542A (es)
EC (1)	ECSP078050A (es)
GT (1)	GT200600224A (es)
IL (1)	IL187361A0 (es)
MX (1)	MX2007014717A (es)
NI (1)	NI200700302A (es)
NO (1)	NO20075997L (es)
PA (1)	PA8676401A1 (es)
PE (1)	PE20070318A1 (es)
RU (1)	RU2007143158A (es)
TW (1)	TW200716516A (es)
WO (1)	WO2006130431A1 (es)
ZA (1)	ZA200710174B (es)

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CN102512429A (zh)	2005-03-14	2012-06-27	惠氏公司	替加环素组合物及制备方法
AR057649A1 (es) *	2005-05-27	2007-12-12	Wyeth Corp	Formas solidas cristalinas de tigeciclina y metodos para preparar las mismas
AR055336A1 (es)	2005-06-16	2007-08-22	Wyeth Corp	Proeso de elaboracion para la produccion de tigeciclina como un polvo reconstituible, polvo de tigeciclina liofilizado y producto hecho mediante el proceso
US20070244335A1 (en) *	2006-04-17	2007-10-18	Teva Pharmaceutical Industries Ltd.	Isolation of tetracycline derivatives
US8198470B2 (en)	2006-04-24	2012-06-12	Teva Pharmaceutical Industries Ltd.	Crystalline form II of tigecycline and processes for preparation thereof
DE202007019460U1 (de) *	2006-04-24	2012-10-24	Teva Pharmaceutical Industries Ltd.	Kristalline Tigecyclin-Formen
US8198469B2 (en)	2006-11-29	2012-06-12	Teva Pharmaceutical Industries Ltd.	Crystalline forms of tigecycline and processes for preparation thereof
BRPI0706517A2 (pt) *	2006-11-30	2011-03-29	Teva Pharma	processos para preparação de f 9-haloacetamidominociclinas
WO2008106234A1 (en) *	2007-03-01	2008-09-04	Teva Pharmaceutical Industries Ltd.	Processes for purification of tigecycline
AU2008246119A1 (en) *	2007-04-27	2008-11-06	Paratek Pharmaceuticals, Inc.	Methods for synthesizing and purifying aminoalkyl tetracycline compounds
EP2178827A1 (en) *	2007-06-21	2010-04-28	Sandoz AG	Crystalline solid forms
US20090099376A1 (en) *	2007-10-16	2009-04-16	Wyeth	Tigecycline and methods of preparing intermediates
ES2532880T3 (es)	2007-11-14	2015-04-01	Sandoz Ag	Formas cristalinas del Clorhidrato de Tigeciclina
CN101450916B (zh) *	2007-11-30	2012-11-21	上海来益生物药物研究开发中心有限责任公司	替加环素的合成方法
US20110124893A1 (en) *	2008-01-23	2011-05-26	Sandoz Ag	Antibiotic compounds
CA2746585C (en)	2008-12-18	2017-08-29	Sandoz Ag	Crystalline form c of tigecycline dihydrochloride and methods for its preparation
CA2751238A1 (en)	2009-03-12	2010-10-07	Wyeth Llc	Nitration of tetracyclines
ES2469829T3 (es) *	2009-11-26	2014-06-20	Sandoz Ag	Reacción de compuestos orgánicos con bajas cantidades de hidrógeno
CN102898325B (zh) *	2011-07-29	2015-07-08	江苏奥赛康药业股份有限公司	替加环素晶体及其制备方法
CN102952035A (zh) *	2011-09-15	2013-03-06	北京海步国际医药科技发展有限公司	替加环素新晶型及其制备方法
CN103091424B (zh) *	2013-01-31	2014-11-19	成都百裕科技制药有限公司	替加环素中杂质的检测方法
CN104515820B (zh) *	2013-10-06	2018-08-14	山东新时代药业有限公司	一种替加环素中间体的分析检测方法
EP3068370A2 (en)	2013-11-12	2016-09-21	Galenicum Health S.L.	Stable pharmaceutical compositions
PT108223B (pt) *	2015-02-13	2018-05-08	Hovione Farm S A	Novas formas polimórficas de minociclina base e processos para a sua preparação
CN105085311A (zh) *	2015-08-13	2015-11-25	江苏豪森药业股份有限公司	替加环素或其盐的高效纯化方法
CN107304173A (zh) *	2016-04-25	2017-10-31	浙江医药股份有限公司新昌制药厂	一种替加环素的晶型及其制备方法
CN111978196A (zh) *	2020-08-03	2020-11-24	河北圣雪大成制药有限责任公司	一种替加环素的纯化方法

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USRE26253E (en) *	1963-05-17	1967-08-15		And z-alkylamino-g-deoxytetracycline
US3433834A (en) *	1966-03-14	1969-03-18	American Cyanamid Co	Nitration of 11a-chloro tetracyclines
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US3518306A (en) *	1968-02-19	1970-06-30	American Cyanamid Co	7- and/or 9-(n-nitrosoalkylamino)-6-demethyl-6-deoxytetracyclines
US3579579A (en) *	1968-04-18	1971-05-18	American Cyanamid Co	Substituted 7- and/or 9-amino-6-demethyl-6-deoxytetracyclines
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US5420272A (en) *	1992-08-13	1995-05-30	American Cyanamid Company	7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
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US5442059A (en) *	1992-08-13	1995-08-15	American Cyanamid Company	9-[(substituted glycyl)amido)]-6-demethyl-6-deoxytetracyclines
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US5843925A (en) *	1994-12-13	1998-12-01	American Cyanamid Company	Methods for inhibiting angiogenesis, proliferation of endothelial or tumor cells and tumor growth
US6506740B1 (en) *	1998-11-18	2003-01-14	Robert A. Ashley	4-dedimethylaminotetracycline derivatives
CZ2003343A3 (cs) *	2000-07-07	2003-05-14	Trustees Of Tufts College	7-Substituované tetracyklinové sloučeniny

2006
- 2006-05-24 AR ARP060102156A patent/AR057034A1/es unknown
- 2006-05-25 GT GT200600224A patent/GT200600224A/es unknown
- 2006-05-25 CA CA002609307A patent/CA2609307A1/en not_active Abandoned
- 2006-05-25 RU RU2007143158/04A patent/RU2007143158A/ru not_active Application Discontinuation
- 2006-05-25 BR BRPI0610057-0A patent/BRPI0610057A2/pt not_active IP Right Cessation
- 2006-05-25 MX MX2007014717A patent/MX2007014717A/es not_active Application Discontinuation
- 2006-05-25 WO PCT/US2006/020270 patent/WO2006130431A1/en not_active Ceased
- 2006-05-25 JP JP2008513713A patent/JP2008545702A/ja not_active Withdrawn
- 2006-05-25 TW TW095118594A patent/TW200716516A/zh unknown
- 2006-05-25 PE PE2006000555A patent/PE20070318A1/es not_active Application Discontinuation
- 2006-05-25 KR KR1020077030569A patent/KR20080016892A/ko not_active Withdrawn
- 2006-05-25 AU AU2006252796A patent/AU2006252796A1/en not_active Abandoned
- 2006-05-25 EP EP06771191A patent/EP1890997A1/en not_active Withdrawn
- 2006-05-25 US US11/440,034 patent/US20070049561A1/en not_active Abandoned
- 2006-05-25 PA PA20068676401A patent/PA8676401A1/es unknown
- 2006-05-25 CN CNA2006800267923A patent/CN101228114A/zh active Pending
2007
- 2007-11-14 IL IL187361A patent/IL187361A0/en unknown
- 2007-11-22 NI NI200700302A patent/NI200700302A/es unknown
- 2007-11-22 CR CR9542A patent/CR9542A/es not_active Application Discontinuation
- 2007-11-23 NO NO20075997A patent/NO20075997L/no not_active Application Discontinuation
- 2007-11-26 ZA ZA200710174A patent/ZA200710174B/xx unknown
- 2007-12-22 EC EC2007008050A patent/ECSP078050A/es unknown

Also Published As

Publication number	Publication date
GT200600224A (es)	2007-01-12
RU2007143158A (ru)	2009-07-10
ZA200710174B (en)	2009-08-26
EP1890997A1 (en)	2008-02-27
TW200716516A (en)	2007-05-01
KR20080016892A (ko)	2008-02-22
AU2006252796A1 (en)	2006-12-07
CA2609307A1 (en)	2006-12-07
PA8676401A1 (es)	2009-03-31
WO2006130431A1 (en)	2006-12-07
JP2008545702A (ja)	2008-12-18
PE20070318A1 (es)	2007-04-11
BRPI0610057A2 (pt)	2010-05-25
MX2007014717A (es)	2008-02-15
CN101228114A (zh)	2008-07-23
AR057034A1 (es)	2007-11-14
ECSP078050A (es)	2008-01-23
IL187361A0 (en)	2008-04-13
US20070049561A1 (en)	2007-03-01
CR9542A (es)	2008-02-20
NI200700302A (es)	2008-07-24

Publication	Publication Date	Title
NO20075997L (no)	2008-02-19	Methoder til furifysering av tigecyklin
NO20076072L (no)	2008-02-19	Tigecyklin og metoder for fremstilling av 9-nitrominocyklin
NO20076001L (no)	2008-02-19	Tigecyklin og metoder for deres fremstilling
NO20075998L (no)	2008-02-19	Tigecyklin og metoder til fremstilling av 9-aminominocyklin
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NO20070391L (no)	2007-03-20	Jernsulfatbasert fosfatadsorbent
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Legal Events

Date	Code	Title	Description
2009-12-21	FC2A	Withdrawal, rejection or dismissal of laid open patent application