AR056154A1 - Procedimiento de preparacion de 8-fluoro-naftalen-1-ilamina y el uso de esta en la obtencion de un intermediario de sintesis de 7-{4-[4-(8-fluoro-naftalen-1-il)-piperazin-1-il]-butoxi}-3, 4-dihidro-1h-[1, 8]naftiridin-2-ona - Google Patents
Procedimiento de preparacion de 8-fluoro-naftalen-1-ilamina y el uso de esta en la obtencion de un intermediario de sintesis de 7-{4-[4-(8-fluoro-naftalen-1-il)-piperazin-1-il]-butoxi}-3, 4-dihidro-1h-[1, 8]naftiridin-2-onaInfo
- Publication number
- AR056154A1 AR056154A1 ARP060104638A AR056154A1 AR 056154 A1 AR056154 A1 AR 056154A1 AR P060104638 A ARP060104638 A AR P060104638A AR 056154 A1 AR056154 A1 AR 056154A1
- Authority
- AR
- Argentina
- Prior art keywords
- fluoro
- naftalen
- ona
- piperazin
- naftiridin
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 238000002360 preparation method Methods 0.000 title abstract 3
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- UGETXCOJGZUORS-UHFFFAOYSA-N 8-fluoronaphthalen-1-amine Chemical compound C1=CC(F)=C2C(N)=CC=CC2=C1 UGETXCOJGZUORS-UHFFFAOYSA-N 0.000 abstract 2
- KRHYYFGTRYWZRS-UHFFFAOYSA-N Fluorane Chemical compound F KRHYYFGTRYWZRS-UHFFFAOYSA-N 0.000 abstract 2
- 229910000040 hydrogen fluoride Inorganic materials 0.000 abstract 2
- CIRXNMWOLOTGND-UHFFFAOYSA-N 1-(8-fluoronaphthalen-1-yl)piperazine Chemical compound C=12C(F)=CC=CC2=CC=CC=1N1CCNCC1 CIRXNMWOLOTGND-UHFFFAOYSA-N 0.000 abstract 1
- JTCCAXGPZWYNEQ-UHFFFAOYSA-N 1h-naphtho[1,8-de][1,2,3]triazine Chemical compound N1N=NC2=CC=CC3=CC=CC1=C32 JTCCAXGPZWYNEQ-UHFFFAOYSA-N 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/067—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents attached to the same carbon chain, which is not interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/64—Preparation of compounds containing amino groups bound to a carbon skeleton by disproportionation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/08—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 condensed with carbocyclic rings or ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Se describe un procedimiento para la preparacion de 8-fluoro-naftalen-1-ilamina que comprende hacer reaccionar 1H-nafto[1,8-de][1,2,3]triazina con fluoruro de hidrogeno o un complejo de fluoruro de hidrogeno y una base n-donadora. Se indica también un procedimiento para uso de 8-fluoro-naftalen-1-ilamina producido como se describio anteriormente en la preparacion de 1-(8-fluoro-naftalen-1-il)-piperazina, que se puede usar como un intermediario en la produccion de 7-{4-[4-(8-fluoro-naftalen-1- il)-piperazin.-1-il]-butoxi}-3,4-dihidro-1H-[1,8]naftiridin-2-ona, un agonista parcial de D2 indicado para posible uso en el tratamiento de esquizofrenia.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72953005P | 2005-10-24 | 2005-10-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR056154A1 true AR056154A1 (es) | 2007-09-19 |
Family
ID=37885854
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060104638 AR056154A1 (es) | 2005-10-24 | 2006-10-24 | Procedimiento de preparacion de 8-fluoro-naftalen-1-ilamina y el uso de esta en la obtencion de un intermediario de sintesis de 7-{4-[4-(8-fluoro-naftalen-1-il)-piperazin-1-il]-butoxi}-3, 4-dihidro-1h-[1, 8]naftiridin-2-ona |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JP2007119461A (es) |
| AR (1) | AR056154A1 (es) |
| TW (1) | TW200800890A (es) |
| WO (1) | WO2007049124A1 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2023007515A (ja) * | 2019-12-10 | 2023-01-19 | 国立大学法人京都大学 | 発光材料、有機発光素子および化合物 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE147852C (es) * |
-
2006
- 2006-10-13 WO PCT/IB2006/002979 patent/WO2007049124A1/en not_active Ceased
- 2006-10-23 JP JP2006287810A patent/JP2007119461A/ja active Pending
- 2006-10-23 TW TW95139020A patent/TW200800890A/zh unknown
- 2006-10-24 AR ARP060104638 patent/AR056154A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2007119461A (ja) | 2007-05-17 |
| WO2007049124A1 (en) | 2007-05-03 |
| TW200800890A (en) | 2008-01-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |