AR055097A1 - Inhibidores de 6- alquiliden - penem beta - lactamasa triciclicos y combinacion de antibioticos de beta lactama : un antibiotico de amplio espectro - Google Patents
Inhibidores de 6- alquiliden - penem beta - lactamasa triciclicos y combinacion de antibioticos de beta lactama : un antibiotico de amplio espectroInfo
- Publication number
- AR055097A1 AR055097A1 ARP060103241A ARP060103241A AR055097A1 AR 055097 A1 AR055097 A1 AR 055097A1 AR P060103241 A ARP060103241 A AR P060103241A AR P060103241 A ARP060103241 A AR P060103241A AR 055097 A1 AR055097 A1 AR 055097A1
- Authority
- AR
- Argentina
- Prior art keywords
- beta
- pharmaceutically acceptable
- designates
- optionally substituted
- acceptable salt
- Prior art date
Links
- 239000003242 anti bacterial agent Substances 0.000 title 1
- 229940088710 antibiotic agent Drugs 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 229940126572 wide-spectrum antibiotic Drugs 0.000 title 1
- 150000003839 salts Chemical class 0.000 abstract 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
- 208000035143 Bacterial infection Diseases 0.000 abstract 3
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 3
- HVFLCNVBZFFHBT-ZKDACBOMSA-N cefepime Chemical compound S([C@@H]1[C@@H](C(N1C=1C([O-])=O)=O)NC(=O)\C(=N/OC)C=2N=C(N)SC=2)CC=1C[N+]1(C)CCCC1 HVFLCNVBZFFHBT-ZKDACBOMSA-N 0.000 abstract 3
- 229960002100 cefepime Drugs 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- 125000006704 (C5-C6) cycloalkyl group Chemical group 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- 238000001727 in vivo Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 239000003782 beta lactam antibiotic agent Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
- 239000002132 β-lactam antibiotic Substances 0.000 abstract 1
- 229940124586 β-lactam antibiotics Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/424—Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
- A61K31/431—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems containing further heterocyclic rings, e.g. ticarcillin, azlocillin, oxacillin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Un antibiotico de beta-lactama tal como cefepime y un compuesto de la formula (1), composiciones y el uso del mismo para el tratamiento de infeccion o enfermedad bacterial en un paciente que necesite del mismo. Reivindicacion 1: Un método para el tratamiento de una infeccion o enfermedad bacteriana caracterizado porque comprende proporcionar a un paciente que necesite del mismo una cantidad efectiva de cefepime o una sal farmacéuticamente aceptable del mismo y un compuesto de la formula (1) o una sal farmacéuticamente aceptable o éster hidrolizable in vivo del mismo en donde: uno de A y B designa H y el otro de A y B designa un grupo heteroarilo tricíclico fusionado opcionalmente sustituido; X es S u O; R5 es H, alquilo C1-6, cicloalquilo C5-6, o CHR3OCOalquilo C1-6; y R3 es H, alquilo C1-6, cicloalquilo C5-6, arilo opcionalmente substituido, o heteroarilo opcionalmente substituido. Reivindicacion 11: Una composicion que comprende un portador farmacéuticamente aceptable, cefepime o una sal farmacéuticamente aceptable del mismo, y un compuesto de la formula (1) o una sal farmacéuticamente aceptable o éster hidrolizable in vivo del mismo caracterizado porque: uno de A y B designa H y el otro de A y B designa un grupo heteroarilo tricíclico fusionado opcionalmente substituido; y X, R5 y R3 son como se definieron en la reivindicacion 1.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70280805P | 2005-07-27 | 2005-07-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR055097A1 true AR055097A1 (es) | 2007-08-08 |
Family
ID=37809337
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060103241A AR055097A1 (es) | 2005-07-27 | 2006-07-27 | Inhibidores de 6- alquiliden - penem beta - lactamasa triciclicos y combinacion de antibioticos de beta lactama : un antibiotico de amplio espectro |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20070027130A1 (es) |
| EP (1) | EP1909786A2 (es) |
| JP (1) | JP2009502932A (es) |
| CN (1) | CN101257902A (es) |
| AR (1) | AR055097A1 (es) |
| AU (1) | AU2006285308A1 (es) |
| BR (1) | BRPI0613928A2 (es) |
| CA (1) | CA2616468A1 (es) |
| GT (1) | GT200600332A (es) |
| MX (1) | MX2008001083A (es) |
| PE (1) | PE20070342A1 (es) |
| TW (1) | TW200738235A (es) |
| WO (1) | WO2007027323A2 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR039475A1 (es) * | 2002-05-01 | 2005-02-23 | Wyeth Corp | 6-alquiliden-penems triciclicos como inhibidores de beta-lactamasa |
| CN101798315B (zh) * | 2008-10-06 | 2012-07-04 | 山东轩竹医药科技有限公司 | 含有环丙烷并氮杂环的头孢菌素衍生物 |
| US20110288063A1 (en) * | 2010-05-19 | 2011-11-24 | Naeja Pharmaceutical Inc. | Novel fused bridged bicyclic heteroaryl substituted 6-alkylidene penems as potent beta-lactamase inhibitors |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4206067A (en) * | 1978-10-02 | 1980-06-03 | Chevron Research Company | Thermally stabilized erosion-inhibited functional fluids containing perhalometal compounds and an organic base |
| EP0041768B1 (en) * | 1980-04-24 | 1987-11-11 | Beecham Group Plc | Beta-lactam compounds, their preparation and use |
| US4891369A (en) * | 1986-12-03 | 1990-01-02 | Taiho Pharmaceutical Company, Limited | 2β-Substituted-methylpenicillanic acid derivatives, and salts and esters thereof |
| CN1094353C (zh) * | 1994-04-25 | 2002-11-20 | 史密斯克莱·比奇曼公司 | 含有β－内酰胺酶抑制性青霉烯与β－内酰胺抗生素复合的药物制剂及其在治疗细菌感染中的应用 |
| US5464616A (en) * | 1994-08-04 | 1995-11-07 | Synphar Laboratories, Ind. | 6β-substituted penicillanic acids as beta-lactamase inhibitors |
| OA11666A (en) * | 1998-10-15 | 2004-12-08 | Sarawak Medichem Pharmaceuticals Inc | Method and composition for treating and preventingtuberculosis. |
| GB9928290D0 (en) * | 1999-12-01 | 2000-01-26 | Univ Belfast | Process for preparing ambient temperature ionic liquids |
| US20040132708A1 (en) * | 2002-05-01 | 2004-07-08 | Wyeth | Process for preparing 6-alkylidene penem derivatives |
| AR039476A1 (es) * | 2002-05-01 | 2005-02-23 | Wyeth Corp | Proceso para preparar derivados de 6-alquiliden penem |
| AR039774A1 (es) * | 2002-05-01 | 2005-03-02 | Wyeth Corp | 6-alquiliden-penems biciclicos como inhibidores de beta-lactamasas |
| AR039475A1 (es) * | 2002-05-01 | 2005-02-23 | Wyeth Corp | 6-alquiliden-penems triciclicos como inhibidores de beta-lactamasa |
| AR046041A1 (es) * | 2003-10-03 | 2005-11-23 | Aventis Pharma Inc | Procedimiento para la preparacion de compuestos heterociclicos n-amino sustituidos |
-
2006
- 2006-07-26 CA CA002616468A patent/CA2616468A1/en not_active Abandoned
- 2006-07-26 CN CNA2006800322600A patent/CN101257902A/zh active Pending
- 2006-07-26 BR BRPI0613928-0A patent/BRPI0613928A2/pt not_active Application Discontinuation
- 2006-07-26 WO PCT/US2006/028883 patent/WO2007027323A2/en not_active Ceased
- 2006-07-26 TW TW095127308A patent/TW200738235A/zh unknown
- 2006-07-26 AU AU2006285308A patent/AU2006285308A1/en not_active Abandoned
- 2006-07-26 PE PE2006000908A patent/PE20070342A1/es not_active Application Discontinuation
- 2006-07-26 EP EP06824782A patent/EP1909786A2/en not_active Withdrawn
- 2006-07-26 GT GT200600332A patent/GT200600332A/es unknown
- 2006-07-26 JP JP2008524076A patent/JP2009502932A/ja not_active Withdrawn
- 2006-07-26 MX MX2008001083A patent/MX2008001083A/es unknown
- 2006-07-26 US US11/493,331 patent/US20070027130A1/en not_active Abandoned
- 2006-07-27 AR ARP060103241A patent/AR055097A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2616468A1 (en) | 2007-03-08 |
| EP1909786A2 (en) | 2008-04-16 |
| MX2008001083A (es) | 2008-03-19 |
| PE20070342A1 (es) | 2007-05-08 |
| WO2007027323A3 (en) | 2007-05-31 |
| US20070027130A1 (en) | 2007-02-01 |
| BRPI0613928A2 (pt) | 2011-02-15 |
| CN101257902A (zh) | 2008-09-03 |
| JP2009502932A (ja) | 2009-01-29 |
| TW200738235A (en) | 2007-10-16 |
| WO2007027323A2 (en) | 2007-03-08 |
| GT200600332A (es) | 2007-03-14 |
| AU2006285308A1 (en) | 2007-03-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |