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AR059896A1 - Derivados estereoisomericos de tetrahidronaftaleno, metodo de preparacion, medicamentos que los contienen, y uso como agentes antiinflamatorios. - Google Patents

Derivados estereoisomericos de tetrahidronaftaleno, metodo de preparacion, medicamentos que los contienen, y uso como agentes antiinflamatorios.

Info

Publication number
AR059896A1
AR059896A1 ARP070101030A ARP070101030A AR059896A1 AR 059896 A1 AR059896 A1 AR 059896A1 AR P070101030 A ARP070101030 A AR P070101030A AR P070101030 A ARP070101030 A AR P070101030A AR 059896 A1 AR059896 A1 AR 059896A1
Authority
AR
Argentina
Prior art keywords
group
groups
optionally substituted
alkyl
atoms
Prior art date
Application number
ARP070101030A
Other languages
English (en)
Inventor
Markus Berger
Hartmut Rehwinkel
Heike Schacke
Stefan Baurle
Norbert Schmees
Original Assignee
Bayer Schering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36754173&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR059896(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag
Publication of AR059896A1 publication Critical patent/AR059896A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C15/00—Cyclic hydrocarbons containing only six-membered aromatic rings as cyclic parts
    • C07C15/20—Polycyclic condensed hydrocarbons
    • C07C15/24—Polycyclic condensed hydrocarbons containing two rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/58—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems with hetero atoms directly attached to the ring nitrogen atom
    • C07D215/60—N-oxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/02—1,2-Oxazines; Hydrogenated 1,2-oxazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/76—Benzo[c]pyrans

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrane Compounds (AREA)
  • Indole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Quinoline Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

Estereoisomeros de la formula general (1) en donde R1 y R2 representan independientemente un átomo de hidrogeno, un grupo hidroxilo, un átomo de halogeno, un grupo alquilo C1-10 opcionalmente sustituido, alcoxilo C1-10 opcionalmente sustituido, alquiltiol C1-10, perfluoroalquilo C1-5, un grupo ciano, nitro, o R1 y R2 representan juntos un grupo seleccionado entre los, grupos -O-(CH2)n-O-, -O-(CH2)n-CH2-, -O-CH=CH-, -(CH2)n+2- ,-NH-(CH2)n+1, -N(C1-3-alquil)-(CH2)n+1, -NH-N=CH-, donde n = 1 o 2, y los átomos de oxígeno, carbono y/o nitrogeno terminales están unidos directamente a los átomos de C adyacentes del anillo, o NR8R9, donde R8 y R9 pueden ser independientemente hidrogeno, alquilo C1-5 o (CO) -C1-5-alquilo, R3 representa un átomo de hidrogeno, un grupo hidroxilo, un átomo de halogeno, un grupo ciano, un grupo alquilo C1-10) opcionalmente sustituido, alcoxilo C1-10, alquiltiol C1-10, perfluoroalquilo C1-5; R4 representa un grupo alquilo C1-10 sustituido opcional- mente con 1-3 grupos hidroxilo, átomos de halogeno, 1-3 grupos alcoxilo C1-5; cicloalquilo C3-7 opcionalmente sustituido, un grupo heterociclilo opcionalmente sustituido, un grupo arilo opcionalmente sustituido, un grupo heteroarilo mono o bicíclico opcionalmente sustituido de forma independiente con uno o más grupos seleccionados entre grupos alquilo C1-5 (que pueden estar opcionalmente sustituidos con 1-3 hidroxilos o 1-3 grupos COOR13), grupos alcoxilo C1-5, átomos de halogeno, grupos hidroxilo, grupos NR8R9, grupos exometileno u oxígeno, que opcionalmente contiene 1-4 átomos de nitrogeno, 1-2 átomos de oxígeno, 1-2 átomos de azufre y/o 1-2 grupos ceto, donde este grupo puede estar unido en cualquier posicion con la amina del sistema de tetrahidro-naftalina, y opcionalmente puede estar hidrogenado en una o más posiciones, R5 representa un grupo alquilo C1-10 o un grupo alquilo C1-10 opcionalmente fluorado de forma parcial o total, un grupo cicloalquilo C3-7, un grupo alquil C1-8-cicloalquilo C3-7, un grupo alquenil C2-8-cicloalquilo C3-7, un grupo heterociclilo, un grupo alquilheterociclilo C1-8, alquenilheterociclilo C2-8, un grupo arilo, alquilarilo C1-8 , un grupo alquenil C2-8-arilo, o grupos alquinilarilo C2-8, un grupo heteroarilo mono o bicíclico opcionalmente sustituido con 1-2 grupos ceto, 1-2 grupos alquilo C1-5, 1-2 grupos alcoxilo C1-5, 1-3 átomos de halogeno, 1-2 grupos exometileno, que contiene 1-3 átomos de nitrogeno, 1-2 átomos de oxígeno y/o 1-2 átomos de azufre, un grupo alquilheteroarilo C1-8 o un grupo alquenilheteroarilo C2-8, alquinilheteroarilo C2-8, donde estos grupos pueden estar unidos con el sistema de tetrahidronaftalina en cualquier posicion, y opcionalmente pueden estar hidrogenados en una o más posiciones, R6 representa un grupo metilo, etilo, propilo, isopropilo o etileno, con la excepcion del 6-fluoro-1-[(2-metilquinolin-5-il)amino]-4-etil-2-(trifluormetil)-1,2,3,4-tetrahidronaftalin-2,5-diol, y también las sales de los estereoisomeros de la formula general (1) con aniones aceptables para el uso fisiologico.
ARP070101030A 2006-03-15 2007-03-14 Derivados estereoisomericos de tetrahidronaftaleno, metodo de preparacion, medicamentos que los contienen, y uso como agentes antiinflamatorios. AR059896A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06090031A EP1834948A1 (de) 2006-03-15 2006-03-15 Tetrahydronaphthalinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer

Publications (1)

Publication Number Publication Date
AR059896A1 true AR059896A1 (es) 2008-05-07

Family

ID=36754173

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP070101030A AR059896A1 (es) 2006-03-15 2007-03-14 Derivados estereoisomericos de tetrahidronaftaleno, metodo de preparacion, medicamentos que los contienen, y uso como agentes antiinflamatorios.

Country Status (35)

Country Link
US (2) US7880042B2 (es)
EP (2) EP1834948A1 (es)
JP (1) JP2009532337A (es)
KR (1) KR20080112233A (es)
CN (1) CN101553472A (es)
AR (1) AR059896A1 (es)
AT (1) ATE517092T1 (es)
AU (1) AU2007224593A1 (es)
BR (1) BRPI0708860A2 (es)
CA (1) CA2637597A1 (es)
CR (1) CR10286A (es)
CU (1) CU23744B7 (es)
CY (1) CY1111954T1 (es)
DK (1) DK1994005T3 (es)
DO (1) DOP2007000050A (es)
EA (1) EA015834B1 (es)
EC (1) ECSP088740A (es)
ES (1) ES2370176T3 (es)
GT (1) GT200800182A (es)
IL (1) IL193155A0 (es)
MX (1) MX2008011790A (es)
MY (1) MY146671A (es)
NO (1) NO20084301L (es)
NZ (1) NZ570407A (es)
PA (1) PA8718801A1 (es)
PE (1) PE20071024A1 (es)
PL (1) PL1994005T3 (es)
PT (1) PT1994005E (es)
SG (1) SG136072A1 (es)
SI (1) SI1994005T1 (es)
TW (1) TW200804287A (es)
UA (1) UA94603C2 (es)
UY (1) UY30211A1 (es)
WO (1) WO2007104582A1 (es)
ZA (1) ZA200808754B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1670458E (pt) * 2003-10-08 2007-03-30 Schering Ag Derivados de tetra-hidronaftaleno, processo para a sua preparação e utilização como inibidor de inflamação
US7662821B2 (en) 2003-10-08 2010-02-16 Bayer Schering Pharma Ag Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents
US7638515B2 (en) * 2003-10-08 2009-12-29 Bayer Schering Pharma Aktiengesellschaft Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents
US20080153859A1 (en) * 2004-04-05 2008-06-26 Hartmut Rehwinkel Multiply-substituted tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents
US20060084652A1 (en) * 2004-09-09 2006-04-20 Stefan Baeurle Alkylidene-tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents
US20060229305A1 (en) * 2005-03-22 2006-10-12 Markus Berger Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents
EP2072509A1 (en) * 2007-12-18 2009-06-24 Bayer Schering Pharma Aktiengesellschaft 1-Aryl-1H-quinoline-2-ones: process for their production and their use as anti-inflammatory agents
WO2011146610A2 (en) * 2010-05-19 2011-11-24 Dr. Reddy's Laboratories Ltd. An enantioselective synthesis of chiral amines for the production of rotigotine
JP6115303B2 (ja) * 2012-05-18 2017-04-19 Jnc株式会社 隣接基としてカルボニル基を有するフェノール化合物およびその用途
PL233977B1 (pl) * 2018-01-10 2019-12-31 Politechnika Warszawska Sposób otrzymywania 7-metoksy-1,2,3-tris(4-metoksyfenylo)- 1,2,3,4-tetrahydronaftalenu

Family Cites Families (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE791474A (fr) 1971-11-25 1973-03-16 Yamanouchi Pharma Co Ltd Procede de preparation de derives d'acides cycloalcoylaminoarylcarboxyliques
JPS63220242A (ja) 1987-03-10 1988-09-13 Fuji Photo Film Co Ltd フオトレジスト組成物
US5225436A (en) 1987-05-15 1993-07-06 Schering Corporation Aryl substituted naphthalene derivatives
WO1988008836A2 (en) 1987-05-15 1988-11-17 Schering Corporation Aryl substituted naphthalene, benzoxepine, benzazepine, benzocycloheptene derivatives
CA1327796C (en) 1987-07-16 1994-03-15 Jorg Senn-Bilfinger Diazoles
US5059609A (en) 1987-10-19 1991-10-22 Pfizer Inc. Substituted tetralins, chromans and related compounds in the treatment of asthma, arthritis and related diseases
JPH0717589B2 (ja) 1990-01-22 1995-03-01 ファイザー製薬株式会社 新規１，３―ジカルボニル化合物およびその組成物
JPH0641038A (ja) 1992-07-17 1994-02-15 Mitsubishi Kasei Corp カルボン酸誘導体
AU698527B2 (en) 1994-12-29 1998-10-29 Allergan, Inc. Acetylenes disubstituted with a 5 or 8 substituted tetrahydronaphthyl or dihydronaphthyl group and with an aryl or heteroaryl groups having retinoid-like biological activity
US5489584A (en) 1994-12-29 1996-02-06 Allergan, Inc. Acetylenes disubstituted with a 5-amino or substituted 5-amino substituted tetrahydronaphthyl group and with an aryl or heteroaryl group having retinoid-like biological activity
CA2284747A1 (en) 1997-03-24 1998-10-01 Byk Gulden Lomberg Chemische Fabrik Gmbh Tetrahydropyrido compounds
EP1003495A4 (en) 1997-07-22 2002-08-28 Lilly Co Eli PHARMACEUTICAL COMPOUNDS
GB9716244D0 (en) 1997-07-31 1997-10-08 Electrophoretics International Pharmaceutical compounds
US6333337B1 (en) 1998-01-27 2001-12-25 Icagen, Inc. Potassium channel inhibitors
US7468422B2 (en) * 1998-03-05 2008-12-23 Centre National De La Recherche Scientifique - Cnrs Mechanosensitive mammalian potassium channel activatable by polyunsaturated fatty acids
US6013830A (en) 1998-03-30 2000-01-11 Sepracor Inc. Asymmetric grignard synthesis with cyclic 1,2 aminoalcohols
AU5682299A (en) 1998-08-21 2000-03-14 Scripps Research Institute, The Catalytic asymmetric aminohydroxylation with amino-substituted heterocycles
JP2000256255A (ja) 1999-03-10 2000-09-19 Kuraray Co Ltd （±）−トランス−ペルメトリン酸の光学分割法
SE9903930D0 (sv) 1999-10-29 1999-10-29 Astra Pharma Inc Novel compounds and a novel process for their preparation
DE10038639A1 (de) 2000-07-28 2002-02-21 Schering Ag Nichtsteroidale Entzündungshemmer
CA2417507A1 (en) 2000-08-21 2002-02-28 Pacific Corporation Novel thiourea derivatives and the pharmaceutical compositions containing the same
ES2193839B1 (es) 2001-06-22 2005-02-16 Almirall Prodesfarma, S.A. Nuevos derivados de 6-fenildihidropirrolpirimidindiona.
NZ531135A (en) 2001-09-21 2006-09-29 Lilly Co Eli Muscarinic agonists
PE20030547A1 (es) 2001-09-24 2003-08-18 Bayer Corp Derivados de imidazol para el tratamiento de la obesidad
DK1446387T3 (da) 2001-11-21 2009-12-21 Pharmacia & Upjohn Co Llc Substituerede aryl, 1,4-pyrazinderivater
US6875866B2 (en) 2002-02-21 2005-04-05 Schering Corporation Process for synthesis of D1 receptor antagonists
US7528173B2 (en) 2002-03-21 2009-05-05 Schering Aktiengesellshaft Plasma carboxypeptidase B inhibitors
KR101022977B1 (ko) 2002-03-26 2011-03-18 베링거 인겔하임 파마슈티칼즈, 인코포레이티드 글루코코르티코이드 모사체, 이의 제조방법, 약제학적조성물 및 이의 용도
US6897224B2 (en) 2002-04-02 2005-05-24 Schering Ag Quinoline and isoquinoline derivatives, a process for their production and their use as inflammation inhibitors
DE10215316C1 (de) 2002-04-02 2003-12-18 Schering Ag Chinolin- und Isochinolin-Derivate, ein pharmazeutisches Mittel und ihre Verwendung als Entzündungshemmer
ATE461166T1 (de) 2002-08-26 2010-04-15 Merck Patent Gmbh Cyclopenta [b]naphthalinderivate
MXPA05006872A (es) 2003-01-03 2005-08-16 Boehringer Ingelheim Pharma Derivados de 1-propanol y 1-propilamina y su uso como ligandos glucocorticoides.
US20040224992A1 (en) 2003-02-27 2004-11-11 Boehringer Ingelheim Pharmaceuticals, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
RS20050974A (sr) 2003-07-01 2007-09-21 Schering Aktiengesellschaft, Heterociklično supstituisani pentanol-derivati,postupak za njihovo dobijanje i njihova primena kao supresora zapaljenja
US20050090559A1 (en) 2003-07-01 2005-04-28 Markus Berger Heterocyclically-substituted pentanol derivatives, process for their production and their use as anti-inflammatory agents
US7575785B2 (en) 2003-08-22 2009-08-18 Merck Patent Gmbh Cyclopenta[a]naphthaline derivatives
CN1239441C (zh) 2003-09-12 2006-02-01 中国科学院上海有机化学研究所 利用固载化的双辛可尼类生物碱配体催化不对称羟胺化和双羟化反应的方法
PT1670458E (pt) 2003-10-08 2007-03-30 Schering Ag Derivados de tetra-hidronaftaleno, processo para a sua preparação e utilização como inibidor de inflamação
US7638515B2 (en) * 2003-10-08 2009-12-29 Bayer Schering Pharma Aktiengesellschaft Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents
US7662821B2 (en) 2003-10-08 2010-02-16 Bayer Schering Pharma Ag Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents
US7179919B2 (en) 2004-03-18 2007-02-20 Boehringer Ingelheim Pharmaceuticals, Inc. Stereoselective synthesis of certain trifluoromethyl-substituted alcohols
US20050222154A1 (en) 2004-04-05 2005-10-06 Hartmut Rehwinkel Multiply-substituted tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents
US20080153859A1 (en) 2004-04-05 2008-06-26 Hartmut Rehwinkel Multiply-substituted tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents
GB0418045D0 (en) 2004-08-12 2004-09-15 Glaxo Group Ltd Compounds
US20060084652A1 (en) 2004-09-09 2006-04-20 Stefan Baeurle Alkylidene-tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents
DE102004044680B3 (de) 2004-09-09 2006-06-08 Schering Ag Alkyliden-Tetrahydronaphthalinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer sowie diese enthaltende pharmazeutische Präparate
DE102004063227A1 (de) 2004-12-22 2006-07-06 Schering Ag Tricylische Aminoalkohole, Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer
US20060167025A1 (en) 2004-12-22 2006-07-27 Markus Berger Tricyclic amino alcohols, processes for synthesis of same and use of same as anti-inflammatory drugs
US20060229305A1 (en) 2005-03-22 2006-10-12 Markus Berger Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents
DE102005014089A1 (de) 2005-03-22 2006-09-28 Schering Ag Tetrahydronaphthalinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer
US20060247292A1 (en) * 2005-03-22 2006-11-02 Hartmut Rehwinkel Benzocycloheptene derivatives, process for their production and their use as anti-inflammatory agents
US20070015750A1 (en) 2005-04-14 2007-01-18 Stefan Baeurle Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents
US8093281B2 (en) 2005-04-14 2012-01-10 Glaxo Group Limited Indazoles as glucocorticoid receptor ligands
US20070129359A1 (en) 2005-04-14 2007-06-07 Christoph Huwe Tetrahydronaphthalene derivatives, processes for their preparation and their use as antiinflammatory agents
DE102005017286B3 (de) 2005-04-14 2006-12-28 Schering Ag Tetrahydronaphthalinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer
US20070015761A1 (en) 2005-04-14 2007-01-18 Anne Mengel Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents
AU2006324097B2 (en) 2005-12-09 2011-08-25 F. Hoffmann-La Roche Ag Glucocorticoid receptor modulators as antiinflammatory agents

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MY146671A (en) 2012-09-14
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US20070225290A1 (en) 2007-09-27
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US7880042B2 (en) 2011-02-01
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