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AR054818A1 - Proceso para preparar rosuvastatina e intermediarios - Google Patents

Proceso para preparar rosuvastatina e intermediarios

Info

Publication number
AR054818A1
AR054818A1 ARP060102897A ARP060102897A AR054818A1 AR 054818 A1 AR054818 A1 AR 054818A1 AR P060102897 A ARP060102897 A AR P060102897A AR P060102897 A ARP060102897 A AR P060102897A AR 054818 A1 AR054818 A1 AR 054818A1
Authority
AR
Argentina
Prior art keywords
formula
alkyl
compound
intermediaries
independently selected
Prior art date
Application number
ARP060102897A
Other languages
English (en)
Original Assignee
Astrazeneca Uk Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Uk Ltd filed Critical Astrazeneca Uk Ltd
Publication of AR054818A1 publication Critical patent/AR054818A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/30—Halogen atoms or nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

También se describen compuestos intermedios y procesos para su preparacion. Reivindicacion 1: Un proceso para la manufactura de un compuesto de formula (5) que comprende a) reaccion de un compuesto de formula (2), donde cada R1 se selecciona independientemente de alquilo C1-6, y R se selecciona de alquilo C1-6, cicloalquilo C3-6 o arilalquilo C1-6; con un compuesto de formula (3) en presencia de un catalizador de titanio (IV) de formula (4) (donde cada R2 se selecciona independientemente entre alquilo C1-6 y la porcion binaftilo está en la configuracion S), una sal haluro de metal alcalino y una amina, en un disolvente inerte.
ARP060102897A 2005-07-08 2006-07-05 Proceso para preparar rosuvastatina e intermediarios AR054818A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0514078.5A GB0514078D0 (en) 2005-07-08 2005-07-08 Chemical process

Publications (1)

Publication Number Publication Date
AR054818A1 true AR054818A1 (es) 2007-07-18

Family

ID=34896960

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP060102897A AR054818A1 (es) 2005-07-08 2006-07-05 Proceso para preparar rosuvastatina e intermediarios

Country Status (17)

Country Link
US (1) US20100228028A1 (es)
EP (1) EP1904456A1 (es)
JP (1) JP2009500388A (es)
KR (1) KR20080024538A (es)
CN (1) CN101218210B (es)
AR (1) AR054818A1 (es)
AU (1) AU2006268024B2 (es)
BR (1) BRPI0612851A2 (es)
CA (1) CA2614281A1 (es)
GB (1) GB0514078D0 (es)
IL (1) IL188201A0 (es)
MX (1) MX2008000362A (es)
NO (1) NO20076660L (es)
NZ (1) NZ564609A (es)
TW (1) TW200726754A (es)
WO (1) WO2007007119A1 (es)
ZA (1) ZA200711085B (es)

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GB0011120D0 (en) 2000-05-09 2000-06-28 Avecia Ltd Process
NL1015744C2 (nl) * 2000-07-19 2002-01-22 Dsm Nv Werkwijze voor de bereiding van 2-(6-gesubstitueerde-1,3-dioxan-4-yl) azijnzuurderivaten.
NZ531033A (en) 2001-07-13 2005-07-29 Astrazeneca Uk Ltd Preparation of a 2-(N-methyl-N-methanesulfonylamino)pyrimidine compound or analogous aminopyrimidine compounds
GB0218781D0 (en) * 2002-08-13 2002-09-18 Astrazeneca Ab Chemical process
GB0312896D0 (en) 2003-06-05 2003-07-09 Astrazeneca Ab Chemical process
EP1562912A2 (en) 2003-08-28 2005-08-17 Teva Pharmaceutical Industries Limited Process for preparation of rosuvastatin calcium
GB0324791D0 (en) * 2003-10-24 2003-11-26 Astrazeneca Ab Chemical process
CA2546701C (en) 2003-11-24 2010-07-27 Teva Pharmaceutical Industries Ltd. Crystalline ammonium salts of rosuvastatin
TWI351958B (en) 2003-12-02 2011-11-11 Teva Pharma Degradation products as reference standard for ana
US7851624B2 (en) 2003-12-24 2010-12-14 Teva Pharamaceutical Industries Ltd. Triol form of rosuvastatin and synthesis of rosuvastatin
GB0428328D0 (en) 2004-12-24 2005-02-02 Astrazeneca Uk Ltd Chemical process
MX2007010138A (es) 2005-02-22 2007-09-27 Teva Pharma Preparacion de rosuvastatina.
BRPI0605917A2 (pt) 2005-08-16 2009-05-26 Teva Pharma intermediário cristalino de rosuvastatina
US8318933B2 (en) 2006-10-31 2012-11-27 Aurobindo Pharma Ltd Process for preparing rosuvastatin calcium
TW200831469A (en) * 2006-12-01 2008-08-01 Astrazeneca Uk Ltd Chemical process
WO2008072078A1 (en) 2006-12-13 2008-06-19 Aurobindo Pharma Limited An improved process for preparing rosuvastatin caclium
US8212035B2 (en) 2007-02-08 2012-07-03 Aurobindo Pharma Ltd. Process for preparation of rosuvastatin calcium field of the invention
EP2134696B1 (en) 2007-04-03 2017-05-17 LEK Pharmaceuticals d.d. Processes for the preparation of statins, particularly rosuvastatin, and intermediates for the preparation thereof
EP1978020A1 (en) * 2007-04-03 2008-10-08 LEK Pharmaceuticals D.D. Processes for the preparation of statins, particularly rosuvastatin, and intermediates for the preparation thereof
CN101323597B (zh) * 2007-06-11 2012-09-05 安徽省庆云医药化工有限公司 4-(4-氟苯基)-6-异丙基-2-(n-甲基-n-甲磺酰氨基)嘧啶-5-甲醛的制备方法
EP2178847A2 (en) * 2007-08-20 2010-04-28 Ratiopharm GmbH Process for preparing pyrimidine derivatives
US8394956B2 (en) * 2008-09-30 2013-03-12 Aurobindo Pharma Ltd. Process for preparing pyrimidine propenaldehyde
KR101157314B1 (ko) 2009-06-05 2012-06-15 주식회사종근당 로수바스타틴의 신규한 제조방법, 이 제조에 유용한 중간체 화합물 및 그의 제조방법
EP2467363A1 (en) 2009-08-17 2012-06-27 Aurobindo Pharma Limited Process for the manufacture of rosuvastatin calcium using crystalline rosuvastatin ethyl ester
US8256574B2 (en) 2010-06-23 2012-09-04 3M Innovative Properties Company Centrifugally-operated apparatus
US8430206B2 (en) 2010-06-23 2013-04-30 3M Innovative Properties Company Safety devices comprising a load-bearing composite polymeric housing and a load-bearing anchorage plate
US8430207B2 (en) 2010-06-23 2013-04-30 3M Innovative Properties Company Preassembled and pretorqued friction brake and method of making a safety device containing such a friction brake
EP2423195A1 (en) 2010-07-26 2012-02-29 LEK Pharmaceuticals d.d. Process for the preparation of key intermediates for the synthesis of statins or pharmaceutically acceptable salts thereof
WO2015030001A1 (ja) * 2013-08-30 2015-03-05 日産化学工業株式会社 光学活性５－ヒドロキシ－３－ケトエステル類の製造方法
JP2016188175A (ja) * 2013-08-30 2016-11-04 日産化学工業株式会社 光学活性５−ヒドロキシ−３−ケトエステル化合物の製造方法
WO2015074328A1 (zh) * 2013-11-25 2015-05-28 复旦大学 一种瑞舒伐他汀钠的制备方法
WO2016056658A1 (ja) * 2014-10-10 2016-04-14 株式会社エーピーアイ コーポレーション スタチン系化合物の精製方法
KR20160126700A (ko) 2015-04-24 2016-11-02 미래파인켐 주식회사 스타틴의 중간체, 이의 제조방법 및 이를 이용한 로수바스타틴의 제조방법

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GB0428328D0 (en) * 2004-12-24 2005-02-02 Astrazeneca Uk Ltd Chemical process
CN100351240C (zh) * 2005-01-19 2007-11-28 安徽省庆云医药化工有限公司 瑞舒伐他汀钙的合成方法
US20090124803A1 (en) * 2005-03-22 2009-05-14 Pandurang Balwant Deshpande Process for preparation of rosuvastatin
TW200831469A (en) * 2006-12-01 2008-08-01 Astrazeneca Uk Ltd Chemical process

Also Published As

Publication number Publication date
NZ564609A (en) 2010-07-30
MX2008000362A (es) 2008-03-07
IL188201A0 (en) 2008-03-20
CN101218210A (zh) 2008-07-09
WO2007007119A1 (en) 2007-01-18
AU2006268024A1 (en) 2007-01-18
BRPI0612851A2 (pt) 2011-03-01
CA2614281A1 (en) 2007-01-18
JP2009500388A (ja) 2009-01-08
TW200726754A (en) 2007-07-16
EP1904456A1 (en) 2008-04-02
GB0514078D0 (en) 2005-08-17
CN101218210B (zh) 2011-08-03
ZA200711085B (en) 2009-09-30
US20100228028A1 (en) 2010-09-09
NO20076660L (no) 2008-01-09
AU2006268024B2 (en) 2010-07-01
KR20080024538A (ko) 2008-03-18

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Legal Events

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