[go: up one dir, main page]

BRPI0605917A2 - intermediário cristalino de rosuvastatina - Google Patents

intermediário cristalino de rosuvastatina

Info

Publication number
BRPI0605917A2
BRPI0605917A2 BRPI0605917-1A BRPI0605917A BRPI0605917A2 BR PI0605917 A2 BRPI0605917 A2 BR PI0605917A2 BR PI0605917 A BRPI0605917 A BR PI0605917A BR PI0605917 A2 BRPI0605917 A2 BR PI0605917A2
Authority
BR
Brazil
Prior art keywords
rosuvastatin
crystalline intermediate
crystalline
crystaline
intermediary
Prior art date
Application number
BRPI0605917-1A
Other languages
English (en)
Inventor
Valerie Niddam-Hildesheim
Natalia Shenkar
Shlomit Wizel
Original Assignee
Teva Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharma filed Critical Teva Pharma
Publication of BRPI0605917A2 publication Critical patent/BRPI0605917A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

INTERMEDIáRIO CRISTALINO DE ROSUVASTATINA. São fornecidos um intermediário cristalino de rosuvastatina e seus processos para preparaçâo.
BRPI0605917-1A 2005-08-16 2006-08-16 intermediário cristalino de rosuvastatina BRPI0605917A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US70892005P 2005-08-16 2005-08-16
US71093005P 2005-08-23 2005-08-23
PCT/US2006/032539 WO2007022488A2 (en) 2005-08-16 2006-08-16 Crystalline rosuvastatin intermediate

Publications (1)

Publication Number Publication Date
BRPI0605917A2 true BRPI0605917A2 (pt) 2009-05-26

Family

ID=37671343

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0605917-1A BRPI0605917A2 (pt) 2005-08-16 2006-08-16 intermediário cristalino de rosuvastatina

Country Status (10)

Country Link
US (1) US7868169B2 (pt)
EP (1) EP1805148A2 (pt)
JP (1) JP2008515931A (pt)
KR (1) KR20070062996A (pt)
BR (1) BRPI0605917A2 (pt)
CA (1) CA2619576C (pt)
IL (1) IL186221A (pt)
MX (1) MX2007004427A (pt)
TW (1) TW200800917A (pt)
WO (1) WO2007022488A2 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070167625A1 (en) * 2005-02-22 2007-07-19 Anna Balanov Preparation of rosuvastatin
JP2008515931A (ja) 2005-08-16 2008-05-15 テバ ファーマシューティカル インダストリーズ リミティド 結晶形ロスバスタチン中間体
WO2009143776A1 (zh) 2008-05-27 2009-12-03 常州制药厂有限公司 瑞舒伐他汀钙盐的制备方法及其中间体
IT1397912B1 (it) * 2010-01-28 2013-02-04 Chemi Spa Nuovo polimorfo dell'estere 6-dietilamminometil-2-naftilico dell'acido 4-idrossicarbamoil-fenil-carbammico cloridrato.
US8716305B2 (en) 2011-04-18 2014-05-06 Basf Se Multicomponent crystalline system of rosuvastatin calcium salt and vanillin

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4231938A (en) 1979-06-15 1980-11-04 Merck & Co., Inc. Hypocholesteremic fermentation products and process of preparation
US4444784A (en) 1980-08-05 1984-04-24 Merck & Co., Inc. Antihypercholesterolemic compounds
DK149080C (da) 1980-06-06 1986-07-28 Sankyo Co Fremgangsmaade til fremstilling af derivater af ml-236b-carboxylsyre
US4739073A (en) 1983-11-04 1988-04-19 Sandoz Pharmaceuticals Corp. Intermediates in the synthesis of indole analogs of mevalonolactone and derivatives thereof
NO177005C (no) 1988-01-20 1995-07-05 Bayer Ag Analogifremgangsmåte for fremstilling av substituerte pyridiner, samt mellomprodukter til bruk ved fremstillingen
US5177080A (en) 1990-12-14 1993-01-05 Bayer Aktiengesellschaft Substituted pyridyl-dihydroxy-heptenoic acid and its salts
WO1992022560A1 (fr) 1991-06-19 1992-12-23 Shionogi Seiyaku Kabushiki Kaisha Intermediaire optiquement actif et production de celui-ci
JP2648897B2 (ja) 1991-07-01 1997-09-03 塩野義製薬株式会社 ピリミジン誘導体
JP3400038B2 (ja) 1993-10-19 2003-04-28 塩野義製薬株式会社 ピリミジン誘導体の製造方法
GB9626746D0 (en) 1996-12-23 1997-02-12 Knoll Ag Process
GB9812413D0 (en) 1998-06-10 1998-08-05 Glaxo Group Ltd Compound and its use
TW550263B (en) 1998-09-01 2003-09-01 Nissan Chemical Ind Ltd Method for reducing an organic solvent remaining in tris-(2,3-epoxypropyl)-isocyanurate crystals
SI20070A (sl) 1998-09-18 2000-04-30 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Nove soli inhibitorjev HMG-CoA reduktaze
GB9900339D0 (en) 1999-01-09 1999-02-24 Zeneca Ltd Chemical compounds
GB9903472D0 (en) 1999-02-17 1999-04-07 Zeneca Ltd Chemical process
GB0001621D0 (en) 2000-01-26 2000-03-15 Astrazeneca Ab Pharmaceutical compositions
GB0003305D0 (en) 2000-02-15 2000-04-05 Zeneca Ltd Pyrimidine derivatives
US6777552B2 (en) 2001-08-16 2004-08-17 Teva Pharmaceutical Industries, Ltd. Processes for preparing calcium salt forms of statins
GB0028429D0 (en) 2000-11-22 2001-01-10 Astrazeneca Ab Therapy
DK1404642T3 (da) 2001-07-06 2010-05-17 Basf Se Fremgangsmåde til fremstillimg af 7-amino-syn-3,5-dihydroxyheptansyrederivater, mellemprodukter derfor og fremgangsmåder til deres fremstilling
CN100430405C (zh) 2001-08-16 2008-11-05 特瓦制药工业有限公司 制备他汀类的钙盐形式的方法
SE0103509D0 (sv) 2001-10-19 2001-10-19 Astrazeneca Ab Rosuvastatin in pre demented states
KR100511533B1 (ko) * 2002-04-09 2005-08-31 임광민 키랄 중간체, 그의 제조방법 및 그를 이용한 HMG-CoA환원저해제의 제조방법
WO2003097614A2 (en) * 2002-05-21 2003-11-27 Ranbaxy Laboratories Limited Process for the preparation of rosuvastatin
GB0218781D0 (en) 2002-08-13 2002-09-18 Astrazeneca Ab Chemical process
CN1742000A (zh) 2002-12-10 2006-03-01 兰贝克赛实验室有限公司 制备若舒伐他汀的方法
GB0312896D0 (en) 2003-06-05 2003-07-09 Astrazeneca Ab Chemical process
WO2005021511A1 (en) 2003-08-27 2005-03-10 Hetero Drugs Limited A novel process for amorphous rosuvastatin calcium
CA2657076A1 (en) 2003-08-28 2005-03-17 Teva Pharmaceutical Industries Ltd. Process for the preparation of rosuvastatin calcium
EP1601658A1 (en) 2003-11-24 2005-12-07 Teva Pharmaceutical Industries Limited Crystalline ammonium salts of rosuvastatin
WO2005054207A1 (en) 2003-12-04 2005-06-16 Glenmark Pharmaceuticals Limited Process for the preparation of pyrimidine derivatives
WO2005063728A2 (en) 2003-12-24 2005-07-14 Teva Pharmaceutical Industries Ltd. Process for preparation of statins with high syn to anti ratio
WO2006035277A2 (en) 2004-09-27 2006-04-06 Ranbaxy Laboratories Limited Novel processes for preparing amorphous rosuvastatin calcium and a novel polymorphic form of rosuvastatin sodium
CN1807417A (zh) 2005-01-18 2006-07-26 何如钧 新型无水无结晶型态的罗伐他汀钙盐
JP2008528542A (ja) 2005-01-31 2008-07-31 チバ ホールディング インコーポレーテッド ロスバスタチンカルシウム塩の結晶形
US20070167625A1 (en) 2005-02-22 2007-07-19 Anna Balanov Preparation of rosuvastatin
US20070037979A1 (en) * 2005-02-22 2007-02-15 Valerie Niddam-Hildesheim Preparation of rosuvastatin
US20090124803A1 (en) 2005-03-22 2009-05-14 Pandurang Balwant Deshpande Process for preparation of rosuvastatin
EP1869005A1 (en) 2005-04-04 2007-12-26 Unichem Laboratories Limited Process for preparation of calcium salt of rosuvastatin
CN1872841A (zh) 2005-06-01 2006-12-06 信谊药厂 瑞舒伐他汀钙及其关键中间体的制备方法
JP5416403B2 (ja) 2005-06-24 2014-02-12 レツク・フアーマシユーテイカルズ・デー・デー 純粋な非結晶ロスバスタチンカルシウムの調製方法
CA2612587C (en) 2005-06-24 2013-02-19 Lek Pharmaceuticals D.D. Process for preparing amorphous rosuvastatin calcium free of impurities
GB0514078D0 (en) 2005-07-08 2005-08-17 Astrazeneca Uk Ltd Chemical process
JP2008515931A (ja) 2005-08-16 2008-05-15 テバ ファーマシューティカル インダストリーズ リミティド 結晶形ロスバスタチン中間体
CN100352821C (zh) 2005-08-22 2007-12-05 鲁南制药集团股份有限公司 一种瑞舒伐他汀钙中间体的制备方法

Also Published As

Publication number Publication date
WO2007022488A2 (en) 2007-02-22
TW200800917A (en) 2008-01-01
US20070123550A1 (en) 2007-05-31
IL186221A (en) 2011-11-30
JP2008515931A (ja) 2008-05-15
MX2007004427A (es) 2007-06-14
EP1805148A2 (en) 2007-07-11
IL186221A0 (en) 2008-01-20
CA2619576C (en) 2011-12-06
CA2619576A1 (en) 2007-02-22
KR20070062996A (ko) 2007-06-18
US7868169B2 (en) 2011-01-11
WO2007022488A3 (en) 2007-05-03

Similar Documents

Publication Publication Date Title
CR9902A (es) Drrivados de amida heterociclica utiles como microbiocidas
SMP200800041B (it) Derivati di pirimidinil-aril-urea attivi come-fgf-inibitori
NO20082514L (no) Aminopyrimidiner anvendelige som kinaseinhibitorer
ECSP078055A (es) Formas sólidas cristalinas de tigeciclina y métodos para preparar las mismas
NL2000323A1 (nl) Pyrimidine-derivaten.
TW200716512A (en) Processes for preparing cinacalcet hydrochloride crystal form I
CU20060039A7 (es) Forma cristalina beta del clorhidrato de la ivabradina, su procedimiento de preparación y las composiciones farmacéuticas que la contienen
BR112013000673A2 (pt) formas sólidas de romidepsina e seus usos
AR061311A1 (es) Procesos para preparar clorhidrato de cinacalcet y formas polimorficas del mismo
ATE521238T1 (de) Kristalline modifikationen des pyraclostrobins
DOP2010000216A (es) (r)-2-(4-ciclopropansulfonil-fenil)-n-pirazin-2-il-3-(tetrahidropiran-4-il)-propionamida cristalina
EP1881773A4 (en) LOCKING CHUCK
DE112005003586A5 (de) Bohrfutter
BRPI0513149A (pt) uso de 2-tio-3,5-diciano-4-fenil-6-aminopiridinas substituìdas no tratamento de náuseas e vÈmito
DE502006001228D1 (de) Federsystem
HN2006029142A (es) Proceso
CL2005003456A1 (es) Proceso de preparacion del beta-anomero enriquecido de clorhidrato de gemcitabina; compuesto intermediario involucrado en dicho proceso; y su proceso de preparacion.
BRPI0605917A2 (pt) intermediário cristalino de rosuvastatina
DE502005004020D1 (de) Membranspannfutter
UY3556Q (es) Reloj brazalete
DE602005006734D1 (de) Uhrwerk
BRPI0605901A (pt) formas polimórficas de maleato de tegaserode
DE502006006543D1 (de) Werkzeughalter
BRPI0606169A2 (pt) preparo de rosuvastatina
ES1060318Y (es) Panel de vidrio para cerramientos exteriores.

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 4A, 5A E 6A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2165 DE 03/07/2012.