AR054269A1 - Derivados de 2-amido-6-amino-8-oxopurina - Google Patents
Derivados de 2-amido-6-amino-8-oxopurinaInfo
- Publication number
- AR054269A1 AR054269A1 AR20060101788A ARP060101788A AR054269A1 AR 054269 A1 AR054269 A1 AR 054269A1 AR 20060101788 A AR20060101788 A AR 20060101788A AR P060101788 A ARP060101788 A AR P060101788A AR 054269 A1 AR054269 A1 AR 054269A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- heterocycle
- cycloalkyl
- phenyl
- naphthyl
- Prior art date
Links
- 125000000623 heterocyclic group Chemical group 0.000 abstract 16
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 12
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 12
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 11
- 125000001624 naphthyl group Chemical group 0.000 abstract 9
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 125000004429 atom Chemical group 0.000 abstract 5
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 5
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 5
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 150000002367 halogens Chemical class 0.000 abstract 4
- 101100295741 Gallus gallus COR4 gene Proteins 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 208000036142 Viral infection Diseases 0.000 abstract 2
- 208000027866 inflammatory disease Diseases 0.000 abstract 2
- 230000009385 viral infection Effects 0.000 abstract 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 1
- 208000035473 Communicable disease Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 230000008484 agonism Effects 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 206010003246 arthritis Diseases 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 208000006454 hepatitis Diseases 0.000 abstract 1
- 231100000283 hepatitis Toxicity 0.000 abstract 1
- 230000001900 immune effect Effects 0.000 abstract 1
- 208000026278 immune system disease Diseases 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
- 229940083251 peripheral vasodilators purine derivative Drugs 0.000 abstract 1
- 125000000561 purinyl group Chemical class N1=C(N=C2N=CNC2=C1)* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Virology (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Pain & Pain Management (AREA)
- Gastroenterology & Hepatology (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Más en particular, la presente se refiere al uso de derivados de purina en el tratamiento de diversas infecciones víricas y de trastornos inmunologicos o inflamatorios, entre ellos aquellos en los cuales se encuentra implicada la modulacion, y en particular el agonismo, de receptores similares al receptor Toll (siglas inglesas TLR). En consecuencia, los compuestos de la presente son utiles en el tratamiento de enfermedades infecciosas tales como hepatitis (por ejemplo las HCV, HBV), infecciones víricas relacionadas genéticamente, enfermedades inflamatorias tales como el asma y la artritis, y el cáncer. Reivindicacion 1: Un compuesto de formula (1) un tautomero del mismo, o una sal, solvato o polimorfo, farmacéuticamente aceptable, de dicho compuesto o tautomero, en la cual: R1 y R2 son cada uno, de manera independiente, H, alquilo C1-6, cicloalquilo C3-7, alquilo C1-6 sustituido con 1 a 3 cicloalquilo C3-7, un fenilo, naftilo o un heterociclo; cicloalquilo C3-7 sustituido con alquilo C1-6; S(O)nR8, o heterociclo, o bien R1 y R2, considerados junto con el átomo de N al cual están unidos, forman un heterociclo; estando en cada caso dichos alquilo, cicloalquilo, fenilo, naftilo y heterociclo sustituidos opcionalmente con 1 a 3 átomos o grupos seleccionados de oxo, halogeno, CF3, CN, R4, OR4, NR4R5, COR4, CO2R4, S(O)nR4, S(O)nR4R5, CONR4R5 y NR4COR5; R3 es alquilo C1-6, cicloalquilo C3-7, fenilo, naftilo, o heterociclo, estando dichos alquilo, cicloalquilo, fenilo, naftilo y heterociclo sustituidos opcionalmente con 1 a 3 átomos o grupos seleccionados de oxo, halogeno, CF3, CN, R4, OR4, NR4R5, COR4, CO2R4, S(O)nR4, S(O)nR4R5, CONR4R5 y NR4COR5; R4 y R5 son cada uno, de manera independiente, H, alquilo C1-6, cicloalquilo C3-7, alquenilo C2-6 o alquinilo C2-6, o bien R4 y R5, cuando están unidos al mismo átomo de N, forman un heterociclo, estando dichos alquilo, cicloalquilo y heterociclo sustituidos opcionalmente con 1 a 3 átomos o grupos seleccionados de fenilo, OR6, NR6R7, S(O)nR6, S(O)nR6R7 y NR6COR7; R6 y R7 son, de manera independiente, H, alquilo C1-6, o alquilo C1-6 sustituido con cicloalquilo C3-7, o bien R6 y R7, cuando están unidos al mismo átomo de N, forman un heterociclo; R8 es H, alquilo C1-6, cicloalquilo C3-7, fenilo, naftilo, o heterociclo, estando dichos alquilo, cicloalquilo, fenilo, naftilo y heterociclo sustituidos opcionalmente con 1 a 3 átomos o grupos seleccionados de oxo, halogeno, CF3, CN, fenilo, R4, OR4, NR4R5, COR4, CO2R4, S(O)nR4, S(O)nR4R5, CONR4R5 y NR4COR5; R9 es R10, COR10, CO2R10 o CONR10R11, y R9a está ausente, o bien R9a es R10, COR10, CO2R10, o CONR10R11, y R9 está ausente; R10 y R11 son cada uno, de manera independiente, H, alquilo C1-6, cicloalquilo C3-7, alquilo C1-6 sustituido con 1 a 3 cicloalquilos C3-7, un fenilo, naftilo o un heterociclo, cicloalquilo C3-7 sustituido con alquilo C1-6, fenilo, naftilo o heterociclo, o bien R10 y R11, considerados junto con el átomo de N al cual están unidos, forman un heterociclo, estando en cada caso dichos alquilo, cicloalquilo, fenilo, naftilo y heterociclo sustituidos opcionalmente con 1 a 3 átomos o grupos seleccionados de oxo, halogeno, CF3, CN, R12, OR12, NR12R13, COR12, CO2R12, S(O)pR12, S(O)pNR12R13, CONR12R13 y NR12COR13; R12 y R13 son, de manera independiente, H, alquilo C1-6 o alquilo C1-6 sustituido con cicloalquilo C3-7, o bien R12 y R13, cuando están unidos al mismo átomo de N, forman un heterociclo; Y es un enlace directo o un alquileno C1-4; n es 0, 1 o 2; p es 0, 1 o 2; con la salvedad de que, cuando Y sea metileno y R3 sea fenilo, R1 y R2 no sean simultáneamente metilo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67805405P | 2005-05-04 | 2005-05-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR054269A1 true AR054269A1 (es) | 2007-06-13 |
Family
ID=36698805
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AR20060101788A AR054269A1 (es) | 2005-05-04 | 2006-05-03 | Derivados de 2-amido-6-amino-8-oxopurina |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US7642350B2 (es) |
| EP (1) | EP1888587A1 (es) |
| JP (1) | JP2008540396A (es) |
| KR (1) | KR20080006004A (es) |
| CN (1) | CN101203519A (es) |
| AR (1) | AR054269A1 (es) |
| AU (1) | AU2006242920A1 (es) |
| BR (1) | BRPI0611435A2 (es) |
| CA (1) | CA2607780A1 (es) |
| DO (1) | DOP2006000102A (es) |
| EA (1) | EA200702235A1 (es) |
| GT (1) | GT200600184A (es) |
| IL (1) | IL187135A0 (es) |
| MA (1) | MA29533B1 (es) |
| MX (1) | MX2007013780A (es) |
| NL (1) | NL1031741C2 (es) |
| NO (1) | NO20076185L (es) |
| PE (1) | PE20061439A1 (es) |
| TN (1) | TNSN07411A1 (es) |
| TW (1) | TW200716125A (es) |
| UY (1) | UY29516A1 (es) |
| WO (1) | WO2006117670A1 (es) |
| ZA (1) | ZA200709591B (es) |
Families Citing this family (109)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110033542A1 (en) | 2009-08-07 | 2011-02-10 | Monosol Rx, Llc | Sublingual and buccal film compositions |
| US20070281003A1 (en) | 2001-10-12 | 2007-12-06 | Fuisz Richard C | Polymer-Based Films and Drug Delivery Systems Made Therefrom |
| US8900497B2 (en) | 2001-10-12 | 2014-12-02 | Monosol Rx, Llc | Process for making a film having a substantially uniform distribution of components |
| US7357891B2 (en) | 2001-10-12 | 2008-04-15 | Monosol Rx, Llc | Process for making an ingestible film |
| US11207805B2 (en) | 2001-10-12 | 2021-12-28 | Aquestive Therapeutics, Inc. | Process for manufacturing a resulting pharmaceutical film |
| US8900498B2 (en) | 2001-10-12 | 2014-12-02 | Monosol Rx, Llc | Process for manufacturing a resulting multi-layer pharmaceutical film |
| US20190328679A1 (en) | 2001-10-12 | 2019-10-31 | Aquestive Therapeutics, Inc. | Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions |
| US8765167B2 (en) | 2001-10-12 | 2014-07-01 | Monosol Rx, Llc | Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions |
| US8603514B2 (en) | 2002-04-11 | 2013-12-10 | Monosol Rx, Llc | Uniform films for rapid dissolve dosage form incorporating taste-masking compositions |
| US10285910B2 (en) | 2001-10-12 | 2019-05-14 | Aquestive Therapeutics, Inc. | Sublingual and buccal film compositions |
| ES2387388T3 (es) * | 2002-09-27 | 2012-09-21 | Dainippon Sumitomo Pharma Co., Ltd. | Compuesto de adenina y uso del mismo |
| MXPA06011080A (es) | 2004-03-26 | 2007-04-16 | Astrazeneca Ab | Compuesto de 8-oxoadenina 9-sustituido. |
| US20090118263A1 (en) * | 2005-09-22 | 2009-05-07 | Dainippon Sumitomo Pharma Co., Ltd. | Novel Adenine Compound |
| WO2008004948A1 (en) | 2006-07-05 | 2008-01-10 | Astrazeneca Ab | 8-oxoadenine derivatives acting as modulators of tlr7 |
| DE602007008470D1 (en) * | 2006-10-17 | 2010-09-23 | Bend Res Inc | Off |
| TW200831105A (en) * | 2006-12-14 | 2008-08-01 | Astrazeneca Ab | Novel compounds |
| ATE490249T1 (de) * | 2007-02-19 | 2010-12-15 | Glaxosmithkline Llc | Purinderivate als immunmodulatoren |
| US8067413B2 (en) * | 2007-03-19 | 2011-11-29 | Astrazeneca Ab | 9-substituted-8-oxo-adenine compounds as toll-like receptor (TLR7 ) modulators |
| WO2008114006A1 (en) * | 2007-03-19 | 2008-09-25 | Astrazeneca Ab | 9-substituted-8-oxo-adenine compounds as toll-like receptor (tlr7) modulators |
| AR065784A1 (es) * | 2007-03-20 | 2009-07-01 | Dainippon Sumitomo Pharma Co | Derivados de 8-oxo adenina,medicamentos que los contienen y usos como agentes terapeuticos para enfermedades alergicas, antivirales o antibacterianas. |
| WO2008114819A1 (ja) | 2007-03-20 | 2008-09-25 | Dainippon Sumitomo Pharma Co., Ltd. | 新規アデニン化合物 |
| US8568777B2 (en) * | 2007-03-30 | 2013-10-29 | Monosol Rx, Llc | Packaged film dosage unit containing a complexate |
| US8436178B2 (en) * | 2007-05-08 | 2013-05-07 | Astrazeneca Ab | Imidazoquinolines with immuno-modulating properties |
| ES2541434T3 (es) | 2007-06-29 | 2015-07-20 | Gilead Sciences, Inc. | Derivados de purina y su uso como moduladores del receptor de tipo Toll 7 |
| PE20091156A1 (es) | 2007-12-17 | 2009-09-03 | Astrazeneca Ab | Sales de (3-{[[3-(6-amino-2-butoxi-8-oxo-7,8-dihidro-9h-purin-9-il)propil](3-morfolin-4-ilpropil)amino]metil}fenil)acetato de metilo |
| KR20100125245A (ko) | 2008-01-17 | 2010-11-30 | 다이닛본 스미토모 세이야꾸 가부시끼가이샤 | 아데닌 화합물의 제조 방법 |
| WO2009091031A1 (ja) * | 2008-01-17 | 2009-07-23 | Dainippon Sumitomo Pharma Co., Ltd. | アデニン化合物の製造方法 |
| US8575181B2 (en) | 2008-08-11 | 2013-11-05 | Glaxosmithkline Llc | Purine derivatives for use in the treatment of allergic, inflammatory and infectious diseases |
| US8802684B2 (en) | 2008-08-11 | 2014-08-12 | Glaxosmithkline Llc | Adenine derivatives |
| CA2733750C (en) | 2008-08-11 | 2016-10-11 | Glaxosmithkline Llc | Novel adenine derivatives |
| UA103195C2 (uk) | 2008-08-11 | 2013-09-25 | Глаксосмитклайн Ллк | Похідні пурину для застосування у лікуванні алергій, запальних та інфекційних захворювань |
| TW201639852A (zh) | 2008-12-09 | 2016-11-16 | 吉李德科學股份有限公司 | 用於製備可用作類鐸受體調節劑之化合物的中間體化合物 |
| WO2010088924A1 (en) | 2009-02-06 | 2010-08-12 | Telormedix Sa | Pharmaceutical compositions comprising imidazoquinolin(amines) and derivatives thereof suitable for local administration |
| ES2661850T3 (es) | 2009-09-14 | 2018-04-04 | Gilead Sciences, Inc. | Moduladores de receptores del tipo toll |
| NO2491035T3 (es) | 2009-10-22 | 2018-01-27 | ||
| WO2011068233A1 (en) * | 2009-12-03 | 2011-06-09 | Dainippon Sumitomo Pharma Co., Ltd. | Imidazoquinolines which act via toll - like receptors (tlr) |
| WO2011079016A1 (en) * | 2009-12-22 | 2011-06-30 | Gilead Sciences, Inc. | Methods of treating hbv and hcv infection |
| EP2534148A1 (en) | 2010-02-10 | 2012-12-19 | GlaxoSmithKline LLC | Purine derivatives and their pharmaceutical uses |
| US20130202629A1 (en) * | 2010-04-30 | 2013-08-08 | The Regents Of The University Of California | Uses of phospholipid conjugates of synthetic tlr7 agonists |
| US9149959B2 (en) | 2010-10-22 | 2015-10-06 | Monosol Rx, Llc | Manufacturing of small film strips |
| CN103370317B (zh) | 2010-12-16 | 2015-10-07 | 阿斯利康(瑞典)有限公司 | 可用于治疗的咪唑并[4,5-c]喹啉-1-基衍生物 |
| EP2651943B1 (en) | 2010-12-17 | 2017-03-22 | Sumitomo Dainippon Pharma Co., Ltd. | Purine derivatives |
| JP6046694B2 (ja) | 2011-04-08 | 2016-12-21 | ヤンセン・サイエンシズ・アイルランド・ユーシー | ウイルス感染治療用のピリミジン誘導体 |
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| US5376645A (en) | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
| KR0166088B1 (ko) | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
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| TW200745114A (en) * | 2005-09-22 | 2007-12-16 | Astrazeneca Ab | Novel compounds |
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- 2006-04-24 JP JP2008509532A patent/JP2008540396A/ja not_active Withdrawn
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| DOP2006000102A (es) | 2006-11-15 |
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| BRPI0611435A2 (pt) | 2010-09-08 |
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| KR20080006004A (ko) | 2008-01-15 |
| WO2006117670A1 (en) | 2006-11-09 |
| CA2607780A1 (en) | 2006-11-09 |
| ZA200709591B (en) | 2010-01-27 |
| UY29516A1 (es) | 2006-11-30 |
| NL1031741C2 (nl) | 2007-07-10 |
| US20060264448A1 (en) | 2006-11-23 |
| IL187135A0 (en) | 2008-02-09 |
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