AR054132A1 - Derivados de azolopiridin-2-ona como inhibidores de lipasas y fosfolipasas - Google Patents
Derivados de azolopiridin-2-ona como inhibidores de lipasas y fosfolipasasInfo
- Publication number
- AR054132A1 AR054132A1 ARP060102373A ARP060102373A AR054132A1 AR 054132 A1 AR054132 A1 AR 054132A1 AR P060102373 A ARP060102373 A AR P060102373A AR P060102373 A ARP060102373 A AR P060102373A AR 054132 A1 AR054132 A1 AR 054132A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- alkylene
- identically
- differently
- aryl
- Prior art date
Links
- 102000004882 Lipase Human genes 0.000 title 1
- 108090001060 Lipase Proteins 0.000 title 1
- 239000004367 Lipase Substances 0.000 title 1
- 102000015439 Phospholipases Human genes 0.000 title 1
- 108010064785 Phospholipases Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 8
- 125000002947 alkylene group Chemical group 0.000 abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- -1 C1-6-mercapto alkyl Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 3
- 125000000041 C6-C10 aryl group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004122 cyclic group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 2
- 229920006395 saturated elastomer Polymers 0.000 abstract 2
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 abstract 1
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 abstract 1
- 125000006652 (C3-C12) cycloalkyl group Chemical group 0.000 abstract 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 1
- 125000004980 cyclopropylene group Chemical group 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/424—Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Reivindicacion 1: Un compuesto de la formula (1), en la que: X de forma idéntica o diferente, es =C(-R)- o =N-, donde al menos uno y como máximo dos =C(-R-)- están reemplazados por =N-; Y es -O- o -S-; R de forma idéntica o diferente, es hidrogeno, halogeno, alquilo C1-6, alquiloxiC1-3-alquilenoC1-3, hidroxi, alquilC1-6-mercapto, amino, alquilC1-6-amino, di-alquilC2-12-amino, alquilC1-6-carbonilo, COOR3, trifluorometilo, alquilC1-6-sulfonilo, alquilC1-6-sulfinilo, aminosulfonilo, pentafluorosulfanilo, arilo C6-10, heteroarilo C5-12, CO-NR6R7, O-CO-NR6R7, O-CO-alquilenC1-6-CO-O-alquiloC1-6, O-CO-alquilenC1-6-CO-OH, O-CO-alquilenC1-6-CO-NR6R7 o alquiloxi C1-6 no sustituido o mono- o poli-F-sustituido; R1 es alquilo C4-16, alquilenC1-4-ariloC6-10, alquilenC1-4-heteroariloC5-12, alquilenC1-4-cicloalquiloC3-12, biciclo C8-14, donde los arilo, heteroarilo, cicloalquilo o biciclo pueden estar sustituidos una o más veces con halogeno, alquilo C1-6, alquiloxi C1-3, hidroxi, alquilC1-6-mercapto, amino, alquilC1-6-amino, di-alquilC2-12-amino, mono-alquilC1-6-aminocarbonilo, di-alquilC2-8-aminocarbonilo, alcoxiC1-6-carbonilo, alquilC1-6-carbonilo, ciano, trifluorometilo, trifluorometoxi, alquilC1-6-sulfonilo, aminosulfonilo; R2 es hidrogeno, alquilo C1-6; o R1 y R2 forman junto con el átomo de nitrogeno al que están unidos un sistema de anillos monocíclico, saturado o parcialmente insaturado, de 4 a 7 miembros o un sistema de anillos bicíclico saturado o parcialmente insaturado, de 8 a 14 miembros, cuyos miembros individuales del sistema de anillos pueden estar reemplazados por uno a tres átomos o grupos atomicos de la serie -CHR4-, -CR4R5-, -(C=R4)-, -NR6-, -C(=O)-, -O-, -S-, -SO-, -SO2-, con la condicion de que dos unidades de la serie -O-, -S-, -SO-, -SO2- no pueden ser adyacentes; R3 es hidrogeno, alquilo C1-6, bencilo; R4, R5 de forma idéntica o diferente, son alquilo C1-6, halogeno, trifluorometilo, COOR3, ciclopropilo, ciclopropileno; R6, R7 de forma idéntica o diferente, son hidrogeno, alquilo C1-6, arilo C6-10, heteroarilo C5-12, cicloalquilo C3-12, alquilenC1-4-ariloC6-10, alquilenC1-4-heteroariloC5-12, alquilenC1-4-cicloalquiloC4-12, biciclo C8-14; y las formas tautomeros de los compuestos y las sales fisiologicamente toleradas de los mismos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102005026762A DE102005026762A1 (de) | 2005-06-09 | 2005-06-09 | Azolopyridin-2-on-derivate als Inhibitoren von Lipasen und Phospholipasen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR054132A1 true AR054132A1 (es) | 2007-06-06 |
Family
ID=37076291
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060102373A AR054132A1 (es) | 2005-06-09 | 2006-06-07 | Derivados de azolopiridin-2-ona como inhibidores de lipasas y fosfolipasas |
Country Status (30)
| Country | Link |
|---|---|
| US (2) | US7846943B2 (es) |
| EP (1) | EP1896485B1 (es) |
| JP (1) | JP2008542410A (es) |
| KR (1) | KR20080019215A (es) |
| CN (1) | CN101193896A (es) |
| AR (1) | AR054132A1 (es) |
| AT (1) | ATE468342T1 (es) |
| AU (1) | AU2006257022A1 (es) |
| BR (1) | BRPI0611688A2 (es) |
| CA (1) | CA2610325A1 (es) |
| CY (1) | CY1110213T1 (es) |
| DE (2) | DE102005026762A1 (es) |
| DK (1) | DK1896485T3 (es) |
| ES (1) | ES2346561T3 (es) |
| HR (1) | HRP20100409T1 (es) |
| IL (1) | IL187730A0 (es) |
| MA (1) | MA29481B1 (es) |
| MX (1) | MX2007015347A (es) |
| MY (1) | MY142792A (es) |
| NO (1) | NO20080133L (es) |
| NZ (1) | NZ564063A (es) |
| PL (1) | PL1896485T3 (es) |
| PT (1) | PT1896485E (es) |
| RS (1) | RS51268B (es) |
| RU (1) | RU2414473C2 (es) |
| SI (1) | SI1896485T1 (es) |
| TW (1) | TW200716653A (es) |
| UY (1) | UY29593A1 (es) |
| WO (1) | WO2006131231A1 (es) |
| ZA (1) | ZA200709501B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102006014685A1 (de) | 2006-03-28 | 2007-10-04 | Sanofi-Aventis | Imidazo-pyridin-2-on-derivate als Inhibitoren von Lipasen und Phospholiphasen |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| UY31968A (es) | 2008-07-09 | 2010-01-29 | Sanofi Aventis | Nuevos derivados heterocíclicos, sus procesos para su preparación, y sus usos terapéuticos |
| EP2351744B1 (en) | 2008-10-17 | 2015-01-07 | Shionogi & Co., Ltd. | Acetic acid amide derivative having inhibitory activity on vascular endothelial lipase |
| CA2779303A1 (en) * | 2009-10-29 | 2011-05-19 | Sirtris Pharmaceuticals, Inc. | Bicyclic pyridines and analogs as sirtuin modulators |
| KR20120123325A (ko) | 2009-12-15 | 2012-11-08 | 시오노기세야쿠 가부시키가이샤 | 혈관 내피 리파아제 저해 활성을 갖는 옥사디아졸 유도체 |
| US8933024B2 (en) | 2010-06-18 | 2015-01-13 | Sanofi | Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases |
| CN114560873B (zh) * | 2021-12-27 | 2023-02-28 | 浙江日出药业有限公司 | 一种3-氯甲基-6-氯-噁唑[4,5-b]吡啶-2(3H)酮的制备方法 |
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| DE10231370B4 (de) | 2002-07-11 | 2006-04-06 | Sanofi-Aventis Deutschland Gmbh | Thiophenglycosidderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zur Herstellung dieser Arzneimittel |
| DE10247680B4 (de) | 2002-10-12 | 2005-09-01 | Aventis Pharma Deutschland Gmbh | Neue bicyclische Inhibitoren der Hormon Sensitiven Lipase |
| DE10258007B4 (de) | 2002-12-12 | 2006-02-09 | Sanofi-Aventis Deutschland Gmbh | Aromatische Fluorglycosidderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zur Herstellung dieser Arzneimittel |
| DE10258008B4 (de) | 2002-12-12 | 2006-02-02 | Sanofi-Aventis Deutschland Gmbh | Heterocyclische Fluorglycosidderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zur Herstellung dieser Arzneimittel |
| EP1615900A1 (en) | 2003-04-01 | 2006-01-18 | Eli Lilly And Company | Benzisothiazol-3-one-carboxylic acid amides as phospholipase inhibitors |
| EP1613608A1 (en) | 2003-04-01 | 2006-01-11 | Eli Lilly And Company | Phospholipase inhibitors |
| RU2229478C1 (ru) * | 2003-05-20 | 2004-05-27 | ООО "Исследовательский институт химического разнообразия" | Замещенные [1.3]оксазоло[4,5-d]пиридазины и комбинаторная библиотека |
| DE102004005172A1 (de) | 2004-02-02 | 2005-08-18 | Aventis Pharma Deutschland Gmbh | Indazolderivate als Inhibitoren der Hormon Sensitiven Lipase |
| DE102004028241B4 (de) | 2004-06-11 | 2007-09-13 | Sanofi-Aventis Deutschland Gmbh | Neue Fluorglykosidderivate von Pyrazolen, diese Verbindungen enthaltende Arzneimittel und Herstellung dieser Arzneimittel |
-
2005
- 2005-06-09 DE DE102005026762A patent/DE102005026762A1/de not_active Withdrawn
-
2006
- 2006-05-27 DE DE502006006986T patent/DE502006006986D1/de active Active
- 2006-05-27 AT AT06753937T patent/ATE468342T1/de active
- 2006-05-27 MX MX2007015347A patent/MX2007015347A/es active IP Right Grant
- 2006-05-27 ES ES06753937T patent/ES2346561T3/es active Active
- 2006-05-27 WO PCT/EP2006/005095 patent/WO2006131231A1/de not_active Ceased
- 2006-05-27 AU AU2006257022A patent/AU2006257022A1/en not_active Abandoned
- 2006-05-27 HR HR20100409T patent/HRP20100409T1/hr unknown
- 2006-05-27 CN CNA2006800202416A patent/CN101193896A/zh active Pending
- 2006-05-27 CA CA002610325A patent/CA2610325A1/en not_active Abandoned
- 2006-05-27 DK DK06753937.9T patent/DK1896485T3/da active
- 2006-05-27 RU RU2007145499/04A patent/RU2414473C2/ru not_active IP Right Cessation
- 2006-05-27 KR KR1020077028710A patent/KR20080019215A/ko not_active Withdrawn
- 2006-05-27 SI SI200630748T patent/SI1896485T1/sl unknown
- 2006-05-27 EP EP06753937A patent/EP1896485B1/de active Active
- 2006-05-27 PT PT06753937T patent/PT1896485E/pt unknown
- 2006-05-27 PL PL06753937T patent/PL1896485T3/pl unknown
- 2006-05-27 RS RSP-2010/0270A patent/RS51268B/sr unknown
- 2006-05-27 JP JP2008515095A patent/JP2008542410A/ja not_active Abandoned
- 2006-05-27 NZ NZ564063A patent/NZ564063A/en not_active IP Right Cessation
- 2006-05-27 BR BRPI0611688-4A patent/BRPI0611688A2/pt not_active IP Right Cessation
- 2006-06-07 MY MYPI20062625A patent/MY142792A/en unknown
- 2006-06-07 TW TW095120135A patent/TW200716653A/zh unknown
- 2006-06-07 AR ARP060102373A patent/AR054132A1/es not_active Application Discontinuation
- 2006-06-09 UY UY29593A patent/UY29593A1/es not_active Application Discontinuation
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2007
- 2007-11-05 ZA ZA200700950A patent/ZA200709501B/xx unknown
- 2007-11-22 MA MA30415A patent/MA29481B1/fr unknown
- 2007-11-28 IL IL187730A patent/IL187730A0/en unknown
- 2007-12-05 US US11/950,932 patent/US7846943B2/en not_active Expired - Fee Related
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2008
- 2008-01-08 NO NO20080133A patent/NO20080133L/no not_active Application Discontinuation
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2010
- 2010-07-20 CY CY20101100675T patent/CY1110213T1/el unknown
- 2010-10-28 US US12/914,045 patent/US20110039883A1/en not_active Abandoned
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