AR043367A2 - Derivados de benzofenona, composiciones farmaceuticas y procesos de preparacion. - Google Patents
Derivados de benzofenona, composiciones farmaceuticas y procesos de preparacion.Info
- Publication number
- AR043367A2 AR043367A2 ARP040100563A ARP040100563A AR043367A2 AR 043367 A2 AR043367 A2 AR 043367A2 AR P040100563 A ARP040100563 A AR P040100563A AR P040100563 A ARP040100563 A AR P040100563A AR 043367 A2 AR043367 A2 AR 043367A2
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- group
- aryl
- benzophenone
- halogen
- Prior art date
Links
- RWCCWEUUXYIKHB-UHFFFAOYSA-N benzophenone Chemical class C=1C=CC=CC=1C(=O)C1=CC=CC=C1 RWCCWEUUXYIKHB-UHFFFAOYSA-N 0.000 title abstract 6
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 7
- 229910052736 halogen Inorganic materials 0.000 abstract 6
- 125000005915 C6-C14 aryl group Chemical group 0.000 abstract 5
- 239000012965 benzophenone Substances 0.000 abstract 5
- 125000000623 heterocyclic group Chemical group 0.000 abstract 5
- 125000001424 substituent group Chemical group 0.000 abstract 5
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 4
- 150000002367 halogens Chemical group 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000003282 alkyl amino group Chemical group 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 1
- 108010078851 HIV Reverse Transcriptase Proteins 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 150000008366 benzophenones Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
- 230000009385 viral infection Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
- C07C311/46—Y being a hydrogen or a carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C311/51—Y being a hydrogen or a carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C311/52—Y being a hetero atom
- C07C311/53—X and Y not being nitrogen atoms, e.g. N-sulfonylcarbamic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Uso de la benzofenona o derivado para la fabricación de un medicamento para el tratamiento o profilaxis de una infección por virus, composición farmacéutica que comprende la benzofenona o derivado junto con un portador farmacéuticamente aceptable; y un proceso para la preparación de la benzofenona. Los compuestos benzofenonas y sus derivados farmacéuticamente son útiles en la inhibición de la transcriptasa inversa del VIH, particularmente resistentes. Reivindicación 1: Una benzofenona o un derivado farmacéuticamente aceptable de la misma, caracterizado porque dicha benzofenona tiene la fórmula (1), en donde: R1 es uno o más sustituyentes seleccionados independientemente del grupo que consiste en halógeno, -CF3, alquilo C1-8, alquilamino C1-8, alcoxi, -CN, -NO2, -NH2, -SR8, -S(O)R8, -S(O)2R8, -C(O)R8; alquenilo C2-6 que puede opcionalmente sustituirse con un sustituyente seleccionado del grupo que consiste de hidroxi, halógeno, arilo C6-14, cicloalquilo C3-6, arilo C6-14 y heterociclo; alquinilo C2-6 que puede opcionalmente sustituirse con un sustituyente seleccionado del grupo que consiste de hidroxi, halógeno, cicloalquilo C3-6, arilo C6-14, y heterociclo; y heterociclo opcionalmente sustituido con uno o más sustituyentes seleccionados del grupo que consiste de halógeno, alquilo C1-8, -CN, arilo(C6-14)-alquilo(C1-8), y heterociclo; R2 se selecciona del grupo que consiste de hidrógeno, halógeno, alquilo C1-8, -NO2, -NH2, alquilamino C1-8, -CF3 y alcoxi; R3 se selecciona del grupo que consiste de hidroxi, halógeno, -CF3, -NO2 y alquilo C1-8; R8 se selecciona del grupo que consiste de alquilo C1-8, cicloalquilo(C3-6)-alquilo(C1-8), cicloalquilo C3-6, arilo C6-14, y heterociclo; R15 y R16 están seleccionados independientemente del grupo que consiste de hidrógeno, alquilo C1-8, cicloalquilo C3-6 y arilo C6-14, o R15 y R16 junto con el átomo al cual están enlazados forman un anillo que incluye opcionalmente uno o más heteroátomos seleccionados del grupo que consiste de N, O y S, en donde N puede sustituirse opcionalmente con un sustituyente seleccionado del grupo que consiste de hidrógeno, alquilo C1-8 y arilo(C6-14)-alquilo(C1-8).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27295301P | 2001-03-02 | 2001-03-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR043367A2 true AR043367A2 (es) | 2005-07-27 |
Family
ID=23041935
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020100764A AR035436A1 (es) | 2001-03-02 | 2002-03-01 | Una benzofenona o derivado farmaceuticamente aceptable, sales, formas salinas, composiciones farmaceuticas, usos para la fabricacion de un medicamento, y proceso para la preparacion de una benzofenona |
| ARP040100563A AR043367A2 (es) | 2001-03-02 | 2004-02-23 | Derivados de benzofenona, composiciones farmaceuticas y procesos de preparacion. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020100764A AR035436A1 (es) | 2001-03-02 | 2002-03-01 | Una benzofenona o derivado farmaceuticamente aceptable, sales, formas salinas, composiciones farmaceuticas, usos para la fabricacion de un medicamento, y proceso para la preparacion de una benzofenona |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US6995283B2 (es) |
| EP (1) | EP1363877A2 (es) |
| JP (1) | JP2004525914A (es) |
| KR (1) | KR100638954B1 (es) |
| CN (1) | CN1494528A (es) |
| AR (2) | AR035436A1 (es) |
| AU (1) | AU2002254056C1 (es) |
| BR (1) | BR0207752A (es) |
| CA (1) | CA2439820A1 (es) |
| CZ (1) | CZ20032366A3 (es) |
| HU (1) | HUP0303326A2 (es) |
| IL (1) | IL157348A0 (es) |
| MX (1) | MXPA03007883A (es) |
| NO (1) | NO20033857L (es) |
| NZ (1) | NZ527864A (es) |
| PL (1) | PL364658A1 (es) |
| WO (1) | WO2002070470A2 (es) |
| ZA (1) | ZA200306549B (es) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO3429B1 (ar) | 2001-08-13 | 2019-10-20 | Janssen Pharmaceutica Nv | مشتقات برميدينات مثبطة فيروس الايدز |
| US7638522B2 (en) | 2001-08-13 | 2009-12-29 | Janssen Pharmaceutica N.V. | Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino] benzonitrile |
| US8101629B2 (en) | 2001-08-13 | 2012-01-24 | Janssen Pharmaceutica N.V. | Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile |
| AR039540A1 (es) * | 2002-05-13 | 2005-02-23 | Tibotec Pharm Ltd | Compuestos microbicidas con contenido de pirimidina o triazina |
| CA2686429C (en) | 2002-08-09 | 2010-11-16 | Janssen Pharmaceutica N.V. | Processes for the preparation of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile |
| EP1545483B1 (en) | 2002-08-23 | 2011-04-06 | Ardea Biosciences, Inc. | Non-nucleoside reverse transcriptase inhibitors |
| US7642277B2 (en) | 2002-12-04 | 2010-01-05 | Boehringer Ingelheim International Gmbh | Non-nucleoside reverse transcriptase inhibitors |
| NZ541902A (en) * | 2003-02-07 | 2008-12-24 | Janssen Pharmaceutica Nv | Pyrimidine derivatives for the prevention of HIV infection |
| JP2006521402A (ja) | 2003-03-27 | 2006-09-21 | スミスクライン ビーチャム コーポレーション | 逆転写酵素阻害剤を調製するための方法 |
| WO2005026114A1 (en) * | 2003-09-17 | 2005-03-24 | Pfizer Inc. | Hiv protease inhibitors, compositions containing the same and their pharmaceutical uses |
| US20080132549A1 (en) * | 2004-04-14 | 2008-06-05 | Pfizer Inc. | Sulphur-Linked Imidazone Compounds for the Treatment of Hiv/Aids |
| US20060025480A1 (en) * | 2004-08-02 | 2006-02-02 | Boehringer Ingelheim International Gmbh | Benzoic acid derivatives as non nucleoside reverse transcriptase inhibitors |
| WO2007050087A1 (en) | 2004-08-25 | 2007-05-03 | Ardea Biosciences, Inc. | N[S(4-aryl-triazol-3-yl)α -mercaptoacetyl]-p-amino benozoic acids AS HIV REVERSE TRANSCRIPTASE INHIBITORS |
| CN101083987B (zh) | 2004-08-25 | 2011-01-26 | 阿迪亚生命科学公司 | 作为HIV逆转录酶抑制剂的S-三唑基α-巯基乙酰苯胺 |
| EP1797062B8 (en) * | 2004-09-30 | 2011-05-25 | Boehringer Ingelheim International GmbH | Alkynyl based dervatives of benzophenone as non-nucleoside reverse transcriptase inhibitors |
| CA2592092A1 (en) * | 2004-12-22 | 2006-06-29 | Pfizer Limited | Nonnucleoside inhibitors of hiv-1 reverse transcriptase |
| US20070264334A1 (en) * | 2005-04-08 | 2007-11-15 | Ju Tzuchi R | Pharmaceutical formulations |
| AR057455A1 (es) | 2005-07-22 | 2007-12-05 | Merck & Co Inc | Inhibidores de la transcriptasa reversa de vih y composicion farmaceutica |
| AR060491A1 (es) * | 2006-04-17 | 2008-06-18 | Smithkline Beecham Corp | Compuestos quimicos |
| TW200808307A (en) * | 2006-04-17 | 2008-02-16 | Smithkline Beecham Corp | Chemical compounds |
| TW200814993A (en) * | 2006-04-17 | 2008-04-01 | Smithkline Beecham Corp | Chemical compounds |
| UA95955C2 (ru) * | 2006-07-24 | 2011-09-26 | Кореа Ресерч Инститьют Оф Кемикал Текнолоджи | Ингибиторы обратной транскриптазы вич |
| CN101407476B (zh) * | 2007-10-12 | 2012-07-18 | 中国人民解放军军事医学科学院毒物药物研究所 | 作为非核苷类hiv逆转录酶抑制剂的间二芳烃-多取代苯胺类化合物、其制备方法及用途 |
| JP5099794B2 (ja) | 2007-11-27 | 2012-12-19 | アルデア バイオサイエンシーズ インク． | 新規化合物、組成物、及び使用方法 |
| CN101450911B (zh) * | 2007-11-30 | 2012-02-29 | 山东轩竹医药科技有限公司 | 被金刚烷取代的苯甲酸衍生物 |
| CN102212022A (zh) * | 2011-04-20 | 2011-10-12 | 复旦大学 | 二苯甲醇衍生物及其制备方法和用途 |
| CN102206177A (zh) * | 2011-04-20 | 2011-10-05 | 复旦大学 | 1-萘基苯甲酮衍生物及其制备方法和用途 |
| CN102219717A (zh) * | 2011-04-20 | 2011-10-19 | 复旦大学 | N-苯基芳基甲酰胺衍生物及其制备方法和用途 |
| CN110015963A (zh) * | 2019-04-12 | 2019-07-16 | 上海优合生物科技有限公司 | 一种2-氯-6-甲基苯胺的制备方法 |
| WO2020231979A1 (en) * | 2019-05-13 | 2020-11-19 | The Trustees Of Princeton University | Small molecule inhibitors of viral replication |
| US11116737B1 (en) | 2020-04-10 | 2021-09-14 | University Of Georgia Research Foundation, Inc. | Methods of using probenecid for treatment of coronavirus infections |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH03198050A (ja) * | 1989-12-27 | 1991-08-29 | Fuji Photo Film Co Ltd | ハロゲン化銀カラー写真感光材料 |
-
2002
- 2002-02-28 CN CNA028058828A patent/CN1494528A/zh active Pending
- 2002-02-28 AU AU2002254056A patent/AU2002254056C1/en not_active Ceased
- 2002-02-28 EP EP02723265A patent/EP1363877A2/en not_active Withdrawn
- 2002-02-28 PL PL02364658A patent/PL364658A1/xx not_active Application Discontinuation
- 2002-02-28 JP JP2002569791A patent/JP2004525914A/ja not_active Ceased
- 2002-02-28 US US10/469,104 patent/US6995283B2/en not_active Expired - Fee Related
- 2002-02-28 WO PCT/US2002/006037 patent/WO2002070470A2/en not_active Ceased
- 2002-02-28 HU HU0303326A patent/HUP0303326A2/hu unknown
- 2002-02-28 MX MXPA03007883A patent/MXPA03007883A/es unknown
- 2002-02-28 KR KR1020037011471A patent/KR100638954B1/ko not_active Expired - Fee Related
- 2002-02-28 BR BR0207752-3A patent/BR0207752A/pt not_active IP Right Cessation
- 2002-02-28 CA CA002439820A patent/CA2439820A1/en not_active Abandoned
- 2002-02-28 CZ CZ20032366A patent/CZ20032366A3/cs unknown
- 2002-02-28 NZ NZ527864A patent/NZ527864A/en unknown
- 2002-02-28 IL IL15734802A patent/IL157348A0/xx unknown
- 2002-03-01 AR ARP020100764A patent/AR035436A1/es not_active Application Discontinuation
-
2003
- 2003-08-21 ZA ZA200306549A patent/ZA200306549B/xx unknown
- 2003-09-01 NO NO20033857A patent/NO20033857L/no not_active Application Discontinuation
-
2004
- 2004-02-23 AR ARP040100563A patent/AR043367A2/es not_active Application Discontinuation
-
2005
- 2005-09-09 US US11/223,634 patent/US20060009651A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002070470A2 (en) | 2002-09-12 |
| AR035436A1 (es) | 2004-05-26 |
| CZ20032366A3 (en) | 2004-04-14 |
| NO20033857L (no) | 2003-10-27 |
| KR20030086283A (ko) | 2003-11-07 |
| BR0207752A (pt) | 2004-03-23 |
| AU2002254056C1 (en) | 2006-04-13 |
| ZA200306549B (en) | 2004-11-22 |
| CA2439820A1 (en) | 2002-09-12 |
| HUP0303326A2 (hu) | 2004-01-28 |
| CN1494528A (zh) | 2004-05-05 |
| MXPA03007883A (es) | 2003-12-04 |
| JP2004525914A (ja) | 2004-08-26 |
| IL157348A0 (en) | 2004-02-19 |
| US6995283B2 (en) | 2006-02-07 |
| EP1363877A2 (en) | 2003-11-26 |
| US20040122064A1 (en) | 2004-06-24 |
| NO20033857D0 (no) | 2003-09-01 |
| KR100638954B1 (ko) | 2006-10-25 |
| US20060009651A1 (en) | 2006-01-12 |
| WO2002070470A3 (en) | 2003-03-06 |
| NZ527864A (en) | 2004-05-28 |
| AU2002254056B2 (en) | 2005-09-29 |
| PL364658A1 (en) | 2004-12-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR043367A2 (es) | Derivados de benzofenona, composiciones farmaceuticas y procesos de preparacion. | |
| AR033344A1 (es) | Compuestos derivados de benzofenonas como inhibidores de la transcriptasa inversa, su uso en la fabricacion de medicamentos, intermediarios y composiciones farmaceuticas | |
| PE20241341A1 (es) | Compuestos terapeuticos para la infeccion por el virus vih | |
| PE20230376A1 (es) | Compuestos moduladores de la diacilglicerol quinasa | |
| AR048315A1 (es) | Compuestos heterociclicos inhibidores de la produccion de citocinas; composiciones farmaceuticas que los contienen y su uso en el tratamiento de enfermedades inflamatorias y oncologicas. | |
| AR081848A1 (es) | Inhibidores de la proteina ns5a del vhc | |
| AR012964A1 (es) | Compuetos derivados de bencimidazol, composiciones farmaceuticas que los contienen y su uso en la manufactura de medicamentos para tratar infeccionesvirales | |
| AR048537A1 (es) | Derivados de nucleosidos para tratar infecciones por virus de hepatitis c. | |
| AR020551A2 (es) | Compuestos macrolidos, composiciones y su uso para la preparacion de medicamentos. | |
| AR040031A1 (es) | Compuestos de pirazol-pirimidina anilina utiles como inhibidores de cinasa y composiciones farmaceuticas que los contienen | |
| AR054560A1 (es) | Espiropiperidina como inhibidores de beta-secretasa para el tratamiento de la enfermedad de alzheimer | |
| AR035892A1 (es) | Derivados de oxazol, proceso para su preparacion, composiciones farmaceuticas que los comprenden, y el uso de dichos compuestos en la preparacion de medicamentos | |
| AR022848A1 (es) | Compuestos de imidazol sustituido con un anillo heterociclico de seis o siete miembros que contiene dos atomos de nitrogeno | |
| AR062503A1 (es) | Derivados de pirido[2, 3-d]pirimidina y pirazin[2, 3-d]pirimidina, composiciones farmaceuticas que los comprenden y su uso en la preparacion de medicamentos para el tratamiento de enfermedades mediadas por la inhibicion de mtor. | |
| AR066020A1 (es) | Derivados de imidazolidin-2, 4-diona, una composicion farmaceutica que los comprende y su uso en la preparacion de un medicamento para el tratamiento de enfermedades mediadas por la inhibicion de parp-1. | |
| DK2266958T1 (da) | Antiviralt middel | |
| AR046297A1 (es) | Inhibidores de la dpp - iv metodos para prepararlos y composiciones farmaceuticas que los contienen como agente activo | |
| PE20030137A1 (es) | Derivados antimicrobianos de quinolona | |
| ES2530943T3 (es) | Derivados de la cromenona con actividad antitumoral | |
| AR075587A1 (es) | Derivados de bifenilo para el tratamiento de hepatitis c | |
| AR041997A1 (es) | Derivados de oxaxol sustituidos, composiciones farmaceuticas que los contienen y su uso en la fabricacion de medicamentos para el tratamiento de la diabetes | |
| ECSP055815A (es) | Composición para el tratamiento de la infección por virus flaviviridae | |
| ECSP034547A (es) | Derivados de pirazol para el tratamiento de enfermedades virales | |
| AR020016A2 (es) | Compuestos derivados de la eritromicina, composiciones que los contienen, uso de los mismos para preparar un medicamento | |
| PE20242071A1 (es) | Compuestos moduladores de diacilglicerol quinasa |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |