AR035436A1 - Una benzofenona o derivado farmaceuticamente aceptable, sales, formas salinas, composiciones farmaceuticas, usos para la fabricacion de un medicamento, y proceso para la preparacion de una benzofenona - Google Patents
Una benzofenona o derivado farmaceuticamente aceptable, sales, formas salinas, composiciones farmaceuticas, usos para la fabricacion de un medicamento, y proceso para la preparacion de una benzofenonaInfo
- Publication number
- AR035436A1 AR035436A1 ARP020100764A ARP020100764A AR035436A1 AR 035436 A1 AR035436 A1 AR 035436A1 AR P020100764 A ARP020100764 A AR P020100764A AR P020100764 A ARP020100764 A AR P020100764A AR 035436 A1 AR035436 A1 AR 035436A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- group
- benzophenone
- cycloalkyl
- aryl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
- C07C311/46—Y being a hydrogen or a carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C311/51—Y being a hydrogen or a carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C311/52—Y being a hetero atom
- C07C311/53—X and Y not being nitrogen atoms, e.g. N-sulfonylcarbamic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Una benzofenona o un derivado farmacéuticamente aceptable de la misma, donde dicha benzofenona tiene la fórmula (1) en donde: R1 es uno o más sustituyentes independientemente seleccionados del grupo que consiste de halógeno, -CF3, alquilo C1-8, amino alquilo C1-8, alcoxi, -CN, -NO2, -NH2-, SR8, -S(O)R8, -S(O)2R8, -C(O)R8; alquenilo C2-6 que puede opcionalmente sustituirse con un sustituyente seleccionado del grupo que consiste de hidroxi, halógeno, cicloalquilo C3-6, arilo C6-14 y heterociclo; alquinilo C2-6 que puede opcionalmente sustituirse con un sustituyente seleccionado del grupo que consiste de hidroxi, halógeno, arilo C6-14, cicloalquilo C3-6, y heterociclo; y heterociclo, opcionalmente sustituido con uno o más sustituyentes seleccionados del grupo que consiste de halógeno, alquilo C1-8, -CN, alquilo C1-8arilo C6-14, y heterociclo; R2 se selecciona del grupo que consiste de hidrógeno, halógeno, alquilo C1-8, -NO2, -NH2, alquilamino C1-8, -CF3 y alcoxi; R3 se selecciona del grupo que consiste de hidroxi, halógeno, -CF3, -NO2 y alquilo C1-8; R4 se selecciona del grupo que consiste de -S(O)2NR5R6, -S(O)2N=C(OR7)2 y -S(O)2N=CR7(OR7); R5 se selecciona del grupo que consiste de hidrógeno, arilo, C6-14, alquilo C1-8, cicloalquil C3-6alquilo C1-8 y cicloalquilo C3-6; R6 se selecciona del grupo que consiste de -C(O)R7, -C(O)OR7, -C(O)C(O)OR7, -C(O)CH(NR12R13)R11, alcoxi alquilo C1-8 y -CH2O-(CH2CH2O)n-CH2CH2OCH3, donde n es 0-4; R7 se selecciona del grupo que consiste de cicloalquil C3-6alquilo C1-8, hidroxi alquilo C1-8, arilo C6-14, heterociclo opcionalmente sustituido con alquilo C1-8, aril C6-14alquilo C1-8, -(CH2CH2-O)n-CH3, donde n = 1-4, alcoxi alquilo C1-8, y alquilo C1-8 opcionalmente sustituido con -O-C(O)R12; R8 se selecciona del grupo que consiste de alquilo C1-8, cicloalquil C3-6alquilo C1-8, cicloalquilo C3-6, arilo C6-14 y heterociclo; R11 se selecciona del grupo que consiste de hidrógeno, y un resto del grupo de fórmulas (2); R12 y R13 son independientemente seleccionados del grupo que consiste de hidrógeno, alquilo C1-8, cicloalquilo C3-6, y arilo C6-14; sales de los mismos; formas salinas de sodio, colina o calcio de 2-[4-cloro-2-(3-cloro-5-cianobenzoil)fenoxi]-N-{2-metil-4-[(propionil amino)sulfonil]fenil}acetamida o de un derivado farmacéuticamente aceptable de la misma; uso de la benzofenona o derivado para la fabricación de un medicamento para el tratamiento o profilaxis de una infección por virus, composición farmacéutica que comprende la benzofenona o derivado junto con un portador farmacéuticamente aceptable; y un proceso para la preparación de benzofenona. Los compuestos y sus derivados farmacéuticamente aceptables son útiles en la inhibición de la transcriptasa inversa del VIH, particularmente de sus variedades resistentes.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27295301P | 2001-03-02 | 2001-03-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR035436A1 true AR035436A1 (es) | 2004-05-26 |
Family
ID=23041935
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020100764A AR035436A1 (es) | 2001-03-02 | 2002-03-01 | Una benzofenona o derivado farmaceuticamente aceptable, sales, formas salinas, composiciones farmaceuticas, usos para la fabricacion de un medicamento, y proceso para la preparacion de una benzofenona |
| ARP040100563A AR043367A2 (es) | 2001-03-02 | 2004-02-23 | Derivados de benzofenona, composiciones farmaceuticas y procesos de preparacion. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP040100563A AR043367A2 (es) | 2001-03-02 | 2004-02-23 | Derivados de benzofenona, composiciones farmaceuticas y procesos de preparacion. |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US6995283B2 (es) |
| EP (1) | EP1363877A2 (es) |
| JP (1) | JP2004525914A (es) |
| KR (1) | KR100638954B1 (es) |
| CN (1) | CN1494528A (es) |
| AR (2) | AR035436A1 (es) |
| AU (1) | AU2002254056C1 (es) |
| BR (1) | BR0207752A (es) |
| CA (1) | CA2439820A1 (es) |
| CZ (1) | CZ20032366A3 (es) |
| HU (1) | HUP0303326A2 (es) |
| IL (1) | IL157348A0 (es) |
| MX (1) | MXPA03007883A (es) |
| NO (1) | NO20033857L (es) |
| NZ (1) | NZ527864A (es) |
| PL (1) | PL364658A1 (es) |
| WO (1) | WO2002070470A2 (es) |
| ZA (1) | ZA200306549B (es) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7638522B2 (en) | 2001-08-13 | 2009-12-29 | Janssen Pharmaceutica N.V. | Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino] benzonitrile |
| JO3429B1 (ar) | 2001-08-13 | 2019-10-20 | Janssen Pharmaceutica Nv | مشتقات برميدينات مثبطة فيروس الايدز |
| US8101629B2 (en) | 2001-08-13 | 2012-01-24 | Janssen Pharmaceutica N.V. | Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile |
| AR039540A1 (es) | 2002-05-13 | 2005-02-23 | Tibotec Pharm Ltd | Compuestos microbicidas con contenido de pirimidina o triazina |
| ES2422196T3 (es) | 2002-08-09 | 2013-09-09 | Janssen Pharmaceutica Nv | Procesos para la preparación de 4-4-4-(2-cianoetenil)-2,6-dimetilfenil)amino)-2-pirimidinil)aminobenzonitrilo |
| WO2004030611A2 (en) | 2002-08-23 | 2004-04-15 | Ribapharm Inc. | Non-nucleoside reverse transcriptase inhibitors |
| US7642277B2 (en) | 2002-12-04 | 2010-01-05 | Boehringer Ingelheim International Gmbh | Non-nucleoside reverse transcriptase inhibitors |
| CL2004000192A1 (es) * | 2003-02-07 | 2005-03-18 | Janssen Pharmaceutica Nv | Uso de compuestos derivados de 2-aminopirimidina para preparar un medicamento para la prevencion de una infeccion por vih relaciones sexuales o un contacto intimo en la pareja. |
| US7378550B2 (en) | 2003-03-27 | 2008-05-27 | Smithkline Beecham Corporation | Process for preparing reverse transcriptase inhibitors |
| WO2005026114A1 (en) * | 2003-09-17 | 2005-03-24 | Pfizer Inc. | Hiv protease inhibitors, compositions containing the same and their pharmaceutical uses |
| JP2007532626A (ja) * | 2004-04-14 | 2007-11-15 | ファイザー・インク | Ｈｉｖ治療用硫黄連結イミダゾール化合物 |
| US20060025480A1 (en) * | 2004-08-02 | 2006-02-02 | Boehringer Ingelheim International Gmbh | Benzoic acid derivatives as non nucleoside reverse transcriptase inhibitors |
| WO2007050087A1 (en) | 2004-08-25 | 2007-05-03 | Ardea Biosciences, Inc. | N[S(4-aryl-triazol-3-yl)α -mercaptoacetyl]-p-amino benozoic acids AS HIV REVERSE TRANSCRIPTASE INHIBITORS |
| EP2433633A1 (en) | 2004-08-25 | 2012-03-28 | Ardea Biosciences, Inc. | Triazolyl alpha -mercaptoacetanildes as inhibitors of HIV reverse transcriptase |
| JP5036543B2 (ja) * | 2004-09-30 | 2012-09-26 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 非ヌクレオシド逆転写酵素インヒビターとしてのベンゾフェノンのアルキニル誘導体 |
| WO2006067587A2 (en) * | 2004-12-22 | 2006-06-29 | Pfizer Limited | Nonnucleoside inhibitors of hiv-1 reverse transcriptase |
| WO2006135480A2 (en) * | 2005-04-08 | 2006-12-21 | Abbott Laboratories | Oral pharmaceutical formulations comprising fenofibric acid and/or its salts |
| AR057455A1 (es) | 2005-07-22 | 2007-12-05 | Merck & Co Inc | Inhibidores de la transcriptasa reversa de vih y composicion farmaceutica |
| WO2007121418A2 (en) * | 2006-04-17 | 2007-10-25 | Smithkline Beecham Corporation | Chemical compounds |
| WO2007121415A2 (en) * | 2006-04-17 | 2007-10-25 | Smithkline Beecham Corporation | Chemical compounds |
| WO2007121416A2 (en) * | 2006-04-17 | 2007-10-25 | Smithkline Beecham Corporation | Chemical compounds |
| SG174016A1 (en) * | 2006-07-24 | 2011-09-29 | Korea Res Inst Chem Tech | Hiv reverse transcriptase inhibitors |
| CN101407476B (zh) * | 2007-10-12 | 2012-07-18 | 中国人民解放军军事医学科学院毒物药物研究所 | 作为非核苷类hiv逆转录酶抑制剂的间二芳烃-多取代苯胺类化合物、其制备方法及用途 |
| ES2513390T3 (es) | 2007-11-27 | 2014-10-27 | Ardea Biosciences, Inc. | Nuevos compuestos y composiciones, y métodos de uso |
| CN101450911B (zh) * | 2007-11-30 | 2012-02-29 | 山东轩竹医药科技有限公司 | 被金刚烷取代的苯甲酸衍生物 |
| CN102206177A (zh) * | 2011-04-20 | 2011-10-05 | 复旦大学 | 1-萘基苯甲酮衍生物及其制备方法和用途 |
| CN102212022A (zh) * | 2011-04-20 | 2011-10-12 | 复旦大学 | 二苯甲醇衍生物及其制备方法和用途 |
| CN102219717A (zh) * | 2011-04-20 | 2011-10-19 | 复旦大学 | N-苯基芳基甲酰胺衍生物及其制备方法和用途 |
| CN110015963A (zh) * | 2019-04-12 | 2019-07-16 | 上海优合生物科技有限公司 | 一种2-氯-6-甲基苯胺的制备方法 |
| US20220362276A1 (en) * | 2019-05-13 | 2022-11-17 | The Trustees Of Princeton University | Small Molecule Inhibitors of Viral Replication |
| US11116737B1 (en) | 2020-04-10 | 2021-09-14 | University Of Georgia Research Foundation, Inc. | Methods of using probenecid for treatment of coronavirus infections |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH03198050A (ja) * | 1989-12-27 | 1991-08-29 | Fuji Photo Film Co Ltd | ハロゲン化銀カラー写真感光材料 |
-
2002
- 2002-02-28 US US10/469,104 patent/US6995283B2/en not_active Expired - Fee Related
- 2002-02-28 CZ CZ20032366A patent/CZ20032366A3/cs unknown
- 2002-02-28 WO PCT/US2002/006037 patent/WO2002070470A2/en not_active Ceased
- 2002-02-28 CN CNA028058828A patent/CN1494528A/zh active Pending
- 2002-02-28 KR KR1020037011471A patent/KR100638954B1/ko not_active Expired - Fee Related
- 2002-02-28 MX MXPA03007883A patent/MXPA03007883A/es unknown
- 2002-02-28 HU HU0303326A patent/HUP0303326A2/hu unknown
- 2002-02-28 PL PL02364658A patent/PL364658A1/xx not_active Application Discontinuation
- 2002-02-28 CA CA002439820A patent/CA2439820A1/en not_active Abandoned
- 2002-02-28 EP EP02723265A patent/EP1363877A2/en not_active Withdrawn
- 2002-02-28 JP JP2002569791A patent/JP2004525914A/ja not_active Ceased
- 2002-02-28 NZ NZ527864A patent/NZ527864A/en unknown
- 2002-02-28 BR BR0207752-3A patent/BR0207752A/pt not_active IP Right Cessation
- 2002-02-28 AU AU2002254056A patent/AU2002254056C1/en not_active Ceased
- 2002-02-28 IL IL15734802A patent/IL157348A0/xx unknown
- 2002-03-01 AR ARP020100764A patent/AR035436A1/es not_active Application Discontinuation
-
2003
- 2003-08-21 ZA ZA200306549A patent/ZA200306549B/xx unknown
- 2003-09-01 NO NO20033857A patent/NO20033857L/no not_active Application Discontinuation
-
2004
- 2004-02-23 AR ARP040100563A patent/AR043367A2/es not_active Application Discontinuation
-
2005
- 2005-09-09 US US11/223,634 patent/US20060009651A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1363877A2 (en) | 2003-11-26 |
| KR100638954B1 (ko) | 2006-10-25 |
| NZ527864A (en) | 2004-05-28 |
| AU2002254056B2 (en) | 2005-09-29 |
| US20060009651A1 (en) | 2006-01-12 |
| NO20033857D0 (no) | 2003-09-01 |
| ZA200306549B (en) | 2004-11-22 |
| US20040122064A1 (en) | 2004-06-24 |
| AU2002254056C1 (en) | 2006-04-13 |
| JP2004525914A (ja) | 2004-08-26 |
| KR20030086283A (ko) | 2003-11-07 |
| IL157348A0 (en) | 2004-02-19 |
| US6995283B2 (en) | 2006-02-07 |
| WO2002070470A2 (en) | 2002-09-12 |
| PL364658A1 (en) | 2004-12-13 |
| CA2439820A1 (en) | 2002-09-12 |
| AR043367A2 (es) | 2005-07-27 |
| WO2002070470A3 (en) | 2003-03-06 |
| HUP0303326A2 (hu) | 2004-01-28 |
| MXPA03007883A (es) | 2003-12-04 |
| CZ20032366A3 (en) | 2004-04-14 |
| BR0207752A (pt) | 2004-03-23 |
| CN1494528A (zh) | 2004-05-05 |
| NO20033857L (no) | 2003-10-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR035436A1 (es) | Una benzofenona o derivado farmaceuticamente aceptable, sales, formas salinas, composiciones farmaceuticas, usos para la fabricacion de un medicamento, y proceso para la preparacion de una benzofenona | |
| PE20030137A1 (es) | Derivados antimicrobianos de quinolona | |
| AR048315A1 (es) | Compuestos heterociclicos inhibidores de la produccion de citocinas; composiciones farmaceuticas que los contienen y su uso en el tratamiento de enfermedades inflamatorias y oncologicas. | |
| CY1110951T1 (el) | Αζαϊνδολες | |
| AR040031A1 (es) | Compuestos de pirazol-pirimidina anilina utiles como inhibidores de cinasa y composiciones farmaceuticas que los contienen | |
| NO900991L (no) | Analogifremgangsmaate for fremstilling av terapeutisk virksomme 2-(l-piperazinyl)-4-fenylcycloalkanopyridin-derivater | |
| CO6260070A2 (es) | Entidades quimicas de imidazopiridina paea el tratamiento de infecciones con hepatitis c | |
| ES2062458T3 (es) | Derivados del 1,2-benzisoxazol, sus procedimientos de preparacion y las composiciones farmaceuticas que los contienen. | |
| AR046046A1 (es) | Imidazoquinolinas alcoxi sustituidas. composiciones farmaceuticas. | |
| AR081848A1 (es) | Inhibidores de la proteina ns5a del vhc | |
| AR036032A1 (es) | Compuesto derivado de quinolina, composicion que lo comprende; uso del mismo en la fabricacion de medicamentos, proceso para prepararlo, y metodo para detectar y seleccionar un agente que module la actividad del mif | |
| BR9812046A (pt) | Compostos, processos para a preperação do composto e para tratar um paciente humano ou animal, composição farmacêutica, e, uso de um composto | |
| AR035260A1 (es) | Derivados de piperidina amino sustituidas, composiciones farmaceuticas y el uso de dichos derivados para la preparacion de medicamentos como inhibidores de la gama secretasa, y para el tratamiento de la enfermedad de alzheimer | |
| DK0649418T3 (da) | 7-(2-aminoethyl)benzothiazolon | |
| AR037517A1 (es) | Derivados de naftiridinas, un proceso para su preparacion, composicion farmaceutica y el uso de los mismos para la preparacion de un medicamento para el tratamiento de una enfermedad inflamatoria | |
| RU2010116253A (ru) | Производные n-гидроксилсульфонамида как новые физиологически применимые доноры нитроксила | |
| AR019789A2 (es) | Compuestos derivados de la eritromicina, composiciones que los contienen, uso de los mismos para preparar un medicamento | |
| ES2038172T3 (es) | Procedimiento para preparar carboxamidas heterociclicas. | |
| BR112022027045A2 (pt) | Derivados de benzodiazepina úteis no tratamento de uma infecção pelo vírus sincicial respiratório | |
| NO983493L (no) | Nye benzimidazol-, benzoksazol- og benzotiazolforbindelser, fremgangsmÕte ved fremstilling derav og farmas°ytiske sammensetninger inneholdende slike | |
| HRP20040243B1 (en) | Cross-linked glycopeptide-cephalosporin antibiotics | |
| AR035465A1 (es) | Compuestos de imidazopiridina, procesos para su preparacion,formulacion farmaceutica, usos de estos compuestos para la fabricacion de medicamentos e intermediarios | |
| PE20030705A1 (es) | Inhibidores de la 17beta-hidroxiesteroide deshidrogenasa tipo 3 para el tratamiento de enfermedades androgeno-dependientes | |
| ES2110977T3 (es) | Espiro-isoquinolein-pirrolidinas y analogos de las mismas, utiles como inhibidores de la aldosa-reductasa. | |
| AR035110A1 (es) | Compuesto derivado de piperazina, uso del mismo para la preparacion de una composicion farmaceutica, composicion farmaceutica que lo comprende y procedimiento para la preparacion de dicho compuesto |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |