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AR042511A1 - Intermedio de formulacion no higroscopico que comprende un farmaco higroscopico - Google Patents

Intermedio de formulacion no higroscopico que comprende un farmaco higroscopico

Info

Publication number
AR042511A1
AR042511A1 ARP030104684A ARP030104684A AR042511A1 AR 042511 A1 AR042511 A1 AR 042511A1 AR P030104684 A ARP030104684 A AR P030104684A AR P030104684 A ARP030104684 A AR P030104684A AR 042511 A1 AR042511 A1 AR 042511A1
Authority
AR
Argentina
Prior art keywords
hygroscopic
drug
polymer
composition
composition according
Prior art date
Application number
ARP030104684A
Other languages
English (en)
Original Assignee
Pharmacia Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Corp filed Critical Pharmacia Corp
Publication of AR042511A1 publication Critical patent/AR042511A1/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
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    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Ophthalmology & Optometry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Reproductive Health (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pregnancy & Childbirth (AREA)
  • Inorganic Chemistry (AREA)
  • Biophysics (AREA)
  • Gynecology & Obstetrics (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)

Abstract

Composición particulada sólida que comprende un fármaco higroscópico y/o delicuescente y al menos un polímero no higroscópico. El fármaco y el por lo menos un polímero están en asociación íntima y la composición es no higroscópica. Reivindicación 1: Una composición sólida particulada caracterizada porque comprende un fármaco y al menos un polímero no higroscópico, en la que el fármaco y dicho al menos un polímero no higroscópico están en asociación íntima, dicha composición es aceptablemente no higroscópica y el fármaco es higroscópico y/o delicuescente. Reivindicación 2: La composición según la reivindicación 1 ó 2 caracterizado porque el fármaco es un inhibidor iNOS. Reivindicación 3: La composición según la reivindicación 2, caracterizada porque el fármaco es S-[2-[(1-iminoetil)amino]etil]-2-meril-L-cisteína, o una sal farmacéuticamente aceptable del mismo. Reivindicación 5: La composición según una cualquiera de las reivindicaciones 1-4, caracterizada porque al menos un polímero no higroscópico es un polímero celulósico. Reivindicación 15: Un procedimiento para preparar una composición según una cualquiera de las reivindicaciones 1-14, caracterizada porque el procedimiento comprende una primera etapa de dispersión de un fármaco higroscópico y/o delicuescente y al menos un polímero no higroscópico en un líquido acuoso para formar una dispersión y una segunda etapa de eliminación del líquido acuoso de la dispersión.
ARP030104684A 2002-12-19 2003-12-17 Intermedio de formulacion no higroscopico que comprende un farmaco higroscopico AR042511A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US43542202P 2002-12-19 2002-12-19
US43502202P 2002-12-19 2002-12-19
US43514702P 2002-12-19 2002-12-19

Publications (1)

Publication Number Publication Date
AR042511A1 true AR042511A1 (es) 2005-06-22

Family

ID=32719157

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP030104684A AR042511A1 (es) 2002-12-19 2003-12-17 Intermedio de formulacion no higroscopico que comprende un farmaco higroscopico
ARP030104716A AR042536A1 (es) 2002-12-19 2003-12-18 Dispersiones solidas que comprenden un farmaco higroscopico y/o delicuescente

Family Applications After (1)

Application Number Title Priority Date Filing Date
ARP030104716A AR042536A1 (es) 2002-12-19 2003-12-18 Dispersiones solidas que comprenden un farmaco higroscopico y/o delicuescente

Country Status (17)

Country Link
US (2) US20040197411A1 (es)
EP (2) EP1575563B1 (es)
JP (2) JP2006513238A (es)
AR (2) AR042511A1 (es)
AT (1) ATE353633T1 (es)
AU (2) AU2003298010A1 (es)
BR (2) BR0317392A (es)
CA (2) CA2511385A1 (es)
DE (1) DE60311875T2 (es)
ES (1) ES2280835T3 (es)
HN (1) HN2003000417A (es)
MX (2) MXPA05006802A (es)
NL (1) NL1025069C2 (es)
PE (1) PE20040972A1 (es)
TW (2) TW200423971A (es)
UY (1) UY28138A1 (es)
WO (2) WO2004060352A1 (es)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1243262E (pt) 2001-03-20 2006-10-31 Sanol Arznei Schwarz Gmbh Nova utilizacao de uma classe de compostos peptideos para o tratamento da dor inflamatoria nao neuropatica
ES2185606T3 (es) 2001-03-21 2003-05-01 Sanol Arznei Schwarz Gmbh Nuevo uso de una clase de compuestos peptidicos para tratamiento de la alodinia u otros tipos diferentes de dolor cronico o fantasma.
SE521512C2 (sv) * 2001-06-25 2003-11-11 Niconovum Ab Anordning för administrering av en substans till främre delen av en individs munhåla
CA2511385A1 (en) * 2002-12-19 2004-07-22 Pharmacia Corporation Non-hygroscopic formulation comprising a hydroscopic drug
DK3473251T3 (da) * 2002-12-20 2024-01-22 Niconovum Ab Nikotin-cellulose-kombination
US8377952B2 (en) 2003-08-28 2013-02-19 Abbott Laboratories Solid pharmaceutical dosage formulation
US8025899B2 (en) 2003-08-28 2011-09-27 Abbott Laboratories Solid pharmaceutical dosage form
FR2865133B1 (fr) * 2004-01-19 2008-01-18 Rytek Compositions pour le traitement de pathologies digestives
EP1579862A1 (en) 2004-03-25 2005-09-28 Boehringer Ingelheim Vetmedica Gmbh Use of PDE III inhibitors for the reduction of heart size in mammals suffering from heart failure
US8980894B2 (en) 2004-03-25 2015-03-17 Boehringer Ingelheim Vetmedica Gmbh Use of PDE III inhibitors for the treatment of asymptomatic (occult) heart failure
CN1950101B (zh) 2004-04-16 2011-03-30 舒沃茨药物股份公司 肽化合物用于预防和治疗慢性头痛的用途
EP1765309B1 (en) * 2004-07-02 2009-08-05 Radi Medical Biodegradable AB Smokeless toabacco product
EP1781276B1 (en) * 2004-08-27 2010-06-23 UCB Pharma GmbH Use of peptide compounds for treating bone cancer pain, chemotherapy- and nucleoside-induced pain
US20060147518A1 (en) * 2004-12-30 2006-07-06 Pierre Fabre Medicament Stable solid dispersion of a derivative of vinca alkaloid and process for manufacturing it
US20070043120A1 (en) * 2005-08-18 2007-02-22 Bettina Beyreuther Therapeutic combination for painful medical conditions
EP1754476A1 (en) * 2005-08-18 2007-02-21 Schwarz Pharma Ag Lacosamide (SPM 927) for treating myalgia, e.g. fibromyalgia
US20070048372A1 (en) * 2005-08-18 2007-03-01 Srz Properties, Inc. Method for treating non-inflammatory osteoarthritic pain
WO2007060540A1 (en) * 2005-11-25 2007-05-31 Aurobindo Pharma Limited Stable dosage forms of an antidepressant
CA2646942C (en) 2006-03-16 2014-07-29 Niconovum Ab Improved snuff composition
ES2372983T3 (es) * 2006-06-06 2012-01-30 Tibotec Pharmaceuticals Proceso para preparar formulaciones secadas por aspersión de tmc125.
PT2462990E (pt) 2006-06-15 2014-04-02 Ucb Pharma Gmbh Composição farmacêutica com efeito anticonvulsivo sinergístico
EP1920785A1 (en) 2006-11-07 2008-05-14 Boehringer Ingelheim Vetmedica Gmbh Liquid preparation comprising a complex of pimobendan and cyclodextrin
CA2673536A1 (en) * 2006-12-22 2008-07-03 Yuhan Corporation Revaprazan-containing solid dispersion and process for the preparation thereof
US9358242B2 (en) * 2007-08-30 2016-06-07 Prelief Inc. Calcium glycerophosphate for treating and preventing respiratory diseases or conditions
WO2009029705A1 (en) * 2007-08-30 2009-03-05 Prelief Inc. Calcium glycerophosphate for treating and preventing respiratory diseases or conditions
KR101499533B1 (ko) 2008-02-15 2015-03-09 주식회사 씨티씨바이오 콜린 알포세레이트 함유 약학 제제
DE102008020701A1 (de) * 2008-04-24 2009-10-29 Bayer Technology Services Gmbh Formulierung mit reduzierter Hygroskopizität
DE102008047910A1 (de) 2008-09-19 2010-03-25 Molkerei Meggle Wasserburg Gmbh & Co. Kg Tablettierhilfsstoff auf Laktose- und Cellulosebasis
KR101172699B1 (ko) 2011-05-16 2012-08-09 한국프라임제약주식회사 콜린알포세레이트를 함유하는 약학 제제, 및 그의 제조방법
CA2841048A1 (en) 2011-07-07 2013-01-10 The Lubrizol Corporation Lubricant providing improved cleanliness for two-stroke cycle engines
CN102525992A (zh) * 2012-03-09 2012-07-04 徐奎 L-α-甘油磷酸胆碱薄膜衣片及其制备方法
WO2013135852A1 (en) 2012-03-15 2013-09-19 Boehringer Ingelheim Vetmedica Gmbh Pharmaceutical tablet formulation for the veterinary medical sector, method of production and use thereof
WO2013175505A1 (en) * 2012-05-21 2013-11-28 Hetero Research Foundation Elvitegravir solid dispersion
WO2017161387A1 (en) * 2016-03-18 2017-09-21 Reid Christopher Brian Compositions of natural extracts and use thereof in methods for preventing or treating diseases
CA2915445C (en) 2013-07-19 2024-04-23 Boehringer Ingelheim Vetmedica Gmbh Preserved etherified cyclodextrin derivatives containing liquid aqueous pharmaceutical composition
EA201992230A1 (ru) 2013-12-04 2020-02-28 Бёрингер Ингельхайм Ветмедика Гмбх Улучшенные фармацевтические композиции пимобендана
GB2525170A (en) * 2014-04-07 2015-10-21 Nokia Technologies Oy Stereo viewing
CN104739776A (zh) * 2015-04-15 2015-07-01 福州乾正药业有限公司 左卡尼汀的固体分散体组合物及其制备方法和药物应用
WO2017013591A1 (en) * 2015-07-22 2017-01-26 Leiutis Pharmaceuticals Pvt Ltd Stabilized liquid formulation of levothyroxine
US10537570B2 (en) 2016-04-06 2020-01-21 Boehringer Ingelheim Vetmedica Gmbh Use of pimobendan for the reduction of heart size and/or the delay of onset of clinical symptoms in patients with asymptomatic heart failure due to mitral valve disease
WO2019189733A1 (ja) * 2018-03-30 2019-10-03 株式会社カネカ 酸化型グルタチオンを含む固体組成物及びその製造方法
CN112316678A (zh) * 2020-10-12 2021-02-05 常州市永勃机械有限公司 一种变电站柜体用驱潮剂制备工艺制备方法
IT202100018578A1 (it) * 2021-07-14 2023-01-14 Indena Spa Dispersione amorfa di maltolo ferrico e relativo processo di preparazione

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4835187A (en) * 1987-06-15 1989-05-30 American Home Products Corporation Spray dried ibuprofen
JPH02218621A (ja) * 1989-02-20 1990-08-31 Nippon Chemiphar Co Ltd 徐放性製剤
US5582837A (en) * 1992-03-25 1996-12-10 Depomed, Inc. Alkyl-substituted cellulose-based sustained-release oral drug dosage forms
SE9303574D0 (sv) * 1993-11-01 1993-11-01 Kabi Pharmacia Ab Composition for drug delivery and method the manufacturing thereof
EP0729748B1 (en) * 1993-11-18 2003-02-26 Nippon Shinyaku Company, Limited Process for producing stable medicinal composition
JPH08157392A (ja) * 1994-12-01 1996-06-18 Kanegafuchi Chem Ind Co Ltd 放出制御型製剤
GB9607955D0 (en) * 1996-04-17 1996-06-19 Tillotts Pharma Ag Hydrophobic carbomer salt compositions
JPH10182448A (ja) * 1996-12-24 1998-07-07 Zensei Yakuhin Kogyo Kk 圧縮製剤用組成物の製造方法
MA25590A1 (fr) * 1998-09-14 2002-12-31 Inhale Therapeutic Syst Agent actif de delivraison de poudre seche
US6264981B1 (en) * 1999-10-27 2001-07-24 Anesta Corporation Oral transmucosal drug dosage using solid solution
BR0109386A (pt) * 2000-03-24 2003-04-15 Pharmacia Corp Composto de amidino e sais deste útil como inibidores de sintase de óxido nìtrico
US20020143058A1 (en) * 2001-01-24 2002-10-03 Taro Pharmaceutical Inductries Ltd. Process for preparing non-hygroscopic sodium valproate composition
CA2511385A1 (en) * 2002-12-19 2004-07-22 Pharmacia Corporation Non-hygroscopic formulation comprising a hydroscopic drug

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BR0317392A (pt) 2005-12-20
AR042536A1 (es) 2005-06-22
CA2509261A1 (en) 2004-07-22
JP2006514052A (ja) 2006-04-27
AU2003296948A1 (en) 2004-07-29
US20050013856A1 (en) 2005-01-20
TW200423971A (en) 2004-11-16
NL1025069C2 (nl) 2005-02-16
HN2003000417A (es) 2005-11-01
EP1575563B1 (en) 2007-02-14
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MXPA05005667A (es) 2005-07-26
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AU2003298010A1 (en) 2004-07-29
PE20040972A1 (es) 2004-12-14
CA2511385A1 (en) 2004-07-22
ES2280835T3 (es) 2007-09-16
TW200413006A (en) 2004-08-01
WO2004060352A8 (en) 2005-09-15
UY28138A1 (es) 2004-08-31
WO2004060353A1 (en) 2004-07-22
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NL1025069A1 (nl) 2004-07-01
DE60311875D1 (de) 2007-03-29

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