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AR042340A1 - Liberacion controlada de una sustancia activa a un entorno rico en grasa - Google Patents

Liberacion controlada de una sustancia activa a un entorno rico en grasa

Info

Publication number
AR042340A1
AR042340A1 ARP030104525A ARP030104525A AR042340A1 AR 042340 A1 AR042340 A1 AR 042340A1 AR P030104525 A ARP030104525 A AR P030104525A AR P030104525 A ARP030104525 A AR P030104525A AR 042340 A1 AR042340 A1 AR 042340A1
Authority
AR
Argentina
Prior art keywords
controlled release
composition
active substance
environment
fat
Prior art date
Application number
ARP030104525A
Other languages
English (en)
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of AR042340A1 publication Critical patent/AR042340A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Composición de liberación controlada que puede administrarse a un entorno de uso rico en grasa tal como el tracto gastrointestinal humano después de una comida rica en grasa. La composición e liberación se incorpora en forma de núcleo rodeado por una membrana polimérica asimétrica. En una realización preferida, la membrana polimérica asimétrica es celulosa acetato. Envase terapéutico con dicha composición. Reivindicación 1:Un procedimiento para la liberación controlada de una sustancia activa a un entorno de uso, caracterizado porque comprende: (a) preparar una composición de liberación controlada que comprende un núcleo que contiene sustancia activa y un recubrimiento polimérico asimétrico sobre él, en la que el polímero utilizado para formar dicho recubrimiento polimérico asimétrico es aquel que, cuando se ensaya mediante imbibición durante al menos 16 horas en una solución acuosa que comprende 0,5% en peso de grasa de la dieta, gana menos de aproximadamente un 15% en peso, y (b) administrar dicha composición a dicho entorno de uso, comprendiendo dicho entorno de uso al menos aproximadamente un 0,5% en peso de grasa de la dieta.
ARP030104525A 2002-12-11 2003-12-09 Liberacion controlada de una sustancia activa a un entorno rico en grasa AR042340A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US43286002P 2002-12-11 2002-12-11

Publications (1)

Publication Number Publication Date
AR042340A1 true AR042340A1 (es) 2005-06-15

Family

ID=32508002

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP030104525A AR042340A1 (es) 2002-12-11 2003-12-09 Liberacion controlada de una sustancia activa a un entorno rico en grasa

Country Status (18)

Country Link
US (1) US20040121015A1 (es)
EP (1) EP1572163A1 (es)
JP (1) JP2006510655A (es)
KR (1) KR20050088311A (es)
CN (1) CN1726012A (es)
AR (1) AR042340A1 (es)
AU (1) AU2003283688A1 (es)
BR (1) BR0317275A (es)
CA (1) CA2508722A1 (es)
CO (1) CO5570656A2 (es)
MX (1) MXPA05005812A (es)
NO (1) NO20053068L (es)
NZ (1) NZ539915A (es)
PL (1) PL377479A1 (es)
RU (1) RU2308263C2 (es)
TW (1) TWI257302B (es)
WO (1) WO2004052343A1 (es)
ZA (1) ZA200503812B (es)

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Also Published As

Publication number Publication date
EP1572163A1 (en) 2005-09-14
NZ539915A (en) 2007-09-28
NO20053068L (no) 2005-09-07
CO5570656A2 (es) 2005-10-31
BR0317275A (pt) 2005-11-08
PL377479A1 (pl) 2006-02-06
CA2508722A1 (en) 2004-06-24
JP2006510655A (ja) 2006-03-30
US20040121015A1 (en) 2004-06-24
ZA200503812B (en) 2006-07-26
NO20053068D0 (no) 2005-06-22
TWI257302B (en) 2006-07-01
AU2003283688A1 (en) 2004-06-30
MXPA05005812A (es) 2005-08-16
KR20050088311A (ko) 2005-09-05
RU2005118101A (ru) 2006-01-20
CN1726012A (zh) 2006-01-25
RU2308263C2 (ru) 2007-10-20
TW200425888A (en) 2004-12-01
WO2004052343A1 (en) 2004-06-24

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