AR041565A1 - Nuevos inhibidores biciclicos de la lipasa sensible a hormonas - Google Patents
Nuevos inhibidores biciclicos de la lipasa sensible a hormonasInfo
- Publication number
- AR041565A1 AR041565A1 ARP030103676A ARP030103676A AR041565A1 AR 041565 A1 AR041565 A1 AR 041565A1 AR P030103676 A ARP030103676 A AR P030103676A AR P030103676 A ARP030103676 A AR P030103676A AR 041565 A1 AR041565 A1 AR 041565A1
- Authority
- AR
- Argentina
- Prior art keywords
- represent
- och3
- substituents
- hormone
- ring
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C07D249/18—Benzotriazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Los compuestos presentan un efecto inhibidor sobre la lipasa sensible a hormonas. Reivindica también procedimientos para su preparación y un medicamento para el tratamiento de la diabetes mellitus no insulino dependiente o del síndrome diabético o síndrome X. Reivindicación 1: Un benzotriazol de la fórmula 1, en la cual los significados de los sustituyentes son R1 a R8 H donde uno de estos radicales R2 o R3 puede representar: Br, Cl, CH3, CN, NH2, NO2, CF3, OCH3, fenoxi, benzoilo, CH(OH)-fenilo, S-ciclohexilo, CO-OCH3; o dos sustituyentes de esta serie son: R1= Cl y R3 = CF3 o R2 = F y R3 = Cl; n es un número entero entre 0, 1 o 2; y uno de los sustituyentes R6 o R7 puede representar: R6 CH3; R7 CH3, C2H5, CH(CH3)2, C(CH3)3, CF3, Br, Cl, bencilo o CO-OC2H5; o R6 y R7 son ambos CH3; o el anillo puede contener un doble enlace en lugar de R6 y R7, R5 y R6 o R6 y R7 pueden combinarse con los átomos de carbono que los soportan para representar un anillo benzocondensado o si no, si n = o pueden representar ciclohexanodiilo; donde en el caso del cierre del anillo R6/R7 este sustituyente puede estar opcionalmente sustituido individualmetne con NH2 o NO2 o individualemtne o doblemente con OCH3, y R7 y R8 juntos son ciclopentilo, diazepina o =CH2; donde los compuestos con R1 a R5 y R8 = H, n = 1 y R6/R7 = anillo benzocondensado y R1, R3-R8 =H, R2 = CH3 y n = 1,serán excluidos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10247680A DE10247680B4 (de) | 2002-10-12 | 2002-10-12 | Neue bicyclische Inhibitoren der Hormon Sensitiven Lipase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR041565A1 true AR041565A1 (es) | 2005-05-18 |
Family
ID=32038583
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP030103676A AR041565A1 (es) | 2002-10-12 | 2003-10-09 | Nuevos inhibidores biciclicos de la lipasa sensible a hormonas |
Country Status (38)
| Country | Link |
|---|---|
| EP (1) | EP1554259B1 (es) |
| JP (2) | JP4658607B2 (es) |
| KR (1) | KR20050059254A (es) |
| CN (1) | CN100366616C (es) |
| AR (1) | AR041565A1 (es) |
| AT (1) | ATE349433T1 (es) |
| AU (1) | AU2003275997B8 (es) |
| BR (1) | BR0315257A (es) |
| CA (1) | CA2501734C (es) |
| CR (1) | CR7717A (es) |
| CY (1) | CY1106358T1 (es) |
| DE (2) | DE10247680B4 (es) |
| DK (1) | DK1554259T3 (es) |
| EC (1) | ECSP055729A (es) |
| ES (1) | ES2277152T3 (es) |
| GT (1) | GT200300214A (es) |
| HN (1) | HN2003000316A (es) |
| HR (1) | HRP20050325A2 (es) |
| IL (1) | IL167907A (es) |
| JO (1) | JO2497B1 (es) |
| MA (1) | MA27404A1 (es) |
| MX (1) | MXPA05003359A (es) |
| MY (1) | MY138057A (es) |
| NO (1) | NO20052291D0 (es) |
| OA (1) | OA12941A (es) |
| PA (1) | PA8585101A1 (es) |
| PE (1) | PE20040776A1 (es) |
| PL (1) | PL374605A1 (es) |
| PT (1) | PT1554259E (es) |
| RS (1) | RS51543B (es) |
| RU (1) | RU2325385C2 (es) |
| SV (1) | SV2004001633A (es) |
| TN (1) | TNSN05105A1 (es) |
| TW (1) | TWI313265B (es) |
| UA (1) | UA79994C2 (es) |
| UY (1) | UY28015A1 (es) |
| WO (1) | WO2004035550A1 (es) |
| ZA (1) | ZA200501757B (es) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102005002130A1 (de) | 2005-01-17 | 2006-07-27 | Sanofi-Aventis Deutschland Gmbh | Substituierte N-Aminomethylensulfonamide, ihre Herstellung und Verwendung als Arzneimittel |
| DE102005026808A1 (de) | 2005-06-09 | 2006-12-14 | Sanofi-Aventis Deutschland Gmbh | Benzooxazol-2-on-derivate als Inhibitoren von Lipasen und Phospholipasen |
| DE102005026762A1 (de) | 2005-06-09 | 2006-12-21 | Sanofi-Aventis Deutschland Gmbh | Azolopyridin-2-on-derivate als Inhibitoren von Lipasen und Phospholipasen |
| DE102005026809A1 (de) | 2005-06-09 | 2006-12-14 | Sanofi-Aventis Deutschland Gmbh | Benzothiazol-2-on-derivate als Inhibitoren von Lipasen und Phospholipasen |
| DE102005048897A1 (de) | 2005-10-12 | 2007-04-19 | Sanofi-Aventis Deutschland Gmbh | Diacylindazol-derivate als Inhibitoren von Lipasen und Phospholipasen |
| DE102005049954A1 (de) * | 2005-10-19 | 2007-05-31 | Sanofi-Aventis Deutschland Gmbh | Triazolopyridin-derivate als Inhibitoren von Lipasen und Phospholipasen |
| DE102005049953A1 (de) | 2005-10-19 | 2007-04-26 | Sanofi-Aventis Deutschland Gmbh | Carbamoylbenzotriazol-derivate als Inhibitoren von Lipasen und Phospholipasen |
| FR2915199B1 (fr) | 2007-04-18 | 2010-01-22 | Sanofi Aventis | Derives de triazolopyridine-carboxamides et triazolopyrimidine-carboxamides, leur preparation et leur application en therapeutique. |
| FR2915198B1 (fr) | 2007-04-18 | 2009-12-18 | Sanofi Aventis | Derives de triazolopyridine-carboxamides et triazolopyridine -carboxamides, leur preparation et leur application en therapeutique. |
| FR2915197B1 (fr) * | 2007-04-18 | 2009-06-12 | Sanofi Aventis Sa | Derives de triazolopyridine-carboxamides, leur preparation et leur application therapeutique. |
| UY31968A (es) | 2008-07-09 | 2010-01-29 | Sanofi Aventis | Nuevos derivados heterocíclicos, sus procesos para su preparación, y sus usos terapéuticos |
| AR075111A1 (es) * | 2008-12-24 | 2011-03-09 | Bial Portela & Ca Sa | Derivados heterociclicos de diazoles y triazoles, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de trastornos del metabolismo y del sistema nervioso, entre otros. |
| US8329904B2 (en) * | 2009-05-12 | 2012-12-11 | Hoffmann-La Roche Inc. | Azacyclic derivatives |
| US8440710B2 (en) * | 2009-10-15 | 2013-05-14 | Hoffmann-La Roche Inc. | HSL inhibitors useful in the treatment of diabetes |
| US8097634B2 (en) * | 2010-04-15 | 2012-01-17 | Hoffmann-La Roche Inc. | Azacyclic derivatives |
| US8450350B2 (en) * | 2010-05-05 | 2013-05-28 | Infinity Pharmaceuticals, Inc. | Triazoles as inhibitors of fatty acid synthase |
| US8722721B2 (en) * | 2011-03-16 | 2014-05-13 | Hoffmann-La Roche Inc. | SEC-hydroxycyclohexyl derivatives |
| US8703807B2 (en) * | 2011-03-17 | 2014-04-22 | Hoffmann-La Roche Inc. | Azaspirodecanone compounds |
| US8809384B2 (en) | 2011-03-25 | 2014-08-19 | Hoffmann-La Roche Inc. | Azaspirodecanone compounds |
| UA119247C2 (uk) | 2013-09-06 | 2019-05-27 | РОЙВЕНТ САЙЕНСИЗ ҐмбГ | Спіроциклічні сполуки як інгібітори триптофангідроксилази |
| GB201321740D0 (en) * | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
| WO2015089137A1 (en) | 2013-12-11 | 2015-06-18 | Karos Pharmaceuticals, Inc. | Acylguanidines as tryptophan hydroxylase inhibitors |
| WO2016109501A1 (en) | 2014-12-30 | 2016-07-07 | Karos Pharmaceuticals, Inc. | Amide compounds as tryptophan hydroxylase inhibitors |
| US9611201B2 (en) | 2015-03-05 | 2017-04-04 | Karos Pharmaceuticals, Inc. | Processes for preparing (R)-1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanol and 1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanone |
| US11203597B2 (en) | 2018-11-14 | 2021-12-21 | Altavant Sciences Gmbh | Crystalline spirocyclic compound, a dosage form containing, a method for using in treatment of disease, and a method for recrystallizing |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1124716A (en) * | 1978-10-20 | 1982-06-01 | Michael J. Simons | Blocked benzotriazole compounds as development restrainer precursors |
| US5369086A (en) * | 1993-04-28 | 1994-11-29 | Zeneca Limited | N-benzotriazoles |
| DE19942354A1 (de) * | 1999-09-04 | 2001-03-08 | Aventis Pharma Gmbh | Substituierte 3-Phenyl-5-alkoxi-1,3,4-oxdiazol-2-one, ihre Herstellung und Verwendung in Arzneimitteln |
| MXPA03010129A (es) * | 2001-05-05 | 2004-03-10 | Smithkline Beecham Plc | N-aroilaminas-ciclicas. |
| EP1458374A2 (en) * | 2001-12-14 | 2004-09-22 | Novo Nordisk A/S | Compounds and uses thereof for decreasing activity of hormone-sensitive lipase |
-
2002
- 2002-10-12 DE DE10247680A patent/DE10247680B4/de not_active Expired - Fee Related
-
2003
- 2003-09-27 DK DK03808700T patent/DK1554259T3/da active
- 2003-09-27 PT PT03808700T patent/PT1554259E/pt unknown
- 2003-09-27 MX MXPA05003359A patent/MXPA05003359A/es active IP Right Grant
- 2003-09-27 BR BR0315257-0A patent/BR0315257A/pt not_active IP Right Cessation
- 2003-09-27 JP JP2004544048A patent/JP4658607B2/ja not_active Expired - Fee Related
- 2003-09-27 CN CNB038241420A patent/CN100366616C/zh not_active Expired - Fee Related
- 2003-09-27 WO PCT/EP2003/010765 patent/WO2004035550A1/de not_active Ceased
- 2003-09-27 AT AT03808700T patent/ATE349433T1/de active
- 2003-09-27 RU RU2005114394/04A patent/RU2325385C2/ru not_active IP Right Cessation
- 2003-09-27 ES ES03808700T patent/ES2277152T3/es not_active Expired - Lifetime
- 2003-09-27 RS YUP-2005/0207A patent/RS51543B/sr unknown
- 2003-09-27 KR KR1020057006312A patent/KR20050059254A/ko not_active Ceased
- 2003-09-27 DE DE50306134T patent/DE50306134D1/de not_active Expired - Lifetime
- 2003-09-27 CA CA2501734A patent/CA2501734C/en not_active Expired - Fee Related
- 2003-09-27 AU AU2003275997A patent/AU2003275997B8/en not_active Ceased
- 2003-09-27 OA OA1200500103A patent/OA12941A/en unknown
- 2003-09-27 PL PL03374605A patent/PL374605A1/xx not_active Application Discontinuation
- 2003-09-27 HR HR20050325A patent/HRP20050325A2/xx not_active Application Discontinuation
- 2003-09-27 UA UAA200504422A patent/UA79994C2/uk unknown
- 2003-09-27 EP EP03808700A patent/EP1554259B1/de not_active Expired - Lifetime
- 2003-09-29 JO JO2003123A patent/JO2497B1/en active
- 2003-09-29 GT GT200300214A patent/GT200300214A/es unknown
- 2003-10-08 TW TW092127898A patent/TWI313265B/zh active
- 2003-10-08 SV SV2003001633A patent/SV2004001633A/es not_active Application Discontinuation
- 2003-10-09 PE PE2003001028A patent/PE20040776A1/es not_active Application Discontinuation
- 2003-10-09 HN HN2003000316A patent/HN2003000316A/es unknown
- 2003-10-09 PA PA20038585101A patent/PA8585101A1/es unknown
- 2003-10-09 AR ARP030103676A patent/AR041565A1/es unknown
- 2003-10-10 MY MYPI20033883A patent/MY138057A/en unknown
- 2003-10-10 UY UY28015A patent/UY28015A1/es unknown
-
2005
- 2005-03-01 ZA ZA200501757A patent/ZA200501757B/en unknown
- 2005-03-07 CR CR7717A patent/CR7717A/es unknown
- 2005-04-07 IL IL167907A patent/IL167907A/en not_active IP Right Cessation
- 2005-04-11 EC EC2005005729A patent/ECSP055729A/es unknown
- 2005-04-11 MA MA28213A patent/MA27404A1/fr unknown
- 2005-04-11 TN TNP2005000105A patent/TNSN05105A1/en unknown
- 2005-05-10 NO NO20052291A patent/NO20052291D0/no not_active Application Discontinuation
-
2007
- 2007-03-06 CY CY20071100315T patent/CY1106358T1/el unknown
-
2010
- 2010-10-08 JP JP2010228107A patent/JP2011026342A/ja not_active Abandoned
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