AR040970A1 - Metodo para la separacion de intermediarios que pueden ser utilizados para la preparacion de escitalopram - Google Patents
Metodo para la separacion de intermediarios que pueden ser utilizados para la preparacion de escitalopramInfo
- Publication number
- AR040970A1 AR040970A1 ARP030102904A ARP030102904A AR040970A1 AR 040970 A1 AR040970 A1 AR 040970A1 AR P030102904 A ARP030102904 A AR P030102904A AR P030102904 A ARP030102904 A AR P030102904A AR 040970 A1 AR040970 A1 AR 040970A1
- Authority
- AR
- Argentina
- Prior art keywords
- formula
- alkyl
- amino
- hal
- halogen
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 238000000926 separation method Methods 0.000 title 1
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 8
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 7
- 150000001875 compounds Chemical class 0.000 abstract 6
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 6
- 229910052736 halogen Inorganic materials 0.000 abstract 6
- 150000002367 halogens Chemical class 0.000 abstract 6
- 125000003118 aryl group Chemical group 0.000 abstract 5
- 229910052760 oxygen Inorganic materials 0.000 abstract 5
- 229910052717 sulfur Inorganic materials 0.000 abstract 5
- 125000000027 (C1-C10) alkoxy group Chemical group 0.000 abstract 4
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 abstract 4
- 125000003282 alkyl amino group Chemical group 0.000 abstract 4
- 125000004414 alkyl thio group Chemical group 0.000 abstract 4
- 125000000304 alkynyl group Chemical group 0.000 abstract 4
- 125000001072 heteroaryl group Chemical group 0.000 abstract 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 4
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 4
- 125000001424 substituent group Chemical group 0.000 abstract 4
- 150000003839 salts Chemical class 0.000 abstract 3
- 125000005110 aryl thio group Chemical group 0.000 abstract 2
- 125000004104 aryloxy group Chemical group 0.000 abstract 2
- 150000002009 diols Chemical class 0.000 abstract 2
- 230000002255 enzymatic effect Effects 0.000 abstract 2
- 239000012948 isocyanate Substances 0.000 abstract 2
- 150000002513 isocyanates Chemical class 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 239000007858 starting material Substances 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 230000010933 acylation Effects 0.000 abstract 1
- 238000005917 acylation reaction Methods 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 230000020176 deacylation Effects 0.000 abstract 1
- 238000005947 deacylation reaction Methods 0.000 abstract 1
- 125000006222 dimethylaminomethyl group Chemical group [H]C([H])([H])N(C([H])([H])[H])C([H])([H])* 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 229910052720 vanadium Inorganic materials 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B57/00—Separation of optically-active compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/53—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and hydroxy groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/32—Separation; Purification; Stabilisation; Use of additives
- C07C253/34—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/34—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring with cyano groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by unsaturated carbon chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
- C07C255/59—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/001—Amines; Imines
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/002—Nitriles (-CN)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/008—Preparation of nitrogen-containing organic compounds containing a N-O bond, e.g. nitro (-NO2), nitroso (-NO)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
- C12P41/007—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures by reactions involving acyl derivatives of racemic amines
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/22—Preparation of oxygen-containing organic compounds containing a hydroxy group aromatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Reivindicación 1: Un método para la preparación del enantiómero R o S de un diol que tiene la fórmula (1) donde R es ciano o un grupo que puede convertirse a un grupo ciano, Z es un grupo -CH2-N(R´ R") donde R´ y R" son alquilo C1-6 o R´ y R" están conectados entre sí para formar una estructura cíclica incluyendo el átomo N al cual están unido, o Z es un grupo que puede convertirse a un grupo dimetilaminometilo, la línea punteada representa un enlace doble o simple y Hal es halógeno o una sal del mismo, y/o el enantiómero opuesto de un diol acilado que tiene la fórmula (2), donde R, Z, la línea punteada y Hal son tal como se definieron anteriormente, W es O o S, y R3 es -Y-R1, donde R1 es alquilo C1-10, alquenilo C2-10 o alquinilo C2-10 todos los cuales pueden estar opcionalmente sustituidos una o más veces con sustituyentes seleccionados a partir de alcoxi C1-10, alquiltio C1-10, hidroxi, halógeno, amino, nitro, ciano, alquilamino C1-10, di-(alquil C1-10)amino, arilo, ariloxi, ariltio y heteroarilo, o R1 es arilo, en donde cualquiera de los grupos arilo y heteroarilo pueden estar opcionalmente sustituidos una o más veces con sustituyentes seleccionados a partir de alquilo C1-10, alquenilo C2-10, alquinilo C2-10, alcoxi C1-10, alquiltio C1-10, hidroxi, halógeno, amino, nitro, ciano, alquilamino C1-10 y di-(alquil C1-10)amino e Y es un enlace, O, S o NH, o una sal del mismo, que comprende: a) someter un compuesto racémico de fórmula (3) donde R, Z, la línea punteada y Hal son tal como se definieron anteriormente, para la acilación enzimática selectiva utilizando un agente acilante que tiene la fórmula (4), o (5), o (6) o un isocianato que tiene la fórmula R1-N=C=O o un isocianato que tiene la fórmula R1-N=C=S; donde X es O o S; W es O o S; U es O o S, V es halógeno; R0 es alquilo C1-10, alquenilo C2-10 o alquinilo C2-10 todos los cuales pueden estar opcionalmente sustituidos una o más veces con sustituyentes seleccionados a partir de alcoxi C1-10, alquiltio C1-10, hidroxi, halógeno, amino, nitro, ciano, alquilamino C1-10, di-(alquil C1-10)amino, arilo, ariloxi, ariltio y heteroarilo, o R0 es arilo, donde cualquiera de los grupos arilo y heteroarilo pueden estar opcionalmente sustituidos una o más veces con sustituyentes seleccionados a partir de alquilo C1-10, alquenilo C2-10, alquinilo C2-10, alcoxi C1-10, alquiltio C1-10,hidroxi, halógeno, amino, nitro, ciano, alquilamino C1-10 y di-(alquil C1-10)amino; R1 es como se definió para R0; R2 es como se definió para R0, o R2 es un grupo saliente apropiado; o R0 y R1 juntos forman una cadena de 3 a 5 átomos de C; siempre que W y U no sean S cuando X es S; para formar una mezcla del material de partida de la fórmula (1) en cualquier forma R o S y el enantiómero opuesto de un compuesto que tiene la fórmula (2) en donde R, W, Hal, R3, la línea punteada y Z son como se definieron anteriormente; o b) someter un compuesto racémico de fórmula (2) en donde R, Z, W, Hal la línea punteada y R3 son como se definieron anteriormente, para desacilación enzimático selectiva para formar una mezcla de un compuesto deacilado de fórmula (1) en donde R, Hal, la línea punteada y Z son como se definieron anteriormente en cualquier forma R o S y el material de partida acilado de la fórmula (2) en la forma del enantiómero opuesto, opcionalmente seguido de, en cualquier orden, aislamiento del enantiómero S o R del compuesto de fórmula (1) y/o el enantiómero opuesto del compuesto de fórmula (2) o una sal del mismo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200201201 | 2002-08-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR040970A1 true AR040970A1 (es) | 2005-04-27 |
Family
ID=34717090
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP030102904A AR040970A1 (es) | 2002-08-12 | 2003-08-11 | Metodo para la separacion de intermediarios que pueden ser utilizados para la preparacion de escitalopram |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US20070129561A1 (es) |
| EP (2) | EP1534654A1 (es) |
| JP (3) | JP4694837B2 (es) |
| KR (1) | KR20050053618A (es) |
| CN (2) | CN100548939C (es) |
| AR (1) | AR040970A1 (es) |
| AU (1) | AU2003250321B2 (es) |
| BR (1) | BR0313114A (es) |
| CA (1) | CA2495118C (es) |
| EA (1) | EA011762B1 (es) |
| IL (1) | IL166319A0 (es) |
| IS (1) | IS7642A (es) |
| ME (1) | ME00028B (es) |
| MX (1) | MXPA05001400A (es) |
| NO (1) | NO20051292L (es) |
| NZ (1) | NZ537785A (es) |
| PE (1) | PE20040991A1 (es) |
| PL (1) | PL374835A1 (es) |
| RS (1) | RS20050092A (es) |
| TW (1) | TWI306846B (es) |
| UA (1) | UA78840C2 (es) |
| WO (1) | WO2004014821A1 (es) |
| ZA (1) | ZA200500728B (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004085416A1 (en) * | 2003-03-24 | 2004-10-07 | Hetero Drugs Limited | Novel crystalline forms of (s)-citalopram oxalate |
| ES2228274B1 (es) * | 2003-09-24 | 2006-06-01 | Astur Pharma, S.A. | Sintesis quimioenzimatica de (+)-citalopram y (-)-citalopram. |
| TWI339651B (en) * | 2004-02-12 | 2011-04-01 | Lundbeck & Co As H | Method for the separation of intermediates which may be used for the preparation of escitalopram |
| US20050196453A1 (en) | 2004-03-05 | 2005-09-08 | H. Lundbeck A/S | Crystalline composition containing escitalopram |
| EP1732514A1 (en) * | 2004-03-05 | 2006-12-20 | H. Lundbeck A/S | Crystalline composition containing escitalopram oxalate |
| ITMI20040717A1 (it) * | 2004-04-09 | 2004-07-09 | Adorkem Technology Spa | Procedimento chemo-enzimatico per la preparazione dell'escitalopram |
| ITMI20041872A1 (it) * | 2004-10-01 | 2005-01-01 | Adorkem Technology Spa | Processo per la preparazione di citalopram e di scitalopram |
| EP1736550A1 (en) * | 2005-06-22 | 2006-12-27 | Adorkem Technology SpA | Chemoenzymatic process for the synthesis of escitalopram |
| GB0601286D0 (en) | 2006-01-23 | 2006-03-01 | Sandoz Ag | Asymmetric synthesis |
| WO2008059514A2 (en) * | 2006-07-31 | 2008-05-22 | Cadila Healthcare Limited | Process for preparing escitalopram |
| US7686946B2 (en) | 2007-08-17 | 2010-03-30 | Uop Llc | Method of altering a feed to a reaction zone |
| CN100548974C (zh) * | 2007-10-11 | 2009-10-14 | 浙江大学 | 西酞普兰中间体的萃取分离方法 |
| TWI380812B (zh) * | 2008-01-25 | 2013-01-01 | Xenoport Inc | （３ｓ）-胺甲基-５-甲基己酸前藥之晶形及使用方法 |
| ITMI20120448A1 (it) | 2012-01-30 | 2013-07-31 | Carthesia Sas | Composizione liofilizzata di escitalopram ossalato per somministrazione sublinguale |
| ES2554563B2 (es) * | 2014-05-05 | 2016-08-16 | Universidad De Sevilla | Cepas bacterianas y sus usos en reacciones de acilación y/o desacilación |
| WO2017009866A1 (en) * | 2015-07-11 | 2017-01-19 | Ipca Laboratories Limited | Novel recovery and recycling process of racemic 4-(4-dimethylamino)-1-(4'-fluorophenyl)-1-(hydroxybutyl)-3-(hydroxymethyl)-benzonitrile |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1526331A (en) * | 1976-01-14 | 1978-09-27 | Kefalas As | Phthalanes |
| GB8419963D0 (en) | 1984-08-06 | 1984-09-12 | Lundbeck & Co As H | Intermediate compound and method |
| GB8814057D0 (en) * | 1988-06-14 | 1988-07-20 | Lundbeck & Co As H | New enantiomers & their isolation |
| JP3097145B2 (ja) | 1991-02-27 | 2000-10-10 | 日産化学工業株式会社 | コーリーラクトンジオールの光学分割方法 |
| SE511903C2 (sv) | 1996-06-28 | 1999-12-13 | Sca Hygiene Prod Ab | Absorberande alster innefattande en absorptionskropp med förbättrade vätskeinsläppsegenskaper |
| IT236075Y1 (it) | 1997-06-26 | 2000-07-26 | Emilio Brocco | Macchina segatrice per la divisione in lastre di blocchi di materialelapideo |
| UA62985C2 (en) * | 1997-11-10 | 2004-01-15 | Lunnbeck As H | A method for the preparation of citalopram |
| SK283907B6 (sk) | 1997-11-11 | 2004-04-06 | H. Lundbeck A/S | Spôsob výroby citalopramu a medziprodukty |
| JPH1129418A (ja) * | 1998-06-12 | 1999-02-02 | Takeda Chem Ind Ltd | 農園芸用殺虫殺菌組成物 |
| DE19832547A1 (de) | 1998-07-21 | 2000-01-27 | Basf Ag | Enzymhaltige Polymere |
| US6294571B1 (en) * | 1998-09-11 | 2001-09-25 | Independent Ink, Inc. | Method for using neem extracts and derivatives for protecting wood and other cellulosic composites |
| ES2189502T3 (es) | 1998-10-20 | 2003-07-01 | Lundbeck & Co As H | Metodo para la prevencion de citalopram. |
| AR022329A1 (es) | 1999-01-29 | 2002-09-04 | Lundbeck & Co As H | Metodo para la preparacion de 5-cianoftalida |
| SI1173431T2 (sl) * | 1999-04-14 | 2009-12-31 | Lundbeck & Co As H | Postopek za pripravo citaloprama |
| ITMI991579A1 (it) | 1999-06-25 | 2001-01-15 | Lundbeck & Co As H | Metodo per la preparazione di citalopram |
| ITMI991581A1 (it) | 1999-06-25 | 2001-01-15 | Lundbeck & Co As H | Metodo per la preparazione di citalopram |
| ITMI991486A1 (it) | 1999-07-06 | 2001-01-06 | Vis Farmaceutici S P A | Processo per la sintesi di citalopram |
| HUP0200169A3 (en) * | 1999-10-25 | 2002-11-28 | Lundbeck & Co As H | Method for the preparation of citalopram |
| TR200101874T1 (tr) * | 1999-10-25 | 2002-02-21 | H. Lundbeck A/S | Sitalopram hazırlanması için yöntem |
| FR2805812A1 (fr) | 2000-02-24 | 2001-09-07 | Lundbeck & Co As H | Procede de preparation du citalopram |
| NL1017417C1 (nl) | 2000-03-03 | 2001-03-16 | Lundbeck & Co As H | Werkwijze voor de bereiding van Citalopram. |
| GB0005477D0 (en) * | 2000-03-07 | 2000-04-26 | Resolution Chemicals Limited | Process for the preparation of citalopram |
| NZ521201A (en) | 2000-03-13 | 2004-02-27 | H | Method for the preparation of citalopram |
| TR200202195T2 (tr) | 2000-03-13 | 2002-12-23 | H. Lundbeck A/S | 5-Yer değiştirmiş 1-(4-florofenil)-1,3- dihidroizobenzofuran'ın adım adım alkillenmesi |
| PL360107A1 (en) | 2000-03-14 | 2004-09-06 | H.Lundbeck A/S | Method for the preparation of citalopram |
| WO2001068632A1 (en) | 2000-03-16 | 2001-09-20 | H. Lundbeck A/S | Method for the preparation of 5-cyano-1-(4-fluorophenyl)-1,3-dihydroisobenzofurans |
| IL144816A (en) * | 2000-08-18 | 2005-09-25 | Lundbeck & Co As H | Method for the preparation of citalopram |
| AR034612A1 (es) * | 2001-06-25 | 2004-03-03 | Lundbeck & Co As H | Proceso para la preparacion del citalopram racemico y/o del s- o r-citalopram mediante la separacion de una mezcla de r- y s-citalopram |
| AR034759A1 (es) | 2001-07-13 | 2004-03-17 | Lundbeck & Co As H | Metodo para la preparacion de escitalopram |
| EA006213B1 (ru) | 2001-07-31 | 2005-10-27 | Х. Лундбекк А/С | Кристаллическая композиция, содержащая эсциталопрам |
| IS7239A (is) * | 2001-12-14 | 2004-04-29 | H. Lundbeck A/S | Aðferð til framleiðslu á essítalóprami |
| CA2381341A1 (en) * | 2002-04-09 | 2003-10-09 | Torcan Chemical Ltd. | Process and intermediates for preparing escitalopram |
| CN1510024A (zh) * | 2002-12-24 | 2004-07-07 | 北京德众万全药物技术开发有限公司 | 可用于制备西酞普兰(s)-对映异构体的新的化合物及其制备方法 |
-
2003
- 2003-08-11 AR ARP030102904A patent/AR040970A1/es unknown
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- 2003-08-12 EP EP11165320A patent/EP2360150A1/en not_active Withdrawn
- 2003-08-12 KR KR1020057002554A patent/KR20050053618A/ko not_active Ceased
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2005
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2010
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