AR042936A1 - Derivados de urea ciclica, su preparacion y su utilizacion farmaceutica como inhibidores de quinasas - Google Patents
Derivados de urea ciclica, su preparacion y su utilizacion farmaceutica como inhibidores de quinasasInfo
- Publication number
- AR042936A1 AR042936A1 ARP040100233A ARP040100233A AR042936A1 AR 042936 A1 AR042936 A1 AR 042936A1 AR P040100233 A ARP040100233 A AR P040100233A AR P040100233 A ARP040100233 A AR P040100233A AR 042936 A1 AR042936 A1 AR 042936A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- radicals
- different
- cycloalkyl
- chosen
- Prior art date
Links
- 108091000080 Phosphotransferase Proteins 0.000 title 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical class NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 102000020233 phosphotransferase Human genes 0.000 title 1
- -1 heterocyclic radical Chemical class 0.000 abstract 26
- 125000000217 alkyl group Chemical group 0.000 abstract 15
- 150000003254 radicals Chemical class 0.000 abstract 9
- 125000003118 aryl group Chemical group 0.000 abstract 8
- 125000001072 heteroaryl group Chemical group 0.000 abstract 8
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 7
- 125000003342 alkenyl group Chemical group 0.000 abstract 6
- 125000003545 alkoxy group Chemical group 0.000 abstract 6
- 125000004429 atom Chemical group 0.000 abstract 6
- 229910052760 oxygen Inorganic materials 0.000 abstract 6
- 229910052717 sulfur Inorganic materials 0.000 abstract 5
- 125000000304 alkynyl group Chemical group 0.000 abstract 4
- 125000004432 carbon atom Chemical group C* 0.000 abstract 4
- 125000005842 heteroatom Chemical group 0.000 abstract 4
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 4
- 229910052757 nitrogen Inorganic materials 0.000 abstract 4
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 3
- 229910006074 SO2NH2 Inorganic materials 0.000 abstract 2
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000002837 carbocyclic group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 2
- 239000011707 mineral Substances 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- 101001043818 Mus musculus Interleukin-31 receptor subunit alpha Proteins 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 150000005840 aryl radicals Chemical class 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000004446 heteroarylalkyl group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000005885 heterocycloalkylalkyl group Chemical group 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 235000005985 organic acids Nutrition 0.000 abstract 1
- 150000007530 organic bases Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
- 125000000464 thioxo group Chemical group S=* 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Obesity (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Reivindicación 1: Productos de la fórmula (1) en la que p representa un número entero de 0 a 2; R y R1, iguales o diferentes, representan O o NH, R2 y R3, iguales o diferentes, representan H,alquilo, alquenilo, alquinilo, cicloalquilo, arilo y heteroarilo eventualmente sustituidos o bien R2 y R3 forman conjuntamente con el átomo de C al que están unidos un radical carbocíclico o heterocíclico, y estos radicales están constituidos por 3 a 10 eslabones y comprendiendo el radical heterocíclico uno o varios heteroátomos escogidos entre O, S, N y NR7, y todos estos radicales están eventualmente sustituidos. A1 representa un enlace sencillo, un radical alquilo, un radical alquenilo o alquinilo, Y e Y1, iguales o diferentes, son tales que uno de Y e Y1 se escoge entre OCF3, -O-CF2-CHF2, -O-CHF2, -O-CH2CF3, -SO2NR5R6, SF5 y S(O)n-alquilo y el otro de Y e Y1 es escogido entre estos mismos valores y además entre los valores siguientes: H, halógeno, hidroxilo, alcoxi, nitro, CN, NR5R6, alquilo eventualmente sustituido, arilo y heteroarilo eventualmente sustituido, CF3, O-alquenilo, O-alquinilo, O-cicloalquilo, S(O)n-alquenilo, S(O)n-alquinilo, S(O)n-cicloalquilo, carboxi libre, salificado o esterificado y CONR5R6,o bien el radical fenilo forma con sus sustituyentes Y e Y1 los radicales que se muestran en los restos de fórmulas (2), en donde p representa el número entero 2, 3 o 4, estando eventualmente sustituido el radical así formado con uno o varios radicales alquilo que están ellos mismos eventualmente sustituidos. R5 y R6, iguales o diferentes, son escogidos entre H, alquilo, alquenilo, alquinilo, cicloalquilo, cicloalquenilo, heterocicloalquilo, arilo y heteroarilo eventualmente sustituido o bien R5 y R6 forman con el átomo de N al que están unidos un radical heterocíclico que comprende 3 a 10 eslabones que comprenden uno o varios heteroátomos escogidos entre O, S, N y NR7 eventualmente sustituido; A2, igual o diferente a A1, representa los valores de A1 y CO y SO2; B2 representa un radical heterocíclico monocíclico o bicíclico, saturado o insaturado, que comprende uno a varios heteroátomos iguales o diferentes escogidos entre O, S, N y NR7, eventualmente sustituidos con uno o varios sustituyentes iguales o diferentes escogidos entre los valores de Y2. R7 representa un átomo de H, un radical alquilo, cicloalquilo, fenilo, acilo, S(O)2ALK, S(O)2arilo, S(O)2heteroarilo y S(O)2NR5R6, Y2 representa H, halógeno hidroxilo, ciano, alquilo, alcoxi, cicloalquilo, heterocicloalquilo, arilo, heteroarilo, -O-alquenilo, -O-alquinilo, -O-cicloalquilo, -S(O)n-alquilo, -S(O)n-alquenilo, -S(O)n-alquinilo, S(O)n-cicloalquilo, COOR13, -OCOR13, NR5R6, CONR5R6, S(O)n-NR5R6, -NR10-CO-R13, -NR10-SO2-R13, NH-SO2-NR5R6, NR10-CO-NR5R6, NR10-CS-NR5R6, -NR10-COOR13, y todos estos radicales están eventualmente sustituidos, todos los radicales anteriores alquilo, alquenilo, alquinilo y alcoxi son lineales o ramificados y comprenden como máximo 6 átomos de C, todos los radicales anteriores cicloalquilo y heterocicloalquilo comprenden como máximo 7 átomos de C, todos los radicales anteriores arilo y heteroarilo comprenden como máximo 10 átomos de C, todos los radicales anteriores alquilo, alquenilo, alquinilo, alcoxi, cicloalquilo, heterocicloalquilo, arilo y heteroarilo, carbocíclicos y heterocíclicos así como el ciclo formado por R5 y R6 con el átomo al que están unidos, están eventualmente sustituidos con uno o varios radicales iguales o diferentes escogidos entre átomos de halógenos y los radicales ciano, hidroxi, alcoxi, CF3, nitro, arilo, heteroarilo, -C(=O)-OR9, -C(=O)-R8, -NR11R12, -C(=O)-NR11R12, -N(R10)-C(=O)-R8, -N(R10)-C(=O)-OR9, N(R10)-C(=O)-NR11R12, -N(R10)-S(O)n-R8, -S(O)n-R8, -N(R10)-S(O)n-NR11R12 o S(O)n-NR11R12, todos los radicales arilo y heteroarilo anteriores están además eventualmente sustituidos con uno o varios radicales escogidos entre los radicales alquilo, alcoxi y alquilendioxi, todos los radicales cíclicos anteriores, así como el ciclo formado por R5 y R6 con el átomo al que están unidos, están además eventualmente sustituidos con uno o varios radicales escogidos entre oxo y tioxo, n representa un número entero de 0 a 2, R8 representa alquilo, alquenilo, cicloalquilo, cicloalquilalquilo, heterocicloalquilo, heterocicloalquilalquilo, arilo, arilalquilo, heteroarilo y heteroarilalquilo, R9 representa los valores de R8 e H, R10 representa H o alquilo, R11 y R12, iguales o diferentes representan H, cicloalquilo C3-6, alquilo C1-4 y fenilo eventualmente sustituidos con uno o varios radicales iguales o diferentes escogidos entre los átomos de halógenos y los radicales ciano, hidroxi, alcoxi, CF3, nitro, fenilo y carboxi libre, salificado, esterificado o amidificado, o bien R11 y R12 forman con el átomo de N al que están unidos un radical cíclico que comprende 5 a 7 eslabones que comprenden uno o varios heteroátomos escogidos entre O, S, N y NR7 y preferentemente una amina cíclica, R13, igual o diferente a R5 y R6, escogida entre los valores de R5 o R6, debiendo entenderse que los productos de fórmula (1) son como se definen con posterioridad en los apartados a) a d); a) cuando p representa el número entero 0, R representa O, R1 representa O, A1 representa un enlace sencillo o alquilo, Y e Y1, iguales o diferentes, son tales que al menos uno representa OCF3 o S-alk, A2 representa un enlace sencillo o alquilo y B2 representa un radical heterocíclico eventualmente sustituido, entonces R2 y R3 no representan un átomo de H y el otro imidazolialquilo, b) cuando p representa el número entero 0, R y R1 representan O, A1 representa un enlace sencillo o alquilo, Y e Y1, iguales o diferentes, son tales que uno al menos representa OCF3, SO-Alk, S(O)2-Alk o SO2NH2, A2 representa CH2 y B2 representa un radical heterocíclico eventualmente sustituido, entonces R2 y R3 no representan un átomo de H y el otro una cadena alquilo eventualmente interrumpida por O, S, N-alk siempre sustituida con un hidroxamato -CO-NHOH, c) cuando p representa el número entero 0, R y R1 representan O, A1 representa un enlace sencillo o alquilo, Y e Y1, iguales o diferentes, son tales que uno al menos representa S(O)n-Alk, A2 representa un enlace sencillo y B2 representa un radical heterocíclico aromático que comprende 5 o 6 eslabones eventualmente sustituidos, entonces R2 y R3 no son escogidos entre H, alquilo, arilalquilo, arilo y heteroarilo, d) cuando p representa un número entero de 0 a 2, R y R1 representan O, A1 representa un enlace sencillo, Y e Y1, iguales o diferentes son tales que uno representa SO2-Alk o SO2NH2 y el otro representa NR5R6, A2 representa un enlace sencillo o alquileno y B2 representa un radical heterocíclico que comprende 5 a 10 eslabones eventualmente sustituidos, entonces R2 y R3 no representan los dos H, dichos productos de fórmula (1) están en todas las formas isómeras posibles racémicas, enantiómeras y diastereoisómeras, así como las sales por adición de ácidos minerales y orgánicos o de bases minerales y orgánicas de dichos productos de fórmula (1).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0301098A FR2850652B1 (fr) | 2003-01-31 | 2003-01-31 | Nouveaux derives d'uree cyclique, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de kinases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR042936A1 true AR042936A1 (es) | 2005-07-06 |
Family
ID=32696243
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP040100233A AR042936A1 (es) | 2003-01-31 | 2004-01-27 | Derivados de urea ciclica, su preparacion y su utilizacion farmaceutica como inhibidores de quinasas |
Country Status (24)
| Country | Link |
|---|---|
| EP (1) | EP1599464B1 (es) |
| JP (1) | JP4604020B2 (es) |
| KR (1) | KR20050098286A (es) |
| CN (1) | CN1768054A (es) |
| AR (1) | AR042936A1 (es) |
| AT (1) | ATE482207T1 (es) |
| AU (1) | AU2004209319A1 (es) |
| BR (1) | BRPI0407091A (es) |
| CA (1) | CA2513631A1 (es) |
| DE (1) | DE602004029236D1 (es) |
| FR (1) | FR2850652B1 (es) |
| HR (1) | HRP20050679A2 (es) |
| MA (1) | MA27651A1 (es) |
| ME (1) | MEP22608A (es) |
| MX (1) | MXPA05007407A (es) |
| NO (1) | NO20054006L (es) |
| NZ (1) | NZ541270A (es) |
| PE (1) | PE20040808A1 (es) |
| PL (1) | PL377811A1 (es) |
| RS (1) | RS20050657A (es) |
| RU (1) | RU2341523C2 (es) |
| TW (1) | TW200505898A (es) |
| WO (1) | WO2004070050A2 (es) |
| ZA (1) | ZA200505934B (es) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2567135T3 (es) * | 2003-08-29 | 2016-04-20 | The Brigham And Women's Hospital, Inc. | Derivados de hidantoína como inhibidores de necrosis celular |
| US7592348B2 (en) | 2003-12-15 | 2009-09-22 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
| US7763609B2 (en) | 2003-12-15 | 2010-07-27 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
| US7700603B2 (en) | 2003-12-15 | 2010-04-20 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
| NZ548209A (en) | 2003-12-19 | 2009-07-31 | Univ California | Methods and materials for assessing prostate cancer thearapies |
| US7718684B2 (en) | 2004-02-24 | 2010-05-18 | The Regents Of The University Of California | Methods and materials for assessing prostate cancer therapies and compounds |
| EP1621535A1 (en) * | 2004-07-27 | 2006-02-01 | Aventis Pharma S.A. | Substituted cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors |
| EP1621536A1 (en) * | 2004-07-27 | 2006-02-01 | Aventis Pharma S.A. | Amino cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors |
| KR101782236B1 (ko) | 2005-05-13 | 2017-09-26 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | 디아릴히단토인 화합물 |
| US7709517B2 (en) | 2005-05-13 | 2010-05-04 | The Regents Of The University Of California | Diarylhydantoin compounds |
| US7709516B2 (en) * | 2005-06-17 | 2010-05-04 | Endorecherche, Inc. | Helix 12 directed non-steroidal antiandrogens |
| FR2896503B1 (fr) * | 2006-01-23 | 2012-07-13 | Aventis Pharma Sa | Nouveaux derives soufres d'uree cyclique, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de kinases |
| FR2896504B1 (fr) | 2006-01-23 | 2012-07-13 | Aventis Pharma Sa | Nouveaux derives d'uree cyclique, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de kinases |
| SI2656841T1 (sl) | 2006-03-27 | 2016-11-30 | The Regents Of The University Of California | Modulator androgenih receptorjev za zdravljanje raka prostate in bolezni, povezanih z androgenimi receptorji |
| EP3020706A1 (en) | 2006-03-29 | 2016-05-18 | The Regents Of The University Of California | Diarylthiohydantoin compounds useful for the treatment of a hyperproliferative disorder |
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| FR2329276A1 (fr) * | 1975-10-29 | 1977-05-27 | Roussel Uclaf | Nouvelles imidazolidines substituees, procede de preparation, application comme medicament et compositions les renfermant |
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| DE19732928C2 (de) * | 1997-07-31 | 2000-05-18 | Gruenenthal Gmbh | Verwendung substituierter Imidazolidin-2,4-dion-Verbindungen als Schmerzmittel |
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-
2003
- 2003-01-31 FR FR0301098A patent/FR2850652B1/fr not_active Expired - Fee Related
-
2004
- 2004-01-22 PE PE2004000090A patent/PE20040808A1/es not_active Application Discontinuation
- 2004-01-27 AR ARP040100233A patent/AR042936A1/es unknown
- 2004-01-28 CA CA002513631A patent/CA2513631A1/fr not_active Abandoned
- 2004-01-28 KR KR1020057014096A patent/KR20050098286A/ko not_active Ceased
- 2004-01-28 AU AU2004209319A patent/AU2004209319A1/en not_active Abandoned
- 2004-01-28 ME MEP-226/08A patent/MEP22608A/xx unknown
- 2004-01-28 WO PCT/FR2004/000188 patent/WO2004070050A2/fr not_active Ceased
- 2004-01-28 AT AT04705838T patent/ATE482207T1/de not_active IP Right Cessation
- 2004-01-28 DE DE602004029236T patent/DE602004029236D1/de not_active Expired - Lifetime
- 2004-01-28 CN CNA2004800088356A patent/CN1768054A/zh active Pending
- 2004-01-28 MX MXPA05007407A patent/MXPA05007407A/es active IP Right Grant
- 2004-01-28 EP EP04705838A patent/EP1599464B1/fr not_active Expired - Lifetime
- 2004-01-28 RU RU2005127335/04A patent/RU2341523C2/ru not_active IP Right Cessation
- 2004-01-28 PL PL377811A patent/PL377811A1/pl not_active Application Discontinuation
- 2004-01-28 BR BR0407091-7A patent/BRPI0407091A/pt not_active IP Right Cessation
- 2004-01-28 JP JP2006502123A patent/JP4604020B2/ja not_active Expired - Fee Related
- 2004-01-28 NZ NZ541270A patent/NZ541270A/en unknown
- 2004-01-28 RS YUP-2005/0657A patent/RS20050657A/sr unknown
- 2004-01-28 HR HR20050679A patent/HRP20050679A2/xx not_active Application Discontinuation
- 2004-01-30 TW TW093102064A patent/TW200505898A/zh unknown
-
2005
- 2005-07-22 ZA ZA200505934A patent/ZA200505934B/en unknown
- 2005-07-29 MA MA28417A patent/MA27651A1/fr unknown
- 2005-08-29 NO NO20054006A patent/NO20054006L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2004209319A1 (en) | 2004-08-19 |
| PL377811A1 (pl) | 2006-02-20 |
| NO20054006D0 (no) | 2005-08-29 |
| ATE482207T1 (de) | 2010-10-15 |
| MEP22608A (en) | 2010-06-10 |
| WO2004070050A3 (fr) | 2005-02-17 |
| JP2006517569A (ja) | 2006-07-27 |
| MA27651A1 (fr) | 2005-12-01 |
| FR2850652B1 (fr) | 2008-05-30 |
| RU2005127335A (ru) | 2006-09-10 |
| ZA200505934B (en) | 2007-06-27 |
| RS20050657A (sr) | 2007-06-04 |
| BRPI0407091A (pt) | 2006-01-24 |
| MXPA05007407A (es) | 2005-09-12 |
| DE602004029236D1 (de) | 2010-11-04 |
| EP1599464B1 (fr) | 2010-09-22 |
| EP1599464A2 (fr) | 2005-11-30 |
| CN1768054A (zh) | 2006-05-03 |
| FR2850652A1 (fr) | 2004-08-06 |
| NO20054006L (no) | 2005-10-13 |
| CA2513631A1 (fr) | 2004-08-19 |
| NZ541270A (en) | 2008-11-28 |
| TW200505898A (en) | 2005-02-16 |
| KR20050098286A (ko) | 2005-10-11 |
| HRP20050679A2 (en) | 2006-12-31 |
| WO2004070050A2 (fr) | 2004-08-19 |
| JP4604020B2 (ja) | 2010-12-22 |
| PE20040808A1 (es) | 2004-12-31 |
| RU2341523C2 (ru) | 2008-12-20 |
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