AR048829A1 - 17alfa - fluoroesteroides con actividad inhibidora de 5 alfa-reductasa; composiciones farmaceuticas que los contienen y su uso en la preparacion de medicamentos para el tratamiento de enfermedades cancerosas influidas por androgenos. - Google Patents
17alfa - fluoroesteroides con actividad inhibidora de 5 alfa-reductasa; composiciones farmaceuticas que los contienen y su uso en la preparacion de medicamentos para el tratamiento de enfermedades cancerosas influidas por androgenos.Info
- Publication number
- AR048829A1 AR048829A1 ARP050101485A ARP050101485A AR048829A1 AR 048829 A1 AR048829 A1 AR 048829A1 AR P050101485 A ARP050101485 A AR P050101485A AR P050101485 A ARP050101485 A AR P050101485A AR 048829 A1 AR048829 A1 AR 048829A1
- Authority
- AR
- Argentina
- Prior art keywords
- treatment
- pharmaceutical compositions
- fluorosteroids
- reductasa
- 17alfa
- Prior art date
Links
- 239000003098 androgen Substances 0.000 title abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 206010028980 Neoplasm Diseases 0.000 title 1
- 229940030486 androgens Drugs 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 229940124558 contraceptive agent Drugs 0.000 abstract 1
- 239000003433 contraceptive agent Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000000262 estrogen Substances 0.000 abstract 1
- 229940011871 estrogen Drugs 0.000 abstract 1
- 230000003054 hormonal effect Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 210000000056 organ Anatomy 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 239000000583 progesterone congener Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 229960003604 testosterone Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0038—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an androstane skeleton, including 18- or 19-substituted derivatives, 18-nor derivatives and also derivatives where position 17-beta is substituted by a carbon atom not directly bonded to a further carbon atom and not being part of an amide group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/16—Masculine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Derivados de 17?-fluoroesteroides de la formula general (1) donde R1 es un átomo de hidrogeno o un grupo metilo, R2 y R3 son un átomo de hidrogeno, un átomo de cloro o un grupo metilo y entre los C6-7 puede haber una union simple o doble y entre los C9-10 puede haber una union simple o doble y a las composiciones farmacéuticas que los contienen. Los compuestos descriptos poseen un perfil de efecto de carácter híbrido, ya que actuan como inhibidores de la 5?-reductasa y al mismo tiempo como gestágeno de gran potencia. Por lo tanto son apropiados para el tratamiento de enfermedades que se originan en ciertos organos y tejidos del hombre y de la mujer como consecuencia de un nivel aumentado de androgeno. En combinacion con otras sustancias hormonales tales como un estrogeno, testosterona o un androgeno fuerte, estos compuestos son apropiados como contraceptivos y otras aplicaciones en la mujer y en el hombre.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102004019406A DE102004019406A1 (de) | 2004-04-19 | 2004-04-19 | 17α-Fluorsteroide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR048829A1 true AR048829A1 (es) | 2006-05-31 |
Family
ID=34964632
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050101485A AR048829A1 (es) | 2004-04-19 | 2005-04-15 | 17alfa - fluoroesteroides con actividad inhibidora de 5 alfa-reductasa; composiciones farmaceuticas que los contienen y su uso en la preparacion de medicamentos para el tratamiento de enfermedades cancerosas influidas por androgenos. |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP1737880B1 (es) |
| JP (1) | JP2007532688A (es) |
| AR (1) | AR048829A1 (es) |
| AT (1) | ATE464313T1 (es) |
| DE (2) | DE102004019406A1 (es) |
| GT (1) | GT200500092A (es) |
| PA (1) | PA8630501A1 (es) |
| PE (1) | PE20060337A1 (es) |
| SV (1) | SV2006002086A (es) |
| TW (1) | TW200538134A (es) |
| UY (1) | UY28857A1 (es) |
| WO (1) | WO2005100376A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE202007019049U1 (de) * | 2007-11-05 | 2010-05-12 | Bayer Schering Pharma Aktiengesellschaft | Verwendung eines Gestagens in Kombination mit einem Estrogen zur Prophylaxe der Laktoseintoleranz bei der oralen Kontrazeption |
| US20130203718A1 (en) * | 2010-05-07 | 2013-08-08 | Marie-Edith Rafestin-Oblin | Progesterone receptor antagonists and uses thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7199115B2 (en) * | 2004-04-19 | 2007-04-03 | Schering Ag | 17α-fluorosteroids, pharmaceutical compositions containing 17α-fluorosteroids and a method of making them |
-
2004
- 2004-04-19 DE DE102004019406A patent/DE102004019406A1/de not_active Withdrawn
-
2005
- 2005-03-04 TW TW094106621A patent/TW200538134A/zh unknown
- 2005-04-15 DE DE502005009416T patent/DE502005009416D1/de not_active Expired - Fee Related
- 2005-04-15 UY UY28857A patent/UY28857A1/es not_active Application Discontinuation
- 2005-04-15 GT GT200500092A patent/GT200500092A/es unknown
- 2005-04-15 EP EP05732355A patent/EP1737880B1/de not_active Expired - Lifetime
- 2005-04-15 PA PA20058630501A patent/PA8630501A1/es unknown
- 2005-04-15 AT AT05732355T patent/ATE464313T1/de not_active IP Right Cessation
- 2005-04-15 JP JP2007508792A patent/JP2007532688A/ja active Pending
- 2005-04-15 PE PE2005000421A patent/PE20060337A1/es not_active Application Discontinuation
- 2005-04-15 SV SV2005002086A patent/SV2006002086A/es not_active Application Discontinuation
- 2005-04-15 AR ARP050101485A patent/AR048829A1/es not_active Application Discontinuation
- 2005-04-15 WO PCT/EP2005/003977 patent/WO2005100376A1/de not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| DE502005009416D1 (de) | 2010-05-27 |
| WO2005100376A1 (de) | 2005-10-27 |
| ATE464313T1 (de) | 2010-04-15 |
| DE102004019406A1 (de) | 2005-11-03 |
| EP1737880A1 (de) | 2007-01-03 |
| TW200538134A (en) | 2005-12-01 |
| PE20060337A1 (es) | 2006-05-25 |
| JP2007532688A (ja) | 2007-11-15 |
| EP1737880B1 (de) | 2010-04-14 |
| GT200500092A (es) | 2006-05-09 |
| PA8630501A1 (es) | 2006-05-16 |
| UY28857A1 (es) | 2005-11-30 |
| SV2006002086A (es) | 2006-02-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |