PE20011005A1 - Combinaciones de un inhibidor de fosfodiesterasa 4 y un antiinflamatorio esteroideo para el tratamiento de las enfermedades pulmonares - Google Patents
Combinaciones de un inhibidor de fosfodiesterasa 4 y un antiinflamatorio esteroideo para el tratamiento de las enfermedades pulmonaresInfo
- Publication number
- PE20011005A1 PE20011005A1 PE2000001168A PE0011682000A PE20011005A1 PE 20011005 A1 PE20011005 A1 PE 20011005A1 PE 2000001168 A PE2000001168 A PE 2000001168A PE 0011682000 A PE0011682000 A PE 0011682000A PE 20011005 A1 PE20011005 A1 PE 20011005A1
- Authority
- PE
- Peru
- Prior art keywords
- phosphodiesterase
- inhibitor
- pulmonary diseases
- inflammatory
- combinations
- Prior art date
Links
- 208000019693 Lung disease Diseases 0.000 title abstract 2
- 229940123932 Phosphodiesterase 4 inhibitor Drugs 0.000 title 1
- 230000003110 anti-inflammatory effect Effects 0.000 title 1
- 239000002587 phosphodiesterase IV inhibitor Substances 0.000 title 1
- 150000003431 steroids Chemical class 0.000 title 1
- MSYGAHOHLUJIKV-UHFFFAOYSA-N 3,5-dimethyl-1-(3-nitrophenyl)-1h-pyrazole-4-carboxylic acid ethyl ester Chemical compound CC1=C(C(=O)OCC)C(C)=NN1C1=CC=CC([N+]([O-])=O)=C1 MSYGAHOHLUJIKV-UHFFFAOYSA-N 0.000 abstract 1
- KUVIULQEHSCUHY-XYWKZLDCSA-N Beclometasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)COC(=O)CC)(OC(=O)CC)[C@@]1(C)C[C@@H]2O KUVIULQEHSCUHY-XYWKZLDCSA-N 0.000 abstract 1
- 101100296719 Caenorhabditis elegans pde-4 gene Proteins 0.000 abstract 1
- 102000011017 Type 4 Cyclic Nucleotide Phosphodiesterases Human genes 0.000 abstract 1
- 108010037584 Type 4 Cyclic Nucleotide Phosphodiesterases Proteins 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000003470 adrenal cortex hormone Substances 0.000 abstract 1
- 229960004495 beclometasone Drugs 0.000 abstract 1
- RKHQGWMMUURILY-UHRZLXHJSA-N cortivazol Chemical compound C([C@H]1[C@@H]2C[C@H]([C@]([C@@]2(C)C[C@H](O)[C@@H]1[C@@]1(C)C2)(O)C(=O)COC(C)=O)C)=C(C)C1=CC1=C2C=NN1C1=CC=CC=C1 RKHQGWMMUURILY-UHRZLXHJSA-N 0.000 abstract 1
- 229960002714 fluticasone Drugs 0.000 abstract 1
- MGNNYOODZCAHBA-GQKYHHCASA-N fluticasone Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(O)[C@@]2(C)C[C@@H]1O MGNNYOODZCAHBA-GQKYHHCASA-N 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 229960002744 mometasone furoate Drugs 0.000 abstract 1
- WOFMFGQZHJDGCX-ZULDAHANSA-N mometasone furoate Chemical compound O([C@]1([C@@]2(C)C[C@H](O)[C@]3(Cl)[C@@]4(C)C=CC(=O)C=C4CC[C@H]3[C@@H]2C[C@H]1C)C(=O)CCl)C(=O)C1=CC=CO1 WOFMFGQZHJDGCX-ZULDAHANSA-N 0.000 abstract 1
- 229960002117 triamcinolone acetonide Drugs 0.000 abstract 1
- YNDXUCZADRHECN-JNQJZLCISA-N triamcinolone acetonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O YNDXUCZADRHECN-JNQJZLCISA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
SE REFIERE AL USO DE UNA COMBINACION QUE COMPRENDE:UN INHIBIDOR DE FOSFODIESTERASA 4 (PDE 4) TAL COMO EL ACIDO CIS-4-CIANO-(3-CICLOPENTILOXI-4-METOXIFENIL)CICLOHEXANO-1-CARBOXILICO Y UN CORTICOIDE TAL COMO DEXAMETASONA, FLUTICASONA, BECLOMETASONA, BUDENOSINA, FLUNICOLIDA, FUROATO DE MOMETASONA, ACETONIDO DE TRIAMCINOLONA; LOS QUE SE ADMINISTRAN JUNTOS O POR SEPARADO. LA COMBINACION PUEDE SER UTIL PARA PREVENIR O REDUCIR ENFERMEDADES PULMONARES
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16315899P | 1999-11-02 | 1999-11-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20011005A1 true PE20011005A1 (es) | 2001-09-28 |
Family
ID=22588737
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2000001168A PE20011005A1 (es) | 1999-11-02 | 2000-11-02 | Combinaciones de un inhibidor de fosfodiesterasa 4 y un antiinflamatorio esteroideo para el tratamiento de las enfermedades pulmonares |
Country Status (29)
| Country | Link |
|---|---|
| EP (1) | EP1225866A4 (es) |
| JP (1) | JP2003513028A (es) |
| KR (1) | KR20020057988A (es) |
| CN (1) | CN1387404A (es) |
| AP (1) | AP2002002496A0 (es) |
| AR (1) | AR029189A1 (es) |
| AU (1) | AU1357501A (es) |
| BG (1) | BG106748A (es) |
| BR (1) | BR0015270A (es) |
| CA (1) | CA2388333A1 (es) |
| CO (1) | CO5261512A1 (es) |
| CZ (1) | CZ20021512A3 (es) |
| DZ (1) | DZ3225A1 (es) |
| EA (1) | EA200200518A1 (es) |
| EC (1) | ECSP003747A (es) |
| HK (1) | HK1049107A1 (es) |
| HU (1) | HUP0203152A3 (es) |
| IL (1) | IL149367A0 (es) |
| MA (1) | MA26841A1 (es) |
| MX (1) | MXPA02004350A (es) |
| NO (1) | NO20022057L (es) |
| OA (1) | OA12076A (es) |
| PE (1) | PE20011005A1 (es) |
| PL (1) | PL355261A1 (es) |
| SK (1) | SK7592002A3 (es) |
| TR (1) | TR200201211T2 (es) |
| TW (1) | TWI242431B (es) |
| WO (1) | WO2001032127A2 (es) |
| ZA (1) | ZA200203435B (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL160271A0 (en) | 2001-09-19 | 2004-07-25 | Altana Pharma Ag | Pharmaceutical compositions containing pde4-inhibitors and nsaid |
| HUP0401984A3 (en) * | 2001-10-31 | 2005-06-28 | Merck Patent Gmbh | Use of type 4 phosphodiesterase inhibitors for preparation of pharmaceutical compositions and combination with other active ingredients |
| UA82323C2 (uk) * | 2002-08-09 | 2008-04-10 | Меда Фарма Гмбх & Ко. Кг | Нова комбінація глюкокортикоїду та pde-інгібітору для лікування респіраторних захворювань, алергічних захворювань, астми та хронічних обструктивних легеневих захворювань |
| TW200410923A (en) * | 2002-10-17 | 2004-07-01 | Ono Pharmaceutical Co | Therapeutic agent for chronic obstructive pulmonary disease |
| EP1616569A1 (en) * | 2003-03-31 | 2006-01-18 | Kyowa Hakko Kogyo Co., Ltd. | Medicinal composition |
| US20050026883A1 (en) * | 2003-07-31 | 2005-02-03 | Robinson Cynthia B. | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a PDE-4 inhibitor for treatment of asthma or chronic obstructive pulmonary disease |
| US20070287689A1 (en) * | 2004-10-13 | 2007-12-13 | Kyowa Hakko Kogyo Co., Ltd. | Therapeutic And/Or Preventive Agents For Chronic Skin Diseases |
| US20090054382A1 (en) * | 2005-10-19 | 2009-02-26 | Abhijit Ray | Compositions of phosphodiesterase type iv inhibitors |
| US8991390B2 (en) | 2010-01-05 | 2015-03-31 | Microdose Therapeutx, Inc. | Inhalation device and method |
| WO2015063669A1 (en) | 2013-10-30 | 2015-05-07 | Wockhardt Limited | Pharmaceutical compositions comprising combination of roflumilast and acebrophylline or pharmaceutically acceptable salts thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0710109B1 (en) * | 1993-06-18 | 2004-09-15 | Smithkline Beecham Corporation | Method for identifying a PDE IV inhibitor |
| DE4332041C2 (de) * | 1993-09-21 | 1997-12-11 | Rentschler Arzneimittel | Verwendung von Pentoxifyllin bei bestimmten Lungenerkrankungen |
| PE44995A1 (es) * | 1994-01-27 | 1995-12-18 | Schering Corp | Furoato de mometasona para el tratamiento de las enfermedades pulmonares y de las vias respiratorias |
| SE9801368D0 (sv) * | 1998-04-20 | 1998-04-20 | Astra Ab | New use |
-
2000
- 2000-10-31 EC EC2000003747A patent/ECSP003747A/es unknown
- 2000-10-31 AR ARP000105742A patent/AR029189A1/es not_active Application Discontinuation
- 2000-11-01 HK HK02109234.5A patent/HK1049107A1/zh unknown
- 2000-11-01 WO PCT/US2000/030113 patent/WO2001032127A2/en not_active Ceased
- 2000-11-01 AP APAP/P/2002/002496A patent/AP2002002496A0/en unknown
- 2000-11-01 MX MXPA02004350A patent/MXPA02004350A/es unknown
- 2000-11-01 SK SK759-2002A patent/SK7592002A3/sk unknown
- 2000-11-01 EA EA200200518A patent/EA200200518A1/ru unknown
- 2000-11-01 OA OA1200200124A patent/OA12076A/en unknown
- 2000-11-01 KR KR1020027005609A patent/KR20020057988A/ko not_active Ceased
- 2000-11-01 BR BR0015270-6A patent/BR0015270A/pt not_active IP Right Cessation
- 2000-11-01 AU AU13575/01A patent/AU1357501A/en not_active Abandoned
- 2000-11-01 PL PL00355261A patent/PL355261A1/xx not_active Application Discontinuation
- 2000-11-01 CZ CZ20021512A patent/CZ20021512A3/cs unknown
- 2000-11-01 CA CA002388333A patent/CA2388333A1/en not_active Abandoned
- 2000-11-01 TR TR2002/01211T patent/TR200201211T2/xx unknown
- 2000-11-01 JP JP2001534335A patent/JP2003513028A/ja active Pending
- 2000-11-01 IL IL14936700A patent/IL149367A0/xx unknown
- 2000-11-01 HU HU0203152A patent/HUP0203152A3/hu unknown
- 2000-11-01 CN CN00815265A patent/CN1387404A/zh active Pending
- 2000-11-01 DZ DZ003225A patent/DZ3225A1/fr active
- 2000-11-01 EP EP00975533A patent/EP1225866A4/en not_active Withdrawn
- 2000-11-02 CO CO00083427A patent/CO5261512A1/es not_active Application Discontinuation
- 2000-11-02 PE PE2000001168A patent/PE20011005A1/es not_active Application Discontinuation
- 2000-11-22 TW TW089123039A patent/TWI242431B/zh not_active IP Right Cessation
-
2002
- 2002-04-30 ZA ZA200203435A patent/ZA200203435B/xx unknown
- 2002-04-30 NO NO20022057A patent/NO20022057L/no not_active Application Discontinuation
- 2002-05-02 MA MA26621A patent/MA26841A1/fr unknown
- 2002-05-29 BG BG106748A patent/BG106748A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR0015270A (pt) | 2002-06-18 |
| WO2001032127A3 (en) | 2001-12-06 |
| KR20020057988A (ko) | 2002-07-12 |
| MA26841A1 (fr) | 2004-12-20 |
| IL149367A0 (en) | 2002-11-10 |
| HK1049107A1 (zh) | 2003-05-02 |
| BG106748A (en) | 2003-02-28 |
| JP2003513028A (ja) | 2003-04-08 |
| HUP0203152A3 (en) | 2004-06-28 |
| DZ3225A1 (fr) | 2001-05-10 |
| EP1225866A4 (en) | 2004-04-21 |
| EA200200518A1 (ru) | 2002-10-31 |
| SK7592002A3 (en) | 2002-11-06 |
| OA12076A (en) | 2006-05-04 |
| WO2001032127A2 (en) | 2001-05-10 |
| TR200201211T2 (tr) | 2002-08-21 |
| HUP0203152A2 (hu) | 2003-01-28 |
| CA2388333A1 (en) | 2001-05-10 |
| TWI242431B (en) | 2005-11-01 |
| PL355261A1 (en) | 2004-04-05 |
| CN1387404A (zh) | 2002-12-25 |
| CZ20021512A3 (cs) | 2003-04-16 |
| AU1357501A (en) | 2001-05-14 |
| AR029189A1 (es) | 2003-06-18 |
| MXPA02004350A (es) | 2002-11-07 |
| EP1225866A2 (en) | 2002-07-31 |
| NO20022057D0 (no) | 2002-04-30 |
| ZA200203435B (en) | 2003-06-25 |
| AP2002002496A0 (en) | 2002-06-30 |
| ECSP003747A (es) | 2002-05-23 |
| NO20022057L (no) | 2002-06-27 |
| CO5261512A1 (es) | 2003-03-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |