AR048462A1 - Metodo para la praparacion de intermediarios utiles para la sintesis de analogos de la vitamina d - Google Patents
Metodo para la praparacion de intermediarios utiles para la sintesis de analogos de la vitamina dInfo
- Publication number
- AR048462A1 AR048462A1 ARP050101304A ARP050101304A AR048462A1 AR 048462 A1 AR048462 A1 AR 048462A1 AR P050101304 A ARP050101304 A AR P050101304A AR P050101304 A ARP050101304 A AR P050101304A AR 048462 A1 AR048462 A1 AR 048462A1
- Authority
- AR
- Argentina
- Prior art keywords
- vitamin
- synthesis
- preparation
- fragment
- aralkyl
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 230000015572 biosynthetic process Effects 0.000 title abstract 3
- 238000002360 preparation method Methods 0.000 title abstract 3
- 238000003786 synthesis reaction Methods 0.000 title abstract 3
- 229940088594 vitamin Drugs 0.000 title 1
- 229930003231 vitamin Natural products 0.000 title 1
- 235000013343 vitamin Nutrition 0.000 title 1
- 239000011782 vitamin Substances 0.000 title 1
- 150000003722 vitamin derivatives Chemical class 0.000 title 1
- 229930003316 Vitamin D Natural products 0.000 abstract 4
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 abstract 4
- 229910052799 carbon Inorganic materials 0.000 abstract 4
- 239000012634 fragment Substances 0.000 abstract 4
- 235000019166 vitamin D Nutrition 0.000 abstract 4
- 239000011710 vitamin D Substances 0.000 abstract 4
- 150000003710 vitamin D derivatives Chemical class 0.000 abstract 4
- 229940046008 vitamin d Drugs 0.000 abstract 4
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- LWQQLNNNIPYSNX-UROSTWAQSA-N calcipotriol Chemical compound C1([C@H](O)/C=C/[C@@H](C)[C@@H]2[C@]3(CCCC(/[C@@H]3CC2)=C\C=C\2C([C@@H](O)C[C@H](O)C/2)=C)C)CC1 LWQQLNNNIPYSNX-UROSTWAQSA-N 0.000 abstract 2
- 150000001721 carbon Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000001188 haloalkyl group Chemical group 0.000 abstract 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 2
- 239000002243 precursor Substances 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 abstract 1
- 229960002882 calcipotriol Drugs 0.000 abstract 1
- -1 carboxy hydroxy Chemical group 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B37/00—Reactions without formation or introduction of functional groups containing hetero atoms, involving either the formation of a carbon-to-carbon bond between two carbon atoms not directly linked already or the disconnection of two directly linked carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/72—Benzo[c]thiophenes; Hydrogenated benzo[c]thiophenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
El uso de los intermediarios producidos con dichos métodos para la elaboracion del calcipotriol o calcipotriol monohidrato. Reivindicacion 1: Un método para la preparacion de un compuesto de la estructura general de formula (1), en la cual el carbono marcado con un asterisco está conectado por un enlace simple a un átomo de carbono del fragmento de análogo de la Vitamina D en C-17, o bien a un fragmento de un precursor para la síntesis de un análogo de la vitamina D en la posicion análoga C1-7, método que comprende la reaccion de un compuesto de la estructura general de formula (2), en la cual el carbono marcado con un asterisco está conectado por un enlace simple a un átomo de carbono del fragmento de análogo de la Vitamina D en C-17, o bien a fragmento de un precursor para la síntesis de un análogo de la Vitamina D en la posicion análogo C1-7, con un fosfonato de la estructura general de formula (3), en la cual R3 y R4 son iguales o diferentes y representan alquilo, haloalquilo, hidroxialquilo, alquenilo, alquinilo, aralquilo, aralquenilo, aralquinilo o arilo, cada uno de los cuales está optativamente sustituido con uno o más sustituyentes seleccionados del grupo conformado por alquilo, aralquilo, cicloalquilo, cicloalquenilo, haloalquilo, hidroxialquilo, alquenilo, alquinilo, aralquilo, aralquenilo, aralquinilo, arilo, oxo, alcoxicarbonilo, alquilcarboniloxi, halogeno, alcoxi, carboxi, sulfo o hidroxi, en presencia de una base.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55854604P | 2004-04-02 | 2004-04-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR048462A1 true AR048462A1 (es) | 2006-04-26 |
Family
ID=34961754
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050101304A AR048462A1 (es) | 2004-04-02 | 2005-04-01 | Metodo para la praparacion de intermediarios utiles para la sintesis de analogos de la vitamina d |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20070135395A1 (es) |
| EP (1) | EP1735276B1 (es) |
| JP (1) | JP4744507B2 (es) |
| KR (1) | KR20070056001A (es) |
| CN (1) | CN1938268B (es) |
| AR (1) | AR048462A1 (es) |
| AT (1) | ATE498609T1 (es) |
| BR (1) | BRPI0508704A (es) |
| CA (1) | CA2561590C (es) |
| DE (2) | DE05715124T1 (es) |
| ES (1) | ES2361389T3 (es) |
| IL (1) | IL177357A (es) |
| MX (1) | MXPA06010824A (es) |
| MY (1) | MY146099A (es) |
| RU (1) | RU2378252C2 (es) |
| TW (1) | TWI322800B (es) |
| UA (1) | UA94568C2 (es) |
| WO (1) | WO2005095336A2 (es) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1948283B (zh) * | 2005-10-14 | 2010-12-29 | 台耀化学股份有限公司 | 维生素d衍生物的制备方法 |
| ES2406735T3 (es) | 2006-03-17 | 2013-06-07 | Leo Pharma A/S | Isomerización de compuestos intermedios farmacéuticos |
| WO2009057136A2 (en) * | 2007-08-03 | 2009-05-07 | Glenmark Generics Limited | Epimerization by stereoselective synthesis of vitamin d analogues |
| EP2299809B1 (en) * | 2008-06-17 | 2018-10-17 | Ben Gurion University Of The Negev R&D Authority | Substituted cyclohexylidene-ethylidene-octahydro-indene compounds |
| US20120184514A1 (en) * | 2009-07-01 | 2012-07-19 | Vitamin Derivatives Inc. | Vitamin d compounds and methods for preparing same |
| CN101607932B (zh) * | 2009-07-23 | 2012-05-09 | 青岛正大海尔制药有限公司 | 一种光化学反应制备骨化三醇的方法及其装置 |
| CN103980172A (zh) * | 2014-04-26 | 2014-08-13 | 湖南华腾制药有限公司 | 一种1α,25-二羟基维生素D2的制备方法 |
| CN103980173A (zh) * | 2014-04-26 | 2014-08-13 | 湖南华腾制药有限公司 | 一种帕立骨化醇中间体的制备方法 |
| CN105624215B (zh) * | 2014-10-27 | 2020-10-27 | 天津金耀集团有限公司 | 一种卡泊三醇合成新方法 |
| CN104447211A (zh) * | 2014-12-12 | 2015-03-25 | 重庆华邦制药有限公司 | 维生素d类药物的中间体化合物及制备方法 |
| CN105777665B (zh) * | 2014-12-17 | 2018-11-06 | 上虞京新药业有限公司 | 卡泊三醇的中间体化合物及其制备方法 |
| ES2575744B1 (es) * | 2014-12-30 | 2017-02-09 | Laboratorios Viñas S.A. | Procedimiento para proteger derivados de vitamina D con SO2 y uso correspondiente |
| CN106905358B (zh) * | 2015-12-23 | 2020-12-01 | 重庆华邦胜凯制药有限公司 | 一种制备维生素d3类似物中间体的方法 |
| CN105717206B (zh) * | 2016-01-27 | 2018-02-06 | 重庆华邦制药有限公司 | 分离测定卡泊三醇中间体f及其杂质的方法 |
| CN107643354B (zh) * | 2016-07-22 | 2022-02-01 | 重庆华邦胜凯制药有限公司 | 卡泊三醇起始原料a及相关杂质的分离与测定方法 |
| ES2674336B1 (es) * | 2016-12-28 | 2019-04-11 | Laboratorios Vinas S A | Procedimiento para reducir derivados carbonilicos de vitamina d y uso correspondiente |
| CN113845541B (zh) * | 2021-10-19 | 2023-11-07 | 重庆华邦胜凯制药有限公司 | 一种制备维生素d3类似物的方法 |
| CN116396268A (zh) * | 2021-12-27 | 2023-07-07 | 上海信谊万象药业股份有限公司 | 一种阿法骨化醇中间体合成方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU603340B2 (en) * | 1985-08-02 | 1990-11-15 | Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselskab) | Novel vitamin d analogues |
| US5244104A (en) * | 1992-01-02 | 1993-09-14 | Sias Equipment Company | Drying rack and spacer |
| US5247104A (en) * | 1992-11-04 | 1993-09-21 | Wisconsin Alumni Research Foundation | Preparation of 1α, 24-dihydroxyvitamin D analogs |
| JPH08325226A (ja) * | 1995-05-30 | 1996-12-10 | Teijin Ltd | ビタミンｄ３ 誘導体の製造法 |
| WO2004037781A1 (en) * | 2002-10-23 | 2004-05-06 | Leo Pharma A/S | Vitamin d analogues, compositions comprising said analogues and their use |
| ES2233209B1 (es) * | 2003-11-28 | 2006-04-01 | Laboratorios Viñas S.A. | Compuestos monohalogenovinilderivados de vitamina d. |
| WO2005087719A1 (en) * | 2004-03-18 | 2005-09-22 | Leo Pharma A/S | Stereoselective synthesis of vitamin d analogues |
-
2005
- 2005-03-23 CA CA002561590A patent/CA2561590C/en not_active Expired - Fee Related
- 2005-03-23 ES ES05715124T patent/ES2361389T3/es not_active Expired - Lifetime
- 2005-03-23 AT AT05715124T patent/ATE498609T1/de active
- 2005-03-23 EP EP05715124A patent/EP1735276B1/en not_active Expired - Lifetime
- 2005-03-23 KR KR1020067022977A patent/KR20070056001A/ko not_active Abandoned
- 2005-03-23 MX MXPA06010824A patent/MXPA06010824A/es active IP Right Grant
- 2005-03-23 RU RU2006138613/04A patent/RU2378252C2/ru active
- 2005-03-23 UA UAA200611527A patent/UA94568C2/ru unknown
- 2005-03-23 WO PCT/DK2005/000203 patent/WO2005095336A2/en not_active Ceased
- 2005-03-23 DE DE05715124T patent/DE05715124T1/de active Pending
- 2005-03-23 JP JP2007505379A patent/JP4744507B2/ja not_active Expired - Fee Related
- 2005-03-23 US US10/588,800 patent/US20070135395A1/en not_active Abandoned
- 2005-03-23 BR BRPI0508704-0A patent/BRPI0508704A/pt not_active IP Right Cessation
- 2005-03-23 DE DE602005026378T patent/DE602005026378D1/de not_active Expired - Lifetime
- 2005-03-23 CN CN200580009943XA patent/CN1938268B/zh not_active Expired - Fee Related
- 2005-03-25 MY MYPI20051315A patent/MY146099A/en unknown
- 2005-04-01 TW TW094110536A patent/TWI322800B/zh not_active IP Right Cessation
- 2005-04-01 AR ARP050101304A patent/AR048462A1/es unknown
-
2006
- 2006-08-08 IL IL177357A patent/IL177357A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| DE05715124T1 (de) | 2008-02-21 |
| ES2361389T3 (es) | 2011-06-16 |
| US20070135395A1 (en) | 2007-06-14 |
| JP4744507B2 (ja) | 2011-08-10 |
| BRPI0508704A (pt) | 2007-08-07 |
| CN1938268B (zh) | 2010-06-02 |
| UA94568C2 (ru) | 2011-05-25 |
| WO2005095336A3 (en) | 2005-11-10 |
| MY146099A (en) | 2012-06-29 |
| CA2561590C (en) | 2008-11-18 |
| EP1735276A2 (en) | 2006-12-27 |
| CA2561590A1 (en) | 2005-10-13 |
| JP2007530602A (ja) | 2007-11-01 |
| TWI322800B (en) | 2010-04-01 |
| CN1938268A (zh) | 2007-03-28 |
| DE602005026378D1 (de) | 2011-03-31 |
| WO2005095336A2 (en) | 2005-10-13 |
| IL177357A (en) | 2008-04-13 |
| EP1735276B1 (en) | 2011-02-16 |
| ATE498609T1 (de) | 2011-03-15 |
| TW200613257A (en) | 2006-05-01 |
| MXPA06010824A (es) | 2007-01-17 |
| RU2378252C2 (ru) | 2010-01-10 |
| KR20070056001A (ko) | 2007-05-31 |
| HK1098124A1 (en) | 2007-07-13 |
| RU2006138613A (ru) | 2008-05-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |