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AR077215A1 - Derivados de piperidina, composiciones farmaceuticas y metodos relacionados con ellos - Google Patents

Derivados de piperidina, composiciones farmaceuticas y metodos relacionados con ellos

Info

Publication number
AR077215A1
AR077215A1 ARP100102227A ARP100102227A AR077215A1 AR 077215 A1 AR077215 A1 AR 077215A1 AR P100102227 A ARP100102227 A AR P100102227A AR P100102227 A ARP100102227 A AR P100102227A AR 077215 A1 AR077215 A1 AR 077215A1
Authority
AR
Argentina
Prior art keywords
alkyl
ralk
heterocycle
aryl
case
Prior art date
Application number
ARP100102227A
Other languages
English (en)
Inventor
Neil J Ashweek
Florence Jovic
Nicole Harriott
Junko Tamiya
Timothy Coon
Joe A Tran
Tro Vickers
Chen Chen
Brian Dyck
Original Assignee
Boehringer Ingelheim Int
Neurocrine Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int, Neurocrine Biosciences Inc filed Critical Boehringer Ingelheim Int
Publication of AR077215A1 publication Critical patent/AR077215A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Compuestos relacionados con el tratamiento de una diversidad de afecciones relacionadas con el metabolismo en un paciente. También composiciones farmacéuticas que comprenden un compuesto de ésta, así como métodos relacionados con el uso de los mismos en un paciente que lo necesita. Reivindicacion 1: Un compuesto caracterizado porque tiene la formula (1) en la que: Ar es arilo o heteroarilo, donde dichos arilo y heteroarilo están opcionalmente sustituidos con 1 - 5 R4; R1 en cada caso es independientemente alquilo C1-4, F, hidroxi, alquil C1-4-O, -CO2R7 o -C(=O)N(R6)2; R2 en cada caso es independientemente alquilo C1-4, F, hidroxi o alquil C1-4-O-; R3 es RAlk, aril-alquilo C1-4, heterociclo-alquilo C1-4, -C(=O)R6, -CO2R5, -SO2R5, -C(=X)N(R6)2, arilo o heterociclo, donde cada grupo alquilo, RAlk, arilo y heterociclo está opcionalmente sustituido con 1 - 4 sustituyentes seleccionados independientemente entre sí entre R8; R4 en cada caso es independientemente halogeno, ciano, hidroxi, RAlk, -NO2, -C(=O)H, -C(=O)R5, -alquil C1-3-C(=O)R5, -CO2H, -CO2R5, -C(=O)N(R6)2, -alquil C1-3-C(=O)N(R6)2, -SO2N(R6)2, -S(=O)R5, -S(=O)2R5, -S(=O)2-O-R5, RAlk-O-, RAlk-S-, -N(R6)2, arilo, arilalquilo C1-6, heterociclo, heterociclo-alquilo C1-6, -NR6C(=O)R5, -NR6S(=O)2R5, -NR6C(=O)N(R6)2, -NR6C(=O)OR7, -NR6C(=NR6)N(R6)2 o -NR6S(=O)2N(R6)2, donde cada alquilo, RAlk, arilo y heterociclo está opcionalmente sustituido con 1 - 5 sustituyentes seleccionados independientemente entre sí entre R8; R5 es RAlk, heterociclo, arilo, heterociclo-alquilo C1-3 o aril-alquilo C1-3, donde cada grupo alquilo, RAlk, heterociclo y arilo está opcionalmente sustituido con 1 - 4 sustituyentes seleccionados independientemente entre sí entre R8; R6 en cada caso es independientemente H, RAlk, heterociclo, heterociclo-alquilo C1-6, arilo o aril-alquilo C1-3, donde cada RAlk, heterociclo, arilo y alquilo está opcionalmente sustituido con 1 - 4 de halogeno, hidroxi, -N(R7)2, alquil C1-4-O- y -CO2R7; R7 en cada caso es independientemente H o alquilo C1-4; R8 en cada caso es independientemente ciano, hidroxi, RAlk, arilo, aril-alquilo C1-6, heterociclo, heterociclo-alquilo C1-6, halogeno, oxo, haloalquilo C1-4, -NO2, -C(=O)H, -CO2R7, -OC(=O)RAlk, -C(O)N(R6)2, -SO2N(R6)2, -S(=O)RAlk, -S(=O)2RAlk, alquil C1-6-O-, haloalquil C1-4-O-, -N(R6)2, -SR6, -NR6C(O)RAlk, -NR6S(=O)2RAlk, -NR6C(=O)ORAlk, -NR6C(=O)N(R6)2 o -NR6S(=O)2N(R6)2, donde cada RAlk, alquilo, arilo y heterociclo está opcionalmente sustituido con 1 - 4 sustituyentes seleccionados independientemente entre sí entre halogeno, hidroxi, -N(R7)2, alquil C1-4-O-, -NR6CO2R6, -NR6SO2R6 y -CO2R7; RAlk en cada caso es independientemente alquilo C1-6, alquenilo C2-6, alquinilo C2-6, cicloalquilo C3-8, cicloalquil C3-8-alquilo C1-3, cicloalquenilo C4-8 o cicloalquenil C4-8-alquilo C1-3; X representa O o S; n en cada caso es 0, 1 o 2; p en cada caso es 0 o 1; y q es 0, 1 o 2; incluyendo cualquier tautomero y estereoisomero de los mismos, o una sal de los mismos o un solvato o hidrato de los mismos.
ARP100102227A 2009-06-24 2010-06-23 Derivados de piperidina, composiciones farmaceuticas y metodos relacionados con ellos AR077215A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US22013309P 2009-06-24 2009-06-24

Publications (1)

Publication Number Publication Date
AR077215A1 true AR077215A1 (es) 2011-08-10

Family

ID=42557541

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP100102227A AR077215A1 (es) 2009-06-24 2010-06-23 Derivados de piperidina, composiciones farmaceuticas y metodos relacionados con ellos

Country Status (18)

Country Link
US (1) US8293729B2 (es)
EP (1) EP2445878A1 (es)
JP (1) JP5467151B2 (es)
KR (1) KR20120046188A (es)
CN (1) CN102803214A (es)
AR (1) AR077215A1 (es)
AU (1) AU2010264720A1 (es)
BR (1) BR112012000831A2 (es)
CA (1) CA2766696A1 (es)
CL (1) CL2011003079A1 (es)
EA (1) EA201200046A1 (es)
IL (1) IL216388A0 (es)
MX (1) MX2011013648A (es)
NZ (1) NZ596445A (es)
TW (1) TW201111361A (es)
UY (1) UY32731A (es)
WO (1) WO2010149684A1 (es)
ZA (1) ZA201108292B (es)

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TW201111361A (en) 2011-04-01
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MX2011013648A (es) 2012-03-06
WO2010149684A1 (en) 2010-12-29
US20110166116A1 (en) 2011-07-07
IL216388A0 (en) 2012-01-31
US8293729B2 (en) 2012-10-23
EA201200046A1 (ru) 2012-08-30
CN102803214A (zh) 2012-11-28
JP5467151B2 (ja) 2014-04-09
CL2011003079A1 (es) 2012-06-01
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UY32731A (es) 2011-01-31
AU2010264720A1 (en) 2011-12-08

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