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CY1118288T1 - Διαδικασια παρασκευης οιστετρολης - Google Patents

Διαδικασια παρασκευης οιστετρολης

Info

Publication number
CY1118288T1
CY1118288T1 CY20161101223T CY161101223T CY1118288T1 CY 1118288 T1 CY1118288 T1 CY 1118288T1 CY 20161101223 T CY20161101223 T CY 20161101223T CY 161101223 T CY161101223 T CY 161101223T CY 1118288 T1 CY1118288 T1 CY 1118288T1
Authority
CY
Cyprus
Prior art keywords
preparation
oxy
ostetrol
pyrithylene
estra
Prior art date
Application number
CY20161101223T
Other languages
English (en)
Inventor
Johannes Jan Platteeuw
Bennink Herman Jan Tijmen Coelingh
Franciscus Wilhelmus Petrus Damen
Vliet Michiel Christian Alexander Van
Original Assignee
Donesta Bioscience B.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44582248&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1118288(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Donesta Bioscience B.V. filed Critical Donesta Bioscience B.V.
Publication of CY1118288T1 publication Critical patent/CY1118288T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)

Abstract

Η παρούσα εφεύρεση αναφέρεται σε μία διαδικασία για την παρασκευή οιστρα-1,3,5(10)-τριεν-3, 15α, 16α, 17β-τετραόλης (οιστετρόλης), μέσω ενός παραγώγου πυριτυλενολαιθέρα 17-Β-οξυ-3-Α-οξυ-οιστρα-1,3,5(10),16-τετραενίου, όπου το Α είναι μία προστατευτική ομάδα και το Β είναι -Si(R2)3. Η εφεύρεση αναφέρεται περαιτέρω σε μία διαδικασία συνθέσεως 3-Α-οξυ-οιστρα-1,3,5(10),15-τετραεν-17-όνης, όπου το Α είναι μία προστατευτική ομάδα, μέσω του εν λόγω παραγώγου πυριτυλενολαιθέρα.
CY20161101223T 2011-07-19 2016-11-24 Διαδικασια παρασκευης οιστετρολης CY1118288T1 (el)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161509168P 2011-07-19 2011-07-19
EP11174509A EP2383279A1 (en) 2011-07-19 2011-07-19 Process for the preparation of estetrol
EP12742968.6A EP2734536B1 (en) 2011-07-19 2012-07-18 Process for the preparation of estetrol
PCT/NL2012/050514 WO2013012328A1 (en) 2011-07-19 2012-07-18 Process for the preparation of estetrol

Publications (1)

Publication Number Publication Date
CY1118288T1 true CY1118288T1 (el) 2017-06-28

Family

ID=44582248

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20161101223T CY1118288T1 (el) 2011-07-19 2016-11-24 Διαδικασια παρασκευης οιστετρολης

Country Status (16)

Country Link
US (2) US20140235882A1 (el)
EP (2) EP2383279A1 (el)
CN (1) CN103781795B (el)
CA (1) CA2842035C (el)
CY (1) CY1118288T1 (el)
DK (1) DK2734536T3 (el)
ES (1) ES2602227T3 (el)
HR (1) HRP20161467T1 (el)
HU (1) HUE029783T2 (el)
LT (1) LT2734536T (el)
PL (1) PL2734536T3 (el)
PT (1) PT2734536T (el)
RS (1) RS55384B1 (el)
SI (1) SI2734536T1 (el)
SM (2) SMT201600464T1 (el)
WO (1) WO2013012328A1 (el)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103703014A (zh) * 2011-06-01 2014-04-02 埃斯特拉公司 用于产生雌四醇中间体的方法
SI2714712T1 (sl) 2011-06-01 2016-11-30 Estetra S.P.R.L. Postopek za proizvodnjo intermediatov estetrola
EP2383279A1 (en) 2011-07-19 2011-11-02 Pantarhei Bioscience B.V. Process for the preparation of estetrol
CN103890001B (zh) * 2011-10-07 2016-05-04 埃斯特拉有限责任公司 用于制备雌四醇的方法
WO2013034780A2 (en) 2012-12-20 2013-03-14 Crystal Pharma, S.A.U. Process for the preparation of estetrol and related compounds
WO2015040051A1 (en) * 2013-09-18 2015-03-26 Crystal Pharma, S.A.U. Process for the preparation of estetrol
SMT201800232T1 (it) 2015-06-18 2018-07-17 Mithra Pharmaceuticals S A Unita' di dosaggio orodispersibile contenente un componente di estetrolo
MA44205B1 (fr) 2015-06-18 2021-04-30 Estetra Sprl Comprimé orodispersible comprenant estetrol
HUE054551T2 (hu) 2015-06-18 2021-09-28 Estetra Sprl Ösztetrolt tartalmazó, szájban diszpergálódó tabletta
EP3310333B1 (en) 2015-06-18 2020-04-29 Estetra SPRL Orodispersible dosage unit containing an estetrol component
KR102712911B1 (ko) 2016-08-05 2024-10-04 에스테트라, 소시에떼 아 레스폰서빌리떼 리미떼 월경통 및 생리통의 관리방법
TWI801561B (zh) 2018-04-19 2023-05-11 比利時商依思特拉私人有限責任公司 化合物及其用於緩解絕經相關症狀的用途
JOP20200260A1 (ar) 2018-04-19 2019-10-19 Estetra Sprl مركبات واستخداماتها للتخفيف من الأعراض المصاحبة لانقطاع الطمث
HU231240B1 (hu) 2019-09-03 2022-04-28 Richter Gedeon Nyrt. Ipari eljárás nagytisztaságú ösztetrol hatóanyag előállítására
CN116355031A (zh) * 2019-09-27 2023-06-30 工业化学有限公司 制备(15α,16α,17β)-雌-1,3,5(10)-三烯-3,15,16,17-四醇一水合物(雌四醇一水合物)的工艺
TWI893101B (zh) 2020-04-16 2025-08-11 比利時商埃斯特拉有限責任公司 具有降低之副作用之避孕組成物
US20220406595A1 (en) * 2021-06-22 2022-12-22 Applied Materials, Inc. Novel oxidants and strained-ring precursors
IT202100019631A1 (it) 2021-07-23 2023-01-23 Newchem S P A Metodo per produrre estetrolo e i suoi intermedi
WO2023021026A1 (en) 2021-08-17 2023-02-23 Aspen Oss B.V. A synthetic pathway to estra-1,3,5(10)-triene-3,15a,16a,17b-tetrol
HUP2400151A1 (hu) 2024-02-28 2025-09-28 Richter Gedeon Nyrt Ösztetrol-monohidrát kristályosítási eljárás

Family Cites Families (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE144266C (el)
US3138588A (en) 1962-08-24 1964-06-23 American Home Prod 17-ketals of estrone and derivatives thereof
US3177206A (en) 1963-03-07 1965-04-06 American Home Prod Selective bromination of a-ring aromatic 17-ketalized steroids
US3433785A (en) 1966-07-11 1969-03-18 Sterling Drug Inc 15,16-disubstituted aromatic steroids,intermediates and processes
US3673180A (en) 1970-06-18 1972-06-27 Merck & Co Inc 19-nor-6,6-ethylene-20-spiroxenes
US4792620A (en) * 1983-10-14 1988-12-20 Bp Chemicals Limited Carbonylation catalysts
US4739078A (en) 1984-02-17 1988-04-19 The Upjohn Company Use of borohydride-salt lanthanide salt reagents for stereo selective reduction of C-15-keto prostaglandin precursors
IE60780B1 (en) 1987-01-23 1994-08-10 Akzo Nv New 11-aryl steroid derivatives
DE3710728A1 (de) 1987-03-31 1988-10-13 Schering Ag Verfahren zur herstellung von 17(alpha)-ethinyl-17ss-hydroxy-18-methyl-4,15-estradien-3-on und die neuen zwischenprodukte fuer dieses verfahren
US5073374A (en) 1988-11-30 1991-12-17 Schering Corporation Fast dissolving buccal tablet
US5340586A (en) 1991-04-12 1994-08-23 University Of Southern California Methods and formulations for use in treating oophorectomized women
JPH07101977A (ja) 1993-10-05 1995-04-18 Kureha Chem Ind Co Ltd ホルモン作用を軽減した新規なエストラジオール誘導体及びその増殖因子阻害剤
DE4344405C2 (de) 1993-12-24 1995-12-07 Marika Dr Med Ehrlich Ovulationshemmendes Mittel und Verfahren zur hormonalen Kontrazeption
WO1997004752A1 (en) 1995-07-26 1997-02-13 Duramed Pharmaceuticals, Inc. Pharmaceutical compositions of conjugated estrogens and methods for their use
US6117446A (en) 1999-01-26 2000-09-12 Place; Virgil A. Drug dosage unit for buccal administration of steroidal active agents
TW548277B (en) 1999-07-16 2003-08-21 Akzo Nobel Nv Orally active androgens
CZ301376B6 (cs) 1999-12-02 2010-02-03 N.V. Organon Steroidní deriváty s androgenním úcinkem
US20020132801A1 (en) 2001-01-11 2002-09-19 Schering Aktiengesellschaft Drospirenone for hormone replacement therapy
EP1216713A1 (en) 2000-12-20 2002-06-26 Schering Aktiengesellschaft Compositions of estrogen-cyclodextrin complexes
EP1260225A1 (en) 2001-05-18 2002-11-27 Pantarhei Bioscience B.V. A pharmaceutical composition for use in hormone replacement therapy
ATE350041T1 (de) 2001-05-18 2007-01-15 Pantarhei Bioscience Bv Pharmaceutishe zusammensetzung für die hormonersatztherapie
ATE449606T1 (de) 2001-05-23 2009-12-15 Pantarhei Bioscience Bv Tetrahydroxylierte estrogen enthaltendes arzneistoffverabreichungssystem zur verwendung in hormonalen kontrazeption
EP1390042B1 (en) 2001-05-23 2007-11-28 Pantarhei Bioscience B.V. Drug delivery system comprising a tetrahydroxylated estrogen for use in hormonal contraception
WO2003018026A1 (en) 2001-08-31 2003-03-06 Pantarhei Bioscience B.V. Use of estrogenic compounds in combination with progestogenic compounds in hormone-replacement therapy
ATE347365T1 (de) 2001-11-15 2006-12-15 Pantarhei Bioscience Bv Verwendung von öestrogen in kombination mit progestogen für die hormonsubstitutions-therapie
US6723348B2 (en) 2001-11-16 2004-04-20 Ethypharm Orodispersible tablets containing fexofenadine
HU227198B1 (en) 2001-11-27 2010-10-28 Richter Gedeon Nyrt Pharmaceutical composition for emergency contraception containing levonorgestrel
US20050164977A1 (en) 2002-02-21 2005-07-28 Coelingh Bennink Herman J.T. Pharmaceutical compositions comprising one or more steroids one or more tetrahydrofolate components and vitamin b12
US20050147670A1 (en) 2002-05-29 2005-07-07 Impax Laboratories Inc. Oral disintegrating dosage forms
CA2489270C (en) 2002-06-11 2012-08-07 Pantarhei Bioscience B.V. A method of treating human skin and a skin care composition for use in such a method
SI1511496T1 (sl) 2002-06-11 2007-04-30 Pantarhei Bioscience Bv Metoda zdravljenja ali prevencije imunsko mediiranih motenj in farmacevtska formulacija za njeno uporabo
DE60318447T2 (de) 2002-07-12 2009-01-02 Pantarhei Bioscience B.V. Pharmazeutische zusammensetzung enthaltend estetrolderivate und anwendung in der krebsbehandlung
AU2003264203A1 (en) 2002-08-28 2004-03-19 Robert Casper Estrogen replacement regimen
DE60318092T2 (de) 2002-10-23 2008-11-27 Pantarhei Bioscience B.V. Pharmazeutische zusammensetzung enthaltend estetrolderivate und anwendung in der krebsbehandlung
EP1558265B1 (en) 2002-11-05 2010-01-06 Bayer Schering Pharma Aktiengesellschaft Use of drospirenone for the treatment of hypertension
DE60332754D1 (de) 2002-11-08 2010-07-08 Pantarhei Bioscience Bv Synthese von oestetrol aus von oestron abgeleiteten steroiden
CA2526338C (en) 2003-05-22 2012-09-25 Pantarhei Bioscience B.V. Use of compositions comprising an estrogenic component for the treatment and prevention of musculoskeletal pain
EP2409690B1 (en) 2003-09-29 2022-11-09 Novo Nordisk Health Care AG Improved stability of progestogen formulations
EP1670440B1 (en) 2003-09-29 2014-04-30 Novo Nordisk Femcare AG Hrt formulations
EP1535618A1 (en) 2003-11-26 2005-06-01 Schering Aktiengesellschaft Pharmaceutical preparation for continuous hormonal treatment over a period of longer than 21-28 days comprising two estrogen and/or progestin compositions
MY151322A (en) 2004-04-30 2014-05-15 Bayer Ip Gmbh Management of breakthrough bleeding in extended hormonal contraceptive regimens
WO2005115349A1 (de) 2004-05-28 2005-12-08 Grünenthal GmbH Folsäurehaltiges kontrazeptivum
DE102004026670A1 (de) 2004-05-28 2005-12-15 Grünenthal GmbH Hormonales Kontrazeptivum enthaltend eine Kombination aus Ethinylestradiol und Chlormadinonacetat
UA89964C2 (ru) 2004-09-08 2010-03-25 Н.В. Органон 15β-ЗАМЕЩЕННЫЕ СТЕРОИДЫ, КОТОРЫЕ ИМЕЮТ СЕЛЕКТИВНУЮ ЭСТРОГЕННУЮ АКТИВНОСТЬ
UY29527A1 (es) 2005-05-13 2006-12-29 Schering Ag Composicinn farmaccutica que contienen gestrgenos y/o estrngenos y 5-metil - (6s) - tetrhidrofolato.
AU2006251154B2 (en) 2005-05-26 2012-06-28 Solvay Pharmaceuticals Gmbh 17beta-HSD1 and STS inhibitors
CN101228268A (zh) 2005-07-25 2008-07-23 德累斯顿工业大学 Rna扩增和/或rna标记用的rna依赖的rna聚合酶，方法及试剂盒
US20070048369A1 (en) 2005-08-26 2007-03-01 National Starch And Chemical Investment Holding Corporation Mucosal delivery tablet
US20090221540A1 (en) 2006-01-09 2009-09-03 Pantarhei Bioscience B.V. Method of Treating An Acute Vascular Disorder
WO2007106264A2 (en) 2006-03-02 2007-09-20 Warner Chilcott Company, Inc. Extended cycle multiphasic oral contraceptive method
US20080113953A1 (en) 2006-06-08 2008-05-15 Warner Chilcott Company, Inc. Methods to administer solid dosage forms of ethinyl estradiol and prodrugs thereof with improved bioavailability
CN101443015A (zh) 2006-06-08 2009-05-27 沃纳奇尔科特公司 具有改善的生物利用率的乙炔雌二醇及其药物前体的固体剂型的给药方法
US20070286819A1 (en) 2006-06-08 2007-12-13 Warner Chilcott Company, Inc. Methods to administer ethinyl estradiol and prodrugs thereof with improved bioavailability
RU2009102443A (ru) 2006-07-06 2010-08-20 Йенафарм ГмбХ унд Ко КГ (DE) Фармацевтический препарат для контрацепции и для предотвращения риска врожденных пороков развития
CN101489563A (zh) 2006-07-06 2009-07-22 拜耳先灵医药股份有限公司 用于避孕和预防先天性畸形风险的药物制剂
GB0621926D0 (en) 2006-11-03 2006-12-13 Medlock Medical Ltd Multi directional stretch tubular bandages
AR064014A1 (es) 2006-11-29 2009-03-04 Wyeth Corp Tabletas bi-capa de estrogeno/moduladores selectivos de receptores de estrogeno (serm) y estrogeno/progestina
CA2674776A1 (en) 2006-12-20 2008-07-03 Duramed Pharmaceuticals, Inc. Orally disintegrating solid dosage forms comprising progestin and methods of making and use thereof
WO2008085038A2 (en) 2007-01-08 2008-07-17 Pantarhei Bioscience B.V. Method of treating or preventing infertility in a female mammal and pharmaceutical kit for use in such method
EP2117518A2 (en) 2007-01-12 2009-11-18 Wyeth a Corporation of the State of Delaware Tablet-in-tablet compositions
ES2378117T3 (es) 2007-06-21 2012-04-09 Pantarhei Bioscience B.V. Tratamiento del Síndrome de aspiración de meconio con estrógenos
PL2170346T3 (pl) 2007-07-19 2012-03-30 Pantarhei Bioscience Bv Leczenie lub profilaktyka zaburzeń związanych z nadciśnieniem w okresie ciąży lub opóźnienie wzrostu płodu
CN101541725B (zh) 2007-08-31 2013-08-28 国立大学法人名古屋大学 羰基化合物的制造方法和用于制造羰基化合物的氧化促进剂
EP2077272A1 (en) 2007-12-21 2009-07-08 Affibody AB Polypeptide libraries with a predetermined scaffold
EP2077273B1 (en) 2007-12-31 2011-09-14 Animal Technology Institute Taiwan Methods for separating casein from soluble proteins in a composition
US8530636B2 (en) 2008-05-07 2013-09-10 The Board Of Trustees Of The Leland Stanford Junior University Method for regulating protein function in cells in vivo using synthetic small molecules
WO2010033832A2 (en) 2008-09-19 2010-03-25 Evestra, Inc. Estriol formulations
DE102009007771B4 (de) 2009-02-05 2012-02-16 Bayer Schering Pharma Aktiengesellschaft Bukkales Applikationssystem, 17α-Estradiol enthaltend
EP3178476A1 (de) 2009-06-23 2017-06-14 Bayer Intellectual Property GmbH Pharmazeutische zusammensetzung und behandlungsverfahren zur notfallempfängnisverhütung
CN102058604A (zh) 2009-11-17 2011-05-18 北京万全阳光医学技术有限公司 一种含有地诺孕素和戊酸雌二醇的药物组合物及其制备方法
KR20180018827A (ko) 2010-04-15 2018-02-21 바이엘 인텔렉쳐 프로퍼티 게엠베하 초저-용량의 ｈｒｔ용 고체 경구 투여 형태
AR081670A1 (es) 2010-06-29 2012-10-10 Leon Farma Sa Lab Composicion farmaceutica que comprende drospirenona y kit anticonceptivo
US9603860B2 (en) 2010-07-28 2017-03-28 Laboratorios Leon Farma Sa Pharmaceutical compositions comprising active drugs, contraceptive kits comprising active drugs, and methods of administering the same
WO2012055840A1 (en) 2010-10-28 2012-05-03 Bayer Pharma Aktiengesellschaft Composition and preparation for treatment of dysmenorrhea and menstrual pain and use of a hormonal agent and a zinc salt for treatment of menstrual disorders
SI2714712T1 (sl) 2011-06-01 2016-11-30 Estetra S.P.R.L. Postopek za proizvodnjo intermediatov estetrola
CN103703014A (zh) 2011-06-01 2014-04-02 埃斯特拉公司 用于产生雌四醇中间体的方法
EP2383279A1 (en) 2011-07-19 2011-11-02 Pantarhei Bioscience B.V. Process for the preparation of estetrol
CA2842175C (en) 2011-07-19 2019-10-15 Herman Jan Tijmen Coelingh Bennink Tablet containing dehydroepiandrosterone (dhea)
US9579329B2 (en) 2011-08-11 2017-02-28 Estetra S.P.R.L. Use of estetrol as emergency contraceptive
US9731018B2 (en) 2011-09-16 2017-08-15 Ferring B.V. Fast dissolving pharmaceutical composition
CN103890001B (zh) 2011-10-07 2016-05-04 埃斯特拉有限责任公司 用于制备雌四醇的方法
DE202012012822U1 (de) 2011-12-13 2014-02-03 Arstat, Inc. Empfängnisverhütungs-Set zur aufeinanderfolgenden täglichen Anwendung
EP2653163A1 (en) 2012-04-19 2013-10-23 Université de Liège Estrogenic components for use in the treatment of neurological disorders
WO2014159377A1 (en) 2013-03-14 2014-10-02 Teva Women's Health, Inc. Compositions containing tanaproget and natural estrogens
US9161941B2 (en) 2013-05-21 2015-10-20 Predictive Therapeutics, LLC Therapeutic and method of use
WO2015040051A1 (en) 2013-09-18 2015-03-26 Crystal Pharma, S.A.U. Process for the preparation of estetrol
NO3079671T3 (el) 2013-12-12 2018-03-24
ES2957543T3 (es) 2014-09-29 2024-01-22 Univ California Composiciones y métodos para mantener la función cognitiva
HK1251938A1 (zh) 2015-05-18 2019-05-03 敏捷治疗公司 避孕组合物及提高效能和调节副作用的方法
SMT201800232T1 (it) 2015-06-18 2018-07-17 Mithra Pharmaceuticals S A Unita' di dosaggio orodispersibile contenente un componente di estetrolo
EP3310333B1 (en) 2015-06-18 2020-04-29 Estetra SPRL Orodispersible dosage unit containing an estetrol component
MA44205B1 (fr) 2015-06-18 2021-04-30 Estetra Sprl Comprimé orodispersible comprenant estetrol
HUE054551T2 (hu) 2015-06-18 2021-09-28 Estetra Sprl Ösztetrolt tartalmazó, szájban diszpergálódó tabletta
MY187233A (en) 2015-06-23 2021-09-13 Laboratorios Leon Farma Sa Drospirenone-based contraceptive for a female patient affected with excess weight
US10863492B2 (en) 2015-07-16 2020-12-08 Qualcomm Incorporated Low latency device-to-device communication
KR102712911B1 (ko) 2016-08-05 2024-10-04 에스테트라, 소시에떼 아 레스폰서빌리떼 리미떼 월경통 및 생리통의 관리방법
AU2016425935B2 (en) 2016-10-28 2023-01-19 Estetra Srl Method for the management of dysmenorrhea and menstrual pain

Also Published As

Publication number Publication date
RS55384B1 (sr) 2017-03-31
CA2842035A1 (en) 2013-01-24
SMT201600464B (it) 2017-03-08
EP2734536B1 (en) 2016-09-28
EP2734536A1 (en) 2014-05-28
HUE029783T2 (en) 2017-04-28
WO2013012328A1 (en) 2013-01-24
US20140235882A1 (en) 2014-08-21
PL2734536T3 (pl) 2017-03-31
US20170369521A1 (en) 2017-12-28
CN103781795A (zh) 2014-05-07
DK2734536T3 (en) 2016-12-12
HRP20161467T1 (hr) 2017-01-27
US10844088B2 (en) 2020-11-24
SI2734536T1 (sl) 2017-01-31
EP2383279A1 (en) 2011-11-02
SMT201600464T1 (it) 2017-03-08
ES2602227T3 (es) 2017-02-20
LT2734536T (lt) 2016-12-27
CN103781795B (zh) 2016-08-17
PT2734536T (pt) 2017-01-02
CA2842035C (en) 2020-06-23

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