AR048001A1 - Hidroxi - 6 - fenilantridinas que contienen tio con actividad inhibitoria de pde4 y composiciones farmaceuticas que las contienen para el tratamiento de trastornos respiratorios. - Google Patents
Hidroxi - 6 - fenilantridinas que contienen tio con actividad inhibitoria de pde4 y composiciones farmaceuticas que las contienen para el tratamiento de trastornos respiratorios.Info
- Publication number
- AR048001A1 AR048001A1 ARP050100916A ARP050100916A AR048001A1 AR 048001 A1 AR048001 A1 AR 048001A1 AR P050100916 A ARP050100916 A AR P050100916A AR P050100916 A ARP050100916 A AR P050100916A AR 048001 A1 AR048001 A1 AR 048001A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- hydrogen
- alkoxy
- fluorine
- accordance
- Prior art date
Links
- 101100296720 Dictyostelium discoideum Pde4 gene Proteins 0.000 title abstract 2
- 101100082610 Plasmodium falciparum (isolate 3D7) PDEdelta gene Proteins 0.000 title abstract 2
- 230000002401 inhibitory effect Effects 0.000 title abstract 2
- 208000023504 respiratory system disease Diseases 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 14
- 229910052739 hydrogen Inorganic materials 0.000 abstract 10
- 239000001257 hydrogen Substances 0.000 abstract 10
- 150000002431 hydrogen Chemical class 0.000 abstract 5
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 4
- 229910052731 fluorine Inorganic materials 0.000 abstract 4
- 239000011737 fluorine Substances 0.000 abstract 4
- 125000001153 fluoro group Chemical group F* 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229910052757 nitrogen Inorganic materials 0.000 abstract 3
- -1 2,2-difluoroethoxy Chemical group 0.000 abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 150000001204 N-oxides Chemical class 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical class [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 229910052717 sulfur Chemical group 0.000 abstract 1
- 239000011593 sulfur Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/10—Aza-phenanthrenes
- C07D221/12—Phenanthridines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Psychiatry (AREA)
- Ophthalmology & Optometry (AREA)
- Otolaryngology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
Compuestos de formula (1), en donde R1, R2, R3, R31, R4, R5, R6 y R7 tienen los significados indicados en la que exhiben actividad inhibidora de PDE4 y son utiles en el tratamiento de trastornos respiratorios. Reivindicacion 1: Compuestos caracterizados porque responden a la formula (1), en donde: R1 es hidroxilo, C1-4-alcoxi, C3-7-cicloalcoxi, C3-7-cicloalquilmetoxi, 2,2-difluoroetoxi, o C1-4-alcoxi completamente o predominantemente sustituido por fluor; R2 es hidroxilo, C1-4- alcoxi, C3-7-cicloalcoxi, C3-7-cicloalquilmetoxi, 2,2-difluoroetoxi, o C1-4-alcoxi completamente o predominantemente sustituido por fluor; o en donde, R1 y R2 juntos son un grupo C1-2-alquilendioxi; R3 es hidrogeno o C1-4-alquilo; R31 es hidrogeno o C1-4-alquilo, ya sea, en una primera realizacion (realizacion a) de acuerdo con la presente; R4 es -O-R41, en donde, R41 es hidrogeno, C1-4-alquilo, C1-4-alcoxi-C1-4-alquilo, hidroxi-C2-4-alquilo, C1-7-alquilcarbonilo, o C1-4-alquilo completamente o predominantemente sustituido por fluor; y R5 es hidrogeno o C1-4-alquilo; o, en una segunda realizacion (realizacion b) de acuerdo con la presente; R4 es hidrogeno o C1-4-alquilo; y R5 es -O-R51, en donde, R51 es hidrogeno, C1-4-alquilo, C1-4-alcoxi- C1-4-alquilo, hidroxi-C2-4-alquilo, C1-7-alquilcarbonilo, o C1-4-alquilo completamente o predominantemente sustituido por fluor; R6 es hidrogeno, halogeno, C1-4-alquilo o C1-4-alcoxi, en un primer (aspecto 1) de acuerdo con la presente; R7 es - S(O)2N(R8)R9, en donde, R8 es hidrogeno, C1-4-alquilo, C1-4-alcoxi-C2-4-alquilo o C3-7-cicloalquilo; R9 es hidrogeno, C1-4-alquilo o C1-4-alcoxi-C2-4-alquilo, o R8 y R9 juntos e incluyendo el átomo de nitrogeno al que están unidos, forman un anillo heterociclo Het1, en donde, Het1 está opcionalmente sustituido por R81, y es un radical de anillo heterocíclico saturado de 3 a 7 miembros que corresponde el átomo de nitrogeno, al cual R8 y R9 están unidos, y opcionalmente un heteroátomo adicional seleccionado del grupo que consiste de oxígeno, nitrogeno y sulfuro, en donde, R81 es C1-4-alquilo; o, en un segundo aspecto (aspecto 2) de acuerdo con esta presente; R7 es -A-N(R10)S(O)2-R11, en donde, A es un enlace o C1-4-alquileno; R10 es hidrogeno o C1-4-alquilo; R11 es C1-4-alquilo, o fenilo R111-sustituido, en donde R111 es halogeno o C1-4-alquilo; o en un tercer aspecto (aspecto 3) de acuerdo con la presente; R7 es -S(O)nR12, en donde, n es 0, 1 o 2, R12 es C1-4-alquilo, y las sales, los N-oxidos y las sales de los N-oxidos de estos compuestos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04100988 | 2004-03-10 | ||
| EP05100692 | 2005-02-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR048001A1 true AR048001A1 (es) | 2006-03-15 |
Family
ID=34961402
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050100916A AR048001A1 (es) | 2004-03-10 | 2005-03-10 | Hidroxi - 6 - fenilantridinas que contienen tio con actividad inhibitoria de pde4 y composiciones farmaceuticas que las contienen para el tratamiento de trastornos respiratorios. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20080161339A1 (es) |
| EP (1) | EP1725533A1 (es) |
| JP (1) | JP2007527900A (es) |
| KR (1) | KR20060124783A (es) |
| AR (1) | AR048001A1 (es) |
| AU (1) | AU2005221831A1 (es) |
| BR (1) | BRPI0508473A (es) |
| CA (1) | CA2558390A1 (es) |
| IL (1) | IL177499A0 (es) |
| NO (1) | NO20064416L (es) |
| TW (1) | TW200540159A (es) |
| WO (1) | WO2005087744A1 (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003273805B8 (en) | 2002-08-29 | 2010-06-17 | Takeda Gmbh | 3-hydroxy-6-phenylphenanthridines as PDE-4 inhibitors |
| CA2556086C (en) | 2004-02-18 | 2014-04-01 | Altana Pharma Ag | Novel guanidinyl-substituted hydroxy-6-phenylphenenthridines as effective phosphodiesterase (pde) 4 inhibitors |
| EP1723135B1 (en) | 2004-03-03 | 2013-06-19 | Takeda GmbH | Novel hydroxy-6-heroarylphenanthridines and their use as pde4 inhibitors |
| AR049419A1 (es) * | 2004-03-03 | 2006-08-02 | Altana Pharma Ag | Hidroxi-6-fenilfenantridinas sustituidas con heterociclilo |
| MXPA06009892A (es) * | 2004-03-10 | 2007-03-01 | Altana Pharma Ag | Nuevas hidroxi-6-fenilfenantridinas sustituidas con amido y su uso como inhibidores de la fosfodiesterasa tipo 4 (pde4). |
| DK1856093T3 (da) | 2005-03-02 | 2010-03-15 | Nycomed Gmbh | (2R,4aR,10bR)-6-(2,6-dimethoxypyridin-3-yl)-9-ethoxy-8-methoxy-1,2,3,4,4a,10b-hexahydrophenanthridin-2-ol, HCI-salt |
| GB0601951D0 (en) | 2006-01-31 | 2006-03-15 | Novartis Ag | Organic compounds |
| BRPI0718266A2 (pt) | 2006-10-30 | 2014-01-07 | Novartis Ag | Compostos heterocíclicos como agentes anti-inflamatórios. |
| ES2460897T3 (es) | 2007-10-04 | 2014-05-14 | F. Hoffmann-La Roche Ag | Derivados de ciclopropil aril amida y usos de los mismos |
| PT2231642E (pt) | 2008-01-11 | 2014-03-12 | Novartis Ag | Pirimidinas como inibidores de quinase |
| US8637516B2 (en) | 2010-09-09 | 2014-01-28 | Irm Llc | Compounds and compositions as TRK inhibitors |
| WO2012034095A1 (en) | 2010-09-09 | 2012-03-15 | Irm Llc | Compounds and compositions as trk inhibitors |
| EA201391230A1 (ru) | 2011-02-25 | 2014-01-30 | АйАрЭм ЭлЭлСи | Соединения и композиции в качестве ингибиторов trk |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ289340B6 (cs) * | 1996-01-31 | 2002-01-16 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Fenanthridinové deriváty a farmaceutický prostředek s jejich obsahem |
| ES2184077T3 (es) * | 1996-03-26 | 2003-04-01 | Altana Pharma Ag | Nuevas fenantridinas sustituidas en la posicion 6. |
| US6127378A (en) * | 1996-03-26 | 2000-10-03 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Phenanthridines substituted in the 6 position |
| US6121279A (en) * | 1997-07-25 | 2000-09-19 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Substituted 6-phenylphenanthridines |
| EP0998460B1 (en) * | 1997-07-25 | 2004-03-03 | ALTANA Pharma AG | Novel tetrazole derivatives |
| JP2002513793A (ja) * | 1998-05-05 | 2002-05-14 | ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング | 新規ｎ−オキシド |
| SI1147089T1 (sl) * | 1999-01-15 | 2006-04-30 | Altana Pharma Ag | Fenilfenantridini z inhibirajoco aktivnostjo za PDE-IV |
| JP4587294B2 (ja) * | 2002-08-29 | 2010-11-24 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｐｄｅ４インヒビターとしての２−ヒドロキシ−６−フェニルフェナントリジン |
-
2005
- 2005-03-09 CA CA002558390A patent/CA2558390A1/en not_active Abandoned
- 2005-03-09 WO PCT/EP2005/051052 patent/WO2005087744A1/en not_active Ceased
- 2005-03-09 AU AU2005221831A patent/AU2005221831A1/en not_active Abandoned
- 2005-03-09 JP JP2007502342A patent/JP2007527900A/ja not_active Withdrawn
- 2005-03-09 EP EP05716969A patent/EP1725533A1/en not_active Withdrawn
- 2005-03-09 BR BRPI0508473-3A patent/BRPI0508473A/pt not_active IP Right Cessation
- 2005-03-09 US US10/591,768 patent/US20080161339A1/en not_active Abandoned
- 2005-03-09 KR KR1020067020591A patent/KR20060124783A/ko not_active Withdrawn
- 2005-03-10 AR ARP050100916A patent/AR048001A1/es unknown
- 2005-03-10 TW TW094107371A patent/TW200540159A/zh unknown
-
2006
- 2006-08-15 IL IL177499A patent/IL177499A0/en unknown
- 2006-09-29 NO NO20064416A patent/NO20064416L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2007527900A (ja) | 2007-10-04 |
| US20080161339A1 (en) | 2008-07-03 |
| EP1725533A1 (en) | 2006-11-29 |
| AU2005221831A1 (en) | 2005-09-22 |
| CA2558390A1 (en) | 2005-09-22 |
| WO2005087744A1 (en) | 2005-09-22 |
| BRPI0508473A (pt) | 2007-07-31 |
| TW200540159A (en) | 2005-12-16 |
| WO2005087744A8 (en) | 2006-10-26 |
| NO20064416L (no) | 2006-12-07 |
| KR20060124783A (ko) | 2006-12-05 |
| IL177499A0 (en) | 2006-12-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR048001A1 (es) | Hidroxi - 6 - fenilantridinas que contienen tio con actividad inhibitoria de pde4 y composiciones farmaceuticas que las contienen para el tratamiento de trastornos respiratorios. | |
| PE20120357A1 (es) | Derivados de benzofurano | |
| EA200970510A1 (ru) | Гетеромоноциклическое соединение и его применение | |
| AR062409A1 (es) | Compuesto y composicion farmaceutica, utiles como agentes terapeuticos en el tratamiento, prevencion o mejoramiento de enfermedad o trastorno caracterizado por depositos o niveles de b-amiloide elevados o para inhibir o elucidar la enzima b-secretasa, y proceso para la preparacion del compuesto | |
| PE20121471A1 (es) | Derivados de sulfonamida heterociclicos utiles como inhibidores de mek | |
| CY1118969T1 (el) | Ενωσεις πυριμιδινο-2-αμινης και η χρηση τους ως αναστολεις των κινασων jak | |
| PE20190711A1 (es) | N-(fenils ulfonil) benzamidas y compuestos relacionados como inhibidores de bcl-2 | |
| BRPI0612888B8 (pt) | anilino-piridinotriazinas cíclicas como inibidoras de gsk-3, seus usos e composição farmacêutica, intermediário, seu uso e composição farmacêutica | |
| ECSP099728A (es) | Compuestos amino-heterocíclicos | |
| BRPI0616574A2 (pt) | derivado de sulfonamida tendo atividade antagonìstica de receptor de pgd2 | |
| AR083842A1 (es) | Derivados de 2,3-dihidroimidazo[1,2-c]quinazolina sustituidos con aminoalcoholes que son de utilidad para tratar trastornos hiperproliferativos y enfermedades asociadas a las angiogenesis | |
| AR071577A1 (es) | Pirazolo-pirimidinona para el tratamiento de trastornos del sistema nervioso central | |
| UY28578A1 (es) | Derivados de amida | |
| AR083849A1 (es) | Antagonistas de mdm2 de espiro-oxindol | |
| EA201270666A1 (ru) | Соединения и фармацевтические композиции для снижения уровня мочевой кислоты | |
| BRPI0513750A (pt) | 2-fenilamino-benzamidas-5-substituìdas como inibidoras de mek | |
| NI200300053A (es) | Derivados del tropano utiles en terapia. | |
| AR036032A1 (es) | Compuesto derivado de quinolina, composicion que lo comprende; uso del mismo en la fabricacion de medicamentos, proceso para prepararlo, y metodo para detectar y seleccionar un agente que module la actividad del mif | |
| EA202192553A1 (ru) | Protac, расщепляющие рецептор эстрогена | |
| PA8614301A1 (es) | Derivados de tropano | |
| EA200870360A1 (ru) | Бензимидазолы, обладающие активностью в отношении рецепторов м1, и их применение в медицине | |
| DE60206911D1 (de) | Imidazol-2-carbonsäureamid derivate als raf-kinase-inhibitoren | |
| BRPI0408591A (pt) | derivados de 6,7,8,9-tetrahidropirimido[1,2-a] pirimidin-4-ona 8-substituìda | |
| AR066103A1 (es) | Derivados de triazolopiridin - carboxamidas, su preparacion y su aplicacion en terapeutica | |
| BRPI0408605A (pt) | derivados de 8-perfluoralquil-6,7,8,9-tetrahidropirimido[1,2-a]piri midin-4-ona substituìdos |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |