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AR046982A1 - Derivados de 1-piperazin- y 1-homopiperazin-carboxilatos, su preparacion y su aplicacion en terapeutica - Google Patents

Derivados de 1-piperazin- y 1-homopiperazin-carboxilatos, su preparacion y su aplicacion en terapeutica

Info

Publication number
AR046982A1
AR046982A1 ARP040104843A ARP040104843A AR046982A1 AR 046982 A1 AR046982 A1 AR 046982A1 AR P040104843 A ARP040104843 A AR P040104843A AR P040104843 A ARP040104843 A AR P040104843A AR 046982 A1 AR046982 A1 AR 046982A1
Authority
AR
Argentina
Prior art keywords
group
cycloalkyl
alkylene
atom
alkyl
Prior art date
Application number
ARP040104843A
Other languages
English (en)
Inventor
Ahmed Abouabdellah
Garcia Antonio Almario
Christian Hoornaert
Adrien Tak Li
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of AR046982A1 publication Critical patent/AR046982A1/es

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    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
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    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Compuesto que responde a la formula general (1) en la cual m representa un numero entero igual a 1 o 2; R1 representa un grupo de tipo arilo o heteroarilo, eventualmente constituido por uno o varios grupos R3 o R4; R2 representa un grupo de formula general CHR5CONHR6, R3 representa un átomo de halogeno o un grupo hidroxi, ciano, nitro, alquilo C1-6, alcoxi C1-6, tioalquilo C1-6, fluoroalquilo C1-6, fluoroalcoxi C1-6, -O-(alquileno C2-3)-, -O-(alquileno C1-3)-O-, fluorotioalquilo C1-6, cicloalquilo C3-7, cicloalquilo C3-7-alquileno C1-3, piperidinilo benciloxi, piperazinilo, pirrolidinilo, morfolinilo, feniloxi, NR7R8, NHCOR7, NHSO2R7, COR7, CO2R7, CONR7R8, SO2R7 o SO2NR7R8, R4 representa un grupo arilo o heteroarilo; el o los grupos R4 pueden sustituirse por uno o varios grupos R3 idénticos o diferentes entre sí; R5 representa un átomo de H o un grupo alquilo C1-3; R6 representa un átomo de H o un grupo alquilo C1-6, cicloalquilo C3-7 o cicloalquilo C3-7-alquileno C1-3; R7 y R8 representan, independientemente entre sí, un átomo de H, un grupo alquilo C1-3 o un grupo fenilo; en estado de base, de sal de adicion con un ácido, de hidrato o de solvato. Aplicacion en terapéutica.
ARP040104843A 2003-12-23 2004-12-22 Derivados de 1-piperazin- y 1-homopiperazin-carboxilatos, su preparacion y su aplicacion en terapeutica AR046982A1 (es)

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FR0315248A FR2864080B1 (fr) 2003-12-23 2003-12-23 Derives de 1-piperazine-et-1-homopiperazine-carboxylates, leur preparation et leur application en therapeutique

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AU2006215080B2 (en) 2005-02-17 2011-03-10 Astellas Pharma Inc. Pyridyl non-aromatic nitrogenated heterocyclic-1-carboxylate ester derivative
US7541359B2 (en) 2005-06-30 2009-06-02 Janssen Pharmaceutica N.V. N-heteroarylpiperazinyl ureas as modulators of fatty acid amide hydrolase
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