AR046309A1 - Derivados de dihidrobenzofuranilo alcanamina, metodos para su preparacion, composiciones farmaceuticas que los contienen y su uso en el tratamiento de trastornos del sistema nervioso central. - Google Patents
Derivados de dihidrobenzofuranilo alcanamina, metodos para su preparacion, composiciones farmaceuticas que los contienen y su uso en el tratamiento de trastornos del sistema nervioso central.Info
- Publication number
- AR046309A1 AR046309A1 ARP040103868A ARP040103868A AR046309A1 AR 046309 A1 AR046309 A1 AR 046309A1 AR P040103868 A ARP040103868 A AR P040103868A AR P040103868 A ARP040103868 A AR P040103868A AR 046309 A1 AR046309 A1 AR 046309A1
- Authority
- AR
- Argentina
- Prior art keywords
- formula
- compound
- cycloalkyl
- alkyl
- independently
- Prior art date
Links
- 208000015114 central nervous system disease Diseases 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 13
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 4
- 229910052760 oxygen Inorganic materials 0.000 abstract 4
- 125000005010 perfluoroalkyl group Chemical group 0.000 abstract 4
- 150000003839 salts Chemical class 0.000 abstract 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 3
- 229920001774 Perfluoroether Polymers 0.000 abstract 3
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 2
- 125000001313 C5-C10 heteroaryl group Chemical group 0.000 abstract 2
- PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- -1 cyano, hydroxyl Chemical group 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 229920006395 saturated elastomer Polymers 0.000 abstract 2
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 abstract 2
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 1
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 abstract 1
- 125000000172 C5-C10 aryl group Chemical group 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000005119 alkyl cycloalkyl group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000005518 carboxamido group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 230000002490 cerebral effect Effects 0.000 abstract 1
- KXZJHVJKXJLBKO-UHFFFAOYSA-N chembl1408157 Chemical compound N=1C2=CC=CC=C2C(C(=O)O)=CC=1C1=CC=C(O)C=C1 KXZJHVJKXJLBKO-UHFFFAOYSA-N 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 239000004031 partial agonist Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
- 229940076279 serotonin Drugs 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Anesthesiology (AREA)
- Gynecology & Obstetrics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Furan Compounds (AREA)
Abstract
Los compuestos de la presente actúan como agonistas o agonistas parciales de los receptores del subtipo 2c de la serotonina cerebral. Los compuestos, y composiciones que contienen los compuestos, se pueden utilizar para tratar una variedad de trastornos del sistema nervioso central tales como esquizofrenia. Reivindicación 1: Un compuesto de la fórmula (1) o una sal farmacéuticamente aceptable del mismo, donde: R y R' son, independientemente, H, alquilo C1-6, cicloalquilo C3-6, o alquilcicloalquilo C4-12 que tiene de 3 a 6 C en el anillo cicloalquilo; alternativamente R y R' se pueden tomar juntos con el N al que están adheridos para formar un anillo que contiene de 2 a 5 átomos de C, donde uno de los átomos de C del anillo está sustituido opcionalmente por N, S u O. R1 y R2 son, cada uno, independientemente, H, alquilo C1-6, cicloalquilo C3-6, o perfluoroalquilo C1-6; R3a y R3b son, independientemente, H, halógeno, hidroxilo, alquilo C1-6, cicloalquilo C3-6, perfluoroalquilo C1-6, alcoxi C1-6, o perfluoroalcoxi C1-6; R4, R5, R6 y R7 son, independientemente, H, halógeno, ciano, hidroxilo, carboxilo, alquilo C1-8, perfluoroalquilo C1-6, alcoxi C1-6, perfluoroalcoxi C1-6, arilo C5-10, ariloxi C5-10, un heteroarilo de 5 a 10 miembros que tienen de 1 a 3 heteroátomos cada uno de ellos seleccionado independientemente entre N, O, o S, alquenilo C2-8, alcanoilo C2-6, alcanoiloxi C2-6, carboalcoxi C2-6, carboxamido, alcanamido C2-6, alcanosulfonamido C1- 6, amino, monoalquilamino C1-6, dialquilamino C1-6, por estructura de alquilo, cicloalquilo C3-8, o un heterocicloalquilo de 3 a 8 miembros que tienen de 1 a 3 heteroátomos cada uno de ellos seleccionado independientemente entre N, O, o S, donde los grupos cicloalquilo y heterocicloalquilo están saturados o parcialmente saturados; y n es 1, 2 ó 3; donde al menos uno de R4, R5, R6 y R7 es un alquilo ramificado C3-8, un alquenilo ramificado C3-8, o -Y-R8, donde Y está seleccionado entre un enlace directo, un alquilo inferior, un alquenilo inferior, u O, y NH y R8 es un arilo C5-10, un heteroarilo de 5 a 10 miembros, un cicloalquilo C3-8, o un heterocicloalquilo de 3 a 8 miembros; y donde cualquier arilo, heteroarilo, cicloalquilo o heterocicloalquilo puede estar opcionalmente sustituido con de 1 a 5 sustituyentes seleccionados independientemente entre halógeno, hidroxilo, ciano, alquilo C1-6, perfluoroalquilo C1-6, alcoxi C1-6, o perfluoroalcoxi C1-6. Reivindicación 46: Un proceso para preparar un compuesto de fórmula (1) o una sal farmacéuticamente aceptable del mismo como se indica en la reivindicación 1 que comprende uno de los siguientes: a) hacer reaccionar un compuesto de fórmula (2) donde R1, R2, R3, R4, R5, R6 y R7 son como se definen en la reivindicación 1, con azida sódica y reducir el producto para proporcionar un compuesto de fórmula (1) donde n es 1 y R y R' son ambos H; o b) hacer reaccionar un compuesto de fórmula (2) como se define más arriba con una amina de fórmula NHRR' donde R y R' son como se definen en la reivindicación 1 para proporcionar un compuesto correspondiente de fórmula (1) donde n es 1; o c) hacer reaccionar un compuesto de fórmula (2) como se define más arriba con cianuro sódico seguido de reducción para proporcionar un compuesto de fórmula (1) donde n es 2 y R y R' son ambos H; d) convertir un compuesto de fórmula (1) como se define en la reivindicación 1 en una sal farmacéuticamente aceptable o viceversa, o e) aislar un enantiómero o diastereómero específico de un compuesto de fórmula (1) o una sal farmacéuticamente aceptable del mismo como se define en la reivindicación 1 a partir de una mezcla del mismo.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51445403P | 2003-10-24 | 2003-10-24 | |
| US10/970,714 US7435837B2 (en) | 2003-10-24 | 2004-10-21 | Dihydrobenzofuranyl alkanamine derivatives and methods for using same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR046309A1 true AR046309A1 (es) | 2005-11-30 |
Family
ID=34576747
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP040103868A AR046309A1 (es) | 2003-10-24 | 2004-10-25 | Derivados de dihidrobenzofuranilo alcanamina, metodos para su preparacion, composiciones farmaceuticas que los contienen y su uso en el tratamiento de trastornos del sistema nervioso central. |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US7435837B2 (es) |
| EP (1) | EP1675840A1 (es) |
| JP (1) | JP2007509174A (es) |
| KR (1) | KR20060092257A (es) |
| CN (1) | CN1997635A (es) |
| AR (1) | AR046309A1 (es) |
| AU (1) | AU2004287809A1 (es) |
| BR (1) | BRPI0415657A (es) |
| CA (1) | CA2542878A1 (es) |
| CR (1) | CR8349A (es) |
| EC (1) | ECSP066520A (es) |
| IL (1) | IL174953A0 (es) |
| MX (1) | MXPA06004409A (es) |
| NO (1) | NO20062139L (es) |
| PA (1) | PA8615701A1 (es) |
| PE (1) | PE20050482A1 (es) |
| RU (1) | RU2006117789A (es) |
| TW (1) | TW200526615A (es) |
| WO (1) | WO2005044812A1 (es) |
| ZA (1) | ZA200603233B (es) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7435837B2 (en) | 2003-10-24 | 2008-10-14 | Wyeth | Dihydrobenzofuranyl alkanamine derivatives and methods for using same |
| US20050261347A1 (en) * | 2003-10-24 | 2005-11-24 | Wyeth | Dihydrobenzofuranyl alkanamine derivatives and methods for using same |
| WO2005082863A2 (en) * | 2004-02-26 | 2005-09-09 | Bayer Healthcare Ag | 1,4 diaryl-dihydropyrimidin-2 ones and their use as a human neutrophil elastase inhibitors |
| WO2005082864A1 (en) * | 2004-02-26 | 2005-09-09 | Bayer Healthcare Ag | 1,4-diaryl-dihydropyrimidin-2-ones and their use as human neutrophil elastase inhibitors |
| WO2006000902A1 (en) * | 2004-06-25 | 2006-01-05 | Pfizer Products Inc. | Dihydrobenzofuran compounds and uses thereof |
| US8685924B2 (en) | 2004-08-25 | 2014-04-01 | Takeda Pharmaceutical Company Limited | Preventives/remedies for stress urinary incontinence and method of screening the same |
| GT200500297A (es) * | 2004-10-21 | 2006-10-27 | Sintesis asimetrica de dehidrobenzofuranos sustituidos | |
| GT200500296A (es) * | 2004-10-21 | 2006-10-02 | Sintesis asimetrica de derivados del dehidrobenzofurano | |
| CN101198323A (zh) * | 2005-04-22 | 2008-06-11 | 惠氏公司 | 用于治疗或预防精神障碍的治疗组合 |
| JP2008538571A (ja) * | 2005-04-22 | 2008-10-30 | ワイス | ジヒドロベンゾフラン誘導体およびその使用 |
| JP2008536946A (ja) * | 2005-04-22 | 2008-09-11 | ワイス | うつ病の処置または予防のための新規の治療的組み合わせ |
| TW200716595A (en) | 2005-04-22 | 2007-05-01 | Wyeth Corp | Chromane and chromene derivatives and uses thereof |
| CN101203216A (zh) * | 2005-04-22 | 2008-06-18 | 惠氏公司 | 二氢苯并呋喃衍生物及其用途 |
| WO2006116148A2 (en) * | 2005-04-22 | 2006-11-02 | Wyeth | (7-arlysubstituted 2, 3-dihydr0-1-benz0furan-2-yl) alkylamines in the treatment' of substance abuse |
| AU2006239920A1 (en) * | 2005-04-22 | 2006-11-02 | Wyeth | Dihydrobenzofuran derivatives and uses thereof |
| MX2007013179A (es) * | 2005-04-22 | 2008-01-16 | Wyeth Corp | Formas cristalinas de clorhidrato de {[(2r)-7-(diclorofenil)-5- fluoro-2,3-dihidro-1-benzofurano-2-il]metil}amina. |
| CN101189004A (zh) * | 2005-04-22 | 2008-05-28 | 惠氏公司 | 疼痛的治疗 |
| CN101203218A (zh) * | 2005-04-22 | 2008-06-18 | 惠氏公司 | 苯并呋喃基链烷胺衍生物和其作为5－ht2c激动剂的用途 |
| JP2008538784A (ja) * | 2005-04-24 | 2008-11-06 | ワイス | 膀胱機能を調節するための方法 |
| US20090203750A1 (en) * | 2005-08-24 | 2009-08-13 | Alan Kozikowski | 5-HT2C Receptor Agonists as Anorectic Agents |
| WO2007112065A2 (en) * | 2006-03-24 | 2007-10-04 | Wyeth | Methods for treating cognitive and other disorders |
| JP5528699B2 (ja) | 2006-05-16 | 2014-06-25 | 武田薬品工業株式会社 | 縮合複素環化合物およびその用途 |
| CL2007003043A1 (es) * | 2006-10-24 | 2008-05-30 | Wyeth Corp | Compuestos derivados de cromano; composicion farmaceutica que los comprende; y uso para el tratamiento de un trastorno psicotico, bipolar, depresivo y ansiedad entre otros. |
| PE20081139A1 (es) * | 2006-10-25 | 2008-09-18 | Wyeth Corp | Derivados de cromano, su sintesis e intermediarios |
| JP5520051B2 (ja) | 2007-11-15 | 2014-06-11 | 武田薬品工業株式会社 | 縮合ピリジン誘導体およびその用途 |
| CN102421767B (zh) | 2009-03-10 | 2014-06-18 | 武田药品工业株式会社 | 苯并呋喃衍生物 |
| US20120253036A1 (en) | 2009-12-11 | 2012-10-04 | Yukinori Nagakura | Agent for treating fibromyalgia |
| WO2011097336A2 (en) | 2010-02-04 | 2011-08-11 | The Board Of Trustees Of The University Of Illinois | Highly selective 5-ht(2c) receptor agonists having antagonist activity at the 5-ht(2b) receptor |
| WO2012030953A1 (en) | 2010-09-01 | 2012-03-08 | Arena Pharmaceuticals, Inc. | 5-ht2c receptor agonists in the treatment of disorders ameliorated by reduction of norepinephrine level |
| WO2012087289A1 (en) | 2010-12-21 | 2012-06-28 | Colgate-Palmolive Company | Halogenated biphenols as antibacterial agents |
| CN103242273B (zh) * | 2012-02-09 | 2015-06-03 | 中国科学院上海药物研究所 | 2-芳基苯并呋喃-7-甲酰胺类化合物、其制备方法及用途 |
| WO2015066344A1 (en) | 2013-11-01 | 2015-05-07 | Arena Pharmaceuticals, Inc. | 5-ht2c receptor agonists and compositions and methods of use |
| EP3250549B1 (en) | 2015-01-29 | 2021-06-23 | The Board of Trustees of the University of Illinois | Cyclopropylmethanamines as selective 5-ht(2c) receptor agonists |
| CN108084125B (zh) * | 2016-11-23 | 2020-08-18 | 华东理工大学 | 苯并杂环烷基胺类化合物及其用途 |
| JP7337797B2 (ja) * | 2017-11-16 | 2023-09-04 | シンジェンタ パーティシペーションズ アーゲー | 鏡像異性的に及びジアステレオマー的に富化したシクロブタンアミン及びアミドの調製方法 |
| JPWO2019131902A1 (ja) | 2017-12-27 | 2020-12-10 | 武田薬品工業株式会社 | 腹圧性尿失禁および便失禁の治療薬 |
| EP3878447A1 (en) | 2020-03-11 | 2021-09-15 | InterAx Biotech AG | Beta adrenergic receptor antagonists |
| US12191004B2 (en) | 2022-06-27 | 2025-01-07 | Microsoft Technology Licensing, Llc | Machine learning system with two encoder towers for semantic matching |
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| GB1200892A (en) | 1966-10-27 | 1970-08-05 | Ward Blenkinsop & Co Ltd | Production of 2-aminomethyl-2,3-dihydrobenzofurans |
| US3513239A (en) | 1967-03-15 | 1970-05-19 | Smithkline Corp | Pharmaceutical compositions containing 2-aminoalkyl coumaran derivatives and methods of treating depression therewith |
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| AU520682B2 (en) | 1977-06-30 | 1982-02-18 | Shell Internationale Research Maatschappij Bv | Lipogensis inhibitors |
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| US4706551A (en) | 1984-09-20 | 1987-11-17 | Schofield Paul S | Enclosure |
| GB8515388D0 (en) | 1985-06-18 | 1985-07-17 | Ici Plc | Heterocyclic compounds |
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-
2004
- 2004-10-21 US US10/970,714 patent/US7435837B2/en not_active Expired - Fee Related
- 2004-10-22 JP JP2006536881A patent/JP2007509174A/ja not_active Withdrawn
- 2004-10-22 CA CA002542878A patent/CA2542878A1/en not_active Abandoned
- 2004-10-22 TW TW093132199A patent/TW200526615A/zh unknown
- 2004-10-22 RU RU2006117789/04A patent/RU2006117789A/ru not_active Application Discontinuation
- 2004-10-22 KR KR1020067007874A patent/KR20060092257A/ko not_active Withdrawn
- 2004-10-22 PA PA20048615701A patent/PA8615701A1/es unknown
- 2004-10-22 AU AU2004287809A patent/AU2004287809A1/en not_active Withdrawn
- 2004-10-22 CN CNA2004800383041A patent/CN1997635A/zh not_active Withdrawn
- 2004-10-22 BR BRPI0415657-9A patent/BRPI0415657A/pt not_active IP Right Cessation
- 2004-10-22 MX MXPA06004409A patent/MXPA06004409A/es unknown
- 2004-10-22 EP EP04796293A patent/EP1675840A1/en not_active Withdrawn
- 2004-10-22 WO PCT/US2004/035280 patent/WO2005044812A1/en not_active Ceased
- 2004-10-25 PE PE2004001025A patent/PE20050482A1/es not_active Application Discontinuation
- 2004-10-25 AR ARP040103868A patent/AR046309A1/es not_active Application Discontinuation
-
2006
- 2006-04-11 IL IL174953A patent/IL174953A0/en unknown
- 2006-04-20 CR CR8349A patent/CR8349A/es not_active Application Discontinuation
- 2006-04-21 ZA ZA200603233A patent/ZA200603233B/xx unknown
- 2006-04-24 EC EC2006006520A patent/ECSP066520A/es unknown
- 2006-05-12 NO NO20062139A patent/NO20062139L/no not_active Application Discontinuation
-
2008
- 2008-09-15 US US12/210,568 patent/US20090082434A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0415657A (pt) | 2006-12-19 |
| AU2004287809A1 (en) | 2005-05-19 |
| CR8349A (es) | 2007-06-06 |
| NO20062139L (no) | 2006-07-21 |
| TW200526615A (en) | 2005-08-16 |
| CN1997635A (zh) | 2007-07-11 |
| PE20050482A1 (es) | 2005-10-13 |
| US20050143452A1 (en) | 2005-06-30 |
| WO2005044812A1 (en) | 2005-05-19 |
| ZA200603233B (en) | 2008-11-26 |
| US7435837B2 (en) | 2008-10-14 |
| ECSP066520A (es) | 2006-10-10 |
| MXPA06004409A (es) | 2007-01-26 |
| RU2006117789A (ru) | 2007-11-27 |
| PA8615701A1 (es) | 2005-11-25 |
| JP2007509174A (ja) | 2007-04-12 |
| US20090082434A1 (en) | 2009-03-26 |
| KR20060092257A (ko) | 2006-08-22 |
| EP1675840A1 (en) | 2006-07-05 |
| IL174953A0 (en) | 2006-08-20 |
| CA2542878A1 (en) | 2005-05-19 |
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