AR046153A1 - Agonistas kappa - Google Patents
Agonistas kappaInfo
- Publication number
- AR046153A1 AR046153A1 ARP040102408A ARP040102408A AR046153A1 AR 046153 A1 AR046153 A1 AR 046153A1 AR P040102408 A ARP040102408 A AR P040102408A AR P040102408 A ARP040102408 A AR P040102408A AR 046153 A1 AR046153 A1 AR 046153A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- mono
- hal
- cycloalkyl
- so3r
- Prior art date
Links
- 239000000556 agonist Substances 0.000 title 1
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 4
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 3
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 2
- 125000000041 C6-C10 aryl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000002551 irritable bowel syndrome Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Los compuestos de la fórmula (1), en donde significan: A es un sistema de anillos mono o bicíclico aromático o no aromático carba- o heterocíclico insustituido o mono o polisustituido con R1; R1 es H, Hal, NO2, NHR, NRR, OR, CO-R, SO3R, SO2R, SR, CF3, OCF3, SCF3, alquilo C1-8, cicloalquilo C3-14; R2 es H, Hal, NO2, NHR, NRR, OR, CO-R, SO3R, SO2R, SR, CF3, OCF3, SCF3, alquilo C1-8, cicloalquilo C3-14; R3 es alquilo C1-8; X es CO, CS, SO2; Y es un enlace simple, O, NH, CH2; R es H o un grupo alquilo C1-8, cicloalquilo C3-14, arilo C6-10 o aralquilo C7-14, que puede estar mono o polisustituido con R5 y cuya cadena C de alquilo puede estar interrumpida por -O-; Hal es F, Cl, Br o I; m es 0, 1, 2, 3 ó 4; y n es 0, 1, 2 ó 3; así como sus derivados, solvatos y estereoisómeros de utilidad farmacéutica, excluyendo sus mezclas en todas las proporciones, son apropiados como para el tratamiento del síndrome de intestino irritable.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10331723A DE10331723A1 (de) | 2003-07-11 | 2003-07-11 | Kappa-Agonisten |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR046153A1 true AR046153A1 (es) | 2005-11-30 |
Family
ID=34071646
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP040102408A AR046153A1 (es) | 2003-07-11 | 2004-07-08 | Agonistas kappa |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20060178426A1 (es) |
| EP (1) | EP1644327A1 (es) |
| JP (1) | JP2007506677A (es) |
| KR (1) | KR20060030895A (es) |
| CN (1) | CN1819994A (es) |
| AR (1) | AR046153A1 (es) |
| AU (1) | AU2004256892A1 (es) |
| BR (1) | BRPI0412451A (es) |
| CA (1) | CA2531817A1 (es) |
| DE (1) | DE10331723A1 (es) |
| MX (1) | MXPA06000366A (es) |
| RU (1) | RU2006104024A (es) |
| WO (1) | WO2005007626A1 (es) |
| ZA (1) | ZA200601228B (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2170930B3 (en) | 2007-06-04 | 2013-10-02 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| JP2011522828A (ja) | 2008-06-04 | 2011-08-04 | シナジー ファーマシューティカルズ インコーポレイテッド | 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト |
| EP2321341B1 (en) | 2008-07-16 | 2017-02-22 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
| US20100221329A1 (en) | 2008-12-03 | 2010-09-02 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase c agonists and methods of use |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| CN103764672A (zh) | 2011-03-01 | 2014-04-30 | 辛纳吉制药公司 | 制备鸟苷酸环化酶c激动剂的方法 |
| US9708367B2 (en) | 2013-03-15 | 2017-07-18 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase and their uses |
| CA2905435A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
| RS65632B1 (sr) | 2013-06-05 | 2024-07-31 | Bausch Health Ireland Ltd | Ultra-prečišćeni agonisti guanilat-ciklaze c, postupak njihove pripreme i upotrebe |
| US9815824B2 (en) | 2013-06-28 | 2017-11-14 | Nektar Therapeutics | Kappa opioid agonists and uses thereof |
| US20150080466A1 (en) * | 2013-09-19 | 2015-03-19 | Allergan, Inc. | Diphenyl urea derivatives as formyl peptide receptor modulators |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4034785A1 (de) * | 1990-11-02 | 1992-05-07 | Merck Patent Gmbh | 1-(2-arylethyl)-pyrrolidine |
| US6303611B1 (en) * | 1996-03-08 | 2001-10-16 | Adolor Corporation | Kappa agonist compounds and pharmaceutical formulations thereof |
| AU7133098A (en) * | 1997-04-30 | 1998-11-24 | Warner-Lambert Company | Kappa opioid agonists |
| DE19849650A1 (de) * | 1998-10-29 | 2000-05-04 | Merck Patent Gmbh | Kappa-Opiatagonisten für die Behandlung des Irritable Bowel Syndroms (IBS) |
-
2003
- 2003-07-11 DE DE10331723A patent/DE10331723A1/de not_active Withdrawn
-
2004
- 2004-06-18 MX MXPA06000366A patent/MXPA06000366A/es not_active Application Discontinuation
- 2004-06-18 CN CNA2004800197796A patent/CN1819994A/zh active Pending
- 2004-06-18 WO PCT/EP2004/006630 patent/WO2005007626A1/de not_active Ceased
- 2004-06-18 AU AU2004256892A patent/AU2004256892A1/en not_active Abandoned
- 2004-06-18 US US10/563,975 patent/US20060178426A1/en not_active Abandoned
- 2004-06-18 BR BRPI0412451-0A patent/BRPI0412451A/pt not_active Application Discontinuation
- 2004-06-18 JP JP2006519787A patent/JP2007506677A/ja active Pending
- 2004-06-18 KR KR1020067000254A patent/KR20060030895A/ko not_active Withdrawn
- 2004-06-18 EP EP04740074A patent/EP1644327A1/de not_active Withdrawn
- 2004-06-18 RU RU2006104024/04A patent/RU2006104024A/ru not_active Application Discontinuation
- 2004-06-18 CA CA002531817A patent/CA2531817A1/en not_active Abandoned
- 2004-07-08 AR ARP040102408A patent/AR046153A1/es unknown
-
2006
- 2006-02-10 ZA ZA200601228A patent/ZA200601228B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20060178426A1 (en) | 2006-08-10 |
| CN1819994A (zh) | 2006-08-16 |
| BRPI0412451A (pt) | 2006-09-19 |
| WO2005007626A1 (de) | 2005-01-27 |
| RU2006104024A (ru) | 2006-07-27 |
| ZA200601228B (en) | 2007-05-30 |
| DE10331723A1 (de) | 2005-06-16 |
| JP2007506677A (ja) | 2007-03-22 |
| EP1644327A1 (de) | 2006-04-12 |
| KR20060030895A (ko) | 2006-04-11 |
| MXPA06000366A (es) | 2006-03-28 |
| AU2004256892A1 (en) | 2005-01-27 |
| CA2531817A1 (en) | 2005-01-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |