AR063374A1 - Derivados de benzoxazina y sus usos - Google Patents
Derivados de benzoxazina y sus usosInfo
- Publication number
- AR063374A1 AR063374A1 ARP070104706A ARP070104706A AR063374A1 AR 063374 A1 AR063374 A1 AR 063374A1 AR P070104706 A ARP070104706 A AR P070104706A AR P070104706 A ARP070104706 A AR P070104706A AR 063374 A1 AR063374 A1 AR 063374A1
- Authority
- AR
- Argentina
- Prior art keywords
- independently selected
- independently
- nhso2r
- so2r
- ocf3
- Prior art date
Links
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 239000001301 oxygen Chemical group 0.000 abstract 2
- 229910052717 sulfur Chemical group 0.000 abstract 2
- 239000011593 sulfur Chemical group 0.000 abstract 2
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 abstract 1
- 102000040125 5-hydroxytryptamine receptor family Human genes 0.000 abstract 1
- 108091032151 5-hydroxytryptamine receptor family Proteins 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000002619 bicyclic group Chemical group 0.000 abstract 1
- 210000004556 brain Anatomy 0.000 abstract 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000004031 partial agonist Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Son agonistas o agonistas parciales del subtipo 2C de los receptores cerebrales de serotonina. Los compuestos y sus composiciones son utiles para tratar una variedad de trastornos del SNC tales como esquizofrenia. Reivindicacion 1: Un compuesto de formula (1) o su sal aceptable para uso farmacéutico donde n es 1 o 2; uno de X y Z es -O- y el otro de X y Z es -NR5-; Ar es fenilo, un anillo arilo bicíclico de 8-10 miembros, un anillo heteroarilo monocíclico de 5-6 miembros que tiene 1-4 heteroátomos seleccionados independientemente de nitrogeno, oxigeno o azufre, o un anillo heteroarilo bicíclico de 8-10 miembros que tiene 1-5 heteroátomos seleccionados independientemente de nitrogeno, oxigeno o azufre, donde Ar está opcionalmente sustituido con uno o más grupos Rx; cada Rx se selecciona independientemente de -R, -CN, halogeno, -Ph, -OR, -OCF3, -C(O)NH2, -C(O)OR, trifluorometilo, -NHC(O)R, -SO2R o -NHSO2R; y es 0-3; cada R1 es independientemente -R, -CN, halogeno, -OR, -OCF3, -C(O)NH2, -C(O)OR, trifluorometilo, -NHC(O)R, -SO2R, o -NHSO2R; cada Res independientemente hidrogeno o alifático C1-6; R2 es hidrogeno, alquilo C1-3 u -O(alquilo C1-3); y cada uno de R3, R4 y R5 es independientemente R o haloalquilo C1-6.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85381506P | 2006-10-24 | 2006-10-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR063374A1 true AR063374A1 (es) | 2009-01-28 |
Family
ID=39269289
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070104706A AR063374A1 (es) | 2006-10-24 | 2007-10-24 | Derivados de benzoxazina y sus usos |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20100035871A1 (es) |
| AR (1) | AR063374A1 (es) |
| CL (1) | CL2007003044A1 (es) |
| PE (1) | PE20081257A1 (es) |
| TW (1) | TW200827341A (es) |
| WO (1) | WO2008052075A2 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009063992A1 (ja) | 2007-11-15 | 2009-05-22 | Takeda Pharmaceutical Company Limited | 縮合ピリジン誘導体およびその用途 |
| WO2011023753A1 (en) * | 2009-08-27 | 2011-03-03 | Glaxo Group Limited | Benzoxazine derivatives as glycine transport inhibitors |
| WO2012030953A1 (en) | 2010-09-01 | 2012-03-08 | Arena Pharmaceuticals, Inc. | 5-ht2c receptor agonists in the treatment of disorders ameliorated by reduction of norepinephrine level |
| DK2707384T3 (da) | 2011-05-11 | 2022-06-07 | Apellis Pharmaceuticals Inc | Cellereaktiv, langtidsvirkende eller målrettede compstatinanaloger og anvendelser deraf |
| WO2015066296A1 (en) * | 2013-10-31 | 2015-05-07 | Beth Israel Deaconess Medical Center | Near-infrared fluorescent nerve contrast agents and methods of use thereof |
| EP3062825B1 (en) * | 2013-10-31 | 2022-08-24 | Beth Israel Deaconess Medical Center | Near-infrared fluorescent contrast bioimaging agents and methods of use thereof |
| WO2015066344A1 (en) | 2013-11-01 | 2015-05-07 | Arena Pharmaceuticals, Inc. | 5-ht2c receptor agonists and compositions and methods of use |
| WO2020087031A1 (en) | 2018-10-26 | 2020-04-30 | The Research Foundation For The State University Of New York | Combination serotonin specific reuptake inhibitor and serotonin 1a receptor partial agonist for reducing l-dopa-induced dyskinesia |
| US12440585B2 (en) | 2023-09-12 | 2025-10-14 | Curadel Surgical Innovations, Inc. | Zwitterionic metal chelators |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2716680B1 (fr) * | 1994-02-25 | 1996-04-05 | Adir | Nouveaux dérivés de benzodioxane, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. |
| JP2005505586A (ja) * | 2001-10-04 | 2005-02-24 | ワイス | ５−ヒドロキシトリプタミン−６リガンドとしてのクロマン誘導体 |
| ES2193875B2 (es) * | 2002-04-09 | 2005-03-01 | Laboratorios Del Dr. Esteve, S.A. | Derivados de benzoxazinona, su preparacion y su aplicacion como medicamentos. |
| JP4527730B2 (ja) * | 2003-12-09 | 2010-08-18 | エフ．ホフマン−ラ ロシュ アーゲー | ベンゾオキサジン誘導体及びその使用 |
| BRPI0516754A (pt) * | 2004-09-30 | 2008-09-16 | Hoffmann La Roche | usos e derivados de benzoxazina e quinoxalina |
| CA2605580A1 (en) * | 2005-04-22 | 2006-11-02 | Wyeth | Benzodioxane and benzodioxolane derivatives and uses thereof |
-
2007
- 2007-10-23 CL CL200703044A patent/CL2007003044A1/es unknown
- 2007-10-24 TW TW096139855A patent/TW200827341A/zh unknown
- 2007-10-24 WO PCT/US2007/082421 patent/WO2008052075A2/en not_active Ceased
- 2007-10-24 AR ARP070104706A patent/AR063374A1/es unknown
- 2007-10-24 PE PE2007001450A patent/PE20081257A1/es not_active Application Discontinuation
- 2007-10-24 US US12/446,947 patent/US20100035871A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| PE20081257A1 (es) | 2008-10-31 |
| WO2008052075A3 (en) | 2008-06-19 |
| US20100035871A1 (en) | 2010-02-11 |
| CL2007003044A1 (es) | 2008-07-04 |
| TW200827341A (en) | 2008-07-01 |
| WO2008052075A2 (en) | 2008-05-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |