AR046003A2 - Metodo para producir una planta transgenica - Google Patents
Metodo para producir una planta transgenicaInfo
- Publication number
- AR046003A2 AR046003A2 ARP040102598A ARP040102598A AR046003A2 AR 046003 A2 AR046003 A2 AR 046003A2 AR P040102598 A ARP040102598 A AR P040102598A AR P040102598 A ARP040102598 A AR P040102598A AR 046003 A2 AR046003 A2 AR 046003A2
- Authority
- AR
- Argentina
- Prior art keywords
- plant
- cells
- transformed plant
- double
- plant cells
- Prior art date
Links
- 230000009261 transgenic effect Effects 0.000 title abstract 2
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 3
- 102000053602 DNA Human genes 0.000 abstract 2
- 108020004511 Recombinant DNA Proteins 0.000 abstract 2
- 108020000005 Sucrose phosphorylase Proteins 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 108020004414 DNA Proteins 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 229920002472 Starch Polymers 0.000 abstract 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 abstract 1
- 229930006000 Sucrose Natural products 0.000 abstract 1
- 150000001720 carbohydrates Chemical class 0.000 abstract 1
- 235000014633 carbohydrates Nutrition 0.000 abstract 1
- 238000002845 discoloration Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 150000004676 glycans Chemical class 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 230000000813 microbial effect Effects 0.000 abstract 1
- 108091027963 non-coding RNA Proteins 0.000 abstract 1
- 102000042567 non-coding RNA Human genes 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 229920001282 polysaccharide Polymers 0.000 abstract 1
- 239000005017 polysaccharide Substances 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 230000001172 regenerating effect Effects 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 235000019698 starch Nutrition 0.000 abstract 1
- 239000008107 starch Substances 0.000 abstract 1
- 239000005720 sucrose Substances 0.000 abstract 1
- 230000002103 transcriptional effect Effects 0.000 abstract 1
- 230000009466 transformation Effects 0.000 abstract 1
- 230000001131 transforming effect Effects 0.000 abstract 1
- 235000013311 vegetables Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
- C12N15/8245—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified carbohydrate or sugar alcohol metabolism, e.g. starch biosynthesis
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/10—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in agriculture
- Y02A40/146—Genetically Modified [GMO] plants, e.g. transgenic plants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
La introducción de actividad de sacarosa fosforilasa en vegetales por medio de su transformación con un gen de la enzima aumenta la hidrólisis de la sacarosa y conduce a un aumento en los niveles de almidón, aceite y proteína. Se describe un método para producir una planta transgenica, que comprende los pasos de: (a) establemente transformar en el genoma de una célula vegetal una molécula de ADN recombinante de cadena doble que comprende: (i) un promotor que funciona en las células de un tejido vegetal de destino, (ii) una secuencia de ADN estructural, obtenido de una fuente microbiana, que provoca la producción de una secuencia de ARN que codifica una enzima sacarosa fosforilasa, (iii) una secuencia 3' no traducida de ADN que funciona en las células vegetales para producir la terminación transcripcional y el agregado nucleótido poliadenilados al extremo 3' de la secuencia de ARN; (b) seleccionar células vegetales transformadas; y entre (c) regenerar a partir de dichas células vegetales una planta genéticamente transformada cuyo genoma contiene dicha molécula de ADN recombinante de doble cadena de paso entre (a); donde dicha planta genéticamente transformada exhibe una propiedad seleccionada del grupo que consiste de comprender un contenido de carbohidratos modificado; un contenido aumentado de polisacárido; un aumento del rendimiento en el material cosechado; una mejor uniformidad de distribución de sólidos y una disminución en la susceptibilidad a decoloración por un dano.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38686095A | 1995-02-10 | 1995-02-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR046003A2 true AR046003A2 (es) | 2005-11-23 |
Family
ID=23527368
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP960101325A AR000895A1 (es) | 1995-02-10 | 1996-02-08 | Molecula de adn recombinante de doble cadena y celula vegetal |
| ARP040102598A AR046003A2 (es) | 1995-02-10 | 2004-07-22 | Metodo para producir una planta transgenica |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP960101325A AR000895A1 (es) | 1995-02-10 | 1996-02-08 | Molecula de adn recombinante de doble cadena y celula vegetal |
Country Status (19)
| Country | Link |
|---|---|
| US (6) | US5716837A (es) |
| EP (1) | EP0808371B1 (es) |
| JP (1) | JPH10513364A (es) |
| KR (1) | KR19980702105A (es) |
| AR (2) | AR000895A1 (es) |
| AT (1) | ATE342368T1 (es) |
| AU (1) | AU695131B2 (es) |
| BG (1) | BG101883A (es) |
| BR (1) | BR9607586A (es) |
| CA (1) | CA2212560C (es) |
| CZ (1) | CZ254397A3 (es) |
| DE (1) | DE69636620T2 (es) |
| EA (1) | EA000634B1 (es) |
| GE (1) | GEP20012472B (es) |
| HU (1) | HUP9802064A3 (es) |
| NZ (1) | NZ303029A (es) |
| PL (1) | PL321738A1 (es) |
| SK (1) | SK108997A3 (es) |
| WO (1) | WO1996024679A1 (es) |
Families Citing this family (116)
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|---|---|---|---|---|
| US5716837A (en) * | 1995-02-10 | 1998-02-10 | Monsanto Company | Expression of sucrose phosphorylase in plants |
| DE19619917A1 (de) * | 1996-05-17 | 1997-11-20 | Max Planck Gesellschaft | Kartoffelpflanzen mit einer verringerten Aktivität der cytosolischen Stärkephosphorylase und einem veränderten Keimungsverhalten |
| US6420629B1 (en) | 1996-09-09 | 2002-07-16 | B.C. Research Inc. | Process of increasing plant growth and yield and modifying cellulose production in plants |
| GB9624685D0 (en) * | 1996-11-27 | 1997-01-15 | Isis Innovation | Transgenic plants |
| EP1002114A1 (en) * | 1997-06-17 | 2000-05-24 | Monsanto Company | Expression of fructose 1,6 bisphosphate aldolase in transgenic plants |
| US6716474B2 (en) | 1997-06-17 | 2004-04-06 | Monsanto Technology Llc | Expression of fructose 1,6 bisphosphate aldolase in transgenic plants |
| US6441277B1 (en) | 1997-06-17 | 2002-08-27 | Monsanto Technology Llc | Expression of fructose 1,6 bisphosphate aldolase in transgenic plants |
| US6133035A (en) * | 1997-07-16 | 2000-10-17 | Dna Plant Technology Corporation | Method of genetically transforming banana plants |
| CA2328394C (en) * | 1998-05-13 | 2012-08-07 | Planttec Biotechnologie Gmbh | Transgenic plants with modified activity of a plastidial adp/atp translocator |
| US6635806B1 (en) * | 1998-05-14 | 2003-10-21 | Dekalb Genetics Corporation | Methods and compositions for expression of transgenes in plants |
| IL125425A (en) | 1998-07-20 | 2008-12-29 | Israel State | ADPGPPase CONTROL OF STARCH SYNTHESIS IN TOMATOES |
| DE19857654A1 (de) | 1998-12-14 | 2000-06-15 | Max Planck Gesellschaft | Beeinflussung des Blühverhaltens von Pflanzen durch Expression Saccharose-spaltender Proteine |
| AU5756800A (en) * | 1999-06-21 | 2001-01-09 | Pioneer Hi-Bred International, Inc. | Enhanced floral sink strength and increased stability of seed set in plants |
| US7531718B2 (en) * | 1999-08-26 | 2009-05-12 | Monsanto Technology, L.L.C. | Nucleic acid sequences and methods of use for the production of plants with modified polyunsaturated fatty acids |
| US6472588B1 (en) | 1999-09-10 | 2002-10-29 | Texas Tech University | Transgenic cotton plants with altered fiber characteristics transformed with a sucrose phosphate synthase nucleic acid |
| US20020178464A1 (en) * | 1999-11-10 | 2002-11-28 | Whitehead Institute For Biomedical Research | Proton transporters and uses in plants |
| US8697950B2 (en) * | 1999-11-10 | 2014-04-15 | University Of Connecticut | Vacuolar pyrophosphatases and uses in plants |
| US7534933B2 (en) * | 2000-08-18 | 2009-05-19 | University Of Connecticut | Transgenic plants overexpressing a plant vacuolar H + -ATPase |
| CA2438388A1 (en) * | 2001-02-22 | 2002-09-06 | Pioneer Hi-Bred International, Inc. | Manipulation of sucrose synthase genes to improve stalk and grain quality |
| MXPA03009627A (es) | 2001-04-24 | 2004-01-29 | Cornell Res Foundation Inc | MOLECULA SINTETICA DE ACIDO NUCLEICO PARA IMPARTIR CARACTERiSTICAS MULTIPLES. |
| PT1440151E (pt) * | 2001-09-05 | 2008-03-17 | Monsanto Technology Llc | Promotor 7s alfa específico da semente para expressar genes em plantas |
| US20040025202A1 (en) * | 2002-03-15 | 2004-02-05 | Laurie Cathy C. | Nucleic acid molecules associated with oil in plants |
| US20040003432A1 (en) * | 2002-05-06 | 2004-01-01 | Pharmacia Corporation | Production of hexosamines and uses thereof |
| CN1681923B (zh) | 2002-07-18 | 2010-06-02 | 孟山都技术有限公司 | 利用人工的多核苷酸及其组合物来减少转基因沉默的方法 |
| CA2498294C (en) * | 2002-09-10 | 2013-03-05 | Sungene Gmbh & Co. Kgaa | Transgenic expression cassettes for expressing nucleic acid sequences in sink tissues of plants that store carbohydrate |
| US20040133944A1 (en) * | 2003-01-08 | 2004-07-08 | Delta And Pine Land Company | Seed oil suppression to enhance yield of commercially important macromolecules |
| WO2004087878A2 (en) | 2003-03-28 | 2004-10-14 | Monsanto Technology, Llc | Novel plant promoters for use in early seed development |
| US7423203B2 (en) * | 2003-05-07 | 2008-09-09 | Monsanto Technology, Llc | Method of increasing yield in a plant and genes useful therefor |
| DE602004032144D1 (de) * | 2003-06-23 | 2011-05-19 | Univ North Carolina State | Für fructooligosaccharid-nutzende verbindungen codierende nukleinsäuren aus lactobacillus acidophilus und verwendungen davon |
| EP2343364B1 (en) | 2003-08-25 | 2016-10-05 | Monsanto Technology LLC | Tubulin regulatory elements for use in plants |
| DE602004029089D1 (de) | 2003-10-02 | 2010-10-21 | Monsanto Technology Llc | Stapeln von merkmalen zur verbesserung von nutzpflanzen in transgenen pflanzen |
| EP2868749B1 (en) | 2004-01-20 | 2017-10-04 | Monsanto Technology LLC | Chimeric promoters for use in plants |
| EP1818405B2 (en) * | 2004-04-09 | 2025-03-19 | Monsanto Technology, LLC | Compositions and methods for control of insect infestations in plants |
| WO2006023869A2 (en) | 2004-08-24 | 2006-03-02 | Monsanto Technology Llc | Adenylate translocator protein gene non-coding regulatory elements for use in plants |
| US7873911B2 (en) * | 2004-08-31 | 2011-01-18 | Gopalakrishnan Kumar C | Methods for providing information services related to visual imagery |
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| EP1789539A2 (en) | 2004-09-14 | 2007-05-30 | Monsanto Technology, LLC | Promoter molecules for use in plants |
| US7679763B2 (en) * | 2004-11-29 | 2010-03-16 | Hewlett-Packard Development Company, L.P. | System and method for managing capabilities in a network |
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| CA2637588A1 (en) | 2006-02-17 | 2007-08-30 | Monsanto Technology Llc | Chimeric regulatory sequences comprising introns from dicotyledons for plant gene expression |
| EP3608413B1 (en) | 2006-05-16 | 2023-03-15 | Monsanto Technology LLC | Use of non-agrobacterium bacterial species for plant transformation |
| CN101631868B (zh) | 2007-02-16 | 2016-02-10 | 巴斯福植物科学有限公司 | 用于在单子叶植物中调节胚特异性表达的核酸序列 |
| US7838729B2 (en) | 2007-02-26 | 2010-11-23 | Monsanto Technology Llc | Chloroplast transit peptides for efficient targeting of DMO and uses thereof |
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| MY173854A (en) * | 2007-03-13 | 2020-02-25 | Malaysian Palm Oil Board | Expression regulatory elements |
| WO2008131101A1 (en) | 2007-04-20 | 2008-10-30 | Novartis Ag | Dispenser with pivotable extension tube |
| HRP20140328T1 (hr) | 2008-04-07 | 2014-05-09 | Monsanto Technology, Llc | Biljni regulacijski elementi i njihova uporaba |
| JP5158639B2 (ja) | 2008-04-11 | 2013-03-06 | 独立行政法人農業生物資源研究所 | 植物の内胚乳に特異的に発現する遺伝子および該遺伝子のプロモーター、並びにそれらの利用 |
| BRPI0915420A2 (pt) | 2008-06-11 | 2015-08-04 | Syngenta Participations Ag | Composições e métodos para produção de carboidratos fermentáveis em plantas |
| US20100257639A1 (en) * | 2009-02-26 | 2010-10-07 | Robert Edward Bruccoleri | Methods and compositions for altering sugar beet or root crop storage tissue |
| US20120277117A1 (en) | 2009-02-27 | 2012-11-01 | Adel Zayed | Hydroponic apparatus and methods of use |
| UA109110C2 (ru) | 2009-04-22 | 2015-07-27 | Басф Плант Саєнс Компані Гмбх | Полинуклеотид, который обеспечивает возможность специфической экспрессии в целых семенах однодольного растения |
| BR112012000448A2 (pt) | 2009-07-10 | 2015-10-06 | Basf Plant Science Gmbh | cassete de expressão para a regulação da expressão semente-específica de um polinucleotídeo de interesse, vetor, célula hospedeira, tecido de planta, órgão de planta, planta ou semente transgênicos, metodo para expressar um polinucleotídeo de interesse em uma célula hospedeira, métodos para produzir um tecido vegetal, órgão de planta, planta, ou semente transgênicos e uso do cassete de expressão |
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| US4036996A (en) * | 1976-04-26 | 1977-07-19 | The Quaker Oats Company | Process for the production of an improved simulated casein from proteinaceous mixtures |
| US4888170A (en) * | 1981-10-22 | 1989-12-19 | Research Corporation | Vaccines obtained from antigenic gene products of recombinant genes |
| US4770710A (en) * | 1987-07-02 | 1988-09-13 | American Maize-Products Company | Novel starch and products produced therefrom |
| CA1339307C (en) * | 1988-09-06 | 1997-08-19 | Roy Curtiss, Iii | Oral immunization by transgenic plants |
| US5034323A (en) * | 1989-03-30 | 1991-07-23 | Dna Plant Technology Corporation | Genetic engineering of novel plant phenotypes |
| DE4004800C2 (de) * | 1990-02-13 | 2000-12-21 | Aventis Cropscience Gmbh | Im Habitus und Ertrag veränderte transgene Pflanzen |
| US5349123A (en) * | 1990-12-21 | 1994-09-20 | Calgene, Inc. | Glycogen biosynthetic enzymes in plants |
| DE69132916T2 (de) * | 1990-06-18 | 2002-10-31 | Monsanto Technology Llc, St. Louis | Erhöhter stärkegehalt in pflanzen |
| US5498830A (en) * | 1990-06-18 | 1996-03-12 | Monsanto Company | Decreased oil content in plant seeds |
| IL100908A0 (en) * | 1991-02-22 | 1992-11-15 | Salk Inst Biotech Ind | Invertase genes and their use |
| IL103241A0 (en) * | 1991-10-07 | 1993-02-21 | Univ California | Tomato acid invertase gene |
| US5716837A (en) * | 1995-02-10 | 1998-02-10 | Monsanto Company | Expression of sucrose phosphorylase in plants |
| US5713837A (en) * | 1995-12-28 | 1998-02-03 | Royce Medical Company | Unitary orthopaedic brace |
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1996
- 1996-02-06 US US08/596,024 patent/US5716837A/en not_active Expired - Fee Related
- 1996-02-08 AR ARP960101325A patent/AR000895A1/es not_active Application Discontinuation
- 1996-02-08 EA EA199700168A patent/EA000634B1/ru not_active IP Right Cessation
- 1996-02-08 AT AT96905492T patent/ATE342368T1/de not_active IP Right Cessation
- 1996-02-08 HU HU9802064A patent/HUP9802064A3/hu unknown
- 1996-02-08 CZ CZ972543A patent/CZ254397A3/cs unknown
- 1996-02-08 GE GEAP19963870A patent/GEP20012472B/en unknown
- 1996-02-08 PL PL96321738A patent/PL321738A1/xx unknown
- 1996-02-08 DE DE69636620T patent/DE69636620T2/de not_active Expired - Lifetime
- 1996-02-08 SK SK1089-97A patent/SK108997A3/sk unknown
- 1996-02-08 JP JP8524483A patent/JPH10513364A/ja active Pending
- 1996-02-08 CA CA002212560A patent/CA2212560C/en not_active Expired - Lifetime
- 1996-02-08 EP EP96905492A patent/EP0808371B1/en not_active Expired - Lifetime
- 1996-02-08 AU AU49235/96A patent/AU695131B2/en not_active Expired
- 1996-02-08 NZ NZ303029A patent/NZ303029A/xx unknown
- 1996-02-08 WO PCT/US1996/001959 patent/WO1996024679A1/en not_active Ceased
- 1996-02-08 BR BR9607586A patent/BR9607586A/pt not_active IP Right Cessation
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1997
- 1997-08-08 US US08/907,740 patent/US6235971B1/en not_active Ceased
- 1997-08-09 KR KR19970705500A patent/KR19980702105A/ko not_active Ceased
- 1997-09-08 BG BG101883A patent/BG101883A/xx unknown
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1998
- 1998-02-09 US US09/020,818 patent/US6222098B1/en not_active Expired - Lifetime
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2001
- 2001-03-01 US US09/797,467 patent/US6476295B2/en not_active Expired - Lifetime
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2002
- 2002-11-05 US US10/287,933 patent/US20030110535A1/en not_active Abandoned
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2003
- 2003-05-22 US US10/443,787 patent/USRE39114E1/en not_active Expired - Lifetime
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2004
- 2004-07-22 AR ARP040102598A patent/AR046003A2/es active IP Right Grant
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| AU4923596A (en) | 1996-08-27 |
| PL321738A1 (en) | 1997-12-22 |
| NZ303029A (en) | 1999-01-28 |
| BR9607586A (pt) | 1998-07-07 |
| EP0808371A1 (en) | 1997-11-26 |
| AU695131B2 (en) | 1998-08-06 |
| US20010016953A1 (en) | 2001-08-23 |
| WO1996024679A1 (en) | 1996-08-15 |
| DE69636620T2 (de) | 2007-08-30 |
| JPH10513364A (ja) | 1998-12-22 |
| HUP9802064A3 (en) | 2000-11-28 |
| EA000634B1 (ru) | 1999-12-29 |
| AR000895A1 (es) | 1997-08-06 |
| US6222098B1 (en) | 2001-04-24 |
| KR19980702105A (es) | 1998-07-15 |
| GEP20012472B (en) | 2001-06-25 |
| MX9706128A (es) | 1997-11-29 |
| HUP9802064A2 (hu) | 1998-12-28 |
| CZ254397A3 (cs) | 1998-01-14 |
| BG101883A (en) | 1998-07-31 |
| SK108997A3 (en) | 1998-05-06 |
| ATE342368T1 (de) | 2006-11-15 |
| US20030110535A1 (en) | 2003-06-12 |
| CA2212560A1 (en) | 1996-08-15 |
| EP0808371B1 (en) | 2006-10-11 |
| DE69636620D1 (de) | 2006-11-23 |
| CA2212560C (en) | 2008-12-02 |
| USRE39114E1 (en) | 2006-05-30 |
| US6235971B1 (en) | 2001-05-22 |
| US5716837A (en) | 1998-02-10 |
| US6476295B2 (en) | 2002-11-05 |
| EA199700168A1 (ru) | 1997-12-30 |
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