AR032879A1 - Compuestos derivados de ecteinascidina, sus composiciones farmaceuticas, sus usos y metodo de tratamiento de tumores - Google Patents
Compuestos derivados de ecteinascidina, sus composiciones farmaceuticas, sus usos y metodo de tratamiento de tumoresInfo
- Publication number
- AR032879A1 AR032879A1 ARP010101773A ARP010101773A AR032879A1 AR 032879 A1 AR032879 A1 AR 032879A1 AR P010101773 A ARP010101773 A AR P010101773A AR P010101773 A ARP010101773 A AR P010101773A AR 032879 A1 AR032879 A1 AR 032879A1
- Authority
- AR
- Argentina
- Prior art keywords
- ecteinascidin
- pharmaceutical compositions
- compounds
- ecteinascidine
- rings
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 6
- PKVRCIRHQMSYJX-AIFWHQITSA-N trabectedin Chemical compound C([C@@]1(C(OC2)=O)NCCC3=C1C=C(C(=C3)O)OC)S[C@@H]1C3=C(OC(C)=O)C(C)=C4OCOC4=C3[C@H]2N2[C@@H](O)[C@H](CC=3C4=C(O)C(OC)=C(C)C=3)N(C)[C@H]4[C@@H]21 PKVRCIRHQMSYJX-AIFWHQITSA-N 0.000 title abstract 6
- 229960000977 trabectedin Drugs 0.000 title abstract 5
- 206010028980 Neoplasm Diseases 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- -1 ecteinascidin derivative compound Chemical class 0.000 abstract 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Un compuesto derivado de ecteinascidina que tiene un sistema fusionado de cinco anillos de ecteinascidina con un puente 1,4 que tiene la estructura de formulas (1) o (2) y compuestos en los cuales el ûNH2 o el ûOH del puente 1,4 está derivatizado; con la excepcion de la ecteinascidina 583 o 597, y con la excepcion de los 14, 15 o 47 de la Patente de los EE.UU. No. 5721362. Preferiblemente, el sistema de cinco anillos de ecteinascidina tiene la formula (3) donde los anillos A y E son fenolicos, los anillos B y D son tetrahidro, y el anillo C es perhidro. Estos compuestos muestran actividad antitumoral. Composiciones farmacéuticas que contienen compuestos derivados de ecteinascidina. El uso de estos compuestos para la preparacion de un medicamento destinado al tratamiento de un tumor. Método de tratamiento de un tumor que comprende la administracion de una cantidad efectiva de un compuesto derivado de ecteinascidina.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0009043A GB0009043D0 (en) | 2000-04-12 | 2000-04-12 | New autitumoural derivatives of ET-743 |
| PCT/GB2000/001852 WO2000069862A2 (en) | 1999-05-14 | 2000-05-15 | Hemisynthetic method and intermediates thereof |
| GB0022644A GB0022644D0 (en) | 2000-09-14 | 2000-09-14 | Antitumoral derivatives of ET-743 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR032879A1 true AR032879A1 (es) | 2003-12-03 |
Family
ID=26244092
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP010101773A AR032879A1 (es) | 2000-04-12 | 2001-04-16 | Compuestos derivados de ecteinascidina, sus composiciones farmaceuticas, sus usos y metodo de tratamiento de tumores |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US7202361B2 (es) |
| EP (1) | EP1280809B1 (es) |
| JP (1) | JP5219323B2 (es) |
| KR (1) | KR100886496B1 (es) |
| CN (1) | CN1436191B (es) |
| AR (1) | AR032879A1 (es) |
| AT (1) | ATE299146T1 (es) |
| AU (1) | AU784249C (es) |
| BG (1) | BG65987B1 (es) |
| BR (1) | BRPI0110024B8 (es) |
| CA (1) | CA2406080C (es) |
| CZ (1) | CZ304749B6 (es) |
| DE (1) | DE60111845T2 (es) |
| DK (1) | DK1280809T3 (es) |
| EA (1) | EA006206B1 (es) |
| ES (1) | ES2244598T3 (es) |
| HK (1) | HK1049005B (es) |
| HU (1) | HU230918B1 (es) |
| IL (1) | IL152094A (es) |
| MX (1) | MXPA02010088A (es) |
| NO (1) | NO329125B1 (es) |
| NZ (1) | NZ521550A (es) |
| PL (1) | PL210703B1 (es) |
| PT (1) | PT1280809E (es) |
| SI (1) | SI1280809T1 (es) |
| SK (1) | SK288017B6 (es) |
| WO (1) | WO2001077115A1 (es) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE289810T1 (de) * | 1998-05-11 | 2005-03-15 | Pharma Mar Sa | Ecteinascidinderivate |
| MY164077A (en) | 1999-05-13 | 2017-11-30 | Pharma Mar Sa | Compositions and uses of et743 for treating cancer |
| MY130271A (en) * | 1999-05-14 | 2007-06-29 | Pharma Mar Sa | Hemisynthetic method and new compounds |
| US7919493B2 (en) | 2000-04-12 | 2011-04-05 | Pharma Mar, S.A. | Anititumoral ecteinascidin derivatives |
| US7420051B2 (en) * | 2000-05-15 | 2008-09-02 | Pharma Mar, S.A. | Synthetic process for the manufacture of an ecteinaschidin compound |
| MXPA02011319A (es) * | 2000-05-15 | 2003-06-06 | Pharma Mar Sa | Analogos antitumorales de ecteinascidina 743. |
| GB0117402D0 (en) | 2001-07-17 | 2001-09-05 | Pharma Mar Sa | New antitumoral derivatives of et-743 |
| GB0119243D0 (en) * | 2001-08-07 | 2001-10-03 | Pharma Mar Sa | Antitumoral analogs of ET-743 |
| US20050004018A1 (en) * | 2001-10-19 | 2005-01-06 | Jose Jimeno | Use of antitumoral compound in cancer therapy |
| JP4208469B2 (ja) * | 2002-01-29 | 2009-01-14 | 独立行政法人科学技術振興機構 | エクテナサイジン類の全合成方法、エクテナサイジン類に類縁構造を持つ前記全合成用中間体化合物類、及び該中間体化合物類の合成方法 |
| GB0202544D0 (en) | 2002-02-04 | 2002-03-20 | Pharma Mar Sa | The synthesis of naturally occuring ecteinascidins and related compounds |
| CA2544320A1 (en) | 2003-11-13 | 2005-06-02 | Pharma Mar, S.A.U. | Method of treating cancer using a combination comprising et-743 and 5-fluorouracil |
| US20080242670A2 (en) * | 2004-09-29 | 2008-10-02 | Pharma Mar S.A., Sociedad Unipersonal | Anti-Inflammatory Agents |
| WO2006046079A1 (en) | 2004-10-29 | 2006-05-04 | Pharma Mar S.A., Sociedad Unipersonal | Formulations comprising ecteinascidin and a disaccharide |
| US8067462B2 (en) * | 2004-12-20 | 2011-11-29 | The Trustees Of Columbia University In The City Of New York | Processes of making sesquiterpenoid tashironin, its analogs and their uses |
| WO2006079112A2 (en) * | 2005-01-18 | 2006-07-27 | The Trustees Of Columbia University In The City Of New York | Enantioselective synthesis of merrilactone a and its analogs |
| GB0522082D0 (en) | 2005-10-31 | 2005-12-07 | Pharma Mar Sa | Formulations |
| WO2007087220A2 (en) * | 2006-01-25 | 2007-08-02 | The Trustees Of Columbia University In The City Of New York | The total synthesis of ecteinascidin 743 and derivatives thereof |
| FR2936951B1 (fr) * | 2008-10-10 | 2010-12-03 | Novexel | Nouvelles combinaisons de composes heterocycliques azotes antibacteriens avec d'autres composes antibacteriens et leur utilisation comme medicaments |
| CN103038240A (zh) | 2010-05-25 | 2013-04-10 | 法马马有限公司 | 制备海鞘素化合物的合成方法 |
| PL2786754T3 (pl) | 2010-11-12 | 2019-07-31 | Pharma Mar S.A. | Leczenie skojarzone inhibitorem mitozy |
| JOP20190254A1 (ar) | 2017-04-27 | 2019-10-27 | Pharma Mar Sa | مركبات مضادة للأورام |
| CN112679513B (zh) * | 2019-10-18 | 2023-08-25 | 南通诺泰生物医药技术有限公司 | 一种制备曲贝替定的关键中间体的方法 |
| JOP20220118A1 (ar) | 2019-11-21 | 2023-01-30 | Pharma Mar Sa | طرق لعلاج سرطان الرئة للخلايا الصغيرة بصيغ من لوربينيكتيدين |
| CN114940682A (zh) * | 2022-05-18 | 2022-08-26 | 博瑞制药(苏州)有限公司 | 芦比替定的晶型及其制备方法和用途 |
| CN115677728A (zh) * | 2022-11-02 | 2023-02-03 | 成都科岭源医药技术有限公司 | 一种海鞘素类化合物中间体的制备方法 |
| CN120641094A (zh) * | 2023-01-17 | 2025-09-12 | 艾德赛瑞思股份有限公司 | 海鞘素衍生物抗体药物缀合物 |
| WO2025077996A1 (en) | 2023-10-09 | 2025-04-17 | Pharma Mar, S.A. | Synthetic process for the manufacture of ecteinascidin compounds |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59225189A (ja) | 1983-06-03 | 1984-12-18 | Shionogi & Co Ltd | キノナミン誘導体およびその製造法 |
| JPS6084288A (ja) | 1983-10-13 | 1985-05-13 | Shionogi & Co Ltd | シアノキノナミンアセテ−ト類およびその製造法 |
| EP0309477B1 (en) | 1986-06-09 | 1991-11-06 | The Board Of Trustees Of The University Of Illinois | Ecteinascidins 729, 743, 745, 759a, 759b and 770 |
| US5149804A (en) | 1990-11-30 | 1992-09-22 | The Board Of Trustees Of The University Of Illinois | Ecteinascidins 736 and 722 |
| US5256663A (en) * | 1986-06-09 | 1993-10-26 | The Board Of Trustees Of The University Of Illinois | Compositions comprising ecteinascidins and a method of treating herpes simplex virus infections therewith |
| US5089273A (en) * | 1986-06-09 | 1992-02-18 | Board Of Trustees Of The University Of Illinois | Ecteinascidins 729, 743, 745, 759A, 759B and 770 |
| US5721365A (en) * | 1989-09-15 | 1998-02-24 | Us Health | N-substituted piperazine NONOates |
| US5478932A (en) * | 1993-12-02 | 1995-12-26 | The Board Of Trustees Of The University Of Illinois | Ecteinascidins |
| US5721362A (en) | 1996-09-18 | 1998-02-24 | President And Fellows Of Harvard College | Process for producing ecteinascidin compounds |
| US5985876A (en) * | 1997-04-15 | 1999-11-16 | Univ Illinois | Nucleophile substituted ecteinascidins and N-oxide ecteinascidins |
| ATE289810T1 (de) | 1998-05-11 | 2005-03-15 | Pharma Mar Sa | Ecteinascidinderivate |
| US6124292A (en) * | 1998-09-30 | 2000-09-26 | President And Fellows Of Harvard College | Synthetic analogs of ecteinascidin-743 |
| MY130271A (en) | 1999-05-14 | 2007-06-29 | Pharma Mar Sa | Hemisynthetic method and new compounds |
| CA2397597A1 (en) * | 2000-01-19 | 2001-07-26 | The Trustees Of Columbia University In The City Of New York | Compounds of the saframycin-ecteinascidin series, uses, and synthesis thereof |
| MXPA02011319A (es) * | 2000-05-15 | 2003-06-06 | Pharma Mar Sa | Analogos antitumorales de ecteinascidina 743. |
-
2001
- 2001-04-12 BR BRPI0110024-6 patent/BRPI0110024B8/pt not_active IP Right Cessation
- 2001-04-12 DK DK01919669T patent/DK1280809T3/da active
- 2001-04-12 EP EP01919669A patent/EP1280809B1/en not_active Expired - Lifetime
- 2001-04-12 US US10/240,963 patent/US7202361B2/en not_active Expired - Lifetime
- 2001-04-12 HU HUP0300534A patent/HU230918B1/hu unknown
- 2001-04-12 CA CA2406080A patent/CA2406080C/en not_active Expired - Lifetime
- 2001-04-12 PT PT01919669T patent/PT1280809E/pt unknown
- 2001-04-12 CN CN01810939XA patent/CN1436191B/zh not_active Expired - Lifetime
- 2001-04-12 HK HK03101292.0A patent/HK1049005B/en not_active IP Right Cessation
- 2001-04-12 ES ES01919669T patent/ES2244598T3/es not_active Expired - Lifetime
- 2001-04-12 AU AU46729/01A patent/AU784249C/en not_active Expired
- 2001-04-12 PL PL357574A patent/PL210703B1/pl unknown
- 2001-04-12 SI SI200130394T patent/SI1280809T1/sl unknown
- 2001-04-12 CZ CZ2002-3352A patent/CZ304749B6/cs not_active IP Right Cessation
- 2001-04-12 WO PCT/GB2001/001667 patent/WO2001077115A1/en not_active Ceased
- 2001-04-12 DE DE60111845T patent/DE60111845T2/de not_active Expired - Lifetime
- 2001-04-12 NZ NZ521550A patent/NZ521550A/en not_active IP Right Cessation
- 2001-04-12 KR KR1020027013749A patent/KR100886496B1/ko not_active Expired - Lifetime
- 2001-04-12 MX MXPA02010088A patent/MXPA02010088A/es active IP Right Grant
- 2001-04-12 IL IL152094A patent/IL152094A/en active IP Right Grant
- 2001-04-12 AT AT01919669T patent/ATE299146T1/de active
- 2001-04-12 EA EA200201083A patent/EA006206B1/ru not_active IP Right Cessation
- 2001-04-12 SK SK1435-2002A patent/SK288017B6/sk not_active IP Right Cessation
- 2001-04-12 JP JP2001575588A patent/JP5219323B2/ja not_active Expired - Lifetime
- 2001-04-16 AR ARP010101773A patent/AR032879A1/es active IP Right Grant
-
2002
- 2002-10-11 NO NO20024906A patent/NO329125B1/no not_active IP Right Cessation
- 2002-10-24 BG BG107220A patent/BG65987B1/bg unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |