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AR030039A1 - Composicion farmaceutica que comprende una droga inhibidora selectiva de la ciclooxigenasa-2, su uso en la fabricacion de un medicamento para tratar o prevenir afecciones mediadas por la ciclooxigenasa-2 y metodo para hacer dicho medicamento - Google Patents

Composicion farmaceutica que comprende una droga inhibidora selectiva de la ciclooxigenasa-2, su uso en la fabricacion de un medicamento para tratar o prevenir afecciones mediadas por la ciclooxigenasa-2 y metodo para hacer dicho medicamento

Info

Publication number
AR030039A1
AR030039A1 ARP000106475A ARP000106475A AR030039A1 AR 030039 A1 AR030039 A1 AR 030039A1 AR P000106475 A ARP000106475 A AR P000106475A AR P000106475 A ARP000106475 A AR P000106475A AR 030039 A1 AR030039 A1 AR 030039A1
Authority
AR
Argentina
Prior art keywords
cyclooxygenase
medicinal product
drug
manufacture
pharmaceutical composition
Prior art date
Application number
ARP000106475A
Other languages
English (en)
Inventor
Tugrul T Kararli
Mark Kontny
Subhash Desai
Michael Hageman
Royal Haskell
Original Assignee
Pharmacia Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Corp filed Critical Pharmacia Corp
Publication of AR030039A1 publication Critical patent/AR030039A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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Abstract

Composicion farmacéutica que comprende una o más unidades de dosificacion de administracion oral, cada una de las cuales comprende una droga inhibidora selectiva de la ciclooxigenasa-2 de baja solubilidad en agua en una cantidad terapéuticamente efectiva, donde la droga está presente en partículas solidas que tienen un tamano promedio de partícula de 500 nm a 900 nm y donde la droga inhibidora selectiva de la ciclooxigenasa-2 es un compuesto de formula (1) donde: R3 es un grupo metilo o amino; R4 es hidrogeno o un grupo alquilo C1-4 o alcoxilo; X es N o CR5, donde R5 es hidrogeno o halogeno; e Y y Z son independientemente átomos de carbono o de nitrogeno que definen con los átomos adyacentes un anillo de 5 a 6 miembros que no está sustituido o que está sustituido en una o más posiciones con grupos oxo, halo, metilo o halometilo. El uso de dicha composicion en la fabricacion de un medicamento para tratar oralmente de una a seis veces por día mediante una o más unidades de dosificacion, una condicion o una afeccion médica en un sujeto para la cual está indicado el tratamiento con un inhibidor de la ciclooxigenasa-2 y el método para obtener dicho medicamento.
ARP000106475A 1999-12-08 2000-12-06 Composicion farmaceutica que comprende una droga inhibidora selectiva de la ciclooxigenasa-2, su uso en la fabricacion de un medicamento para tratar o prevenir afecciones mediadas por la ciclooxigenasa-2 y metodo para hacer dicho medicamento AR030039A1 (es)

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ARP000106473A AR027897A1 (es) 1999-12-08 2000-12-05 Forma de celecoxib en estado solido que exhiben biodisponibilidad aumentada
ARP000106475A AR030039A1 (es) 1999-12-08 2000-12-06 Composicion farmaceutica que comprende una droga inhibidora selectiva de la ciclooxigenasa-2, su uso en la fabricacion de un medicamento para tratar o prevenir afecciones mediadas por la ciclooxigenasa-2 y metodo para hacer dicho medicamento

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ARP000106473A AR027897A1 (es) 1999-12-08 2000-12-05 Forma de celecoxib en estado solido que exhiben biodisponibilidad aumentada

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MY128366A (en) 2007-01-31
BG65239B1 (bg) 2007-09-28
KR20020002386A (ko) 2002-01-09
CN1411447A (zh) 2003-04-16
AR027897A1 (es) 2003-04-16
CN1216869C (zh) 2005-08-31
CZ20012875A3 (cs) 2002-02-13
EA200401397A1 (ru) 2005-08-25
CO5251445A1 (es) 2003-02-28
BG105808A (en) 2002-09-30
ECSP003807A (es) 2005-07-06
ZA200107146B (en) 2002-08-29
PT1150960E (pt) 2005-06-30
HUP0200580A2 (hu) 2002-11-28
ZA200107149B (en) 2003-02-28
TWI276435B (en) 2007-03-21
OA11831A (en) 2005-08-23
ES2236011T3 (es) 2005-07-16
PT1150959E (pt) 2008-04-21
SV2002000235A (es) 2002-06-13
KR100717570B1 (ko) 2007-05-15
MY128971A (en) 2007-03-30
AU2041201A (en) 2001-06-18
NZ529933A (en) 2005-06-24
PE20010911A1 (es) 2001-09-10
HUP0200580A3 (en) 2002-12-28
WO2001041536A2 (en) 2001-06-14
YU57801A (sh) 2005-07-19

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