AR039468A1 - Pirazolo-pirimidin-4-onas sustituidas - Google Patents
Pirazolo-pirimidin-4-onas sustituidasInfo
- Publication number
- AR039468A1 AR039468A1 ARP030101462A ARP030101462A AR039468A1 AR 039468 A1 AR039468 A1 AR 039468A1 AR P030101462 A ARP030101462 A AR P030101462A AR P030101462 A ARP030101462 A AR P030101462A AR 039468 A1 AR039468 A1 AR 039468A1
- Authority
- AR
- Argentina
- Prior art keywords
- halogen
- alkyl
- substituted
- cyano
- alkoxy
- Prior art date
Links
- 229910052736 halogen Inorganic materials 0.000 abstract 12
- 150000002367 halogens Chemical class 0.000 abstract 9
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 6
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 2
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000004738 (C1-C6) alkyl sulfinyl group Chemical group 0.000 abstract 1
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 abstract 1
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- XUBDVXOHGQSAHX-UHFFFAOYSA-N chembl188441 Chemical compound C12=NC(C)=NC(O)=C2C=NN1C1=C(Cl)C=C(Cl)C=C1Cl XUBDVXOHGQSAHX-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004438 haloalkoxy group Chemical group 0.000 abstract 1
- 239000004009 herbicide Substances 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000005645 nematicide Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Dentistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Plant Pathology (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
A procedimientos para su obtención y a su empleo como herbicidas y / o como nematicidas. Reivindicación 1: Compuestos de la fórmula (1) en la que: Q significa arilo con, respectivamente, hasta 10 átomos de carbono y, si es apropiado, hasta 5 átomos de nitrógeno y/o, si es apropiado, un átomo de oxígeno o de azufre, sustituidos respectivamente con al menos dos sustituyentes iguales o diferentes de la serie formada por nitro, ciano, halógeno y con alquilo C1-6, alcoxi C1-6, alquiltio C1-6, alquilsulfinilo C1-6 o alquilsulfonilo C1-6 sustituidos respectiva y opcionalmente con halógeno; R1 significa hidrógeno, significa alquilo C1-6 o alcoxicarbonilo C1-6 sustituidos respectiva y opcionalmente con ciano, halógeno o alcoxi C1-4, o significa alquenilo C2-6 o alquinilo C2-6 sustituidos respectiva y opcionalmente con halógeno, significa cicloalquilo C3-6 o cicloalquilo(C3-6)-alquilo(C1-4) sustituidos respectiva y opcionalmente con ciano, halógeno o alquilo C1-4, significa arilo o arilalquilo con, respectivamente, hasta 10 átomos de carbono en el grupo arilo y, si es apropiado, hasta 4 átomos de carbono en la porción alquilo sustituidos respectiva y opcionalmente con nitro, ciano, halógeno, alquilo C1-4, halógenoalquilo C1-4, alcoxi C1-4 o halógenoalcoxi C1-4, o significa heterociclilo con hasta 10 átomos de carbono, con hasta 5 átomos de nitrógeno y/o con un átomo de oxígeno o de azufre, sustituido con nitro, ciano, halógeno, alquilo C1-4, halógenoalquilo C1-4, alcoxi C1-4 o halógenoalcoxi C1-4; y R2 significa hidrógeno, significa alquilo C1-6 sustituido opcionalmente con ciano, halógeno, alcoxi C1-4, o alcoxi-carbonilo C1-4 o significa alquenilo C2-6 o alquinilo C2-6 sustituidos respectiva y opcionalmente con halógeno, con excepción de la 1,5-dihidro-6-metil-1-(2,4,6-tricloro-fenil)-4H-pirazolo-[3,4-d]-pirimidin-4-ona.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10219435A DE10219435A1 (de) | 2002-05-02 | 2002-05-02 | Substituierte Pyrazolo-pyrimidin-4-one |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR039468A1 true AR039468A1 (es) | 2005-02-23 |
Family
ID=29224943
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP030101462A AR039468A1 (es) | 2002-05-02 | 2003-04-28 | Pirazolo-pirimidin-4-onas sustituidas |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20050209251A1 (es) |
| EP (1) | EP1504005A2 (es) |
| JP (1) | JP2005531549A (es) |
| AR (1) | AR039468A1 (es) |
| AU (1) | AU2003224111A1 (es) |
| BR (1) | BR0309873A (es) |
| CA (1) | CA2484997A1 (es) |
| DE (1) | DE10219435A1 (es) |
| WO (1) | WO2003093269A2 (es) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2773482B1 (fr) † | 1998-01-13 | 2001-04-20 | Oreal | Composition de teinture d'oxydation des fibres keratiniques et procede de teinture mettant en oeuvre cette composition |
| DE10238722A1 (de) | 2002-08-23 | 2004-03-11 | Bayer Ag | Selektive Phosphodiesterase 9A-Inhibitoren als Arzneimittel zur Verbesserung kognitiver Prozesse |
| DE10238724A1 (de) | 2002-08-23 | 2004-03-04 | Bayer Ag | Alkyl-substituierte Pyrazolpyrimidine |
| DE10238723A1 (de) | 2002-08-23 | 2004-03-11 | Bayer Ag | Phenyl-substituierte Pyrazolyprimidine |
| NZ540612A (en) | 2003-01-14 | 2008-02-29 | Arena Pharm Inc | 1,2,3-Trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto such as diabetes and hyperglycemia |
| DE102004004142A1 (de) * | 2003-05-09 | 2004-11-25 | Bayer Healthcare Ag | 6-Cyclylmethyl- und 6-Alkylmethyl-substituierte Pyrazolopyrimidine |
| US8044060B2 (en) | 2003-05-09 | 2011-10-25 | Boehringer Ingelheim International Gmbh | 6-cyclylmethyl- and 6-alkylmethyl pyrazolo[3,4-D]pyrimidines, methods for their preparation and methods for their use to treat impairments of perception, concentration learning and/or memory |
| JP2006525966A (ja) * | 2003-05-09 | 2006-11-16 | バイエル・ヘルスケア・アクチェンゲゼルシャフト | ６−シクリルメチル−および６−アルキルメチル置換ピラゾロピリミジン類 |
| DE10320785A1 (de) | 2003-05-09 | 2004-11-25 | Bayer Healthcare Ag | 6-Arylmethyl-substituierte Pyrazolopyrimidine |
| DE10328479A1 (de) | 2003-06-25 | 2005-01-13 | Bayer Ag | 6-Arylamino-5-cyano-4-pyrimidinone |
| DE102004001873A1 (de) | 2004-01-14 | 2005-09-29 | Bayer Healthcare Ag | Cyanopyrimidinone |
| DOP2006000009A (es) * | 2005-01-13 | 2006-08-15 | Arena Pharm Inc | Procedimiento para preparar eteres de pirazolo [3,4-d] pirimidina |
| AU2006257638A1 (en) * | 2005-06-15 | 2006-12-21 | Pfizer Limited | Substituted arylpyrazoles |
| US8097712B2 (en) | 2007-11-07 | 2012-01-17 | Beelogics Inc. | Compositions for conferring tolerance to viral disease in social insects, and the use thereof |
| WO2009068617A1 (en) | 2007-11-30 | 2009-06-04 | Boehringer Ingelheim International Gmbh | 1, 5-dihydro-pyrazolo (3, 4-d) pyrimidin-4-one derivatives and their use as pde9a modulators for the teatment of cns disorders |
| UA105362C2 (en) | 2008-04-02 | 2014-05-12 | Бьорингер Ингельхайм Интернациональ Гмбх | 1-heterocyclyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one derivatives and their use as pde9a modulators |
| MX2011002340A (es) | 2008-09-08 | 2011-04-04 | Boehringer Ingelheim Int | Pirazolopirimidinas y su uso para el tratamiento de trastornos del snc. |
| BRPI1011533A2 (pt) | 2009-03-31 | 2016-03-29 | Boehringer Ingelheim Int | derivados de 1-heterocicil-1 5- diidro-pirazolo [3,4--d] pirimidin-4-ona e seu uso como moduladores de pde9a. |
| TW201118099A (en) * | 2009-08-12 | 2011-06-01 | Boehringer Ingelheim Int | New compounds for the treatment of CNS disorders |
| US8962584B2 (en) | 2009-10-14 | 2015-02-24 | Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. | Compositions for controlling Varroa mites in bees |
| JP5856980B2 (ja) | 2010-01-27 | 2016-02-10 | アリーナ ファーマシューティカルズ， インコーポレイテッド | （Ｒ）−２−（７−（４−シクロペンチル−３−（トリフルオロメチル）ベンジルオキシ）−１，２，３，４−テトラヒドロシクロペンタ［ｂ］インドール−３−イル）酢酸およびその塩の調製のためのプロセス |
| MX2012010479A (es) | 2010-03-08 | 2012-10-09 | Monsanto Technology Llc | Moleculas polinucleotidicas para regulacion genetica en plantas. |
| AP2012006631A0 (en) | 2010-08-12 | 2012-12-31 | Boehringer Ingelheim Int | 6-Cycloalkyl-1, 5-dihydro-pyrazolo[3,4-D] pyrimidin-4-one derivatives and their use as PDE9A inhibitors |
| CN103221410B (zh) | 2010-09-22 | 2017-09-15 | 艾尼纳制药公司 | Gpr119受体调节剂和对与其相关的障碍的治疗 |
| US8809345B2 (en) * | 2011-02-15 | 2014-08-19 | Boehringer Ingelheim International Gmbh | 6-cycloalkyl-pyrazolopyrimidinones for the treatment of CNS disorders |
| CN110066794A (zh) | 2011-09-13 | 2019-07-30 | 孟山都技术公司 | 用于杂草控制的方法和组合物 |
| MX362810B (es) | 2011-09-13 | 2019-02-13 | Monsanto Technology Llc | Metodos y composiciones para controlar malezas. |
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| UA116092C2 (uk) | 2011-09-13 | 2018-02-12 | Монсанто Текнолоджи Ллс | Спосіб та композиція для боротьби з бур'янами (варіанти) |
| CN103975068A (zh) | 2011-09-13 | 2014-08-06 | 孟山都技术公司 | 用于杂草控制的方法和组合物 |
| US10806146B2 (en) | 2011-09-13 | 2020-10-20 | Monsanto Technology Llc | Methods and compositions for weed control |
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| MX362812B (es) | 2011-09-13 | 2019-02-13 | Monsanto Technology Llc | Metodos y composiciones para el control de malezas. |
| WO2013175480A1 (en) | 2012-05-24 | 2013-11-28 | A.B. Seeds Ltd. | Compositions and methods for silencing gene expression |
| US10683505B2 (en) | 2013-01-01 | 2020-06-16 | Monsanto Technology Llc | Methods of introducing dsRNA to plant seeds for modulating gene expression |
| MX375327B (es) | 2013-01-01 | 2025-03-06 | A B Seeds Ltd | Métodos para introducir dsrna en semillas de plantas para modular la expresión genética. |
| PT2964646T (pt) * | 2013-03-07 | 2017-06-29 | Hoffmann La Roche | Novos derivados de pirazol |
| CN105074008A (zh) | 2013-03-13 | 2015-11-18 | 孟山都技术有限公司 | 用于杂草控制的方法和组合物 |
| WO2014164797A2 (en) | 2013-03-13 | 2014-10-09 | Monsanto Technology Llc | Methods and compositions for weed control |
| US10568328B2 (en) | 2013-03-15 | 2020-02-25 | Monsanto Technology Llc | Methods and compositions for weed control |
| RS57461B1 (sr) | 2013-05-02 | 2018-09-28 | Hoffmann La Roche | Derivati purina kao agonisti cb2 receptora |
| AU2014261546B2 (en) | 2013-05-02 | 2018-01-18 | F. Hoffmann-La Roche Ag | Pyrrolo[2,3-d]pyrimidine derivatives as CB2 receptor agonists |
| CA2918387C (en) | 2013-07-19 | 2021-11-02 | Monsanto Technology Llc | Compositions and methods for controlling leptinotarsa |
| US9850496B2 (en) | 2013-07-19 | 2017-12-26 | Monsanto Technology Llc | Compositions and methods for controlling Leptinotarsa |
| NZ719544A (en) | 2013-11-04 | 2022-09-30 | Beeologics Inc | Compositions and methods for controlling arthropod parasite and pest infestations |
| UA119253C2 (uk) | 2013-12-10 | 2019-05-27 | Біолоджикс, Інк. | Спосіб боротьби із вірусом у кліща varroa та у бджіл |
| UA121462C2 (uk) | 2014-01-15 | 2020-06-10 | Монсанто Текнолоджі Елелсі | Спосіб та композиція для боротьби із бур'янами з використанням полінуклеотидів epsps |
| US9920059B2 (en) * | 2014-03-10 | 2018-03-20 | Bayer Cropscience Aktiengesellschaft | Heterocyclic compounds as pesticides |
| EP3420809A1 (en) | 2014-04-01 | 2019-01-02 | Monsanto Technology LLC | Compositions and methods for controlling insect pests |
| EP3158067B1 (en) | 2014-06-23 | 2020-08-12 | Monsanto Technology LLC | Compositions and methods for regulating gene expression via rna interference |
| EP3161138A4 (en) | 2014-06-25 | 2017-12-06 | Monsanto Technology LLC | Methods and compositions for delivering nucleic acids to plant cells and regulating gene expression |
| WO2016018887A1 (en) | 2014-07-29 | 2016-02-04 | Monsanto Technology Llc | Compositions and methods for controlling insect pests |
| EP4445956A3 (en) | 2015-01-06 | 2024-12-04 | Arena Pharmaceuticals, Inc. | Compound for use in treating conditions related to the s1p1 receptor |
| CA2974101A1 (en) | 2015-01-22 | 2016-07-28 | Monsanto Technology Llc | Compositions and methods for controlling leptinotarsa |
| WO2016196738A1 (en) | 2015-06-02 | 2016-12-08 | Monsanto Technology Llc | Compositions and methods for delivery of a polynucleotide into a plant |
| CN108024517A (zh) | 2015-06-03 | 2018-05-11 | 孟山都技术公司 | 用于将核酸引入到植物中的方法和组合物 |
| PL3310760T3 (pl) | 2015-06-22 | 2023-03-06 | Arena Pharmaceuticals, Inc. | Krystaliczna sól L-argininy kwasu (R)-2-(7-(4-cyklopentylo-3-(trifluorometylo)benzyloksy)- 1,2,3,4-tetrahydrocyklo-penta[b]indol-3-ilo)octowego do zastosowania w zaburzeniach związanych z receptorem S1P1 |
| MA47504A (fr) | 2017-02-16 | 2019-12-25 | Arena Pharm Inc | Composés et méthodes de traitement de l'angiocholite biliaire primitive |
| ES2987794T3 (es) | 2018-06-06 | 2024-11-18 | Arena Pharm Inc | Procedimientos de tratamiento de afecciones relacionadas con el receptor S1P1 |
| CN110317204B (zh) * | 2019-08-02 | 2022-02-08 | 安徽农业大学 | 吡唑并嘧啶酮类衍生物及其制备方法和应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2925418A (en) * | 1960-02-16 | Certificate of correction | ||
| GB1406412A (en) * | 1974-03-04 | 1975-09-17 | Pfizer | Pyrimidinones and process for preparing them |
| US4496390A (en) * | 1980-02-26 | 1985-01-29 | May & Baker Limited | N-Phenylpyrazole derivatives |
| JPS57167902A (en) * | 1981-04-08 | 1982-10-16 | Otsuka Chem Co Ltd | Herbicidal composition |
| MA19539A1 (fr) * | 1981-07-17 | 1983-04-01 | May & Baker Ltd | N Acylaminophenylpyrazoles |
| DE3420985A1 (de) * | 1983-10-15 | 1985-04-25 | Bayer Ag, 5090 Leverkusen | Substituierte 5-acylamino-1-phenylpyrazole |
| DE3520331A1 (de) * | 1985-06-07 | 1986-12-11 | Bayer Ag, 5090 Leverkusen | 1-aryl-5-alkoximinoalkylamino-pyrazole |
| DE3625686A1 (de) * | 1986-07-30 | 1988-02-04 | Bayer Ag | 4-cyano(nitro)-5-oxy(thio)-pyrazol-derivate |
| US5167691A (en) * | 1991-10-03 | 1992-12-01 | Fmc Corporation | Herbicidal 5-amino-1-phenyl pyrazole compounds |
| IL116507A (en) * | 1991-11-13 | 1997-08-14 | Schering Ag | Pyrazole derivatives |
| US5198014A (en) * | 1991-11-20 | 1993-03-30 | Fmc Corporation | Herbicidal beta-pyrazolylacrylic acid compound |
| US5250504A (en) * | 1991-11-20 | 1993-10-05 | Fmc Corporation | Herbicidal β-pyrazolylacrylic acids |
| HU219150B (hu) * | 1992-10-12 | 2001-02-28 | Schering Ag. | Új szubsztituált pirazolszármazékok, eljárás azok előállítására, valamint herbicidként történő alkalmazásuk |
| TW370529B (en) * | 1992-12-17 | 1999-09-21 | Pfizer | Pyrazolopyrimidines |
| DE19530606A1 (de) * | 1995-08-21 | 1997-02-27 | Basf Ag | 1-(Pyridyl)-pyrazole |
| DE19623892A1 (de) * | 1996-06-06 | 1997-12-11 | Hoechst Schering Agrevo Gmbh | Substituierte Pyrazolyl-pyrazolderivate |
-
2002
- 2002-05-02 DE DE10219435A patent/DE10219435A1/de not_active Withdrawn
-
2003
- 2003-04-22 AU AU2003224111A patent/AU2003224111A1/en not_active Abandoned
- 2003-04-22 JP JP2004501408A patent/JP2005531549A/ja not_active Withdrawn
- 2003-04-22 WO PCT/EP2003/004137 patent/WO2003093269A2/de not_active Ceased
- 2003-04-22 US US10/512,834 patent/US20050209251A1/en not_active Abandoned
- 2003-04-22 CA CA002484997A patent/CA2484997A1/en not_active Abandoned
- 2003-04-22 BR BR0309873-7A patent/BR0309873A/pt not_active IP Right Cessation
- 2003-04-22 EP EP03720510A patent/EP1504005A2/de not_active Withdrawn
- 2003-04-28 AR ARP030101462A patent/AR039468A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003224111A1 (en) | 2003-11-17 |
| CA2484997A1 (en) | 2003-11-13 |
| WO2003093269A3 (de) | 2004-04-08 |
| EP1504005A2 (de) | 2005-02-09 |
| DE10219435A1 (de) | 2003-11-13 |
| US20050209251A1 (en) | 2005-09-22 |
| WO2003093269A2 (de) | 2003-11-13 |
| JP2005531549A (ja) | 2005-10-20 |
| BR0309873A (pt) | 2005-04-26 |
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