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AR038383A1 - Compuesto inhibidor de la hepatitis c - Google Patents

Compuesto inhibidor de la hepatitis c

Info

Publication number
AR038383A1
AR038383A1 ARP030100292A ARP030100292A AR038383A1 AR 038383 A1 AR038383 A1 AR 038383A1 AR P030100292 A ARP030100292 A AR P030100292A AR P030100292 A ARP030100292 A AR P030100292A AR 038383 A1 AR038383 A1 AR 038383A1
Authority
AR
Argentina
Prior art keywords
cycloalkyl
alkyl
hepatitis
inhibiting compound
amido
Prior art date
Application number
ARP030100292A
Other languages
English (en)
Inventor
Montse Llinas-Brunet
Murray Douglas Bailey
Elise Ghiro
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of AR038383A1 publication Critical patent/AR038383A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Compuesto de fórmula (1) en la que R1 es hidroxi o NHSO2R1A en donde R1A es alquilo C1-8, cicloalquilo C3-7 o {alquilo (C1-6)-cicloalquilo C3-7}, que están todos opcionalmente sustituidos de 1 a 3 veces con halo, ciano, nitro O-alquilo C1-6, amido, amino o fenilo, o R1A es arilo C6 o C10 que está opcionalmente sustituido de 1 a 3 veces con halo, ciano, nitro, alquilo C1-6, O-alquilo C1-6, amido, amino o fenilo; R2 es cicloalquilo C4-6; R3 es t-butilo o cicloalquilo C5-6 y R4 es cicloalquilo C4-6, o una sal farmacéuticamente aceptable de los mismos. Los compuestos son útiles como inhibidores de NS3-proteasa de HCV.
ARP030100292A 2002-02-01 2003-01-31 Compuesto inhibidor de la hepatitis c AR038383A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA002370396A CA2370396A1 (en) 2002-02-01 2002-02-01 Hepatitis c inhibitor tri-peptides

Publications (1)

Publication Number Publication Date
AR038383A1 true AR038383A1 (es) 2005-01-12

Family

ID=27626587

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP030100292A AR038383A1 (es) 2002-02-01 2003-01-31 Compuesto inhibidor de la hepatitis c

Country Status (30)

Country Link
EP (1) EP1474441B1 (es)
JP (1) JP4060801B2 (es)
KR (1) KR20040097990A (es)
CN (1) CN100430414C (es)
AR (1) AR038383A1 (es)
AT (1) ATE358137T1 (es)
AU (1) AU2003202347B2 (es)
BR (1) BR0307408A (es)
CA (1) CA2370396A1 (es)
CO (1) CO5611113A2 (es)
DE (1) DE60312824T2 (es)
DK (1) DK1474441T3 (es)
EA (1) EA007742B1 (es)
EC (1) ECSP045226A (es)
ES (1) ES2285085T3 (es)
HR (1) HRP20040697A2 (es)
IL (1) IL163130A (es)
MX (1) MXPA04007515A (es)
MY (1) MY127791A (es)
NO (1) NO20043643L (es)
NZ (1) NZ534689A (es)
PE (1) PE20031012A1 (es)
PL (1) PL371324A1 (es)
RS (1) RS67204A (es)
SA (1) SA03240005B1 (es)
TW (1) TW200400199A (es)
UA (1) UA77758C2 (es)
UY (1) UY27636A1 (es)
WO (1) WO2003064456A1 (es)
ZA (1) ZA200405933B (es)

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