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AR037403A1 - Compuestos, ligandos, receptores nicotinicos, utiles para el tratamiento o para la prevencion de desordenes relacionados con una disfuncion de receptores nicotinicos, particularmente a nivel del sistema nervioso central - Google Patents

Compuestos, ligandos, receptores nicotinicos, utiles para el tratamiento o para la prevencion de desordenes relacionados con una disfuncion de receptores nicotinicos, particularmente a nivel del sistema nervioso central

Info

Publication number
AR037403A1
AR037403A1 ARP020104493A ARP020104493A AR037403A1 AR 037403 A1 AR037403 A1 AR 037403A1 AR P020104493 A ARP020104493 A AR P020104493A AR P020104493 A ARP020104493 A AR P020104493A AR 037403 A1 AR037403 A1 AR 037403A1
Authority
AR
Argentina
Prior art keywords
nicotinic receptors
trifluoro
amino
ligandos
dysfunction
Prior art date
Application number
ARP020104493A
Other languages
English (en)
Inventor
Alistair Lochead
Frederic Galli
Odile Leclerc
Original Assignee
Sanofi Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo filed Critical Sanofi Synthelabo
Publication of AR037403A1 publication Critical patent/AR037403A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Reivindicación 1: Compuesto que responde a la fórmula general (1), donde: R representa un grupo cicloalquilo C3-6 o un grupo fenilo eventualmente sustituido por uno o más grupos seleccionados entre un átomo de halógeno, un grupo alquilo C1-6, alcoxi C1-6, nitro ,amino, diaquil-amino C1-3, trifluoro-metoxi, trifluoro-metilo, ciano, hidroxi, metilen-dioxi, o un grupo piperidin-1-ilo, o morfolin-4-ilo, o pirrolidin-1-ilo, o acetidin-1-ilo o acepin-1-ilo, o piridinilo, o tienilo, o pirazinilo, o furilo, o benzofurilo, o benzotienilo, o indolilo, o pirimidinilo, o isoxazolilo, o fenoxacinilo, o fenoxati-inilo, o dibenzofurilo, o dibenzotienilo, o pirrolilo, o naftilo, donde cada uno de estos grupos puede eventualmente ser sustituido por uno o más grupos seleccionados entre un átomo de halógeno, un grupo alquilo C1-6, alcoxi C1-6, trifluoro-metoxi, trifluoro-metilo, nitro, ciano, hidroxi, amino, dialquilamino C1-3, o cicloalquilamino C3-8, en estado básico o de sal de adición a un ácido.
ARP020104493A 2001-11-23 2002-11-22 Compuestos, ligandos, receptores nicotinicos, utiles para el tratamiento o para la prevencion de desordenes relacionados con una disfuncion de receptores nicotinicos, particularmente a nivel del sistema nervioso central AR037403A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0115154A FR2832713B1 (fr) 2001-11-23 2001-11-23 Derives de 4-(1,3,4-thiadiazol-2-yl)-1,4-diazabicyclo[3.2.2] nonane, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
AR037403A1 true AR037403A1 (es) 2004-11-10

Family

ID=8869706

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP020104493A AR037403A1 (es) 2001-11-23 2002-11-22 Compuestos, ligandos, receptores nicotinicos, utiles para el tratamiento o para la prevencion de desordenes relacionados con una disfuncion de receptores nicotinicos, particularmente a nivel del sistema nervioso central

Country Status (10)

Country Link
US (1) US6998399B2 (es)
EP (1) EP1451189B1 (es)
JP (1) JP4393195B2 (es)
AR (1) AR037403A1 (es)
AT (1) ATE296302T1 (es)
AU (1) AU2002356256A1 (es)
DE (1) DE60204349T2 (es)
FR (1) FR2832713B1 (es)
TW (1) TW200408631A (es)
WO (1) WO2003044020A1 (es)

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DE10164139A1 (de) 2001-12-27 2003-07-10 Bayer Ag 2-Heteroarylcarbonsäureamide
JP4711391B2 (ja) * 2002-09-30 2011-06-29 ニューロサーチ、アクティーゼルスカブ 新規１，４−ジアザビシクロアルカン誘導体及びその製造方法
US7220741B2 (en) 2002-09-30 2007-05-22 Neurosearch A/S 1,4-diazabicycloalkane derivatives, their preparation and use
DE60309740T2 (de) * 2002-11-11 2007-03-29 Neurosearch A/S 1,4-dizabicyclo(3,2,2)nonane derivative, verfahren zu ihrer herstellung und therapeutical verwendung
US7223753B2 (en) 2002-11-11 2007-05-29 Neurosearch A/S Diazabicyclic biaryl derivatives
BRPI0407216A (pt) 2003-02-27 2006-01-24 Neurosearch As Derivado de arila diazabicìclica, composição farmacêutica, uso de um derivado de arila diazabicìclica, e, método de tratamento, prevenção ou alìvio de uma doença ou um distúrbio ou uma condição
US7399765B2 (en) 2003-09-19 2008-07-15 Abbott Laboratories Substituted diazabicycloalkane derivatives
SE0303075D0 (sv) * 2003-11-19 2003-11-19 Astrazeneca Ab 4-substituted imidazoles
SE0303076D0 (sv) * 2003-11-19 2003-11-19 Astrazeneca Ab 5-substituted imidazoles
JP2007520526A (ja) * 2004-02-04 2007-07-26 ノイロサーチ アクティーゼルスカブ コリン作動性受容体モジュレーターとしてのジアザビシクロアリール誘導体
EP1713810B1 (en) * 2004-02-04 2010-12-29 NeuroSearch A/S Diazabicyclic aryl derivatives as nicotinic acetylcholine receptor ligands
EP1809282B1 (en) * 2004-10-18 2013-01-09 Amgen, Inc Thiadiazole compounds and methods of use
US7662812B2 (en) 2005-02-16 2010-02-16 Neurosearch A/S Diazabicyclic aryl derivatives and their use as chinolinergic ligands at nicotinic acetylcholine receptors
CA2632642A1 (en) 2005-12-06 2007-06-14 Neurosearch A/S Novel diazabicyclic aryl derivatives and their medical use
AU2007267174B2 (en) * 2006-05-30 2012-08-02 Neurosearch A/S Novel 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives and their medical use
CA2667545A1 (en) * 2006-10-25 2008-05-02 Neurosearch A/S Oxadiazole and thiadiazole compounds and their use as nicotinic acetylcholine receptor modulators
US8314119B2 (en) 2006-11-06 2012-11-20 Abbvie Inc. Azaadamantane derivatives and methods of use
US20100280015A1 (en) * 2007-08-17 2010-11-04 Neurosearch A/S Noval 1,4-diaza-biclo[3.2.2]nonyl oxadiazolyl derivatives useful as nicotinic acetylcholine receptor ligands
GB0723815D0 (en) * 2007-12-05 2008-01-16 Glaxo Group Ltd Compounds
US8106042B2 (en) 2008-03-11 2012-01-31 Neurosearch A/S 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives useful as modulator of nicotinic acetylcholine receptors
EP2288608A1 (en) * 2008-06-10 2011-03-02 NeuroSearch A/S Novel oxadiazolyl-diazabicyclononane derivatives and their medical use
WO2009158375A1 (en) * 2008-06-25 2009-12-30 Abbott Laboratories Aza-cylic indole- 2 -carboxamides and methods of use thereof
ES2673016T3 (es) 2008-11-19 2018-06-19 Forum Pharmaceuticals Inc. Tratamiento de los síntomas negativos de la esquizofrenia con (R)-7-cloro-N-(quinuclidin-3-il)benzo[b]tiofeno-2-carboxamida y sales farmacéuticamente aceptables de la misma
WO2010084185A1 (en) 2009-01-26 2010-07-29 Neurosearch A/S Novel indolyl-oxadiazolyl-diazabicyclononane derivatives and their medical and diagnostical use
CN102802620A (zh) * 2009-05-11 2012-11-28 英维沃医药有限公司 使用某种α-7烟酸受体与乙酰胆碱酯酶抑制剂结合治疗认知障碍
WO2011073296A1 (en) 2009-12-18 2011-06-23 Neurosearch A/S Diazabicyclononyl oxadiazole compounds and their use as nicotinic acetylcholine receptor modulators
EP3604302A1 (en) 2010-05-17 2020-02-05 Forum Pharmaceuticals Inc. Preparation of crystalline forms of (r)-7-chloro-n-(quinuclidin-3-yl)benzo(b)thiophene-2-carboxamide hydrochloride monohydrate
DE202010012667U1 (de) 2010-09-16 2010-12-02 Almert, Toni H. Dynamisches Lagersystem
CN106074548A (zh) 2010-09-23 2016-11-09 艾伯维巴哈马有限公司 氮杂金刚烷衍生物的一水合物
JP2014510105A (ja) 2011-03-22 2014-04-24 アムジエン・インコーポレーテツド Ｐｉｍ阻害剤としてのアゾール化合物
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US5478939A (en) * 1994-07-20 1995-12-26 American Cyanamid Company (R,R) and (S,S) 2,5-diazabicyclo [2,2,1]heptane derivatives
FR2786770B1 (fr) * 1998-12-04 2001-01-19 Synthelabo Derives de 1,4-diazabicyclo[3.2.2.]nonane, leur preparation et leur application en therapeutique
FR2809732B1 (fr) * 2000-05-31 2002-07-19 Sanofi Synthelabo DERIVES DE 4(-2-PHENYLTHIAZOL-5-yl)-1,4-DIAZABICYCLO-[3.2.2] NONANE, LEUR PREPARATION ET LEUR APPLICATION ENTHERAPEUTIQUE

Also Published As

Publication number Publication date
US6998399B2 (en) 2006-02-14
DE60204349D1 (de) 2005-06-30
JP2005509679A (ja) 2005-04-14
AU2002356256A1 (en) 2003-06-10
US20050020599A1 (en) 2005-01-27
FR2832713A1 (fr) 2003-05-30
WO2003044020A1 (fr) 2003-05-30
ATE296302T1 (de) 2005-06-15
TW200408631A (en) 2004-06-01
FR2832713B1 (fr) 2004-02-13
EP1451189B1 (fr) 2005-05-25
JP4393195B2 (ja) 2010-01-06
EP1451189A1 (fr) 2004-09-01
DE60204349T2 (de) 2006-04-27

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