AR037129A1 - Compuestos retinoides heterociclicos, procedimientos para su preparacion, composiciones farmaceuticas que los comprenden, y uso de dichos compuestos para la preparacion de medicamentos - Google Patents
Compuestos retinoides heterociclicos, procedimientos para su preparacion, composiciones farmaceuticas que los comprenden, y uso de dichos compuestos para la preparacion de medicamentosInfo
- Publication number
- AR037129A1 AR037129A1 ARP020104106A ARP020104106A AR037129A1 AR 037129 A1 AR037129 A1 AR 037129A1 AR P020104106 A ARP020104106 A AR P020104106A AR P020104106 A ARP020104106 A AR P020104106A AR 037129 A1 AR037129 A1 AR 037129A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- preparation
- compounds
- cycloalkyl
- hydrogen
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- -1 RETINOID COMPOUNDS Chemical class 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 7
- 239000001257 hydrogen Substances 0.000 abstract 7
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 150000002431 hydrogen Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 abstract 1
- 206010014561 Emphysema Diseases 0.000 abstract 1
- 208000019693 Lung disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000004476 heterocycloamino group Chemical group 0.000 abstract 1
- 208000020816 lung neoplasm Diseases 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Pyrane Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Abstract
Compuestos retinoides heterocíclicos de fórmula (1) o una sal farmacéutica aceptable, solvato o hidrato de los mismos, en donde; n es un número de 0 a 2; A es arilo o heteroarilo; B es O,S o NR6; R6 es hidrógeno o alquilo; Y es -OR7, -SR7 o -NR8R9; R7 es hidrógeno, alquilo, arilo, arilalquilo, cicloalquilo, o cicloalquil-alquilo; R8 y R9 son independientemente hidrógeno, alquilo, arilo, arilalquilo, cicloalquilo o cicloalquil-alquilo o junto con el átomo de nitrógeno al que están unidos forman un anillo heterocicloamino; Z es -C(R101)2O-, -R102C=CR102-, -C:::C-, -C(R103)2S-, -C(O)O- o -C(O)NR10-; cada uno de R10, R101, R102 y R103 es independientemente hidrógeno o alquilo; R1 y R2 son independientemente hidrógeno o alquilo; R3 es hidrógeno o alquilo; y R4y R5 son independientemente hidrógeno, alquilo (C1-8) o arilalquilo. Dichos compuestos son útiles para el tratamiento y/o prevención de trastornos dermatológicos, y trastornos pulmonares tales como enfermedad pulmonar obstructiva crónica, enfisema y cáncer. También se dan a conocer: procedimientos para su preparación, composiciones farmacéuticas que los comprenden, y uso de dichos compuestos para la preparación de medicamentos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33512901P | 2001-10-31 | 2001-10-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR037129A1 true AR037129A1 (es) | 2004-10-20 |
Family
ID=23310382
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020104106A AR037129A1 (es) | 2001-10-31 | 2002-10-29 | Compuestos retinoides heterociclicos, procedimientos para su preparacion, composiciones farmaceuticas que los comprenden, y uso de dichos compuestos para la preparacion de medicamentos |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US6818652B2 (es) |
| EP (1) | EP1442032B1 (es) |
| JP (1) | JP4234599B2 (es) |
| KR (1) | KR100706589B1 (es) |
| CN (1) | CN1283635C (es) |
| AR (1) | AR037129A1 (es) |
| AT (1) | ATE360010T1 (es) |
| AU (1) | AU2002363170B2 (es) |
| BR (1) | BR0213678A (es) |
| CA (1) | CA2464289C (es) |
| DE (1) | DE60219659T2 (es) |
| ES (1) | ES2283649T3 (es) |
| GT (1) | GT200200225A (es) |
| MX (1) | MXPA04003938A (es) |
| PA (1) | PA8557301A1 (es) |
| PE (1) | PE20030691A1 (es) |
| PL (1) | PL370598A1 (es) |
| RU (1) | RU2275367C2 (es) |
| TW (1) | TW200302085A (es) |
| UY (1) | UY27526A1 (es) |
| WO (1) | WO2003037882A1 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006025395A1 (ja) * | 2004-08-31 | 2006-03-09 | Yasuhiko Shimizu | キャリアフリーの細胞増殖因子を用いた慢性閉塞性肺疾患に対する医薬および処置システム |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4895868A (en) * | 1988-06-29 | 1990-01-23 | Allergan, Inc. | Thiochroman esters of phenols and terephthallates having retinoid-like activity |
| AU626881B2 (en) * | 1988-07-14 | 1992-08-13 | F. Hoffmann-La Roche Ag | Benzofused heterocyclics used as pharmaceuticals |
| FR2713635B1 (fr) * | 1993-12-15 | 1996-01-05 | Cird Galderma | Nouveaux composés propynyl bi-aromatiques, compositions pharmaceutiques et cosmétiques les contenant et utilisations. |
| US5599967A (en) * | 1994-12-29 | 1997-02-04 | Allergan | Acetylenes disubstituted with a 5 substituted tetrahydronaphthyl group and with an aryl of heteroaryl group having retinoid-like biological activity |
| FR2733684B1 (fr) * | 1995-05-03 | 1997-05-30 | Cird Galderma | Utilisation de retinoides dans une composition cosmetique ou pour la fabrication d'une composition pharmaceutique |
| US5675024A (en) * | 1995-11-22 | 1997-10-07 | Allergan | Aryl or heteroaryl amides of tetrahydronaphthalene, chroman, thiochroman and 1,2,3,4,-tetrahydroquinoline carboxylic acids, having an electron withdrawing substituent in the aromatic or heteroaromatic moiety, having retinoid-like biological activity |
| FR2746098B1 (fr) | 1996-03-14 | 1998-04-30 | Composes propynyl biaromatiques | |
| DE69731885T2 (de) * | 1996-07-08 | 2005-12-22 | Galderma Research & Development | Apoptose induzierende adamantyl-derivate und deren verwendung als antikrebsmittel |
| US5739338A (en) * | 1996-11-05 | 1998-04-14 | Allergan | N-aryl substituted tetrahydroquinolines having retinoid agonist, retinoid antagonist or retinoid inverse agonist type biological activity |
| FR2764604B1 (fr) * | 1997-06-13 | 1999-09-10 | Cird Galderma | Composes bi-aromatiques relies par un radical propynylene ou allenylene et compositions pharmaceutiques et cosmetiques les contenant |
| EP1280757B1 (en) * | 2000-05-02 | 2005-08-17 | F. Hoffmann-La Roche Ag | New gamma selective retinoids |
-
2002
- 2002-10-21 DE DE60219659T patent/DE60219659T2/de not_active Expired - Lifetime
- 2002-10-21 KR KR1020047006635A patent/KR100706589B1/ko not_active Expired - Fee Related
- 2002-10-21 MX MXPA04003938A patent/MXPA04003938A/es active IP Right Grant
- 2002-10-21 JP JP2003540163A patent/JP4234599B2/ja not_active Expired - Fee Related
- 2002-10-21 AT AT02802300T patent/ATE360010T1/de active
- 2002-10-21 CN CNB028217608A patent/CN1283635C/zh not_active Expired - Fee Related
- 2002-10-21 PL PL02370598A patent/PL370598A1/xx not_active IP Right Cessation
- 2002-10-21 EP EP02802300A patent/EP1442032B1/en not_active Expired - Lifetime
- 2002-10-21 BR BR0213678-3A patent/BR0213678A/pt not_active IP Right Cessation
- 2002-10-21 ES ES02802300T patent/ES2283649T3/es not_active Expired - Lifetime
- 2002-10-21 AU AU2002363170A patent/AU2002363170B2/en not_active Ceased
- 2002-10-21 WO PCT/EP2002/011746 patent/WO2003037882A1/en not_active Ceased
- 2002-10-21 RU RU2004116695/04A patent/RU2275367C2/ru not_active IP Right Cessation
- 2002-10-21 CA CA002464289A patent/CA2464289C/en not_active Expired - Fee Related
- 2002-10-28 PA PA20028557301A patent/PA8557301A1/es unknown
- 2002-10-29 AR ARP020104106A patent/AR037129A1/es not_active Application Discontinuation
- 2002-10-29 PE PE2002001064A patent/PE20030691A1/es not_active Application Discontinuation
- 2002-10-30 US US10/283,841 patent/US6818652B2/en not_active Expired - Fee Related
- 2002-10-30 UY UY27526A patent/UY27526A1/es not_active Application Discontinuation
- 2002-10-31 TW TW091132266A patent/TW200302085A/zh unknown
- 2002-10-31 GT GT200200225A patent/GT200200225A/es unknown
-
2004
- 2004-10-07 US US10/960,372 patent/US7354931B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| PA8557301A1 (es) | 2004-02-07 |
| CN1283635C (zh) | 2006-11-08 |
| TW200302085A (en) | 2003-08-01 |
| AU2002363170B2 (en) | 2007-12-13 |
| US20050049238A1 (en) | 2005-03-03 |
| RU2275367C2 (ru) | 2006-04-27 |
| US20030158178A1 (en) | 2003-08-21 |
| CA2464289A1 (en) | 2003-05-08 |
| PL370598A1 (en) | 2005-05-30 |
| MXPA04003938A (es) | 2004-06-18 |
| CA2464289C (en) | 2009-09-15 |
| US7354931B2 (en) | 2008-04-08 |
| BR0213678A (pt) | 2004-10-26 |
| GT200200225A (es) | 2003-06-19 |
| ATE360010T1 (de) | 2007-05-15 |
| UY27526A1 (es) | 2003-04-30 |
| JP4234599B2 (ja) | 2009-03-04 |
| DE60219659D1 (de) | 2007-05-31 |
| KR20050038586A (ko) | 2005-04-27 |
| US6818652B2 (en) | 2004-11-16 |
| RU2004116695A (ru) | 2005-11-10 |
| KR100706589B1 (ko) | 2007-04-11 |
| CN1578776A (zh) | 2005-02-09 |
| PE20030691A1 (es) | 2003-08-18 |
| EP1442032B1 (en) | 2007-04-18 |
| WO2003037882A1 (en) | 2003-05-08 |
| JP2005507421A (ja) | 2005-03-17 |
| EP1442032A1 (en) | 2004-08-04 |
| ES2283649T3 (es) | 2007-11-01 |
| DE60219659T2 (de) | 2008-01-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HUP0302526A2 (hu) | Makrolid vegyületek, eljárás az előállításukra, alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények | |
| AR034390A1 (es) | Derivados de 1-sulfonil-tetrahidro quinolinas sustituidas, composiciones farmaceuticas y el uso de las mismas para la elaboracion de medicamentos como inhibidores de la gama secretasa | |
| AR020727A1 (es) | Uso de compuestos derivados 3-amino-4-aril-maleimidas para la preparacion de medicamentos para condiciones asociadas a una necesidad de inhibicion de lagsk-3, dichos compuestos, procedimiento para su preparacion y composiciones farmaceuticas que los comprenden | |
| AR036659A1 (es) | Compuestos derivados de fenil-piperazina, fenil-piperidina y fenil-tetrahidropiridina como inhibidores de la reabsorcion de la serotonina, una composicion farmaceutica y utilizacion de los mismos para la preparacion de medicamentos | |
| NO20052802L (no) | Pyrrolopyrimidinderivativer | |
| BR0206955A (pt) | Ligantes de receptores de canabinóides | |
| AR046297A1 (es) | Inhibidores de la dpp - iv metodos para prepararlos y composiciones farmaceuticas que los contienen como agente activo | |
| SK282721B6 (sk) | Nepeptidové NK3 antagonistické látky, spôsob ich výroby, farmaceutické prostriedky s ich obsahom a ich použitie | |
| DE60311821D1 (de) | Dibenzylaminverbindung und deren medizinische verwendung | |
| KR927003052A (ko) | 2-아릴티아졸 유도체 및 그의 약제학적 조성물 | |
| AR037534A1 (es) | Derivado de adamantano, su uso en la fabricacion de un medicamento para usar en terapia, composicion farmaceutica, proceso para la preparacion de dicho compuesto y dicha composicion y compuestos intermediarios | |
| NO974734L (no) | Nye arylglycinamidderivater, fremgangsmåte for deres fremstilling og farmasaöytiske blandinger inneholdende disse forbindelser | |
| AR035733A1 (es) | Compuestos heterociclicos terapeuticos, uso de dichos compuestos para la preparacion de medicamentos, compuestos relacionados y procedimientos para preparar estos compuestos relacionados | |
| AR035325A1 (es) | Derivados de adamantano, un proceso para su preparacion, composicion farmaceutica, un proceso para la preparacion de dicha composicion, y el uso de dichos derivados para la fabricacion de un medicamento | |
| NO955074L (no) | 1-substituerte istain- og oksindolderivater som inhibitorer til acetylkolinesterase | |
| AR034203A1 (es) | Derivados de 1-aril- o 1-alquilsulfonilbenzazol como ligandos de 5-hidroxitriptamina-6, un metodo para su preparacion, composicion farmaceutica y el uso de los mismos para la fabricacion de un medicamento | |
| MX2009006024A (es) | Derivados de heteroaril piridopirimidona sustituidos. | |
| BR9912621A (pt) | Derivado de ácido aminometilcarboxìlico, composição farmacêutica, e, uso de um derivado de ácido aminometilcarboxìlico | |
| AR029151A1 (es) | Una sal cuaternaria de piperidina, su uso, un proceso para su preparacion, y una composicion farmaceutica que la contiene | |
| RU2004121688A (ru) | 7-аминобензотиазольные производные в качестве лигандов аденозинового рецептора | |
| AR035427A1 (es) | Compuestos derivados de piperidina, su empleo, un procedimiento para prepararlos y medicamentos que los contienen | |
| AR008283A1 (es) | Oligosacaridos modificados, el metodo de preparacion, composiciones farmaceuticas, procedimientos para producir los medicamentos y usos para lamanufactura de un medicamento. | |
| ATE60579T1 (de) | Pyrrolidinamid-derivate mit antipropylendopeptidase-wirkung, zusammenstellungen, die sie enthalten, verfahren zu ihrer herstellung und heilmittel, die sie enthalten. | |
| AR006360A1 (es) | Derivados de 1,2,3,4-tetrahidronaftaleno substituidos, uso de los mismos para la preparacion de medicamentos y procedimiento para su preparacion. | |
| AR067412A1 (es) | Moduladores de propiedades farmaceuticas de productos terapeuticos |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |