PE20030691A1 - Compuestos retinoides heterociclicos - Google Patents
Compuestos retinoides heterociclicosInfo
- Publication number
- PE20030691A1 PE20030691A1 PE2002001064A PE2002001064A PE20030691A1 PE 20030691 A1 PE20030691 A1 PE 20030691A1 PE 2002001064 A PE2002001064 A PE 2002001064A PE 2002001064 A PE2002001064 A PE 2002001064A PE 20030691 A1 PE20030691 A1 PE 20030691A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- arylalkyl
- dimethyl
- compounds
- chroman
- Prior art date
Links
- -1 RETINOID COMPOUNDS Chemical class 0.000 title 1
- 239000005711 Benzoic acid Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000019693 Lung disease Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 150000002391 heterocyclic compounds Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Pyrane Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Abstract
SE REFIEREN A COMPUESTOS HETEROCICLICOS DE FORMULA I DONDE n ES 0-2; A ES ARILO, HETEROARILO; B ES O, S, NR6; R6 ES H, ALQUILO; Y ES -OR7, -SR7; -NR8R9; R7 ES H, ALQUILO, ARILO, ARILALQUILO, CICLOALQUILO; R8 Y R9 SON H, ALQUILO, ARILO, ARILALQUILO, ENTRE OTROS; Z ES -C(R101)2O-, -R102C=CR102-; -C=C-, ENTRE OTROS; R101, R101, R103 SON H, ALQUILO; R1 Y R2 SON H, ALQUILO; R3 ES H, ALQUILO; R4 Y R5 ES H, ALQUILO C1-C8, ARILALQUILO. SON COMPUESTOS PREFERIDOS ACIDO 4-[2-(4,4-DIMETIL-CROMAN-7-IL)-HEPTILOXI]-BENZOICO, ACIDO 4-[2-(4,4-DIMETIL-TIOCROMAN-7-IL)-HEPTILOXI]-BENZOICO, ACIDO 4-[3-(4,4-DIMETIL-CROMAN-7-IL)-OCT-1-ENIL]-BENZOICO, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO PARA LA PREPARACION. LOS COMPUESTOS MENCIONADOS SON UTILES PARA EL TRATAMIENTO DE ENFERMEDADES PULMONARES, CANCER, TRASTORNOS DERMATOLOGICOS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33512901P | 2001-10-31 | 2001-10-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20030691A1 true PE20030691A1 (es) | 2003-08-18 |
Family
ID=23310382
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2002001064A PE20030691A1 (es) | 2001-10-31 | 2002-10-29 | Compuestos retinoides heterociclicos |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US6818652B2 (es) |
| EP (1) | EP1442032B1 (es) |
| JP (1) | JP4234599B2 (es) |
| KR (1) | KR100706589B1 (es) |
| CN (1) | CN1283635C (es) |
| AR (1) | AR037129A1 (es) |
| AT (1) | ATE360010T1 (es) |
| AU (1) | AU2002363170B2 (es) |
| BR (1) | BR0213678A (es) |
| CA (1) | CA2464289C (es) |
| DE (1) | DE60219659T2 (es) |
| ES (1) | ES2283649T3 (es) |
| GT (1) | GT200200225A (es) |
| MX (1) | MXPA04003938A (es) |
| PA (1) | PA8557301A1 (es) |
| PE (1) | PE20030691A1 (es) |
| PL (1) | PL370598A1 (es) |
| RU (1) | RU2275367C2 (es) |
| TW (1) | TW200302085A (es) |
| UY (1) | UY27526A1 (es) |
| WO (1) | WO2003037882A1 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006025395A1 (ja) * | 2004-08-31 | 2006-03-09 | Yasuhiko Shimizu | キャリアフリーの細胞増殖因子を用いた慢性閉塞性肺疾患に対する医薬および処置システム |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4895868A (en) * | 1988-06-29 | 1990-01-23 | Allergan, Inc. | Thiochroman esters of phenols and terephthallates having retinoid-like activity |
| AU626881B2 (en) * | 1988-07-14 | 1992-08-13 | F. Hoffmann-La Roche Ag | Benzofused heterocyclics used as pharmaceuticals |
| FR2713635B1 (fr) * | 1993-12-15 | 1996-01-05 | Cird Galderma | Nouveaux composés propynyl bi-aromatiques, compositions pharmaceutiques et cosmétiques les contenant et utilisations. |
| US5599967A (en) * | 1994-12-29 | 1997-02-04 | Allergan | Acetylenes disubstituted with a 5 substituted tetrahydronaphthyl group and with an aryl of heteroaryl group having retinoid-like biological activity |
| FR2733684B1 (fr) * | 1995-05-03 | 1997-05-30 | Cird Galderma | Utilisation de retinoides dans une composition cosmetique ou pour la fabrication d'une composition pharmaceutique |
| US5675024A (en) * | 1995-11-22 | 1997-10-07 | Allergan | Aryl or heteroaryl amides of tetrahydronaphthalene, chroman, thiochroman and 1,2,3,4,-tetrahydroquinoline carboxylic acids, having an electron withdrawing substituent in the aromatic or heteroaromatic moiety, having retinoid-like biological activity |
| FR2746098B1 (fr) | 1996-03-14 | 1998-04-30 | Composes propynyl biaromatiques | |
| DE69731885T2 (de) * | 1996-07-08 | 2005-12-22 | Galderma Research & Development | Apoptose induzierende adamantyl-derivate und deren verwendung als antikrebsmittel |
| US5739338A (en) * | 1996-11-05 | 1998-04-14 | Allergan | N-aryl substituted tetrahydroquinolines having retinoid agonist, retinoid antagonist or retinoid inverse agonist type biological activity |
| FR2764604B1 (fr) * | 1997-06-13 | 1999-09-10 | Cird Galderma | Composes bi-aromatiques relies par un radical propynylene ou allenylene et compositions pharmaceutiques et cosmetiques les contenant |
| EP1280757B1 (en) * | 2000-05-02 | 2005-08-17 | F. Hoffmann-La Roche Ag | New gamma selective retinoids |
-
2002
- 2002-10-21 DE DE60219659T patent/DE60219659T2/de not_active Expired - Lifetime
- 2002-10-21 KR KR1020047006635A patent/KR100706589B1/ko not_active Expired - Fee Related
- 2002-10-21 MX MXPA04003938A patent/MXPA04003938A/es active IP Right Grant
- 2002-10-21 JP JP2003540163A patent/JP4234599B2/ja not_active Expired - Fee Related
- 2002-10-21 AT AT02802300T patent/ATE360010T1/de active
- 2002-10-21 CN CNB028217608A patent/CN1283635C/zh not_active Expired - Fee Related
- 2002-10-21 PL PL02370598A patent/PL370598A1/xx not_active IP Right Cessation
- 2002-10-21 EP EP02802300A patent/EP1442032B1/en not_active Expired - Lifetime
- 2002-10-21 BR BR0213678-3A patent/BR0213678A/pt not_active IP Right Cessation
- 2002-10-21 ES ES02802300T patent/ES2283649T3/es not_active Expired - Lifetime
- 2002-10-21 AU AU2002363170A patent/AU2002363170B2/en not_active Ceased
- 2002-10-21 WO PCT/EP2002/011746 patent/WO2003037882A1/en not_active Ceased
- 2002-10-21 RU RU2004116695/04A patent/RU2275367C2/ru not_active IP Right Cessation
- 2002-10-21 CA CA002464289A patent/CA2464289C/en not_active Expired - Fee Related
- 2002-10-28 PA PA20028557301A patent/PA8557301A1/es unknown
- 2002-10-29 AR ARP020104106A patent/AR037129A1/es not_active Application Discontinuation
- 2002-10-29 PE PE2002001064A patent/PE20030691A1/es not_active Application Discontinuation
- 2002-10-30 US US10/283,841 patent/US6818652B2/en not_active Expired - Fee Related
- 2002-10-30 UY UY27526A patent/UY27526A1/es not_active Application Discontinuation
- 2002-10-31 TW TW091132266A patent/TW200302085A/zh unknown
- 2002-10-31 GT GT200200225A patent/GT200200225A/es unknown
-
2004
- 2004-10-07 US US10/960,372 patent/US7354931B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| PA8557301A1 (es) | 2004-02-07 |
| CN1283635C (zh) | 2006-11-08 |
| TW200302085A (en) | 2003-08-01 |
| AU2002363170B2 (en) | 2007-12-13 |
| US20050049238A1 (en) | 2005-03-03 |
| RU2275367C2 (ru) | 2006-04-27 |
| US20030158178A1 (en) | 2003-08-21 |
| CA2464289A1 (en) | 2003-05-08 |
| PL370598A1 (en) | 2005-05-30 |
| MXPA04003938A (es) | 2004-06-18 |
| CA2464289C (en) | 2009-09-15 |
| US7354931B2 (en) | 2008-04-08 |
| AR037129A1 (es) | 2004-10-20 |
| BR0213678A (pt) | 2004-10-26 |
| GT200200225A (es) | 2003-06-19 |
| ATE360010T1 (de) | 2007-05-15 |
| UY27526A1 (es) | 2003-04-30 |
| JP4234599B2 (ja) | 2009-03-04 |
| DE60219659D1 (de) | 2007-05-31 |
| KR20050038586A (ko) | 2005-04-27 |
| US6818652B2 (en) | 2004-11-16 |
| RU2004116695A (ru) | 2005-11-10 |
| KR100706589B1 (ko) | 2007-04-11 |
| CN1578776A (zh) | 2005-02-09 |
| EP1442032B1 (en) | 2007-04-18 |
| WO2003037882A1 (en) | 2003-05-08 |
| JP2005507421A (ja) | 2005-03-17 |
| EP1442032A1 (en) | 2004-08-04 |
| ES2283649T3 (es) | 2007-11-01 |
| DE60219659T2 (de) | 2008-01-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |