AR035821A1 - Composiciones que contienen un compuesto imidazotriazinona y al menos un anestesico local para administracion nasal, el uso de dicha composicion para la preparacion de un medicamento para el tratamiento de la disfuncion erectil masculina , un aplicador de pulverizacion nasal y un insuflador de polvo - Google Patents
Composiciones que contienen un compuesto imidazotriazinona y al menos un anestesico local para administracion nasal, el uso de dicha composicion para la preparacion de un medicamento para el tratamiento de la disfuncion erectil masculina , un aplicador de pulverizacion nasal y un insuflador de polvoInfo
- Publication number
- AR035821A1 AR035821A1 ARP020101322A ARP020101322A AR035821A1 AR 035821 A1 AR035821 A1 AR 035821A1 AR P020101322 A ARP020101322 A AR P020101322A AR P020101322 A ARP020101322 A AR P020101322A AR 035821 A1 AR035821 A1 AR 035821A1
- Authority
- AR
- Argentina
- Prior art keywords
- straight
- carbon atoms
- branched chain
- optionally substituted
- same
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 4
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 239000003589 local anesthetic agent Substances 0.000 title abstract 3
- 208000010228 Erectile Dysfunction Diseases 0.000 title abstract 2
- 201000001881 impotence Diseases 0.000 title abstract 2
- 238000009413 insulation Methods 0.000 title 2
- 229940126601 medicinal product Drugs 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 9
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 5
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 4
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 3
- 125000000623 heterocyclic group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 229910052757 nitrogen Inorganic materials 0.000 abstract 3
- ZOOGRGPOEVQQDX-UUOKFMHZSA-N 3',5'-cyclic GMP Chemical compound C([C@H]1O2)OP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=C(NC2=O)N)=C2N=C1 ZOOGRGPOEVQQDX-UUOKFMHZSA-N 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 2
- 125000003386 piperidinyl group Chemical group 0.000 abstract 2
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 229940099471 Phosphodiesterase inhibitor Drugs 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- IJYHVZICHKCLMQ-UHFFFAOYSA-N imidazo[4,5-d]triazin-4-one Chemical compound O=C1N=NN=C2N=CN=C12 IJYHVZICHKCLMQ-UHFFFAOYSA-N 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000002757 morpholinyl group Chemical group 0.000 abstract 1
- 239000007922 nasal spray Substances 0.000 abstract 1
- 229940097496 nasal spray Drugs 0.000 abstract 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000004568 thiomorpholinyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Otolaryngology (AREA)
- Anesthesiology (AREA)
- Pulmonology (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Composición que comprende a menos un compuesto de imidazotriazinona inhibidor de PDE GMPc y a menos un anestésico local, con la condición de que el anestésico local no sea alcohol bencílico, tratándose el inhibidor de PDE GMPc de un compuesto de la fórmula (1) en la que R1 representa hidrógeno o alquilo de cadena lineal o ramificada de hasta 4 átomos de carbono, R2 representa alquilo de cadena lineal de hasta 4 átomos de carbono, R3 y R4 son iguales o distintos y representan una cadena alquilo lineal o ramificada de hasta 5 átomos de carbono, que está sustituida opcionalmente hasta dos veces de forma igual o distinta con hidroxilo o metoxi o R3 y R4 junto con el átomo de nitrógeno forman un anillo de piperidinilo, morfolinilo, tiomorfolinilo, o un radical de fórmula (1) en la que R7 significa hidrógeno, formilo, acilo o alcoxicarbonilo de cadena lineal o ramificada con hasta 6 átomos de carbono respectivamente, o significa alquilo de cadena lineal o ramificada de hasta 6 átomos de carbono que está sustituido opcionalmente de uno a dos veces de forma igual o distinta con hidroxilo, carboxilo, alcoxi de cadena lineal o ramificada o alcoxicarbonilo de hasta 6 átomos de carbono respectivamente , o significa cicloalquilo C3-8, y los heterociclos formados por los citados R3 y R4, junto con el átomo de nitrógeno, están sustituidos opcionalmente de una a dos veces de forma igual o distinta, opcionalmente también geminada, con hidroxilo, formilo, carboxilo, acilo o alcoxicarbonilo de cadena lineal o ramificada de hasta 6 átomos de carbono respectivamente, y/o los heterociclos formados por los citados R3 y R4 junto con el átomo de nitrógeno, están sustituidos opcionalmente con alquilo de cadena lineal o ramificada de hasta 6 átomos de carbono, que está sustituido opcionalmente de una o dos veces de forma igual o distinta con hidroxilo o carboxilo, y/o los heterociclos formados por los citados R3 y R4, junto con el átomo de nitrógeno, están sustituidos opcionalmente con piperidinilo o pirrolidinilo unido con N, R5 y R6 son iguales o distintos y representan hidrógeno, alquilo de cadena lineal o ramificada de hasta 6 átomos de carbono, hidroxilo, o representan alcoxi de cadena lineal o ramificada de hasta 6 átomos de carbono, así como sus sales, isómeros y/o hidratos de éstos; el uso de dicha composición para la preparación de un medicamento para el tratamiento de la disfunción eréctil masculina, un aplicador de pulverización nasal y un insuflador de polvo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10118306A DE10118306A1 (de) | 2001-04-12 | 2001-04-12 | Imidazotriazinonhaltige Zusammensetzungen zur nasalen Applikation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR035821A1 true AR035821A1 (es) | 2004-07-14 |
Family
ID=7681379
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020101322A AR035821A1 (es) | 2001-04-12 | 2002-04-10 | Composiciones que contienen un compuesto imidazotriazinona y al menos un anestesico local para administracion nasal, el uso de dicha composicion para la preparacion de un medicamento para el tratamiento de la disfuncion erectil masculina , un aplicador de pulverizacion nasal y un insuflador de polvo |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US6740306B2 (es) |
| EP (1) | EP1381368A2 (es) |
| JP (1) | JP2004525968A (es) |
| KR (1) | KR20030087072A (es) |
| CN (1) | CN1537004A (es) |
| AR (1) | AR035821A1 (es) |
| BG (1) | BG108245A (es) |
| BR (1) | BR0208813A (es) |
| CA (1) | CA2443639A1 (es) |
| CZ (1) | CZ20032752A3 (es) |
| DE (1) | DE10118306A1 (es) |
| DO (1) | DOP2002000373A (es) |
| EC (1) | ECSP034795A (es) |
| EE (1) | EE200300501A (es) |
| GT (1) | GT200200070A (es) |
| HU (1) | HUP0303877A3 (es) |
| IL (1) | IL158255A0 (es) |
| MX (1) | MXPA03009314A (es) |
| NO (1) | NO20034556L (es) |
| PE (1) | PE20021035A1 (es) |
| PL (1) | PL363033A1 (es) |
| RU (1) | RU2003133143A (es) |
| SK (1) | SK12682003A3 (es) |
| UY (1) | UY27256A1 (es) |
| WO (1) | WO2002083674A2 (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA03010119A (es) * | 2001-05-09 | 2005-03-07 | Bayer Healthcare Ag | Nuevo uso de imidazotriazinonas 2-fenilo sustituidas. |
| DE102004023069A1 (de) * | 2004-05-11 | 2005-12-08 | Bayer Healthcare Ag | Neue Darreichungsformen des PDE 5-Inhibitors Vardenafil |
| CA2587792C (en) * | 2004-12-23 | 2010-07-06 | Roxro Pharma, Inc. | Therapeutic compositions for intranasal administration of ketorolac |
| DE102005001989A1 (de) * | 2005-01-15 | 2006-07-20 | Bayer Healthcare Ag | Intravenöse Formulierungen von PDE-Inhibitoren |
| DE102005009241A1 (de) * | 2005-03-01 | 2006-09-07 | Bayer Healthcare Ag | Arzneiformen mit kontrollierter Bioverfügbarkeit |
| DE102005009240A1 (de) * | 2005-03-01 | 2006-09-07 | Bayer Healthcare Ag | Arzneiformen mit verbesserten pharmakokinetischen Eigenschaften |
| WO2007002125A1 (en) * | 2005-06-23 | 2007-01-04 | Schering Corporation | Rapidly absorbing oral formulations of pde5 inhibitors |
| SG166106A1 (en) * | 2005-09-29 | 2010-11-29 | Bayer Schering Pharma Ag | Pde inhibitors and combinations thereof for the treatment of urological disorders |
| KR20100029762A (ko) * | 2007-06-13 | 2010-03-17 | 바이엘 쉐링 파마 악티엔게젤샤프트 | 청력 장애 치료용 ｐｄｅ 억제제 |
| MX2010013484A (es) * | 2008-06-13 | 2011-03-29 | Roxro Pharma Inc Star | Formulaciones en dosis unitaria de ketorolaco para administración intra-nasal. |
| US8551454B2 (en) * | 2009-03-13 | 2013-10-08 | Luitpold Pharmaceuticals, Inc. | Device for intranasal administration |
| US8277781B2 (en) * | 2009-03-13 | 2012-10-02 | Luitpold Pharmaceuticals, Inc. | Device for intranasal administration |
| WO2017168174A1 (en) | 2016-04-02 | 2017-10-05 | N4 Pharma Uk Limited | New pharmaceutical forms of sildenafil |
| WO2020006606A1 (en) * | 2018-07-05 | 2020-01-09 | Helium 3 Resources Pty Ltd | A pharmaceutical composition and method of use of same |
| SE542968C2 (en) * | 2018-10-26 | 2020-09-22 | Lindahl Anders | Treatment of osteoarthritis |
| WO2021242913A1 (en) * | 2020-05-26 | 2021-12-02 | Strategic Drug Solutions, Inc. | Formulations and methods for treating erectile dysfunction |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4602099A (en) * | 1973-04-02 | 1986-07-22 | Merrell Dow Pharmaceuticals Inc. | Antirhinovirus agents |
| GB9013750D0 (en) | 1990-06-20 | 1990-08-08 | Pfizer Ltd | Therapeutic agents |
| GB9311920D0 (en) | 1993-06-09 | 1993-07-28 | Pfizer Ltd | Therapeutic agents |
| GB9514465D0 (en) | 1995-07-14 | 1995-09-13 | Glaxo Lab Sa | Chemical compounds |
| GB9514473D0 (en) | 1995-07-14 | 1995-09-13 | Glaxo Lab Sa | Chemical compounds |
| US6018046A (en) | 1996-05-31 | 2000-01-25 | Mochida Pharmaceutical Co., Ltd. | Pyridocarbazole derivatives having cGMP-PDE inhibitory activity |
| GB2315673A (en) * | 1996-08-01 | 1998-02-11 | Merck & Co Inc | Treatment of migraine |
| WO1998053819A1 (en) * | 1997-05-29 | 1998-12-03 | Mochida Pharmaceutical Co., Ltd. | Therapeutic agent for erection failure |
| WO1999015177A1 (en) | 1997-09-23 | 1999-04-01 | Eli Lilly And Company | Treatment of attention-deficit/hyperactivity disorder |
| CA2309332C (en) | 1997-11-12 | 2002-12-03 | Bayer Aktiengesellschaft | 2-phenyl substituted imidazotriazinones as phosphodiesterase inhibitors |
| TWI223598B (en) * | 1998-06-22 | 2004-11-11 | Pfizer Ireland Pharmaceuticals | An intranasal pharmaceutical composition for the treatment of male erectile dysfunction or female sexual disorders, an intranasal delivery system or device and sildenafil mesylate |
| WO2000000199A1 (en) * | 1998-06-26 | 2000-01-06 | Nastech Pharmaceutical Company, Inc. | Nasal delivery of sildenafil citrate |
| AU764921B2 (en) * | 1998-12-14 | 2003-09-04 | Cellegy Pharmaceuticals, Inc. | Compositions and methods for the treatment of anorectal disorders |
-
2001
- 2001-04-12 DE DE10118306A patent/DE10118306A1/de not_active Withdrawn
-
2002
- 2002-04-03 HU HU0303877A patent/HUP0303877A3/hu unknown
- 2002-04-03 WO PCT/EP2002/003663 patent/WO2002083674A2/de not_active Ceased
- 2002-04-03 PL PL02363033A patent/PL363033A1/xx not_active Application Discontinuation
- 2002-04-03 BR BR0208813-4A patent/BR0208813A/pt not_active Application Discontinuation
- 2002-04-03 KR KR10-2003-7013280A patent/KR20030087072A/ko not_active Withdrawn
- 2002-04-03 JP JP2002581429A patent/JP2004525968A/ja active Pending
- 2002-04-03 RU RU2003133143/15A patent/RU2003133143A/ru not_active Application Discontinuation
- 2002-04-03 EP EP02732548A patent/EP1381368A2/de not_active Withdrawn
- 2002-04-03 CA CA002443639A patent/CA2443639A1/en not_active Abandoned
- 2002-04-03 CN CNA028114574A patent/CN1537004A/zh active Pending
- 2002-04-03 IL IL15825502A patent/IL158255A0/xx unknown
- 2002-04-03 SK SK1268-2003A patent/SK12682003A3/sk unknown
- 2002-04-03 CZ CZ20032752A patent/CZ20032752A3/cs unknown
- 2002-04-03 EE EEP200300501A patent/EE200300501A/xx unknown
- 2002-04-03 MX MXPA03009314A patent/MXPA03009314A/es unknown
- 2002-04-04 DO DO2002000373A patent/DOP2002000373A/es unknown
- 2002-04-10 AR ARP020101322A patent/AR035821A1/es not_active Application Discontinuation
- 2002-04-11 US US10/122,694 patent/US6740306B2/en not_active Expired - Fee Related
- 2002-04-11 PE PE2002000303A patent/PE20021035A1/es not_active Application Discontinuation
- 2002-04-11 GT GT200200070A patent/GT200200070A/es unknown
- 2002-04-11 UY UY27256A patent/UY27256A1/es not_active Application Discontinuation
-
2003
- 2003-10-08 EC EC2003004795A patent/ECSP034795A/es unknown
- 2003-10-09 BG BG108245A patent/BG108245A/xx unknown
- 2003-10-10 NO NO20034556A patent/NO20034556L/no not_active Application Discontinuation
-
2004
- 2004-03-30 US US10/813,801 patent/US20040248891A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CZ20032752A3 (cs) | 2004-01-14 |
| DE10118306A1 (de) | 2002-10-17 |
| NO20034556D0 (no) | 2003-10-10 |
| ECSP034795A (es) | 2003-12-01 |
| BG108245A (en) | 2005-01-31 |
| US20040248891A1 (en) | 2004-12-09 |
| JP2004525968A (ja) | 2004-08-26 |
| PE20021035A1 (es) | 2002-11-29 |
| WO2002083674A3 (de) | 2003-01-09 |
| CN1537004A (zh) | 2004-10-13 |
| EE200300501A (et) | 2003-12-15 |
| IL158255A0 (en) | 2004-05-12 |
| GT200200070A (es) | 2003-01-31 |
| SK12682003A3 (sk) | 2004-03-02 |
| PL363033A1 (en) | 2004-11-15 |
| UY27256A1 (es) | 2002-11-29 |
| DOP2002000373A (es) | 2002-11-30 |
| KR20030087072A (ko) | 2003-11-12 |
| NO20034556L (no) | 2003-12-10 |
| EP1381368A2 (de) | 2004-01-21 |
| CA2443639A1 (en) | 2002-10-24 |
| HUP0303877A2 (hu) | 2004-03-29 |
| HUP0303877A3 (en) | 2005-05-30 |
| WO2002083674A2 (de) | 2002-10-24 |
| BR0208813A (pt) | 2004-03-09 |
| MXPA03009314A (es) | 2004-03-10 |
| US6740306B2 (en) | 2004-05-25 |
| RU2003133143A (ru) | 2005-04-10 |
| US20030022894A1 (en) | 2003-01-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |