AR034861A1 - Un compuesto de indenoindolona, un procedimiento para su preparacion y una composicion farmaceutica que lo comprende - Google Patents
Un compuesto de indenoindolona, un procedimiento para su preparacion y una composicion farmaceutica que lo comprendeInfo
- Publication number
- AR034861A1 AR034861A1 ARP020100952A ARP020100952A AR034861A1 AR 034861 A1 AR034861 A1 AR 034861A1 AR P020100952 A ARP020100952 A AR P020100952A AR P020100952 A ARP020100952 A AR P020100952A AR 034861 A1 AR034861 A1 AR 034861A1
- Authority
- AR
- Argentina
- Prior art keywords
- branched
- linear
- groups
- alkyl
- group
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- -1 INDENOINDOLONE COMPOUND Chemical class 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
- YBYIRNPNPLQARY-UHFFFAOYSA-N 1H-indene Chemical compound C1=CC=C2CC=CC2=C1 YBYIRNPNPLQARY-UHFFFAOYSA-N 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000005530 alkylenedioxy group Chemical group 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 abstract 2
- 125000006727 (C1-C6) alkenyl group Chemical group 0.000 abstract 1
- 229910003827 NRaRb Inorganic materials 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003302 alkenyloxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000005199 aryl carbonyloxy group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 235000010290 biphenyl Nutrition 0.000 abstract 1
- 239000004305 biphenyl Substances 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 230000001193 melatoninergic effect Effects 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000006684 polyhaloalkyl group Polymers 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001712 tetrahydronaphthyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Emergency Medicine (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Cardiology (AREA)
- Child & Adolescent Psychology (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Un compuesto de indenoindolona de fórmula (1), en donde: R representa un átomo de hidrógeno o un grupo alquenilo C1-6 lineal o ramificado o alquilo C1-6 lineal o ramificado, opcionalmente sustituido por un grupo carboxi o por un grupo de fórmula -NRaRb en donde cada uno de Ra y Rb, que pueden ser iguales o diferentes, representan un átomo de hidrógeno o un grupo alquilo C1-6 lineal o ramificado, o forman junto con el átomo de nitrógeno que los lleva un heterociclo que contiene nitrógeno; cada uno de R1, R2, R3, R4, R5, R6, R7 y R8, que pueden ser iguales o diferentes, representan un átomo de hidrógeno o un grupo alquilo C1-6 lineal o ramificado, alquenilo C1-6 lineal o ramificado, hidroxi, alcoxi C1-6 lineal o ramificado, alqueniloxi C1-6 lineal o ramificado, arilo-alquilo C1-6 en donde la mitad alquilo es lineal o ramificada, arilo-alcoxi C1-6 en donde la mitad alcoxi es lineal o ramificada, carboxi, aciloxi C1-6 lineal o ramificado o arilcarboniloxi; o uno de los grupos R1 a R8 forma con uno adyacente de los grupos R1 a R8 un grupo alquilenodioxi C1-2, sus isómeros ópticos, cuando existen, y sales de adición de los mismos con un ácido o una base farmacéuticamente aceptable; con la condición de que: cuando R no representa un átomo de hidrógeno, entonces por lo menos uno de los grupos R1 a R8 representa un grupo hidroxi o alcoxi C1-6 lineal o ramificado; y los compuestos de fórmula (1) son distintos de indeno[1,2-b]indol-10(5H)-ona; entendiéndose que el término "arilo" significa fenilo, bifenililo, naftilo, o tetrahidronaftilo, siendo cada uno de estos grupos opcionalmente sustituido por uno o más átomos o grupos iguales o diferentes seleccionados entre átomos de halógeno y grupos alquilo C1-6 lineales o ramificados, grupos hidroxi, alcoxi C1-6 lineales o ramificados, polihaloalquilo C1-6 lineales o ramificados, grupos amino (opcionalmente sustituidos por uno o más grupos alquilo C1-6 lineales o ramificados), grupos nitro, acilo C1-6 lineales o ramificados y alquilenodioxi C1-2. También se divulga un procedimiento para la preparación del compuesto y una composición farmacéutica que lo comprende. El compuesto y la composición farmacéutica que lo comprende han probado ser útiles en el tratamiento de los trastornos del sistema melatoninérgico.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0103667A FR2822153B1 (fr) | 2001-03-19 | 2001-03-19 | Nouveaux derives d'indenoindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR034861A1 true AR034861A1 (es) | 2004-03-24 |
Family
ID=8861264
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020100952A AR034861A1 (es) | 2001-03-19 | 2002-03-18 | Un compuesto de indenoindolona, un procedimiento para su preparacion y una composicion farmaceutica que lo comprende |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US6844445B2 (es) |
| EP (1) | EP1245565B1 (es) |
| JP (1) | JP3886829B2 (es) |
| KR (1) | KR100453979B1 (es) |
| CN (1) | CN1185214C (es) |
| AR (1) | AR034861A1 (es) |
| AT (1) | ATE250578T1 (es) |
| AU (1) | AU780027B2 (es) |
| BR (1) | BR0200871A (es) |
| CA (1) | CA2378628C (es) |
| DE (1) | DE60200041T2 (es) |
| DK (1) | DK1245565T3 (es) |
| EA (1) | EA004711B1 (es) |
| ES (1) | ES2207629T3 (es) |
| FR (1) | FR2822153B1 (es) |
| HK (1) | HK1049159B (es) |
| HU (1) | HU226674B1 (es) |
| MX (1) | MXPA02002816A (es) |
| NO (1) | NO321890B1 (es) |
| NZ (1) | NZ517855A (es) |
| PL (1) | PL352866A1 (es) |
| PT (1) | PT1245565E (es) |
| SI (1) | SI1245565T1 (es) |
| ZA (1) | ZA200202220B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102006047231B4 (de) * | 2006-10-04 | 2009-02-12 | Hemmerling, Hans-Jörg, Dr. | Substituierte Indeno[1,2-b]indolderivate als neue Hemmstoffe der Protein Kinase CK2 und ihre Verwendung als Tumor Therapeutika, Cytostatika und Diagnostika |
| ES2580702B1 (es) | 2015-02-25 | 2017-06-08 | Palobiofarma, S.L. | Derivados de 2-aminopiridina como antagonistas del receptor A2b de adenosina y ligandos del receptor MT3 de melatonina |
| PT3684767T (pt) | 2017-09-22 | 2024-07-29 | Jubilant Epipad LLC | Compostos heterocíclicos como inibidores de pad |
| CA3076476A1 (en) | 2017-10-18 | 2019-04-25 | Jubilant Epipad LLC | Imidazo-pyridine compounds as pad inhibitors |
| US11629135B2 (en) | 2017-11-06 | 2023-04-18 | Jubilant Prodell Llc | Pyrimidine derivatives as inhibitors of PD1/PD-L1 activation |
| AU2018372211B2 (en) | 2017-11-24 | 2023-02-02 | Jubilant Episcribe LLC, | Heterocyclic compounds as PRMT5 inhibitors |
| JP7279063B6 (ja) | 2018-03-13 | 2024-02-15 | ジュビラント プローデル エルエルシー | Ｐｄ１／ｐｄ－ｌ１相互作用／活性化の阻害剤としての二環式化合物 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU8713291A (en) * | 1990-10-16 | 1992-05-20 | University Of Bath | Indenoindole compounds |
-
2001
- 2001-03-19 FR FR0103667A patent/FR2822153B1/fr not_active Expired - Fee Related
-
2002
- 2002-03-14 MX MXPA02002816A patent/MXPA02002816A/es active IP Right Grant
- 2002-03-18 SI SI200230003T patent/SI1245565T1/xx unknown
- 2002-03-18 AR ARP020100952A patent/AR034861A1/es unknown
- 2002-03-18 CN CNB021075778A patent/CN1185214C/zh not_active Expired - Fee Related
- 2002-03-18 JP JP2002073851A patent/JP3886829B2/ja not_active Expired - Fee Related
- 2002-03-18 AT AT02290668T patent/ATE250578T1/de not_active IP Right Cessation
- 2002-03-18 PT PT02290668T patent/PT1245565E/pt unknown
- 2002-03-18 DE DE60200041T patent/DE60200041T2/de not_active Expired - Fee Related
- 2002-03-18 NZ NZ517855A patent/NZ517855A/xx unknown
- 2002-03-18 NO NO20021330A patent/NO321890B1/no not_active IP Right Cessation
- 2002-03-18 EP EP02290668A patent/EP1245565B1/fr not_active Expired - Lifetime
- 2002-03-18 DK DK02290668T patent/DK1245565T3/da active
- 2002-03-18 EA EA200200263A patent/EA004711B1/ru unknown
- 2002-03-18 ES ES02290668T patent/ES2207629T3/es not_active Expired - Lifetime
- 2002-03-19 BR BR0200871-8A patent/BR0200871A/pt not_active IP Right Cessation
- 2002-03-19 ZA ZA200202220A patent/ZA200202220B/xx unknown
- 2002-03-19 US US10/100,784 patent/US6844445B2/en not_active Expired - Fee Related
- 2002-03-19 CA CA002378628A patent/CA2378628C/fr not_active Expired - Fee Related
- 2002-03-19 AU AU27469/02A patent/AU780027B2/en not_active Ceased
- 2002-03-19 KR KR10-2002-0014738A patent/KR100453979B1/ko not_active Expired - Fee Related
- 2002-03-19 PL PL02352866A patent/PL352866A1/xx not_active IP Right Cessation
- 2002-03-19 HU HU0201024A patent/HU226674B1/hu not_active IP Right Cessation
-
2003
- 2003-02-18 HK HK03101148.6A patent/HK1049159B/zh not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |