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AR034405A1 - Composiciones farmaceuticas que contienen derivados de 3-amino-azetidina, los nuevos derivados y su preparacion - Google Patents

Composiciones farmaceuticas que contienen derivados de 3-amino-azetidina, los nuevos derivados y su preparacion

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Publication number
AR034405A1
AR034405A1 ARP010101025A ARP010101025A AR034405A1 AR 034405 A1 AR034405 A1 AR 034405A1 AR P010101025 A ARP010101025 A AR P010101025A AR P010101025 A ARP010101025 A AR P010101025A AR 034405 A1 AR034405 A1 AR 034405A1
Authority
AR
Argentina
Prior art keywords
alkyl
alq
radical
cooalq
substituted
Prior art date
Application number
ARP010101025A
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English (en)
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Aventis Pharma Sa
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Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of AR034405A1 publication Critical patent/AR034405A1/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/20—Hypnotics; Sedatives
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P27/00—Drugs for disorders of the senses
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
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  • Hematology (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Nutrition Science (AREA)
  • Immunology (AREA)
  • Reproductive Health (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Se describen composiciones farmacéuticas que contienen como ingrediente activo un compuesto derivado de la 3-amino-azetidina, de fórmula (1), en la que: R1 representa un radical -NHCOR4 o -N(R5)-Y-R6; Y es CO ó SO2; R2 y R3, idénticos o diferentes, representan ya sea un aromático elegido entre fenilo, naftilo e indenilo, estando estos aromáticos no sustituidos o sustituidos por uno o varios halógeno, alquilo, alcoxi, formilo, hidroxi, trifluorometilo, trifluorometoxi, -CO-alq, ciano, -COOH, -COOalq, -CONR7R8, -CO-NH-NR9R10, alquilsulfanilo, alquilsulfinilo, alquilsulfonilo, alquilsulfanilalquilo, alquilsulfinilalquilo, alquilsulfonilalquilo, hidroxialquilo o -alq-NR7R8; o bien un heteroaromático elegido entre los ciclos benzofurilo, benzotiazolilo, benzotienilo, benzoxazolilo, cromanilo, 2,3-dihidrobenzofurilo, 2,3-dihidrobenzotienilo, pirimidinilo, furilo, imidazolilo, isocromanilo, isoquinolilo, pirrolilo, piridilo, quinolilo, 1,2,3,4-tetrahidroisoquinolilo, tiazolilo y tienilo, que estos heteroaromáticos pueden ser no sustituidos o sustituidos por un halógeno, alquilo, alcoxi, hidroxi, trifluorometilo, trifluorometoxi, ciano, -COOH, COOalq, -CO-NH-NR9R10, -CONR7R8, -alq-NR9R10, alquilsulfanilo, alquilsulfinilo, alquilsulfonilo, alquilsulfanilalquilo, alquilsulfinilalquilo, alquilsulfonilalquilo o hidroxialquilo; R4 representa un radical -alq-SO2-R11, alq-SO2-CH=CH-R11, Het sustituido por -SO2-R11 o fenilo sustituido por -SO2-R11 o -alq-SO2-R11; R5 representa un átomo de hidrógeno o un radical alquilo; R6 representa un radical fenilalquilo, Het o Ar; R7 y R8, idénticos o diferentes, representan un átomo de hidrógeno o un radical alquilo o bien R7 y R8 forman junto con el átomo de nitrógeno al que están enlazados un heterociclo mono o bicíclico saturado que tiene 3 a 10 eslabones, que contienen eventualmente otro heteroátomo elegido entre oxígeno, azufre y nitrógeno, y que está eventualmente sustituido por uno o varios alquilo; R9 y R10, idénticos o diferentes, representan un átomo de hidrógeno o un radical alquilo, -COOalq, cicloalquilo, alquilcicloalquilo, -alq-O-alq o hidroxialquilo, o bien R9 y R10 forman junto con el átomo de nitrógeno al que están enlazados un heterociclo mono o bicíclico saturado o insaturado que tiene 3 a 10 eslabones, que contienen eventualmente otro heteroátomo elegido entre oxígeno, azufre y nitrógeno, y que está eventualmente sustituido por uno o varios alquilo, -COalq, -COOalq, -CO-NHalq, -CS-NHalq, oxo, hidroxialquilo, -alq-O-alq ó -CO-NH2; R11 representa un radical alquilo, Ar o Het; Ar representa un radical fenilo, naftilo o indenilo, que estos radicales están eventualmente sustituidos por uno o varios halógeno, alquilo, alcoxi, ciano, -CO-alq, -COOH, -COOalq, -CONR12R13, -CO-NH-NR14R15, alquilsulfanilo, alquilsulfinilo, alquilsulfonilo, -alq-NR14R15, -NR14R15, alquiltioalquilo, formilo, hidroxi, hidroxialquilo, Het, -O-alq-NH-cicloalquilo, OCF3, CF3, -NH-CO-alq, SO2NH2, NH-COCH3, NH-COOalq, Het o bien sobre 2 átomos de carbono adyacentes por dioximetileno; Het representa un heterociclo mono o bicíclico insaturado o saturado, que tiene 3 a 10 eslabones y que contiene uno o varios heteroátomos elegidos entre oxígeno, azufre y nitrógeno, eventualmente sustituido por uno o varios alquilo, alcoxi, vinilo, halógeno, alcoxicarbonilo, oxo, hidroxi, OCF3 o CF3, que los heterociclos nitrogenados están eventualmente bajo su forma N-oxidada; R12 y R13, idénticos o diferentes, representan un átomo de hidrógeno o un radical alquilo o bien R12 y R13 forman junto con el átomo de nitrógeno al que están enlazados un heterociclo mono o bicíclico saturado que tiene 3 a 10 eslabones, que contiene eventualmente otro heteroátomo elegido entre oxígeno azufre y nitrógeno y que está eventualmente sustituido por uno o varios radicales alquilo; R14 y R15, idénticos o diferentes, representan un átomo de hidrógeno o un radical alquilo, -COOalq, cicloalquilo, alquilcicloalquilo, alq-O-alq, hidroxialquilo o bien R14 y R15 forman junto con el átomo de nitrógeno al que están enlazados un heterociclo mono o bicíclico saturado o insaturado que tiene 3 a 10 eslabones, que contiene eventualmente otro heteroátomo elegido entre oxígeno, azufre y nitrógeno y que está eventualmente sustituido por uno o varios radicales alquilo, -CO-alq, -COOalq, -CO-NHalq, -CS-NHalq, oxo, hidroxialquilo, -alq-O-alq ó -CO-NH2; alq representa un radical alquilo o alquileno; los radicales y porciones alquilo y alquileno y los radicales y porciones alcoxi son de cadena recta o ramificada y contienen C1-6 y los radicales cicloalquilo contienen C3-10; un isómero óptico de tal compuesto o una de sus sales farmacéuticamente aceptables. También se describen los derivados de fórmula (1) con exclusión de los compuestos (1), en donde R2 y R3 representan fenilo, R1 representa un radical -N(R5)-Y-R6, Y es SO2, R5 es un radical metilo y R6 es fenilo. Finalmente, se describe el procedimiento para preparar dichos derivados de fórmula (1). Los compuestos (1) son útiles para tratar y prevenir desórdenes que afectan el sistema nervioso central, el sistema inmunitario, el sistema cardio-vascular o endócrino, el sistema respiratorio, el aparato gastro-intestinal y los desórdenes de la reproducción.
ARP010101025A 2000-03-03 2001-03-02 Composiciones farmaceuticas que contienen derivados de 3-amino-azetidina, los nuevos derivados y su preparacion AR034405A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0002777A FR2805810B1 (fr) 2000-03-03 2000-03-03 Compositions pharmaceutiques contenant des derives de 3- amino-azetidine, les nouveaux derives et leur preparation

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AR034405A1 true AR034405A1 (es) 2004-02-25

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EP (1) EP1263721B1 (es)
JP (1) JP2003525269A (es)
KR (1) KR100813740B1 (es)
CN (1) CN1187325C (es)
AR (1) AR034405A1 (es)
AT (1) ATE478840T1 (es)
AU (2) AU3752601A (es)
BG (1) BG107057A (es)
BR (1) BR0108894A (es)
CA (1) CA2400138A1 (es)
CY (1) CY1111075T1 (es)
DE (1) DE60142890D1 (es)
DK (1) DK1263721T3 (es)
DZ (1) DZ3311A1 (es)
EA (1) EA004649B1 (es)
EE (1) EE05081B1 (es)
ES (1) ES2351183T3 (es)
FR (1) FR2805810B1 (es)
HR (1) HRP20020710A2 (es)
HU (1) HUP0300350A2 (es)
IL (2) IL151209A0 (es)
MA (1) MA26879A1 (es)
MX (1) MXPA02008346A (es)
NO (1) NO324523B1 (es)
NZ (1) NZ521076A (es)
OA (1) OA12221A (es)
PL (1) PL365007A1 (es)
PT (1) PT1263721E (es)
SI (1) SI1263721T1 (es)
SK (1) SK12442002A3 (es)
TW (1) TWI294420B (es)
UA (1) UA72319C2 (es)
WO (1) WO2001064633A1 (es)
YU (1) YU65902A (es)
ZA (1) ZA200206916B (es)

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